Grant Details
Grant Number: |
2R01CA088363-06A2 Interpret this number |
Primary Investigator: |
Hayward, Nicholas |
Organization: |
Queensland Institute Of Medical Research |
Project Title: |
Pathways From Genotype and Environment to Melanoma |
Fiscal Year: |
2008 |
Abstract
DESCRIPTION (provided by applicant): For 20 years we have conducted large scale studies into the molecular genetics and epidemiology of melanoma and its risk factors, particularly nevus density which is more heritable than melanoma itself and therefore a better target for gene-finding. With NCI funds we recently followed up a population-based sample of 1,911 melanoma probands to update survival status and risk factor information; we have obtained DNA from all melanoma cases and a sample of unaffected relatives, and have done likewise in previously studied samples of melanoma cases in children (<14y), adolescents (14-19y) and older men (>50y). We now have DNA samples and risk factor information on 2,783 members of approximately 1,500 melanoma families. We also have >4000 DNA samples from adolescent twins and their family members for whom we have nevus counts and pigmentary phenotypes. From the latter study we recently published linkage to flat nevus density on 9p, 9q, 2p and 8q, replicated in one or more recent studies from UK, France (FR) and Netherlands (NL). To find causal variants under our linkage peaks and also in the rest of the genome we shall conduct a genomewide association scan for nevus density (GWAS). In Stage 1 we shall genotype extremes of the nevus density distribution (300 highest, 300 lowest, one individual per family) from our adolescent twins with 1 million SNPs using Illumina Hap1M arrays (>90% of the genome covered at r2>0.9). Arrays are enriched for SNPs in regions of copy number variation, which is plausibly implicated in nevus etiology. Different Bonferroni corrected alpha levels will be used to assess significance of the ~10,000 SNPs under our four nominated linkage peaks (5 x 10-6) and those in the rest of the genome (1.7 x 10-7). In Stage 2 the top 200 significant hits in linkage regions, and the top 200 in the rest of the genome will be typed in replication samples from the UK, FR and NL (N~3600) and in 1500 melanoma cases and 1500 controls from our familial melanoma study. In Stage 3, the top ~50 SNPs from a combined analysis of Stages 1 and 2 will be typed in the remainder of the adolescent nevus and familial melanoma studies (N=3,200). We shall perform within-family and case-control analyses for association of melanoma risk variables including status, age-at-onset, survival, and severity, with SNPs and environmental risk factors, stratified by familial risk and anatomic site of the melanoma. Similar analyses will be conducted for mediating variables such as nevus density, freckling, and pigmentation. We shall test for gene-gene interactions (epistasis) between SNPs of nevus genes and melanoma risk, and for gene-environment interactions of nevogenesis SNPs with measures of sun exposure, on melanoma risk. Relevance: A high mole count is the strongest risk factor for melanoma and our study has the power to find 80% of genes with effect sizes as small as 1% of variation in moliness. These in turn will be tested to assess their risk for melanoma, both singly and in combinations with other genetic and environmental risk factors. The costs of melanoma to society are considerable. In 1994, there were over 28,000 new cases of melanoma in the USA and a total of 6,680 people died from this disease. Incidence rates in Queensland are almost five times those in the United States. The aim of our research is to contribute to the alleviation of this disease burden, and it is our assessment that the potential benefits of this research greatly outweigh the costs.
Publications
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.
Authors: Landi M.T.
, Bishop D.T.
, MacGregor S.
, Machiela M.J.
, Stratigos A.J.
, Ghiorzo P.
, Brossard M.
, Calista D.
, Choi J.
, Fargnoli M.C.
, et al.
.
Source: Nature Genetics, 2020 May; 52(5), p. 494-504.
EPub date: 2020-04-27 00:00:00.0.
PMID: 32341527
Related Citations
Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma.
Authors: Johansson P.A.
, Nathan V.
, Bourke L.M.
, Palmer J.M.
, Zhang T.
, Symmons J.
, Howlie M.
, Patch A.M.
, Read J.
, Holland E.A.
, et al.
.
Source: Melanoma Research, 2019 Oct; 29(5), p. 483-490.
PMID: 31464824
Related Citations
Estimating CDKN2A mutation carrier probability among global familial melanoma cases using GenoMELPREDICT.
