Grant Number:	1R01CA125224-01A2 Interpret this number
Primary Investigator:	Connolly, Gregory
Organization:	Harvard School Of Public Health
Project Title:	Subjective and Behavioral Responses to Prep Design and Marketing
Fiscal Year:	2008

DESCRIPTION (provided by applicant): Tobacco manufacturers have recently introduced what the Institute of Medicine describes as potential reduced (tobacco) exposure products (PREPs), including modified cigarettes, novel nicotine delivery devices and oral snuff. These products are promoted with implied and explicit claims of reduced health risk, made without independent scientific validation. Manufacturers have also altered the design of PREPS, potentially in order to enhance consumer acceptability, contribute to dependence, and alter consumer perceptions of PREP "safety." Despite the lack of research to support PREP health claims, PREPs ultimately may achieve market success through manipulation of product design and marketing to enhance consumer appeal and dependence. PREPs could increase youth initiation or experimentation with tobacco, deter quitting, and help to maintain use among current smokers, thus increasing tobacco-related cancer and other health risk. An effective understanding of the influence of PREP design and marketing on consumer response is urgently required to complement existing research on tobacco harm reduction, and provide an effective public health response to the introduction of new tobacco products. The objectives of this project are to examine the inter-relationships between PREP design and marketing and their effects on consumer response and acceptance, in order to evaluate the potential commercial impact of new and future PREPs. Specifically, the project aims include: 1) identifying and evaluating design characteristics unique to PREPs; 2) evaluating the interaction between messaging and product design; and 3) assessing the influence of product design on smoking behavior and exposure. Multiple dimensions of PREP design and marketing will be investigated, with particular focus on behavioral and sensory response to PREPs as compared with conventional cigarettes. The objectives of this project are to examine the inter-relationships between PREP design and marketing and their effects on consumer response and acceptance, in order to evaluate the potential commercial impact of new and future PREPs. Multiple dimensions of PREP design and marketing will be investigated, with particular focus on behavioral and sensory response to PREPs as compared with conventional cigarettes.




A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction.
Authors: Alpert H.R. , Agaku I.T. , Connolly G.N. .
Source: Tobacco Control, 2016 Jul; 25(4), p. 444-50.
PMID: 26063608
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Effectiveness of the cigarette ignition propensity standard in preventing unintentional residential fires in Massachusetts.
Authors: Alpert H.R. , Christiani D.C. , Orav E.J. , Dockery D.W. , Connolly G.N. .
Source: American Journal Of Public Health, 2014 Apr; 104(4), p. e56-61.
PMID: 24524537
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Has the tobacco industry evaded the FDA's ban on 'Light' cigarette descriptors?
Authors: Connolly G.N. , Alpert H.R. .
Source: Tobacco Control, 2014 Mar; 23(2), p. 140-5.
PMID: 23485704
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Gender and racial differences in smoking of long/ultra-long and king size cigarettes among U.S. adult smokers, NHANES 1999-2012.
Authors: Agaku I.T. , Vardavas C.I. , Ayo-Yusuf O.A. , Alpert H.R. , Connolly G.N. .
Source: Drug And Alcohol Dependence, 2014-03-01 00:00:00.0; 136, p. 28-35.
EPub date: 2014-03-01 00:00:00.0.
PMID: 24417962
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Cigarette rod length and its impact on serum cotinine and urinary total NNAL levels, NHANES 2007-2010.
Authors: Agaku I.T. , Vardavas C.I. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 Jan; 16(1), p. 100-7.
PMID: 24057994
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Predictors and patterns of cigarette and smokeless tobacco use among adolescents in 32 countries, 2007-2011.
Authors: Agaku I.T. , Ayo-Yusuf O.A. , Vardavas C.I. , Connolly G. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2014 Jan; 54(1), p. 47-53.
PMID: 24060573
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Proposed cutoff for identifying adult smokeless tobacco users with urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol: an aggregated analysis of NHANES 2007-2010 data.
Authors: Agaku I.T. , Vardavas C.I. , Connolly G. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2013 Nov; 15(11), p. 1956-61.
PMID: 23956252
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Use of conventional and novel smokeless tobacco products among US adolescents.
Authors: Agaku I.T. , Ayo-Yusuf O.A. , Vardavas C.I. , Alpert H.R. , Connolly G.N. .
Source: Pediatrics, 2013 Sep; 132(3), p. e578-86.
PMID: 23918889
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Role of cigarette sensory cues in modifying puffing topography.
Authors: Rees V.W. , Kreslake J.M. , Wayne G.F. , O'Connor R.J. , Cummings K.M. , Connolly G.N. .
Source: Drug And Alcohol Dependence, 2012-07-01 00:00:00.0; 124(1-2), p. 1-10.
EPub date: 2012-07-01 00:00:00.0.
PMID: 22365895
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R. J. Reynolds goes international with new dissolvable tobacco products.
Authors: Seidenberg A.B. , Rees V.W. , Connolly G.N. .
Source: Tobacco Control, 2012 May; 21(3), p. 368-9.
PMID: 21984408
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Public attitudes regarding banning of cigarettes and regulation of nicotine.
Authors: Connolly G.N. , Behm I. , Healton C.G. , Alpert H.R. .
Source: American Journal Of Public Health, 2012 Apr; 102(4), p. e1-2.
PMID: 22397353
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Influence of measurement setting and home smoking policy on smoking topography.
Authors: June K.M. , Norton K.J. , Rees V.W. , O'Connor R.J. .
Source: Addictive Behaviors, 2012 Jan; 37(1), p. 42-6.
PMID: 21862228
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Applying toxicological risk assessment principles to constituents of smokeless tobacco products: implications for product regulation.
Authors: Ayo-Yusuf O.A. , Connolly G.N. .
Source: Tobacco Control, 2011 Jan; 20(1), p. 53-7.
PMID: 20924040
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Electronic cigarettes: a new 'tobacco' industry?
Authors: Noel J.K. , Rees V.W. , Connolly G.N. .
Source: Tobacco Control, 2011 Jan; 20(1), p. 81.
PMID: 20930060
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Swedish Match marketing on YouTube.
Authors: Seidenberg A.B. , Rees V.W. , Connolly G.N. .
Source: Tobacco Control, 2010 Dec; 19(6), p. 512-3.
PMID: 20930059
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Assessing consumer responses to potential reduced-exposure tobacco products: a review of tobacco industry and independent research methods.
Authors: Rees V.W. , Kreslake J.M. , Cummings K.M. , O'Connor R.J. , Hatsukami D.K. , Parascandola M. , Shields P.G. , Connolly G.N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Dec; 18(12), p. 3225-40.
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