Grant Number:	2R01CA080180-05 Interpret this number
Primary Investigator:	Checkoway, Harvey
Organization:	University Of Washington
Project Title:	Cancer Risks Among Textile Workers in China
Fiscal Year:	2008

DESCRIPTION: During the initial funding cycle, we conducted a comprehensive investigation of cancer risks in relation to occupational exposures among a cohort of 267,400 Shanghai women textile workers. The cohort had been assembled previously for an intervention trial of the efficacy of breast self-exam. In the initial investigation, we determined cancer incidence (1989-1998), developed a comprehensive job/exposure matrix to reconstruct historical exposures, and conducted a nested case-cohort study to investigate associations of 15 site-specific cancers. The strongest prior hypothesis was that endotoxin, a contaminant of cotton dust, would reduce risk for lung cancer. Consistent with this hypothesis, we observed a very strong inverse dose-response gradient of lung cancer risk with cumulative exposure to endotoxin that was most pronounced for early career exposures (lagged 20 years). Not anticipated were very similar inverse dose-response gradients with endotoxin for cancers of the liver, esophagus, stomach, rectum, pancreas, and breast. We also observed associations of site-specific cancer risks with exposures to other agents, such as silica and cancers of the lung, ovary, and endometrium. In this competing renewal application, we are proposing to extend follow-up of the cohort for an additional 8 years through 2006, thus providing the opportunity to determine the consistency of our initial observations regarding endotoxin, and greatly increasing statistical power to examine other associations (e.g., urinary bladder cancer and dyes). An ongoing study of EMF, shift work, and breast cancer that we are conducting in this cohort will provide quantitative data for those exposures. Data on some relevant non- occupational potential confounders (e.g., spousal smoking history) will supplement currently available covariate data on smoking, alcohol use, and reproductive history. The findings from the proposed study will add considerable new information on the potential anti-carcinogenic effect of endotoxin, and the influences of other occupational exposures on risks for multiple different cancers. Exposures to endotoxin, in particular, and to other agents that are common in the textile industry are widespread in many occupational and environmental settings in the US and throughout the world. As such, the findings from this research have good promise to inform disease prevention strategies, and may also have therapeutic implications. PUBLIC HEALTH RELEVANCE: This competing renewal (R01CA80180) is for an updated study to investigate cancer risks among 267,400 women textile workers in Shanghai. We will investigate dose-response relations for endotoxin and other exposures for cancers of the lung, digestive tract, breast, and reproductive organs.




Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin: Follow-Up to a Nested Case-Cohort Study.
Authors: Reul N.K. , Li W. , Gallagher L.G. , Ray R.M. , Romano M.E. , Gao D. , Thomas D.B. , Vedal S. , Checkoway H. .
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PMID: 26849264
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Shift work and breast cancer among women textile workers in Shanghai, China.
Authors: Li W. , Ray R.M. , Thomas D.B. , Davis S. , Yost M. , Breslow N. , Gao D.L. , Fitzgibbons E.D. , Camp J.E. , Wong E. , et al. .
Source: Cancer Causes & Control : Ccc, 2015 Jan; 26(1), p. 143-50.
PMID: 25421377
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Night shift work and lung cancer risk among female textile workers in Shanghai, China.
Authors: Kwon P. , Lundin J. , Li W. , Ray R. , Littell C. , Gao D. , Thomas D.B. , Checkoway H. .
Source: Journal Of Occupational And Environmental Hygiene, 2015; 12(5), p. 334-41.
PMID: 25616851
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Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.
Authors: Checkoway H. , Lundin J.I. , Costello S. , Ray R. , Li W. , Eisen E.A. , Astrakianakis G. , Seixas N. , Applebaum K. , Gao D.L. , et al. .
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EPub date: 2014-07-29 00:00:00.0.
PMID: 24921918
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Occupational exposure to magnetic fields and breast cancer among women textile workers in Shanghai, China.
Authors: Li W. , Ray R.M. , Thomas D.B. , Yost M. , Davis S. , Breslow N. , Gao D.L. , Fitzgibbons E.D. , Camp J.E. , Wong E. , et al. .
Source: American Journal Of Epidemiology, 2013-10-01 00:00:00.0; 178(7), p. 1038-45.
EPub date: 2013-10-01 00:00:00.0.
PMID: 24043439
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Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China.
Authors: Gallagher L.G. , Rosenblatt K.A. , Ray R.M. , Li W. , Gao D.L. , Applebaum K.M. , Checkoway H. , Thomas D.B. .
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PMID: 23584535
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Occupational exposures and mortality from cardiovascular disease among women textile workers in Shanghai, China.
Authors: Gallagher L.G. , Ray R.M. , Li W. , Psaty B.M. , Gao D.L. , Thomas D.B. , Checkoway H. .
Source: American Journal Of Industrial Medicine, 2012 Nov; 55(11), p. 991-9.