Authors: Taylor N.J.
, Mitra N.
, Qian L.
, Avril M.F.
, Bishop D.T.
, Bressac-de Paillerets B.
, Bruno W.
, Calista D.
, Cuellar F.
, Cust A.E.
, et al.
.
Source: Journal Of The American Academy Of Dermatology, 2019 Aug; 81(2), p. 386-394.
EPub date: 2019-02-05 00:00:00.0.
PMID: 30731170
Related Citations
Germline variation at CDKN2A and associations with nevus phenotypes among members of melanoma families.
Authors: Taylor N.J.
, Mitra N.
, Goldstein A.M.
, Tucker M.A.
, Avril M.F.
, Azizi E.
, Bergman W.
, Bishop D.T.
, Bressac-de Paillerets B.
, Bruno W.
, et al.
.
Source: The Journal Of Investigative Dermatology, 2017-08-19 00:00:00.0; , .
EPub date: 2017-08-19 00:00:00.0.
PMID: 28830827
Related Citations
Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia.
Authors: Rees E.
, Kendall K.
, Pardiñas A.F.
, Legge S.E.
, Pocklington A.
, Escott-Price V.
, MacCabe J.H.
, Collier D.A.
, Holmans P.
, O'Donovan M.C.
, et al.
.
Source: Jama Psychiatry, 2016-09-01 00:00:00.0; 73(9), p. 963-9.
PMID: 27602560
Related Citations
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.
Authors: Law M.H.
, Bishop D.T.
, Lee J.E.
, Brossard M.
, Martin N.G.
, Moses E.K.
, Song F.
, Barrett J.H.
, Kumar R.
, Easton D.F.
, et al.
.
Source: Nature Genetics, 2015 Sep; 47(9), p. 987-95.
PMID: 26237428
Related Citations
Parp1 Polymorphisms Play Opposing Roles In Melanoma Occurrence And Survival
Authors: Law M.H.
, Rowe C.J.
, Montgomery G.W.
, Hayward N.K.
, MacGregor S.
, Khosrotehrani K.
.
Source: International Journal Of Cancer, 2015-05-15 00:00:00.0; 136(10), p. 2488-9.
PMID: 25331333
Related Citations
Molecular Analysis Of Common Polymorphisms Within The Human Tyrosinase Locus And Genetic Association With Pigmentation Traits
Authors: Jagirdar K.
, Smit D.J.
, Ainger S.A.
, Lee K.J.
, Brown D.L.
, Chapman B.
, Zhen Zhao Z.
, Montgomery G.W.
, Martin N.G.
, Stow J.L.
, et al.
.
Source: Pigment Cell & Melanoma Research, 2014 Jul; 27(4), p. 552-64.
PMID: 24739399
Related Citations
Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Authors: Qian J.
, Liu H.
, Wei S.
, Liu Z.
, Li Y.
, Wang L.E.
, Chen W.V.
, Amos C.I.
, Lee J.E.
, GenoMEL investigators
, et al.
.
Source: Pigment Cell & Melanoma Research, 2013 May; 26(3), p. 392-401.
PMID: 23360169
Related Citations
Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.
Authors: Liu H.
, Wang L.E.
, Liu Z.
, Chen W.V.
, Amos C.I.
, Lee J.E.
, Q-MEGA and AMFS Investigators
, GenoMEL Investigators
, Iles M.M.
, Law M.H.
, et al.
.
Source: Carcinogenesis, 2013 Apr; 34(4), p. 885-92.
PMID: 23291271
Related Citations
A variant in FTO shows association with melanoma risk not due to BMI.
Authors: Iles M.M.
, Law M.H.
, Stacey S.N.
, Han J.
, Fang S.
, Pfeiffer R.
, Harland M.
, Macgregor S.
, Taylor J.C.
, Aben K.K.
, et al.
.
Source: Nature Genetics, 2013 Apr; 45(4), p. 428-32, 432e1.
PMID: 23455637
Related Citations
Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.
Authors: Law M.H.
, Montgomery G.W.
, Brown K.M.
, Martin N.G.
, Mann G.J.
, Hayward N.K.
, MacGregor S.
, Q-MEGA and AMFS Investigators
.
Source: The Journal Of Investigative Dermatology, 2012 Feb; 132(2), p. 485-7.
