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Grant Details

Grant Number: 5R01CA106807-05 Interpret this number
Primary Investigator: Lazovich, Deann
Organization: University Of Minnesota
Project Title: Indoor Tanning Use, DNA Repair and Risk of Melanoma
Fiscal Year: 2008


Abstract

DESCRIPTION (provided by applicant): The rising popularity of indoor tanning, an artificial source of ultraviolet radiation (UV) raises concerns that the melanoma epidemic will continue to cause unnecessary morbidity and mortality. Most epidemiologic studies of this risk factor and melanoma predate the introduction of modern tanning equipment (ca 1980), thus new epidemiologic studies are urgently needed among individuals with substantial levels of exposure and collection of detailed exposure information. In addition, our understanding of the role of DNA repair in modifying the risks of melanoma associated with UV exposure is just emerging. The specific aims of our proposal are to assess whether frequent and/or long-term use of modern era indoor tanning increases the risk of melanoma, and whether the risk of melanoma may be influenced by variation in inherited polymorphisms that affect DNA repair. We propose to conduct a population-based case-control study of melanoma among 2660 residents of Minnesota (1330 cases, 1330 controls), ages 25-59, a group found to have a high prevalence of exposure to indoor tanning. We will identify cases through the Minnesota Cancer Surveillance System, a pathology-based, statewide cancer registry of high quality and completeness for case ascertainment. Each case and control subject's history of exposure to indoor tanning, and to potential confounders will be collected during a telephone interview. Buccal cell samples from cases and controls will be collected for DNA. Associations between indoor tanning or impaired capacity to repair DNA and melanoma will be measured by the odds ratio, controlling for known confounders. Differences in risk of melanoma associated with exposure to solar or artificial ultraviolet radiation will be explored by skin type and by DNA repair pathways specific to the repair of UVB- or UVA-induced DNA damage in skin. Except for sun exposure, established risk factors for melanoma, such as skin type or family history, are not amenable to change. Indoor tanning behavior, however, is under the control of the individual. If well-designed epidemiologic studies confirm that indoor tanning is a risk factor for melanoma and that some individuals are particularly susceptible to its effects, public health action may be indicated to discourage use and reduce the risk of the melanoma.



Publications

Comparison of quality of life among long-term melanoma survivors and non-melanoma controls: a cross-sectional study.
Authors: Vogel R.I. , Strayer L.G. , Engelman L. , Nelson H.H. , Blaes A.H. , Anderson K.E. , Lazovich D. .
Source: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017 07; 26(7), p. 1761-1766.
EPub date: 2017-02-27.
PMID: 28243994
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Association Between Indoor Tanning and Melanoma in Younger Men and Women.
Authors: Lazovich D. , Isaksson Vogel R. , Weinstock M.A. , Nelson H.H. , Ahmed R.L. , Berwick M. .
Source: JAMA dermatology, 2016 Mar; 152(3), p. 268-75.
PMID: 26818409
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Indoor tanning in businesses and homes and risk of melanoma and nonmelanoma skin cancer in 2 US case-control studies.
Authors: Ferrucci L.M. , Vogel R.I. , Cartmel B. , Lazovich D. , Mayne S.T. .
Source: Journal of the American Academy of Dermatology, 2014 Nov; 71(5), p. 882-7.
EPub date: 2014-07-23.
PMID: 25062934
Related Citations

Exposure to indoor tanning without burning and melanoma risk by sunburn history.
Authors: Vogel R.I. , Ahmed R.L. , Nelson H.H. , Berwick M. , Weinstock M.A. , Lazovich D. .
Source: Journal of the National Cancer Institute, 2014 Jul; 106(7), .
EPub date: 2014-07-16.
PMID: 25031276
Related Citations

Exposure to indoor tanning without burning and melanoma risk by sunburn history.
Authors: Vogel R.I. , Ahmed R.L. , Nelson H.H. , Berwick M. , Weinstock M.A. , Lazovich D. .
Source: Journal of the National Cancer Institute, 2014 Jun; 106(6), p. dju112.
EPub date: 2014-05-28.
PMID: 24872541
Related Citations

Development of a melanoma risk prediction model incorporating MC1R genotype and indoor tanning exposure: impact of mole phenotype on model performance.
Authors: Penn L.A. , Qian M. , Zhang E. , Ng E. , Shao Y. , Berwick M. , Lazovich D. , Polsky D. .
Source: PloS one, 2014; 9(7), p. e101507.
EPub date: 2014-07-08.
PMID: 25003831
Related Citations

A pilot study of genetic variants in dopamine regulators with indoor tanning and melanoma.
Authors: Flores K.G. , Erdei E. , Luo L. , White K.A. , Leng S. , Berwick M. , Lazovich D. .
Source: Experimental dermatology, 2013 Sep; 22(9), p. 576-81.
PMID: 23947671
Related Citations