PMID: 22968969
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Unexpected excessive chronic obstructive pulmonary disease mortality among female silk textile workers in Shanghai, China.
Authors: Cui L. , Gallagher L.G. , Ray R.M. , Li W. , Gao D. , Zhang Y. , Vedal S. , Thomas D.B. , Checkoway H. .
Source: Occupational And Environmental Medicine, 2011 Dec; 68(12), p. 883-7.
PMID: 21486992
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Reproductive history and mortality from cardiovascular disease among women textile workers in Shanghai, China.
Authors: Gallagher L.G. , Davis L.B. , Ray R.M. , Psaty B.M. , Gao D.L. , Checkoway H. , Thomas D.B. .
Source: International Journal Of Epidemiology, 2011 Dec; 40(6), p. 1510-8.
PMID: 22158661
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Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai.
Authors: Agalliu I. , Costello S. , Applebaum K.M. , Ray R.M. , Astrakianakis G. , Gao D.L. , Thomas D.B. , Checkoway H. , Eisen E.A. .
Source: Cancer Causes & Control : Ccc, 2011 Oct; 22(10), p. 1397-404.
PMID: 21732048
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Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China.
Authors: Checkoway H. , Ray R.M. , Lundin J.I. , Astrakianakis G. , Seixas N.S. , Camp J.E. , Wernli K.J. , Fitzgibbons E.D. , Li W. , Feng Z. , et al. .
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PMID: 21131604
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Identification Of Serum Biomarkers For Biliary Tract Cancers By A Proteomic Approach Based On Time-of-flight Mass Spectrometry
Authors: Wang W.J. , Xu W.H. , Liu C.Z. , Rashid A. , Cheng J.R. , Liao P. , Hu H. , Chu L.W. , Gao Y.T. , Yu K. , et al. .
Source: Cancers, 2010-08-18 00:00:00.0; 2(3), p. 1602-16.
PMID: 24281176
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Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China.
Authors: Wong E.Y. , Ray R. , Gao D.L. , Wernli K.J. , Li W. , Fitzgibbons E.D. , Camp J.E. , Heagerty P.J. , De Roos A.J. , Holt V.L. , et al. .
Source: American Journal Of Industrial Medicine, 2010 May; 53(5), p. 497-505.
PMID: 20340112
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Endotoxin and cancer.
Authors: Lundin J.I. , Checkoway H. .
Source: Environmental Health Perspectives, 2009 Sep; 117(9), p. 1344-50.
PMID: 19750096
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Dust and chemical exposures, and miscarriage risk among women textile workers in Shanghai, China.
Authors: Wong E.Y. , Ray R.M. , Gao D.L. , Wernli K.J. , Li W. , Fitzgibbons E.D. , Camp J.E. , Astrakianakis G. , Heagerty P.J. , De Roos A.J. , et al. .
Source: Occupational And Environmental Medicine, 2009 Mar; 66(3), p. 161-8.
PMID: 18805889
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Oral contraceptives and the risk of all cancers combined and site-specific cancers in Shanghai.
Authors: Rosenblatt K.A. , Gao D.L. , Ray R.M. , Nelson Z.C. , Wernli K.J. , Li W. , Thomas D.B. .
Source: Cancer Causes & Control : Ccc, 2009 Feb; 20(1), p. 27-34.
PMID: 18704712
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Occupational risk factors for endometrial cancer among textile workers in Shanghai, China.
Authors: Wernli K.J. , Ray R.M. , Gao D.L. , Fitzgibbons E.D. , Camp J.E. , Astrakianakis G. , Seixas N. , Li W. , De Roos A.J. , Feng Z. , et al. .
Source: American Journal Of Industrial Medicine, 2008 Sep; 51(9), p. 673-9.
PMID: 18626909
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Monthly injectable contraceptives and the risk of all cancers combined and site-specific cancers in Shanghai.
Authors: Rosenblatt K.A. , Gao D.L. , Ray R.M. , Nelson Z.C. , Wernli K.J. , Li W. , Thomas D.B. .
Source: Contraception, 2007 Jul; 76(1), p. 40-4.
PMID: 17586135
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Occupational exposures and breast cancer among women textile workers in Shanghai.
Authors: Ray R.M. , Gao D.L. , Li W. , Wernli K.J. , Astrakianakis G. , Seixas N.S. , Camp J.E. , Fitzgibbons E.D. , Feng Z. , Thomas D.B. , et al. .
Source: Epidemiology (cambridge, Mass.), 2007 May; 18(3), p. 383-92.
PMID: 17435449
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Lung cancer risk among female textile workers exposed to endotoxin.
Authors: Astrakianakis G. , Seixas N.S. , Ray R. , Camp J.E. , Gao D.L. , Feng Z. , Li W. , Wernli K.J. , Fitzgibbons E.D. , Thomas D.B. , et al. .
Source: Journal Of The National Cancer Institute, 2007-03-07 00:00:00.0; 99(5), p. 357-64.