PMID: 21993562
Related Citations
A Novel Recurrent Mutation In Mitf Predisposes To Familial And Sporadic Melanoma
Authors: Yokoyama S.
, Woods S.L.
, Boyle G.M.
, Aoude L.G.
, MacGregor S.
, Zismann V.
, Gartside M.
, Cust A.E.
, Haq R.
, Harland M.
, et al.
.
Source: Nature, 2011-12-01 00:00:00.0; 480(7375), p. 99-103.
PMID: 22080950
Related Citations
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.
Authors: Macgregor S.
, Montgomery G.W.
, Liu J.Z.
, Zhao Z.Z.
, Henders A.K.
, Stark M.
, Schmid H.
, Holland E.A.
, Duffy D.L.
, Zhang M.
, et al.
.
Source: Nature Genetics, 2011-10-09 00:00:00.0; 43(11), p. 1114-8.
EPub date: 2011-10-09 00:00:00.0.
PMID: 21983785
Related Citations
Genome-wide association study identifies three new melanoma susceptibility loci.
Authors: Barrett J.H.
, Iles M.M.
, Harland M.
, Taylor J.C.
, Aitken J.F.
, Andresen P.A.
, Akslen L.A.
, Armstrong B.K.
, Avril M.F.
, Azizi E.
, et al.
.
Source: Nature Genetics, 2011-10-09 00:00:00.0; 43(11), p. 1108-13.
EPub date: 2011-10-09 00:00:00.0.
PMID: 21983787
Related Citations
Polymorphisms In Nevus-associated Genes Mtap, Pla2g6, And Irf4 And The Risk Of Invasive Cutaneous Melanoma
Authors: Kvaskoff M.
, Whiteman D.C.
, Zhao Z.Z.
, Montgomery G.W.
, Martin N.G.
, Hayward N.K.
, Duffy D.L.
.
Source: Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies, 2011 Oct; 14(5), p. 422-32.
PMID: 21962134
Related Citations
Nevi, Family History, And Fair Skin Increase The Risk Of Second Primary Melanoma
Authors: Siskind V.
, Hughes M.C.
, Palmer J.M.
, Symmons J.M.
, Aitken J.F.
, Martin N.G.
, Hayward N.K.
, Whiteman D.C.
.
Source: The Journal Of Investigative Dermatology, 2011 Feb; 131(2), p. 461-7.
PMID: 20944647
Related Citations
Association Of Mc1r Variants And Host Phenotypes With Melanoma Risk In Cdkn2a Mutation Carriers: A Genomel Study
Authors: Demenais F.
, Mohamdi H.
, Chaudru V.
, Goldstein A.M.
, Newton Bishop J.A.
, Bishop D.T.
, Kanetsky P.A.
, Hayward N.K.
, Gillanders E.
, Elder D.E.
, et al.
.
Source: Journal Of The National Cancer Institute, 2010-10-20 00:00:00.0; 102(20), p. 1568-83.
PMID: 20876876
Related Citations
Predictors Of Sun Protection Behaviors And Severe Sunburn In An International Online Study
Authors: Bränström R.
, Kasparian N.A.
, Chang Y.M.
, Affleck P.
, Tibben A.
, Aspinwall L.G.
, Azizi E.
, Baron-Epel O.
, Battistuzzi L.
, Bergman W.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Sep; 19(9), p. 2199-210.
PMID: 20643826
Related Citations
Irf4 Variants Have Age-specific Effects On Nevus Count And Predispose To Melanoma
Authors: Duffy D.L.
, Iles M.M.
, Glass D.
, Zhu G.
, Barrett J.H.
, Höiom V.
, Zhao Z.Z.
, Sturm R.A.
, Soranzo N.
, Hammond C.
, et al.
.
Source: American Journal Of Human Genetics, 2010-07-09 00:00:00.0; 87(1), p. 6-16.
PMID: 20602913
Related Citations
Melanoma Risk Factors, Perceived Threat And Intentional Tanning: An International Online Survey
Authors: Bränström R.
, Chang Y.M.
, Kasparian N.
, Affleck P.
, Tibben A.
, Aspinwall L.G.
, Azizi E.
, Baron-Epel O.
, Battistuzzi L.
