Grant Number:	1R21CA125458-01A2 Interpret this number
Primary Investigator:	Jones, Lee
Organization:	Duke University
Project Title:	Using Message Framing to Promote Physical Activity in Colorectal Cancer Survivors
Fiscal Year:	2008

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) survivors who exercise are at reduced risk of death than their sedentary counterparts. The implementation of efficacious exercise promotion interventions targeting the least active CRC survivors is of paramount importance. Messages that stress the gains (i.e., advantages) of engaging in recommended behaviors or the losses (i.e., disadvantages) of not following recommended behaviors have shown to motivate behavior change. In general, gain frame messages increase intentions to exercise more than loss frame messages. Whether gain-frame messages increase exercise among sedentary CRC survivors has never been tested. Due to their diagnosis and treatment of CRC, serving as a possible "teachable moment", CRC survivors may be especially sensitive to framing effects. A major aim of this study is to determine among 120 early stage sedentary CRC survivors whether gain-frame messages increase total minutes of moderate to vigorous exercise more than loss-framed messages. We will explore mediation for possible effects of framing on exercise. CRC survivors will complete a baseline survey that assesses prevalently-used theoretical frameworks for exercise promotion, including implementation intentions and processes of change. Participants will be assigned at random to receive a brochure containing either gain- or loss-frame messages associated with exercise, along with tips to increase exercise and a toll free number to receive additional instructive brochures on exercise. All participants will complete a one-month follow-up survey to assess exercise, intentions to exercise as well as several of the baseline measures (e.g., perceived risks and worry, barriers to exercise, attitudes towards exercise). This will be the first study to test how framing affects levels of exercise in sedentary CRC survivors as well as possible mediators and moderators. Effect sizes and variances obtained can be used to develop and refine a larger intervention trial to more powerfully test the mechanisms and outcomes discussed above. Public Health Relevance: Colorectal Cancer (CRC) survivors who exercise are at lower risk to have recurrence of CRC and mortality than their sedentary counterparts. As such, this study tests an intervention to whether discussing the advantages of exercising (gain frame messages) versus the disadvantages of not exercising (loss frame messages) increases exercise among 120 sedentary CRC survivors. The study also explores for whom and why these messages may be effective.




Message Framing and Physical Activity Promotion in Colorectal Cancer Survivors.
Authors: Hirschey R. , Lipkus I. , Jones L. , Mantyh C. , Sloane R. , Demark-Wahnefried W. .
Source: Oncology Nursing Forum, 2016-11-01 00:00:00.0; 43(6), p. 697-705.
PMID: 27768135
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Effects And Potential Mechanisms Of Exercise Training On Cancer Progression: A Translational Perspective
Authors: Betof A.S. , Dewhirst M.W. , Jones L.W. .
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S75-87.
PMID: 22610066
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Cardiopulmonary Function And Age-related Decline Across The Breast Cancer Survivorship Continuum
Authors: Jones L.W. , Courneya K.S. , Mackey J.R. , Muss H.B. , Pituskin E.N. , Scott J.M. , Hornsby W.E. , Coan A.D. , Herndon J.E. , Douglas P.S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2012-07-10 00:00:00.0; 30(20), p. 2530-7.
PMID: 22614980
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Exercise Modulation Of The Host-tumor Interaction In An Orthotopic Model Of Murine Prostate Cancer
Authors: Jones L.W. , Antonelli J. , Masko E.M. , Broadwater G. , Lascola C.D. , Fels D. , Dewhirst M.W. , Dyck J.R. , Nagendran J. , Flores C.T. , et al. .
Source: Journal Of Applied Physiology (bethesda, Md. : 1985), 2012 Jul; 113(2), p. 263-72.
PMID: 22604887
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Exercise Therapy In The Management Of Dyspnea In Patients With Cancer
Authors: Koelwyn G.J. , Jones L.W. , Hornsby W. , Eves N.D. .
Source: Current Opinion In Supportive And Palliative Care, 2012 Jun; 6(2), p. 129-37.
PMID: 22516976
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Prognostic Significance Of Functional Capacity And Exercise Behavior In Patients With Metastatic Non-small Cell Lung Cancer
Authors: Jones L.W. , Hornsby W.E. , Goetzinger A. , Forbes L.M. , Sherrard E.L. , Quist M. , Lane A.T. , West M. , Eves N.D. , Gradison M. , et al. .
Source: Lung Cancer (amsterdam, Netherlands), 2012 May; 76(2), p. 248-52.
PMID: 22112290
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Exercise Rehabilitation In Patients With Cancer
Authors: Lakoski S.G. , Eves N.D. , Douglas P.S. , Jones L.W. .
Source: Nature Reviews. Clinical Oncology, 2012 May; 9(5), p. 288-96.
PMID: 22392097
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Modulation Of Anthracycline-induced Cardiotoxicity By Aerobic Exercise In Breast Cancer: Current Evidence And Underlying Mechanisms
Authors: Scott J.M. , Khakoo A. , Mackey J.R. , Haykowsky M.J. , Douglas P.S. , Jones L.W. .
Source: Circulation, 2011-08-02 00:00:00.0; 124(5), p. 642-50.
PMID: 21810673
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Exercise Behavior, Functional Capacity, And Survival In Adults With Malignant Recurrent Glioma
Authors: Ruden E. , Reardon D.A. , Coan A.D. , Herndon J.E. , Hornsby W.E. , West M. , Fels D.R. , Desjardins A. , Vredenburgh J.J. , Waner E. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-07-20 00:00:00.0; 29(21), p. 2918-23.
PMID: 21690470
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Effects Of Aerobic Training On Oxidative Status In Postsurgical Non-small Cell Lung Cancer Patients: A Pilot Study
Authors: Jones L.W. , Eves N.D. , Spasojevic I. , Wang F. , Il'yasova D. .
Source: Lung Cancer (amsterdam, Netherlands), 2011 Apr; 72(1), p. 45-51.
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Effect Of Exercise Training On Peak Oxygen Consumption In Patients With Cancer: A Meta-analysis
Authors: Jones L.W. , Liang Y. , Pituskin E.N. , Battaglini C.L. , Scott J.M. , Hornsby W.E. , Haykowsky M. .
Source: The Oncologist, 2011; 16(1), p. 112-20.
PMID: 21212429
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Association between body mass index and mortality in patients with glioblastoma mutliforme.
Authors: Jones L.W. , Ali-Osman F. , Lipp E. , Marcello J.E. , McCarthy B. , McCoy L. , Rice T. , Wrensch M. , Il'yasova D. .
Source: Cancer Causes & Control : Ccc, 2010 Dec; 21(12), p. 2195-201.
PMID: 20838873
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Erratum To: Exercise Therapy In The Management Of Solid Tumors
Authors: Jones L.W. , Peppercorn J. , Scott J.M. , Battaglini C. .
Source: Current Treatment Options In Oncology, 2010 Dec; 11(3-4), p. 73-86.
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Voluntary Running Prevents Progressive Memory Decline And Increases Adult Hippocampal Neurogenesis And Growth Factor Expression After Whole-brain Irradiation
Authors: Wong-Goodrich S.J. , Pfau M.L. , Flores C.T. , Fraser J.A. , Williams C.L. , Jones L.W. .
Source: Cancer Research, 2010-11-15 00:00:00.0; 70(22), p. 9329-38.
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Pre-exercise Screening And Prescription Guidelines For Cancer Patients
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Source: The Lancet. Oncology, 2010 Oct; 11(10), p. 914-6.
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Exercise Therapy In The Management Of Solid Tumors
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