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Grant Details

Grant Number: 5R01CA109250-05 Interpret this number
Primary Investigator: Audrain-Mcgovern, Janet
Organization: University Of Pennsylvania
Project Title: Longitudinal Patterns and Predictors of Smoking Behavior
Fiscal Year: 2008


DESCRIPTION (provided by applicant): While adolescent smoking rates have declined since the late 1990's, cigarette smoking among young adults (18-22) is an emerging problem. The prevalence of cigarette smoking is one of the highest in this age group and only 22% of young adults who have ever smoked regularly have quit. Despite the public health significance of smoking among young adults, our understanding of the determinants of smoking patterns and transitions in this group is very limited. In order to develop well-informed smoking prevention and treatment programs for young adults, a much more comprehensive understanding of the natural history and determinants of smoking in this population are needed. We propose to address this gap by following our established cohort of about 1,000 adolescents (initiated at age 14 years) into young adulthood (to age 22). Comprehensive data on the socio-environmental and psychological influences on smoking behavior during the adolescent phase (age 14 to age 18) will be supplemented with data collected as these individuals make the transition to young adulthood (age 18 to age 22). Specific phenotypes of interest include longitudinal patterns (trajectories) of smoking, rates of progression to regular smoking and nicotine dependence, and smoking persistence. The primary aims of the proposed study are to empirically identify the longitudinal patterns of smoking behavior (smoking trajectories) from adolescence (age 14) to young adulthood (age 22), to characterize the smoking trajectories by socio-environmental and psychological determinants, and to test mechanisms by which these determinants impact on smoking behavior. This will be one of the first studies to capture smoking transitions from adolescence to young adulthood and to evaluate smoking and its determinants in a longitudinal fashion. Results from this study can be used to inform the timing, level, type, and specific target of smoking interventions.


Declining alternative reinforcers link depression to young adult smoking.
Authors: Audrain-McGovern J. , Rodriguez D. , Rodgers K. , Cuevas J. .
Source: Addiction (Abingdon, England), 2011 Jan; 106(1), p. 178-87.
EPub date: 2010-09-15.
PMID: 20840206
Related Citations

Adolescent smoking and depression: evidence for self-medication and peer smoking mediation.
Authors: Audrain-McGovern J. , Rodriguez D. , Kassel J.D. .
Source: Addiction (Abingdon, England), 2009 Oct; 104(10), p. 1743-56.
EPub date: 2009-06-22.
PMID: 19549056
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Does delay discounting play an etiological role in smoking or is it a consequence of smoking?
Authors: Audrain-McGovern J. , Rodriguez D. , Epstein L.H. , Cuevas J. , Rodgers K. , Wileyto E.P. .
Source: Drug and alcohol dependence, 2009-08-01; 103(3), p. 99-106.
EPub date: 2009-05-14.
PMID: 19443136
Related Citations

Mechanisms underlying the comorbidity of tobacco use in mental health and addictive disorders.
Authors: Morisano D. , Bacher I. , Audrain-McGovern J. , George T.P. .
Source: Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2009 Jun; 54(6), p. 356-67.
PMID: 19527556
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Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report.
Authors: Ziedonis D. , Hitsman B. , Beckham J.C. , Zvolensky M. , Adler L.E. , Audrain-McGovern J. , Breslau N. , Brown R.A. , George T.P. , Williams J. , et al. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008 Dec; 10(12), p. 1691-715.
PMID: 19023823
Related Citations

Effects of inattention and hyperactivity/impulsivity symptoms on development of nicotine dependence from mid adolescence to young adulthood.
Authors: Rodriguez D. , Tercyak K.P. , Audrain-McGovern J. .
Source: Journal of pediatric psychology, 2008 Jul; 33(6), p. 563-75.
EPub date: 2007-10-23.
PMID: 17956929
Related Citations

Contextual consistency and adolescent smoking: testing the indirect effect of home indoor smoking restrictions on adolescent smoking through peer smoking.
Authors: Rodriguez D. , Tscherne J. , Audrain-McGovern J. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007 Nov; 9(11), p. 1155-61.
PMID: 17978989
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High school seniors' smoking initiation and progression 1 year after graduation.
Authors: Tercyak K.P. , Rodriguez D. , Audrain-McGovern J. .
Source: American journal of public health, 2007 Aug; 97(8), p. 1397-8.
EPub date: 2007-06-28.
PMID: 17600259
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The role of CYP2A6 in the emergence of nicotine dependence in adolescents.
Authors: Audrain-McGovern J. , Al Koudsi N. , Rodriguez D. , Wileyto E.P. , Shields P.G. , Tyndale R.F. .
Source: Pediatrics, 2007 Jan; 119(1), p. e264-74.
EPub date: 2006-11-27.
PMID: 17130279
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