, Bruno W.
, et al.
.
Source: European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ecp), 2010 May; 19(3), p. 216-26.
PMID: 20093934
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Digital Quantification Of Human Eye Color Highlights Genetic Association Of Three New Loci
Authors: Liu F.
, Wollstein A.
, Hysi P.G.
, Ankra-Badu G.A.
, Spector T.D.
, Park D.
, Zhu G.
, Larsson M.
, Duffy D.L.
, Montgomery G.W.
, et al.
.
Source: Plos Genetics, 2010 May; 6(5), p. e1000934.
PMID: 20463881
Related Citations
Multiple Pigmentation Gene Polymorphisms Account For A Substantial Proportion Of Risk Of Cutaneous Malignant Melanoma
Authors: Duffy D.L.
, Zhao Z.Z.
, Sturm R.A.
, Hayward N.K.
, Martin N.G.
, Montgomery G.W.
.
Source: The Journal Of Investigative Dermatology, 2010 Feb; 130(2), p. 520-8.
PMID: 19710684
Related Citations
Coexisting Nras And Braf Mutations In Primary Familial Melanomas With Specific Cdkn2a Germline Alterations
Authors: Jovanovic B.
, Egyhazi S.
, Eskandarpour M.
, Ghiorzo P.
, Palmer J.M.
, Bianchi Scarrà G.
, Hayward N.K.
, Hansson J.
.
Source: The Journal Of Investigative Dermatology, 2010 Feb; 130(2), p. 618-20.
PMID: 19759551
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Evaluation Of Association Of Hnf1b Variants With Diverse Cancers: Collaborative Analysis Of Data From 19 Genome-wide Association Studies
Authors: Elliott K.S.
, Zeggini E.
, McCarthy M.I.
, Gudmundsson J.
, Sulem P.
, Stacey S.N.
, Thorlacius S.
, Amundadottir L.
, Grönberg H.
, Xu J.
, et al.
.
Source: Plos One, 2010; 5(5), p. e10858.
PMID: 20526366
Related Citations
A Population-based Study Of Australian Twins With Melanoma Suggests A Strong Genetic Contribution To Liability
Authors: Shekar S.N.
, Duffy D.L.
, Youl P.
, Baxter A.J.
, Kvaskoff M.
, Whiteman D.C.
, Green A.C.
, Hughes M.C.
, Hayward N.K.
, Coates M.
, et al.
.
Source: The Journal Of Investigative Dermatology, 2009 Sep; 129(9), p. 2211-9.
PMID: 19357710
Related Citations
Genome-wide Association Study Identifies Three Loci Associated With Melanoma Risk
Authors: Bishop D.T.
, Demenais F.
, Iles M.M.
, Harland M.
, Taylor J.C.
, Corda E.
, Randerson-Moor J.
, Aitken J.F.
, Avril M.F.
, Azizi E.
, et al.
.
Source: Nature Genetics, 2009 Aug; 41(8), p. 920-5.
PMID: 19578364
Related Citations
Genome-wide Association Study Identifies Variants At 9p21 And 22q13 Associated With Development Of Cutaneous Nevi
Authors: Falchi M.
, Bataille V.
, Hayward N.K.
, Duffy D.L.
, Bishop J.A.
, Pastinen T.
, Cervino A.
, Zhao Z.Z.
, Deloukas P.
, Soranzo N.
, et al.
.
Source: Nature Genetics, 2009 Aug; 41(8), p. 915-9.
PMID: 19578365
Related Citations
Relative Finger Lengths, Sex Differences, And Psychological Traits
Authors: Loehlin J.C.
, Medland S.E.
, Martin N.G.
.
Source: Archives Of Sexual Behavior, 2009 Apr; 38(2), p. 298-305.
PMID: 18340520
Related Citations
Polymorphisms In The Syntaxin 17 Gene Are Not Associated With Human Cutaneous Malignant Melanoma
Authors: Zhao Z.Z.
, Duffy D.L.
, Thomas S.A.
, Martin N.G.
, Hayward N.K.
, Montgomery G.W.
.
Source: Melanoma Research, 2009 Apr; 19(2), p. 80-6.
