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Grant Details

Grant Number: 5R01CA082822-09 Interpret this number
Primary Investigator: Jacobsen, Paul
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Cognitive-Behavioral Aspects of Cancer-Related Fatigue
Fiscal Year: 2008


Abstract

DESCRIPTION (provided by applicant): This competitive renewal application seeks continued support for a four-year study originally funded by the National Cancer Institute (1R01 CA82822). Funding for the original project began on 9/1/99 and will end on 6/30/03. A one year no-cost extension will expire on 6/30/04. The specific aims of the original study were to: 1) determine the severity and course of fatigue associated with treatment for early stage breast cancer; 2) characterize the cognitive, affective, and behavioral manifestations of fatigue associated with treatment for early stage breast cancer; and 3) test the utility of a cognitive-behavioral model designed to explain individual differences in fatigue among women receiving treatment for early stage breast cancer. Our work under the original proposal has yielded new insights into the severity, course, predictors, and correlates of fatigue during the active treatment period and during the first six months following completion of active treatment in women who received either chemotherapy followed radiotherapy or radiotherapy only. We believe that, by continuing to follow these two treated groups of patients as more time elapses following treatment completion, we have an opportunity to add significantly to knowledge about the nature of fatigue and its manifestations during an extended period of breast cancer survivorship. We note, however, the absence in our original design of comparison groups that would allow for determination of the extent to which the fatigue and related cognitive, behavioral, and affective problems exhibited by patients following completion of active treatment differ from "normal." In consideration of these issues, the specific aims of this competing continuation application are to: 1) determine the severity, course, and predictors of fatigue in the two treated groups over the first 3.5 years following completion of active treatment; 2) identify cognitive, behavioral, and affective problems associated with fatigue in the two treated groups over the fast 3.5 years following completion of active treatment; and 3) determine whether women who have completed active treatment for breast cancer experience greater fatigue and more related affective, cognitive and behavioral problems than women with no history of cancer matched for age, education, and geographic residence. To accomplish these aims we propose to: assess the two treated groups of patients again 3 years after completion of the final 6-month follow-up assessment currently being conducted; and recruit samples of women without cancer matched for age, education, and geographic residence with patients in each treated group and assess them on two occasions three years apart in order to generate comparison data. Provision of five years of continued funding will allow for uninterrupted follow-up of patients currently on study, the opportunity to collect complete 6-month and 3.5-year follow-up data on the two treated groups currently being followed, and the opportunity to collect complete initial and 3- year follow-up data matched comparison groups of women with no history of cancer.



Publications

Fatigue screening in breast cancer patients: identifying likely cases of cancer-related fatigue.
Authors: Goedendorp M.M. , Jacobsen P.B. , Andrykowski M.A. .
Source: Psycho-oncology, 2016 Mar; 25(3), p. 275-81.
EPub date: 2015-07-22.
PMID: 26202003
Related Citations

Depressive symptom trajectories during and after adjuvant treatment for breast cancer.
Authors: Donovan K.A. , Gonzalez B.D. , Small B.J. , Andrykowski M.A. , Jacobsen P.B. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2014 Jun; 47(3), p. 292-302.
PMID: 24158626
Related Citations

Factors associated with breast cancer worry 3 years after completion of adjuvant treatment.
Authors: Phillips K.M. , McGinty H.L. , Gonzalez B.D. , Jim H.S. , Small B.J. , Minton S. , Andrykowski M.A. , Jacobsen P.B. .
Source: Psycho-oncology, 2013 Apr; 22(4), p. 936-9.
EPub date: 2012-03-15.
PMID: 22419546
Related Citations

Prolonged impact of chemotherapy on fatigue in breast cancer survivors: a longitudinal comparison with radiotherapy-treated breast cancer survivors and noncancer controls.
Authors: Goedendorp M.M. , Andrykowski M.A. , Donovan K.A. , Jim H.S. , Phillips K.M. , Small B.J. , Laronga C. , Jacobsen P.B. .
Source: Cancer, 2012-08-01; 118(15), p. 3833-41.
EPub date: 2011-11-15.
PMID: 22086766
Related Citations

History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer.
Authors: Jim H.S. , Small B.J. , Minton S. , Andrykowski M. , Jacobsen P.B. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2012 Jun; 43(3), p. 402-8.
PMID: 22167580
Related Citations

Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls.
Authors: Phillips K.M. , Jim H.S. , Small B.J. , Laronga C. , Andrykowski M.A. , Jacobsen P.B. .
Source: Cancer, 2012-04-01; 118(7), p. 1925-32.
EPub date: 2011-12-12.
PMID: 22161750
Related Citations

Breast cancer recurrence risk reduction beliefs in breast cancer survivors: prevalence and relation to behavior.
Authors: Burris J.L. , Jacobsen P.B. , Loftus L.S. , Andrykowski M.A. .
Source: Psycho-oncology, 2012 Apr; 21(4), p. 427-35.
EPub date: 2011-02-10.
PMID: 21312312
Related Citations

