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Grant Details

Grant Number: 5R01CA104842-05 Interpret this number
Primary Investigator: Terry, Mary Beth
Organization: Columbia University Health Sciences
Project Title: Early Determinants of Mammographic Density
Fiscal Year: 2008
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DESCRIPTION (provided by applicant): Numerous studies have shown associations between markers of fetal growth and important domains of adult health. In particular, several recent studies suggest that high birth weight may be associated with an increased risk of breast cancer later in life. The existing literature on birth weight and breast cancer risk, while intriguing, falls short by its inability to address the following: (1) potential confounding by family factors (e.g., socioeconomic status); (2) the importance of and possible interaction with other measures of fetal growth; (3) the independent effect of maternal characteristics and exposures; (4) potential biological mechanisms; (5) the contribution of postnatal growth; and (6) mediation by adult risk factors. We will address these limitations by use of a novel study design examining the association of early life factors with mammographic density, a strong predictor of future breast cancer risk. Specifically, we will recruit a sibling sample of 325 female pairs (n=650) and a single child sample of 350 high birth-weight (>=4000g) females for a total of 1000 subjects. All females are offspring of pregnant women enrolled during 1959 to 1967 in two New England sites (Boston and Providence) of the National Collaborative Perinatal Project (NCPP) and in the Childhood Health and Development Study (CHDS). The sibling design will allow us to control for family effects such as socioeconomic status that may influence both birth-weight and adult risk factor patterns. Exposure information will be derived from prospectively collected pro and postnatal data on mothers, infants, and childhood growth. Maternal sera collected during the third trimester will be used to measure estrogen (El, E2, E3), and testosterone. Along with the mammogram, we will also collect adult risk factor data through interview and laboratory assays (including measures of IGF-I, IGFBP-3). We hypothesize that high birth weight, high placental weight, high placental/birth weight ratio, high maternal pregnancy weight gain, and high maternal estrogen levels will increase mammographic density in the daughters, and that maternal preeclampsia and higher levels of maternal testosterone will decrease mammographic density in the daughters. We will further examine whether any of these associations are mediated by childhood growth patterns and adult risk factors. This study will advance the literature on early determinants of breast cancer risk by directly addressing many of the limitations in the existing literature, allowing a more thorough inspection into what may shape early breast cancer susceptibility.

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In utero DDT exposure and breast density before age 50.
Authors: Krigbaum N.Y. , Cirillo P.M. , Flom J.D. , McDonald J.A. , Terry M.B. , Cohn B.A. .
Source: Reproductive toxicology (Elmsford, N.Y.), 2020 Mar; 92, p. 85-90.
EPub date: 2019-11-08.
PMID: 31711904
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Early-Life Growth and Benign Breast Disease.
Authors: Goldberg M. , Cohn B.A. , Houghton L.C. , Flom J.D. , Wei Y. , Cirillo P. , Michels K.B. , Terry M.B. .
Source: American journal of epidemiology, 2019-09-01; 188(9), p. 1646-1654.
PMID: 31107507
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Do Birth Weight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses.
Authors: Terry M.B. , Cohn B.A. , Goldberg M. , Flom J.D. , Wei Y. , Houghton L.C. , Tehranifar P. , McDonald J.A. , Protacio A. , Cirillo P. , et al. .
Source: American journal of epidemiology, 2019-02-01; 188(2), p. 294-304.
PMID: 30383202
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Why do studies show different associations between intrauterine exposure to maternal smoking and age at menarche?
Authors: Houghton L.C. , Goldberg M. , Wei Y. , Cirillo P.M. , Cohn B.A. , Michels K.B. , Terry M.B. .
Source: Annals of epidemiology, 2018 03; 28(3), p. 197-203.
EPub date: 2018-01-10.
PMID: 29482744
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Earlier age at menarche in girls with rapid early life growth: cohort and within sibling analyses.
Authors: Flom J.D. , Cohn B.A. , Tehranifar P. , Houghton L.C. , Wei Y. , Protacio A. , Cirillo P. , Michels K.B. , Terry M.B. .
Source: Annals of epidemiology, 2017 03; 27(3), p. 187-193.e2.
EPub date: 2017-01-19.
PMID: 28215584
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Maternal and Early Childhood Determinants of Women's Body Size in Midlife: Overall Cohort and Sibling Analyses.
Authors: Ester W.A. , Houghton L.C. , Lumey L.H. , Michels K.B. , Hoek H.W. , Wei Y. , Susser E.S. , Cohn B.A. , Terry M.B. .
Source: American journal of epidemiology, 2017-03-01; 185(5), p. 385-394.
PMID: 28200097
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Early life socioeconomic environment and mammographic breast density.
Authors: Tehranifar P. , Cohn B.A. , Flom J.D. , Protacio A. , Cirillo P. , Lumey L.H. , Michels K.B. , Terry M.B. .
Source: BMC cancer, 2017-01-10; 17(1), p. 41.
EPub date: 2017-01-10.
PMID: 28068940
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Maternal Anthropometry and Mammographic Density in Adult Daughters.
Authors: Michels K.B. , Cohn B.A. , Goldberg M. , Flom J.D. , Dougan M. , Terry M.B. .
Source: Pediatrics, 2016 Nov; 138(Suppl 1), p. S34-S41.
PMID: 27940975
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Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later.
Authors: Houghton L.C. , Ester W.A. , Lumey L.H. , Michels K.B. , Wei Y. , Cohn B.A. , Susser E. , Terry M.B. .
Source: American journal of obstetrics and gynecology, 2016 08; 215(2), p. 246.e1-246.e8.
EPub date: 2016-02-18.
PMID: 26901274
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Alcohol intake from early adulthood to midlife and mammographic density.
Authors: McDonald J.A. , Michels K.B. , Cohn B.A. , Flom J.D. , Tehranifar P. , Terry M.B. .
Source: Cancer causes & control : CCC, 2016 Apr; 27(4), p. 493-502.
EPub date: 2016-02-01.
PMID: 26830901
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Life course exposure to smoke and early menopause and menopausal transition.
Authors: Tawfik H. , Kline J. , Jacobson J. , Tehranifar P. , Protacio A. , Flom J.D. , Cirillo P. , Cohn B.A. , Terry M.B. .
Source: Menopause (New York, N.Y.), 2015 Oct; 22(10), p. 1076-83.
PMID: 25803667
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Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study.
Authors: La Merrill M. , Cirillo P.M. , Terry M.B. , Krigbaum N.Y. , Flom J.D. , Cohn B.A. .
Source: Environmental health perspectives, 2013 May; 121(5), p. 594-9.
EPub date: 2013-03-12.
PMID: 23591545
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Prenatal smoke exposure and mammographic density in mid-life.
Authors: Terry M.B. , Schaefer C.A. , Flom J.D. , Wei Y. , Tehranifar P. , Liao Y. , Buka S. , Michels K.B. .
Source: Journal of developmental origins of health and disease, 2011 Dec; 2(6), p. 340-52.
PMID: 23378890
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Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort.
Authors: Flom J.D. , Ferris J.S. , Liao Y. , Tehranifar P. , Richards C.B. , Cho Y.H. , Gonzalez K. , Santella R.M. , Terry M.B. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Dec; 20(12), p. 2518-23.
EPub date: 2011-10-12.
PMID: 21994404
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