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Grant Details

Grant Number: 5R03CA130061-02 Interpret this number
Primary Investigator: Maskarinec, Gertraud
Organization: University Of Hawaii At Manoa
Project Title: Inflammatory Markers in a 2-Year Soy Intervention Among Premenopausal Women
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): The proposed project makes uses of existing serum samples collected during a 2-year randomized soy trial. Epidemiologic evidence supports a role for soy foods and isoflavones in breast cancer prevention, but the possible mechanisms of action are not well understood. Based on results from animal studies and human interventions, we hypothesize that soy reduces chronic inflammation, a possible risk factor for breast cancer. The original study and other reports indicate that the preventive effects of soy on breast cancer, if they exist, are not mediated by circulating sex hormones. The growing interest in an inflammatory etiology for cancer, as well as findings that link nutritional factors to immune responses, support our hypothesis. The aim of this study is to examine the effects of two daily servings of soy on serum levels of inflammatory markers. In addition, we will explore differences in serum levels of inflammatory markers by ethnicity, body mass index, and lifetime soy intake. During the 2-year nutritional intervention, 220 premenopausal women were randomized and donated multiple blood samples during the luteal phase as determined by an ovulation kit. The intervention group consumed two daily servings of soy foods, predominantly tofu, soy milk, and soy nuts, while the control women maintained their regular diet. According to several measures, compliance with the study regimen was excellent. The number of dropouts did not differ by group: 17 (15.6%) intervention women and 14 (12.6%) controls left the study prematurely. The subjects gave written permission to use their specimens for future analyses. Frozen serum samples stored at -80C will be analyzed for six inflammatory markers, adiponectin, leptin, interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-a, and IL-1b, using established ELISA assays. For each of the 205 subjects (100 intervention subjects and 105 controls) with serum samples, we will analyze four samples, one each collected at baseline, after 6, 12, and 24 months. The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design.

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Publications

Soy Food Intake and Biomarkers of Breast Cancer Risk: Possible Difference in Asian Women?
Authors: Maskarinec G. , Ju D. , Morimoto Y. , Franke A.A. , Stanczyk F.Z. .
Source: Nutrition and cancer, 2017 01; 69(1), p. 146-153.
EPub date: 2016-12-05.
PMID: 27918846
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Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.
Authors: Engel B.J. , Constantinou P.E. , Sablatura L.K. , Doty N.J. , Carson D.D. , Farach-Carson M.C. , Harrington D.A. , Zarembinski T.I. .
Source: Advanced healthcare materials, 2015-08-05; 4(11), p. 1664-74.
EPub date: 2015-06-09.
PMID: 26059746
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Serum coenzyme Q??, ?-tocopherol, ?-tocopherol, and C-reactive protein levels and body mass index in adolescent and premenopausal females.
Authors: Chai W. , Novotny R. , Maskarinec G. , Le Marchand L. , Franke A.A. , Cooney R.V. .
Source: Journal of the American College of Nutrition, 2014; 33(3), p. 192-7.
EPub date: 2014-05-08.
PMID: 24809382
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Leptin, adiponectin, and obesity among Caucasian and Asian women.
Authors: Conroy S.M. , Chai W. , Lim U. , Franke A.A. , Cooney R.V. , Maskarinec G. .
Source: Mediators of inflammation, 2011; 2011, p. 253580.
EPub date: 2011-02-08.
PMID: 21331287
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Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population.
Authors: Chai W. , Maskarinec G. , Cooney R.V. .
Source: European journal of clinical nutrition, 2010 Jun; 64(6), p. 652-4.
EPub date: 2010-03-10.
PMID: 20216557
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Associations between obesity and serum lipid-soluble micronutrients among premenopausal women.
Authors: Chai W. , Conroy S.M. , Maskarinec G. , Franke A.A. , Pagano I.S. , Cooney R.V. .
Source: Nutrition research (New York, N.Y.), 2010 Apr; 30(4), p. 227-32.
PMID: 20534324
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The relation of leptin and adiponectin with breast density among premenopausal women.
Authors: Maskarinec G. , Woolcott C. , Steude J.S. , Franke A.A. , Cooney R.V. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2010 Jan; 19(1), p. 55-60.
PMID: 19927000
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Inflammatory markers in a 2-year soy intervention among premenopausal women.
Authors: Maskarinec G. , Steude J.S. , Franke A.A. , Cooney R.V. .
Source: Journal of inflammation (London, England), 2009-04-07; 6, p. 9.
EPub date: 2009-04-07.
PMID: 19348684
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