Grant Number:	5R01CA104836-06 Interpret this number
Primary Investigator:	Graham, Amanda
Organization:	Georgetown University
Project Title:	Internet and Telephone Treatment for Smoking Cessation
Fiscal Year:	2008

DESCRIPTION (provided by applicant): Tobacco use is the major preventable cause of cancer and disease burden in the U.S. While effective treatments exist, innovative means of efficient delivery are needed to accelerate reduction in smoking prevalence. Telephone counseling and tailored self-change programs have an evidence-base of efficacy and the capability to make an impact on population prevalence. There is a growing movement to provide comprehensive tobacco control services, both through telephone quit lines and tailored self-change via the Internet. Scientists, policy makers and the public need to know if these programs work, for whom, by what mechanisms, and at what cost. There are no rigorous evaluations of the efficacy of Internet-driven cessation services or of combined telephone and Internet treatment At the same time, Internet-based programs are already available to the public and are being used at a very high volume without any evidence that they are effective. This study aims to extend existing theory and application by comparing the efficacy of a popular, full service, Internet intervention (Premium Internet) alone or in conjunction with proactive telephone counseling (Premium Internet plus Telephone) against a standard Internet control (Basic Interact). This study will recruit motivated smokers (N=2,055) who use an Internet search engine to find smoking cessation programs. A subset will be directed to a Web page that will describe the study and enrollment procedures. Using a 3-condition randomized design with repeated measures at baseline, 3, 6, 12, and 18-months post-randomization, consented smokers will be assigned to: 1) Basic Internet; 2) Premium Internet; and 3) Premium Internet plus Proactive Telephone Counseling. The hypotheses tested are that Premium Interact plus Telephone will outperform Premium Internet alone and both will outperform Basic Internet on 7-day point prevalence abstinence measured at 12 months post-randomization (6-months post treatment). Cost-effectiveness will also be examined along with exploratory analyses of theory-driven hypotheses about the mediators and moderators of outcome (e.g., gender, amount and frequency of service use, type of content used, and behavior change variables including self-efficacy, social support, and motivation). Market demand and State health departments are stimulating delivery of Interact and telephone cessation services. There is an urgent need for science to fill the gap and evaluate their efficacy. If effective, such treatments can be widely disseminated and can make a significant impact on population health.




Online community use predicts abstinence in combined Internet/phone intervention for smoking cessation.
Authors: Papandonatos G.D. , Erar B. , Stanton C.A. , Graham A.L. .
Source: Journal of consulting and clinical psychology, 2016 Jul; 84(7), p. 633-44.
EPub date: 2016-04-21.
PMID: 27100127
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Use of an online smoking cessation community promotes abstinence: Results of propensity score weighting.
Authors: Graham A.L. , Papandonatos G.D. , Erar B. , Stanton C.A. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2015 Dec; 34S(0), p. 1286-95.
PMID: 26651470
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Internet and Telephone Treatment for smoking cessation: mediators and moderators of short-term abstinence.
Authors: Graham A.L. , Papandonatos G.D. , Cobb C.O. , Cobb N.K. , Niaura R.S. , Abrams D.B. , Tinkelman D.G. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015 Mar; 17(3), p. 299-308.
EPub date: 2014-08-25.
PMID: 25156528
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Use of non-assigned interventions in a randomized trial of internet and telephone treatment for smoking cessation.
Authors: Cobb C.O. , Graham A.L. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014 Oct; 16(10), p. 1289-97.
EPub date: 2014-05-08.
PMID: 24812022
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Quit now? Quit soon? Quit when you're ready? Insights about target quit dates for smoking cessation from an online quit date tool.
Authors: Cobb C.O. , Niaura R.S. , Donaldson E.A. , Graham A.L. .
Source: Journal of medical Internet research, 2014-02-17; 16(2), p. e55.
EPub date: 2014-02-17.
PMID: 24534139
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Cost-effectiveness of internet and telephone treatment for smoking cessation: an economic evaluation of The iQUITT Study.
Authors: Graham A.L. , Chang Y. , Fang Y. , Cobb N.K. , Tinkelman D.S. , Niaura R.S. , Abrams D.B. , Mandelblatt J.S. .
Source: Tobacco control, 2013 Nov; 22(6), p. e11.
EPub date: 2012-09-25.
PMID: 23010696
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Development and validation of the online social support for smokers scale.
Authors: Graham A.L. , Papandonatos G.D. , Kang H. , Moreno J.L. , Abrams D.B. .
Source: Journal of medical Internet research, 2011-09-28; 13(3), p. e69.
EPub date: 2011-09-28.
PMID: 21955465
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A randomized trial of Internet and telephone treatment for smoking cessation.
Authors: Graham A.L. , Cobb N.K. , Papandonatos G.D. , Moreno J.L. , Kang H. , Tinkelman D.G. , Bock B.C. , Niaura R.S. , Abrams D.B. .
Source: Archives of internal medicine, 2011-01-10; 171(1), p. 46-53.
PMID: 21220660
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Social network structure of a large online community for smoking cessation.
Authors: Cobb N.K. , Graham A.L. , Abrams D.B. .
Source: American journal of public health, 2010 Jul; 100(7), p. 1282-9.
EPub date: 2010-05-13.
PMID: 20466971
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Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions.
Authors: Graham A.L. , Milner P. , Saul J.E. , Pfaff L. .
Source: Journal of medical Internet research, 2008-12-15; 10(5), p. e50.
EPub date: 2008-12-15.
PMID: 19073542
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Reliability of internet- versus telephone-administered questionnaires in a diverse sample of smokers.
Authors: Graham A.L. , Papandonatos G.D. .
Source: Journal of medical Internet research, 2008-03-26; 10(1), p. e8.
EPub date: 2008-03-26.
PMID: 18364345
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Internet- vs. telephone-administered questionnaires in a randomized trial of smoking cessation.
Authors: Graham A.L. , Papandonatos G.D. , Bock B.C. , Cobb N.K. , Baskin-Sommers A. , Niaura R. , Abrams D.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006 Dec; 8 Suppl 1(Suppl 1), p. S49-57.
PMID: 17491171
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Characteristics of smokers reached and recruited to an internet smoking cessation trial: a case of denominators.
Authors: Graham A.L. , Bock B.C. , Cobb N.K. , Niaura R. , Abrams D.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006 Dec; 8 Suppl 1(Suppl 1), p. S43-8.
PMID: 17491170
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Characterizing Internet searchers of smoking cessation information.
Authors: Cobb N.K. , Graham A.L. .
Source: Journal of medical Internet research, 2006-09-19; 8(3), p. e17.
EPub date: 2006-09-19.
PMID: 17032633
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Reducing the cancer burden of lifestyle factors: opportunities and challenges of the Internet.
Authors: Graham A.L. , Abrams D.B. .
Source: Journal of medical Internet research, 2005-07-01; 7(3), p. e26.
EPub date: 2005-07-01.
PMID: 15998617
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Initial evaluation of a real-world Internet smoking cessation system.
Authors: Cobb N.K. , Graham A.L. , Bock B.C. , Papandonatos G. , Abrams D.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2005 Apr; 7(2), p. 207-16.
PMID: 16036277
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