PMID: 19209086
Related Citations
Linkage And Association Analysis Of Spectrophotometrically Quantified Hair Color In Australian Adolescents: The Effect Of Oca2 And Herc2
Authors: Shekar S.N.
, Duffy D.L.
, Frudakis T.
, Sturm R.A.
, Zhao Z.Z.
, Montgomery G.W.
, Martin N.G.
.
Source: The Journal Of Investigative Dermatology, 2008 Dec; 128(12), p. 2807-14.
PMID: 18528436
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A Genome-wide Linkage Scan For Age At Menarche In Three Populations Of European Descent
Authors: Anderson C.A.
, Zhu G.
, Falchi M.
, van den Berg S.M.
, Treloar S.A.
, Spector T.D.
, Martin N.G.
, Boomsma D.I.
, Visscher P.M.
, Montgomery G.W.
.
Source: The Journal Of Clinical Endocrinology And Metabolism, 2008 Oct; 93(10), p. 3965-70.
PMID: 18647812
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Histologic And Epidemiologic Correlates Of P-mapk, Brn-2, Prb, P53, And P16 Immunostaining In Cutaneous Melanomas
Authors: Richmond-Sinclair N.M.
, Lee E.
, Cummings M.C.
, Williamson R.
, Muller K.
, Green A.C.
, Hayward N.K.
, Whiteman D.C.
.
Source: Melanoma Research, 2008 Oct; 18(5), p. 336-45.
PMID: 18781132
Related Citations
Common Sequence Variants On 20q11.22 Confer Melanoma Susceptibility
Authors: Brown K.M.
, Macgregor S.
, Montgomery G.W.
, Craig D.W.
, Zhao Z.Z.
, Iyadurai K.
, Henders A.K.
, Homer N.
, Campbell M.J.
, Stark M.
, et al.
.
Source: Nature Genetics, 2008 Jul; 40(7), p. 838-40.
PMID: 18488026
Related Citations
Genetic Dissection Of Myopia: Evidence For Linkage Of Ocular Axial Length To Chromosome 5q
Authors: Zhu G.
, Hewitt A.W.
, Ruddle J.B.
, Kearns L.S.
, Brown S.A.
, Mackinnon J.R.
, Chen C.Y.
, Hammond C.J.
, Craig J.E.
, Montgomery G.W.
, et al.
.
Source: Ophthalmology, 2008 Jun; 115(6), p. 1053-1057.e2.
PMID: 17964656
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A Comparison Of Cdkn2a Mutation Detection Within The Melanoma Genetics Consortium (genomel)
Authors: Harland M.
, Goldstein A.M.
, Kukalizch K.
, Taylor C.
, Hogg D.
, Puig S.
, Badenas C.
, Gruis N.
, ter Huurne J.
, Bergman W.
, et al.
.
Source: European Journal Of Cancer (oxford, England : 1990), 2008 Jun; 44(9), p. 1269-74.
PMID: 18394881
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A Genome-wide Association Study Identifies Novel Alleles Associated With Hair Color And Skin Pigmentation
Authors: Han J.
, Kraft P.
, Nan H.
, Guo Q.
, Chen C.
, Qureshi A.
, Hankinson S.E.
, Hu F.B.
, Duffy D.L.
, Zhao Z.Z.
, et al.
.
Source: Plos Genetics, 2008-05-16 00:00:00.0; 4(5), p. e1000074.
PMID: 18483556
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Spectrophotometric Methods For Quantifying Pigmentation In Human Hair-influence Of Mc1r Genotype And Environment
Authors: Shekar S.N.
, Duffy D.L.
, Frudakis T.
, Montgomery G.W.
, James M.R.
, Sturm R.A.
, Martin N.G.
.
Source: Photochemistry And Photobiology, 2008 May-Jun; 84(3), p. 719-26.
PMID: 18435620
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The Queensland Study Of Melanoma: Environmental And Genetic Associations (q-mega); Study Design, Baseline Characteristics, And Repeatability Of Phenotype And Sun Exposure Measures
Authors: Baxter A.J.
, Hughes M.C.
, Kvaskoff M.
, Siskind V.
, Shekar S.
, Aitken J.F.
, Green A.C.
, Duffy D.L.
, Hayward N.K.
, Martin N.G.
, et al.
.
Source: Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies, 2008 Apr; 11(2), p. 183-96.
