Grant Number:	5R01CA108933-05 Interpret this number
Primary Investigator:	Schwartz, Marc
Organization:	Georgetown University
Project Title:	Telephone-Based Genetic Counseling: an Equivalence Trial
Fiscal Year:	2008

DESCRIPTION (provided by applicant): Demand for genetic susceptibility counseling for cancer has been steadily increasing and is expected to continue to increase as additional susceptibility genes are identified. Traditional, in-person genetic counseling has been shown to be effective at fostering informed decision making and minimizing adverse outcomes associated with genetic testing. However, the reach and accessibility of in-person genetic counseling is limited. There are large areas of the country which are not served by genetic counselors. This lack of access will worsen as the number of available genetic susceptibility tests for adult-onset diseases continues to grow. Physicians do not have the time or expertise required to provide genetic counseling. Thus, alternatives to the standard genetic counseling delivery model are needed. Such alternatives must expand the reach of genetic counseling without sacrificing efficacy. To date, there has been little research aimed at developing and evaluating alternative models of adult genetic service delivery. In the proposed equivalency trial, we will evaluate telephone-based genetic counseling. Such counseling is already commercially available, but has not been rigorously evaluated in a randomized trial. Thus, in the proposed randomized equivalency trial, we will compare telephone-based genetic counseling to standard, clinic-based genetic counseling among 1248 women with at least a 10 percent prior probability of carrying a BRCAI or BRCA2 mutation. In our previous research, we have provided genetic counseling and testing to over 2000 such women. Guided by the Ottawa Framework for Informed Decision Making and the central tenets of genetic counseling, we will compare these two groups on: 1) utilization of BRCAI/BRCA2 genetic testing and 2) psychosocial, quality of life and informed decision making outcomes. In addition, we will evaluate the applicability of the Ottawa Framework for explaining the beneficial effects of genetic counseling and we will identify individual patient variables, which moderate the effect of the two interventions.




Telephone versus in-person genetic counseling for hereditary cancer risk: Patient predictors of differential outcomes.
Authors: Binion S. , Sorgen L.J. , Peshkin B.N. , Valdimarsdottir H. , Isaacs C. , Nusbaum R. , Graves K.D. , DeMarco T. , Wood M. , McKinnon W. , et al. .
Source: Journal Of Telemedicine And Telecare, 2021-11-15 00:00:00.0; , p. 1357633X211052220.
EPub date: 2021-11-15 00:00:00.0.
PMID: 34779303
Related Citations

Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up.
Authors: Interrante M.K. , Segal H. , Peshkin B.N. , Valdimarsdottir H.B. , Nusbaum R. , Similuk M. , DeMarco T. , Hooker G. , Graves K. , Isaacs C. , et al. .
Source: Jnci Cancer Spectrum, 2017 Sep; 1(1), p. pkx002.
EPub date: 2017-09-22 00:00:00.0.
PMID: 31304457
Related Citations

Patient And Genetic Counselor Perceptions Of In-person Versus Telephone Genetic Counseling For Hereditary Breast/ovarian Cancer
Authors: Jacobs A.S. , Schwartz M.D. , Valdimarsdottir H. , Nusbaum R.H. , Hooker G.W. , DeMarco T.A. , Heinzmann J.E. , McKinnon W. , McCormick S.R. , Davis C. , et al. .
Source: Familial Cancer, 2016-03-11 00:00:00.0; , .
PMID: 26969308
Related Citations

Patient Perceptions Of Telephone Vs. In-person Brca1/brca2 Genetic Counseling
Authors: Peshkin B.N. , Kelly S. , Nusbaum R.H. , Similuk M. , DeMarco T.A. , Hooker G.W. , Valdimarsdottir H.B. , Forman A.D. , Joines J.R. , Davis C. , et al. .
Source: Journal Of Genetic Counseling, 2015-10-12 00:00:00.0; , .
PMID: 26455498
Related Citations

Disparities In Uptake Of Brca1/2 Genetic Testing In A Randomized Trial Of Telephone Counseling
Authors: Butrick M. , Kelly S. , Peshkin B.N. , Luta G. , Nusbaum R. , Hooker G.W. , Graves K. , Feeley L. , Isaacs C. , Valdimarsdottir H.B. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2015 Jun; 17(6), p. 467-75.
PMID: 25232856
Related Citations