DNA repair variants, indoor tanning, and risk of melanoma.
Authors: Torres S.M. , Luo L. , Lilyquist J. , Stidley C.A. , Flores K. , White K.A. , Erdei E. , Gonzales M. , Paine S. , Vogel R.I. , et al. .
Source: Pigment cell & melanoma research, 2013 Sep; 26(5), p. 677-84.
EPub date: 2013-06-03.
PMID: 23659246
Related Citations

Melanoma risk in relation to use of sunscreen or other sun protection methods.
Authors: Lazovich D. , Vogel R.I. , Berwick M. , Weinstock M.A. , Warshaw E.M. , Anderson K.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Dec; 20(12), p. 2583-93.
EPub date: 2011-10-20.
PMID: 22016471
Related Citations

Association between non-steroidal anti-inflammatory drugs and keratinocyte carcinomas of the skin among participants in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Nunes A.P. , Lapane K.L. , Weinstock M.A. , VATTC Trial Group .
Source: Pharmacoepidemiology and drug safety, 2011 Sep; 20(9), p. 922-9.
EPub date: 2011-06-18.
PMID: 21688346
Related Citations

Prospective quality of life impact of keratinocyte carcinomas: observations from the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Lee K.C. , Weinstock M.A. , Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group .
Source: Journal of the American Academy of Dermatology, 2010 Dec; 63(6), p. 1107-9.
PMID: 21093671
Related Citations

Indoor tanning and risk of melanoma: a case-control study in a highly exposed population.
Authors: Lazovich D. , Vogel R.I. , Berwick M. , Weinstock M.A. , Anderson K.E. , Warshaw E.M. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Jun; 19(6), p. 1557-68.
EPub date: 2010-05-26.
PMID: 20507845
Related Citations

Incidence estimate of nonmelanoma skin cancer in the United States, 2006.
Authors: Rogers H.W. , Weinstock M.A. , Harris A.R. , Hinckley M.R. , Feldman S.R. , Fleischer A.B. , Coldiron B.M. .
Source: Archives of dermatology, 2010 Mar; 146(3), p. 283-7.
PMID: 20231499
Related Citations

Melanoma thickness trends in the United States, 1988-2006.
Authors: Criscione V.D. , Weinstock M.A. .
Source: The Journal of investigative dermatology, 2010 Mar; 130(3), p. 793-7.
EPub date: 2009-10-15.
PMID: 19829301
Related Citations

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Geng A. , Weinstock M.A. , Hall R. , Eilers D. , Naylor M. , Kalivas J. , VATTC Trial Group .
Source: The British journal of dermatology, 2009 Oct; 161(4), p. 918-24.
EPub date: 2009-06-11.
PMID: 19681859
Related Citations

Mortality of bullous skin disorders from 1979 through 2002 in the United States.
Authors: Risser J. , Lewis K. , Weinstock M.A. .
Source: Archives of dermatology, 2009 Sep; 145(9), p. 1005-8.
PMID: 19770439
Related Citations

Quality of life in the actinic neoplasia syndrome: The VA Topical Tretinoin Chemoprevention (VATTC) Trial.
Authors: Weinstock M.A. , Lee K.C. , Chren M.M. , Marcolivio K. , VATTC Trial Group .
Source: Journal of the American Academy of Dermatology, 2009 Aug; 61(2), p. 207-15.
EPub date: 2009-04-26.
PMID: 19398145
Related Citations

Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Criscione V.D. , Weinstock M.A. , Naylor M.F. , Luque C. , Eide M.J. , Bingham S.F. , Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group .
Source: Cancer, 2009-06-01; 115(11), p. 2523-30.
PMID: 19382202
Related Citations

Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial.
Authors: Dore D.D. , Lapane K.L. , Trivedi A.N. , Mor V. , Weinstock M.A. .
Source: Annals of internal medicine, 2009-01-06; 150(1), p. 9-18.
PMID: 19124815
Related Citations

Components of a successful intervention for monthly skin self-examination for early detection of melanoma: the "Check It Out" trial.
Authors: Lee K.B. , Weinstock M.A. , Risica P.M. .
Source: Journal of the American Academy of Dermatology, 2008 Jun; 58(6), p. 1006-12.
EPub date: 2008-04-11.
PMID: 18406492
Related Citations

Trends in nonmelanoma skin cancer mortality rates in the United States, 1969 through 2000.
Authors: Lewis K.G. , Weinstock M.A. .
Source: The Journal of investigative dermatology, 2007 Oct; 127(10), p. 2323-7.
EPub date: 2007-05-24.
PMID: 17522705
Related Citations

Melanoma early detection with thorough skin self-examination: the "Check It Out" randomized trial.
Authors: Weinstock M.A. , Risica P.M. , Martin R.A. , Rakowski W. , Dubé C. , Berwick M. , Goldstein M.G. , Acharyya S. , Lasater T. .
Source: American journal of preventive medicine, 2007 Jun; 32(6), p. 517-24.
PMID: 17533068
Related Citations

Progress and prospects on melanoma: the way forward for early detection and reduced mortality.
Authors: Weinstock M.A. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2006-04-01; 12(7 Pt 2), p. 2297s-2300s.
PMID: 16609048
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