Prevalence, predictors, and characteristics of off-treatment fatigue in breast cancer survivors.
Authors: Andrykowski M.A. , Donovan K.A. , Laronga C. , Jacobsen P.B. .
Source: Cancer, 2010-12-15; 116(24), p. 5740-8.
EPub date: 2010-08-23.
PMID: 20734399
Related Citations

Attitudes toward information about genetic risk for cognitive impairment after cancer chemotherapy: breast cancer survivors compared with healthy controls.
Authors: Andrykowski M.A. , Burris J.L. , Walsh E. , Small B.J. , Jacobsen P.B. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-07-20; 28(21), p. 3442-7.
EPub date: 2010-05-24.
PMID: 20498392
Related Citations

Cognitive functioning in breast cancer survivors: a controlled comparison.
Authors: Jim H.S. , Donovan K.A. , Small B.J. , Andrykowski M.A. , Munster P.N. , Jacobsen P.B. .
Source: Cancer, 2009-04-15; 115(8), p. 1776-83.
PMID: 19224550
Related Citations

Magnitude and correlates of response shift in fatigue ratings in women undergoing adjuvant therapy for breast cancer.
Authors: Andrykowski M.A. , Donovan K.A. , Jacobsen P.B. .
Source: Journal of pain and symptom management, 2009 Mar; 37(3), p. 341-51.
EPub date: 2008-08-30.
PMID: 18757176
Related Citations

Relationship of body image to breast and skin self-examination intentions and behaviors.
Authors: Chait S.R. , Thompson J.K. , Jacobsen P.B. .
Source: Body image, 2009 Jan; 6(1), p. 60-3.
EPub date: 2008-11-14.
PMID: 19010096
Related Citations

Identifying clinically meaningful fatigue with the Fatigue Symptom Inventory.
Authors: Donovan K.A. , Jacobsen P.B. , Small B.J. , Munster P.N. , Andrykowski M.A. .
Source: Journal of pain and symptom management, 2008 Nov; 36(5), p. 480-7.
EPub date: 2008-05-20.
PMID: 18495413
Related Citations

Exploring the differential experience of breast cancer treatment-related symptoms: a cluster analytic approach.
Authors: Gwede C.K. , Small B.J. , Munster P.N. , Andrykowski M.A. , Jacobsen P.B. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008 Aug; 16(8), p. 925-33.
EPub date: 2007-11-28.
PMID: 18043948
Related Citations

Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue.
Authors: Jacobsen P.B. , Donovan K.A. , Vadaparampil S.T. , Small B.J. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2007 Nov; 26(6), p. 660-7.
PMID: 18020836
Related Citations

Fatigue after treatment for early stage breast cancer: a controlled comparison.
Authors: Jacobsen P.B. , Donovan K.A. , Small B.J. , Jim H.S. , Munster P.N. , Andrykowski M.A. .
Source: Cancer, 2007-10-15; 110(8), p. 1851-9.
PMID: 17847016
Related Citations

Physical symptoms/side effects during breast cancer treatment predict posttreatment distress.
Authors: Jim H.S. , Andrykowski M.A. , Munster P.N. , Jacobsen P.B. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2007 Oct; 34(2), p. 200-8.
PMID: 17927558
Related Citations

Utility of a cognitive-behavioral model to predict fatigue following breast cancer treatment.
Authors: Donovan K.A. , Small B.J. , Andrykowski M.A. , Munster P. , Jacobsen P.B. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2007 Jul; 26(4), p. 464-72.
PMID: 17605566
Related Citations

Prospective, longitudinal study of leisure-time exercise in women with early-stage breast cancer.
Authors: Andrykowski M.A. , Beacham A.O. , Jacobsen P.B. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 Mar; 16(3), p. 430-8.
PMID: 17372237
Related Citations

Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma.
Authors: Donovan K.A. , Small B.J. , Andrykowski M.A. , Schmitt F.A. , Munster P. , Jacobsen P.B. .
Source: Cancer, 2005-12-01; 104(11), p. 2499-507.
PMID: 16247788
Related Citations

Use of a case definition approach to identify cancer-related fatigue in women undergoing adjuvant therapy for breast cancer.
Authors: Andrykowski M.A. , Schmidt J.E. , Salsman J.M. , Beacham A.O. , Jacobsen P.B. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005-09-20; 23(27), p. 6613-22.
PMID: 16170168
Related Citations

Relationship of problem-focused coping strategies to changes in quality of life following treatment for early stage breast cancer.
Authors: Ransom S. , Jacobsen P.B. , Schmidt J.E. , Andrykowski M.A. .
Source: Journal of pain and symptom management, 2005 Sep; 30(3), p. 243-53.
PMID: 16183008
Related Citations

Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer.
Authors: Donovan K.A. , Jacobsen P.B. , Andrykowski M.A. , Winters E.M. , Balducci L. , Malik U. , Kenady D. , McGrath P. .
Source: Journal of pain and symptom management, 2004 Oct; 28(4), p. 373-80.
PMID: 15471655
Related Citations

Relationship of catastrophizing to fatigue among women receiving treatment for breast cancer.
Authors: Jacobsen P.B. , Andrykowski M.A. , Thors C.L. .
Source: Journal of consulting and clinical psychology, 2004 Apr; 72(2), p. 355-61.
PMID: 15065968
Related Citations




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