Intentions For Risk-reducing Surgery Among High-risk Women Referred For Brca1/brca2 Genetic Counseling
Authors: Tong A. , Kelly S. , Nusbaum R. , Graves K. , Peshkin B.N. , Valdimarsdottir H.B. , Wood M. , McKinnon W. , Garber J. , McCormick S.R. , et al. .
Source: Psycho-oncology, 2015 Jan; 24(1), p. 33-9.
PMID: 24839250
Related Citations

Randomized Noninferiority Trial Of Telephone Versus In-person Genetic Counseling For Hereditary Breast And Ovarian Cancer
Authors: Schwartz M.D. , Valdimarsdottir H.B. , Peshkin B.N. , Mandelblatt J. , Nusbaum R. , Huang A.T. , Chang Y. , Graves K. , Isaacs C. , Wood M. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-03-01 00:00:00.0; 32(7), p. 618-26.
PMID: 24449235
Related Citations

Brief Assessment Of Parents' Attitudes Toward Testing Minor Children For Hereditary Breast/ovarian Cancer Genes: Development And Validation Of The Pediatric Brca1/2 Testing Attitudes Scale (p-tas)
Authors: Peshkin B.N. , DeMarco T.A. , Garber J.E. , Valdimarsdottir H.B. , Patenaude A.F. , Schneider K.A. , Schwartz M.D. , Tercyak K.P. .
Source: Journal Of Pediatric Psychology, 2009 Jul; 34(6), p. 627-38.
PMID: 18385162
Related Citations

Telephone Genetic Counseling For High-risk Women Undergoing Brca1 And Brca2 Testing: Rationale And Development Of A Randomized Controlled Trial
Authors: Peshkin B.N. , Demarco T.A. , Graves K.D. , Brown K. , Nusbaum R.H. , Moglia D. , Forman A. , Valdimarsdottir H. , Schwartz M.D. .
Source: Genetic Testing, 2008 Mar; 12(1), p. 37-52.
PMID: 18373403
Related Citations

Information Needs Of Mothers Regarding Communicating Brca1/2 Cancer Genetic Test Results To Their Children
Authors: Tercyak K.P. , Peshkin B.N. , Demarco T.A. , Patenaude A.F. , Schneider K.A. , Garber J.E. , Valdimarsdottir H.B. , Schwartz M.D. .
Source: Genetic Testing, 2007 Fall; 11(3), p. 249-55.
PMID: 17949286
Related Citations

Structure, Organization, And Transcription Of Drosophila U6 Small Nuclear Rna Genes
Authors: Das G. , Henning D. , Reddy R. .
Source: The Journal Of Biological Chemistry, 1987-01-25 00:00:00.0; 262(3), p. 1187-93.
PMID: 3027083
Related Citations

A New Moderately Repetitive Rat Dna Sequence Detected By A Cloned 4.5 Si Dna
Authors: Saba J.A. , Busch H. , Reddy R. .
Source: The Journal Of Biological Chemistry, 1985-02-10 00:00:00.0; 260(3), p. 1354-7.
PMID: 2578458
Related Citations

Multiple States Of U3 Rna In Novikoff Hepatoma Nucleoli
Authors: Epstein P. , Reddy R. , Busch H. .
Source: Biochemistry, 1984-11-06 00:00:00.0; 23(23), p. 5421-5.
PMID: 6210104
Related Citations

Primary And Secondary Structure Of 7-3 (k) Rna Of Novikoff Hepatoma
Authors: Reddy R. , Henning D. , Subrahmanyam C.S. , Busch H. .
Source: The Journal Of Biological Chemistry, 1984-10-10 00:00:00.0; 259(19), p. 12265-70.
PMID: 6434539
Related Citations

Localization Of Phosphoprotein C23 In Nucleoli By Immunological Methods
Authors: Olson M.O. , Guetzow K. , Busch H. .
Source: Experimental Cell Research, 1981 Oct; 135(2), p. 259-65.
PMID: 6796426
Related Citations

Phosphodipeptide Analysis Of Nonhistone Nuclear Proteins From Novikoff Hepatoma Ascites Cells
Authors: Jones C.E. , Olson M.O. .
Source: International Journal Of Peptide And Protein Research, 1980 Aug; 16(2), p. 135-42.
PMID: 7461896
Related Citations