Skip to main content
Grant Details

Grant Number: 5R01CA098870-06 Interpret this number
Primary Investigator: Risch, Harvey
Organization: Yale University
Project Title: Case-Control Study of Pancreas Cancer Etiologic Factors
Fiscal Year: 2008
Back to top


Abstract

DESCRIPTION (provided by applicant): In the US in 2001, there were about 29,000 new cases of cancer of the pancreas, and nearly that number died from it, making it the 4th most frequent cause of cancer death, after lung, breast/prostate and colorectal cancer. Over the lifetime, more than 1% of the population is affected, with blacks having a bit higher rates than whites. Survival with this cancer is dismal: one year about 20-30%, and 5-year, about 5%. Most patients present with advanced disease, and the standard treatments do not much alter the progressive, fatal course. Aside from major-gene causes underlying perhaps 5% of cases, the one known risk factor for pancreatic cancer is cigarette smoking, which doubles the risk. Studies of dietary factors have not been entirely consistent but do suggest associations of higher risk with animal product intake and lower risk with consumption of fruits or vegetables. This application describes a new hypothesis on the etiology of pancreatic cancer, and provides a substantial body of laboratory and epidemiologic evidence in support of it. To examine this hypothesis, we will conduct, in the state of CT, a population-based case-control study to examine infectious, genetic, dietary, lifestyle and medical history factors. In total, 600 pancreas-cancer cases aged 35-79 years will be identified prospectively via the ultra-rapid program of the Rapid Case Ascertainment Shared Resource at Yale. About 600 randomly selected population controls will be frequency matched to the cases by age and gender. Controls will be identified using enhanced random-digit dialing methods. All subjects will be interviewed in person by trained interviewers using a standardized, structured questionnaire that will include sections on tobacco use and medical history, a standard food frequency/supplements questionnaire, and questions about other factors specific to our hypothesis. A small blood sample will be drawn for use in testing for exposure to certain infections, and for four DNA polymorphisms relevant to our hypothesis. Average daily intake of dietary nutrients will be calculated from the diet histories, and uni- and multivariate analyses will be used to estimate relative risks for comparison of the cases with the controls. The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project.

Back to top


Publications

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study.
Authors: Chen F. , Childs E.J. , Mocci E. , Bracci P. , Gallinger S. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , Bamlet W.R. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 Jul; 28(7), p. 1238-1245.
EPub date: 2019-04-23.
PMID: 31015203
Related Citations

Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews.
Authors: Streicher S.A. , Klein A.P. , Olson S.H. , Amundadottir L.T. , DeWan A.T. , Zhao H. , Risch H.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 10; 26(10), p. 1540-1548.
EPub date: 2017-07-28.
PMID: 28754795
Related Citations

Low-Dose Aspirin and Pancreatic Cancer Risk-Reply.
Authors: Risch H.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 07; 26(7), p. 1155-1156.
EPub date: 2017-06-20.
PMID: 28634185
Related Citations

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis.
Authors: McWilliams R.R. , Maisonneuve P. , Bamlet W.R. , Petersen G.M. , Li D. , Risch H.A. , Yu H. , Fontham E.T. , Luckett B. , Bosetti C. , et al. .
Source: Pancreas, 2016 Feb; 45(2), p. 311-6.
PMID: 26646264
Related Citations

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.
Authors: Campa D. , Rizzato C. , Stolzenberg-Solomon R. , Pacetti P. , Vodicka P. , Cleary S.P. , Capurso G. , Bueno-de-Mesquita H.B. , Werner J. , Gazouli M. , et al. .
Source: International journal of cancer, 2015-11-01; 137(9), p. 2175-83.
EPub date: 2015-06-19.
PMID: 25940397
Related Citations

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Authors: Childs E.J. , Mocci E. , Campa D. , Bracci P.M. , Gallinger S. , Goggins M. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , et al. .
Source: Nature genetics, 2015 Aug; 47(8), p. 911-6.
EPub date: 2015-06-22.
PMID: 26098869
Related Citations

Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Waterhouse M. , Risch H.A. , Bosetti C. , Anderson K.E. , Petersen G.M. , Bamlet W.R. , Cotterchio M. , Cleary S.P. , Ibiebele T.I. , La Vecchia C. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2015 Aug; 26(8), p. 1776-83.
EPub date: 2015-05-14.
PMID: 25977560
Related Citations

Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis.
Authors: Risch H.A. , Yu H. , Lu L. , Kidd M.S. .
Source: American journal of epidemiology, 2015-07-01; 182(1), p. 26-34.
EPub date: 2015-06-06.
PMID: 26049860
Related Citations

Plasma metabolite biomarkers for the detection of pancreatic cancer.
Authors: Xie G. , Lu L. , Qiu Y. , Ni Q. , Zhang W. , Gao Y.T. , Risch H.A. , Yu H. , Jia W. .
Source: Journal of proteome research, 2015-02-06; 14(2), p. 1195-202.
EPub date: 2014-12-08.
PMID: 25429707
Related Citations

Case-control study of aspirin use and risk of pancreatic cancer.
Authors: Streicher S.A. , Yu H. , Lu L. , Kidd M.S. , Risch H.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Jul; 23(7), p. 1254-63.
PMID: 24969230
Related Citations

A new estimation approach for combining epidemiological data from multiple sources.
Authors: Huang H. , Ma X. , Waagepetersen R. , Holford T.R. , Wang R. , Risch H. , Mueller L. , Guan Y. .
Source: Journal of the American Statistical Association, 2014-01-01; 109(505), p. 11-23.
PMID: 24683281
Related Citations

Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bosetti C. , Lucenteforte E. , Bracci P.M. , Negri E. , Neale R.E. , Risch H.A. , Olson S.H. , Gallinger S. , Miller A.B. , Bueno-de-Mesquita H.B. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2013 Nov; 24(11), p. 2903-10.
EPub date: 2013-08-22.
PMID: 23970016
Related Citations

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein A.P. , Lindström S. , Mendelsohn J.B. , Steplowski E. , Arslan A.A. , Bueno-de-Mesquita H.B. , Fuchs C.S. , Gallinger S. , Gross M. , Helzlsouer K. , et al. .
Source: PloS one, 2013; 8(9), p. e72311.
EPub date: 2013-09-13.
PMID: 24058443
Related Citations

Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Duell E.J. , Lucenteforte E. , Olson S.H. , Bracci P.M. , Li D. , Risch H.A. , Silverman D.T. , Ji B.T. , Gallinger S. , Holly E.A. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2012 Nov; 23(11), p. 2964-70.
EPub date: 2012-07-05.
PMID: 22767586
Related Citations

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D. , Duell E.J. , Yu K. , Risch H.A. , Olson S.H. , Kooperberg C. , Wolpin B.M. , Jiao L. , Dong X. , Wheeler B. , et al. .
Source: Carcinogenesis, 2012 Jul; 33(7), p. 1384-90.
EPub date: 2012-04-20.
PMID: 22523087
Related Citations

Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).
Authors: Bosetti C. , Lucenteforte E. , Silverman D.T. , Petersen G. , Bracci P.M. , Ji B.T. , Negri E. , Li D. , Risch H.A. , Olson S.H. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2012 Jul; 23(7), p. 1880-8.
EPub date: 2011-11-21.
PMID: 22104574
Related Citations

Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.
Authors: Zeng H. , Yu H. , Lu L. , Jain D. , Kidd M.S. , Saif M.W. , Chanock S.J. , Hartge P. , PanScan Consortium , Risch H.A. .
Source: Pancreas, 2011 Jul; 40(5), p. 657-63.
PMID: 21487324
Related Citations

Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bertuccio P. , La Vecchia C. , Silverman D.T. , Petersen G.M. , Bracci P.M. , Negri E. , Li D. , Risch H.A. , Olson S.H. , Gallinger S. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2011 Jun; 22(6), p. 1420-6.
EPub date: 2011-01-18.
PMID: 21245160
Related Citations




Back to Top