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Occupational risk factors for pancreatic cancer among female textile workers in Shanghai, China.
Authors: Li W. , Ray R.M. , Gao D.L. , Fitzgibbons E.D. , Seixas N.S. , Camp J.E. , Wernli K.J. , Astrakianakis G. , Feng Z. , Thomas D.B. , et al. .
Source: Occupational And Environmental Medicine, 2006 Dec; 63(12), p. 788-93.
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Induced abortions and the risk of all cancers combined and site-specific cancers in Shanghai.
Authors: Rosenblatt K.A. , Gao D.L. , Ray R.M. , Rowland M.R. , Nelson Z.C. , Wernli K.J. , Li W. , Thomas D.B. .
Source: Cancer Causes & Control : Ccc, 2006 Dec; 17(10), p. 1275-80.
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Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese women.
Authors: Wernli K.J. , Ray R.M. , Gao D.L. , De Roos A.J. , Checkoway H. , Thomas D.B. .
Source: Cancer Causes & Control : Ccc, 2006 Sep; 17(7), p. 949-55.
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Modeling, estimation and validation of cotton dust and endotoxin exposures in Chinese textile operations.
Authors: Astrakianakis G. , Seixas N.S. , Camp J.E. , Christiani D.C. , Feng Z. , Thomas D.B. , Checkoway H. .
Source: The Annals Of Occupational Hygiene, 2006 Aug; 50(6), p. 573-82.
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Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: a case-cohort study.
Authors: Chang C.K. , Astrakianakis G. , Thomas D.B. , Seixas N.S. , Camp J.E. , Ray R.M. , Gao D.L. , Wernli K.J. , Li W. , Fitzgibbons E.D. , et al. .
Source: American Journal Of Industrial Medicine, 2006 Aug; 49(8), p. 690-8.
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Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China.
Authors: Gold L.S. , De Roos A.J. , Ray R.M. , Wernli K. , Fitzgibbons E.D. , Gao D.L. , Astrakianakis G. , Feng Z. , Thomas D. , Checkoway H. .
Source: Scandinavian Journal Of Work, Environment & Health, 2006 Jun; 32(3), p. 178-84.
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Occupational risk factors for esophageal and stomach cancers among female textile workers in Shanghai, China.
Authors: Wernli K.J. , Fitzgibbons E.D. , Ray R.M. , Gao D.L. , Li W. , Seixas N.S. , Camp J.E. , Astrakianakis G. , Feng Z. , Thomas D.B. , et al. .
Source: American Journal Of Epidemiology, 2006-04-15 00:00:00.0; 163(8), p. 717-25.
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Occupational exposures and risks of liver cancer among Shanghai female textile workers--a case-cohort study.
Authors: Chang C.K. , Astrakianakis G. , Thomas D.B. , Seixas N.S. , Ray R.M. , Gao D.L. , Wernli K.J. , Fitzgibbons E.D. , Vaughan T.L. , Checkoway H. .
Source: International Journal Of Epidemiology, 2006 Apr; 35(2), p. 361-9.
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Reproductive history, occupational exposures, and thyroid cancer risk among women textile workers in Shanghai, China.
Authors: Wong E.Y. , Ray R. , Gao D.L. , Wernli K.J. , Li W. , Fitzgibbons E.D. , Feng Z. , Thomas D.B. , Checkoway H. .
Source: International Archives Of Occupational And Environmental Health, 2006 Mar; 79(3), p. 251-8.
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Occupational risk factors for nasopharyngeal cancer among female textile workers in Shanghai, China.
Authors: Li W. , Ray R.M. , Gao D.L. , Fitzgibbons E.D. , Seixas N.S. , Camp J.E. , Wernli K.J. , Astrakianakis G. , Feng Z. , Thomas D.B. , et al. .
Source: Occupational And Environmental Medicine, 2006 Jan; 63(1), p. 39-44.
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Colorectal cancer incidence among female textile workers in Shanghai, China: a case-cohort analysis of occupational exposures.
Authors: De Roos A.J. , Ray R.M. , Gao D.L. , Wernli K.J. , Fitzgibbons E.D. , Ziding F. , Astrakianakis G. , Thomas D.B. , Checkoway H. .
Source: Cancer Causes & Control : Ccc, 2005 Dec; 16(10), p. 1177-88.
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Cancer among women textile workers in Shanghai, China: overall incidence patterns, 1989-1998.
Authors: Wernli K.J. , Ray R.M. , Gao D.L. , Thomas D.B. , Checkoway H. .
Source: American Journal Of Industrial Medicine, 2003 Dec; 44(6), p. 595-9.
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Development of a cancer research study in the Shanghai textile industry.
Authors: Camp J.E. , Seixas N.S. , Wernli K. , Fitzgibbons D. , Astrakianakis G. , Thomas D.B. , Gao D.L. , Checkoway H. .
Source: International Journal Of Occupational And Environmental Health, 2003 Oct-Dec; 9(4), p. 347-56.
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