PMID: 18361720
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A Single Snp In An Evolutionary Conserved Region Within Intron 86 Of The Herc2 Gene Determines Human Blue-brown Eye Color
Authors: Sturm R.A.
, Duffy D.L.
, Zhao Z.Z.
, Leite F.P.
, Stark M.S.
, Hayward N.K.
, Martin N.G.
, Montgomery G.W.
.
Source: American Journal Of Human Genetics, 2008 Feb; 82(2), p. 424-31.
PMID: 18252222
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Estimation Of Variance Components For Age At Menarche In Twin Families
Authors: Anderson C.A.
, Duffy D.L.
, Martin N.G.
, Visscher P.M.
.
Source: Behavior Genetics, 2007 Sep; 37(5), p. 668-77.
PMID: 17680356
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Features Associated With Germline Cdkn2a Mutations: A Genomel Study Of Melanoma-prone Families From Three Continents
Authors: Goldstein A.M.
, Chan M.
, Harland M.
, Hayward N.K.
, Demenais F.
, Bishop D.T.
, Azizi E.
, Bergman W.
, Bianchi-Scarra G.
, Bruno W.
, et al.
.
Source: Journal Of Medical Genetics, 2007 Feb; 44(2), p. 99-106.
PMID: 16905682
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A Three-single-nucleotide Polymorphism Haplotype In Intron 1 Of Oca2 Explains Most Human Eye-color Variation
Authors: Duffy D.L.
, Montgomery G.W.
, Chen W.
, Zhao Z.Z.
, Le L.
, James M.R.
, Hayward N.K.
, Martin N.G.
, Sturm R.A.
.
Source: American Journal Of Human Genetics, 2007 Feb; 80(2), p. 241-52.
PMID: 17236130
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A Genome-wide Scan For Naevus Count: Linkage To Cdkn2a And To Other Chromosome Regions
Authors: Zhu G.
, Montgomery G.W.
, James M.R.
, Trent J.M.
, Hayward N.K.
, Martin N.G.
, Duffy D.L.
.
Source: European Journal Of Human Genetics : Ejhg, 2007 Jan; 15(1), p. 94-102.
PMID: 17063143
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High-risk Melanoma Susceptibility Genes And Pancreatic Cancer, Neural System Tumors, And Uveal Melanoma Across Genomel
Authors: Goldstein A.M.
, Chan M.
, Harland M.
, Gillanders E.M.
, Hayward N.K.
, Avril M.F.
, Azizi E.
, Bianchi-Scarra G.
, Bishop D.T.
, Bressac-de Paillerets B.
, et al.
.
Source: Cancer Research, 2006-10-15 00:00:00.0; 66(20), p. 9818-28.
PMID: 17047042
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Rapid Screening Of 4000 Individuals For Germ-line Variations In The Braf Gene
Authors: James M.R.
, Dumeni T.
, Stark M.S.
, Duffy D.L.
, Montgomery G.W.
, Martin N.G.
, Hayward N.K.
.
Source: Clinical Chemistry, 2006 Sep; 52(9), p. 1675-8.
PMID: 16873291
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Sun Exposure And Host Phenotype As Predictors Of Cutaneous Melanoma Associated With Neval Remnants Or Dermal Elastosis
Authors: Lee E.Y.
, Williamson R.
, Watt P.
, Hughes M.C.
, Green A.C.
, Whiteman D.C.
.
Source: International Journal Of Cancer, 2006-08-01 00:00:00.0; 119(3), p. 636-42.
PMID: 16572428
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Anatomic Site, Sun Exposure, And Risk Of Cutaneous Melanoma
Authors: Whiteman D.C.
, Stickley M.
, Watt P.
, Hughes M.C.
, Davis M.B.
, Green A.C.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2006-07-01 00:00:00.0; 24(19), p. 3172-7.
PMID: 16809740
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A Genome Scan For Epidermal Skin Pattern In Adolescent Twins Reveals Suggestive Linkage On 12p13.31
Authors: Shekar S.N.
, Duffy D.L.
, Montgomery G.W.
, Martin N.G.
.
Source: The Journal Of Investigative Dermatology, 2006 Feb; 126(2), p. 277-82.
PMID: 16374462
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Replicated Linkage For Eye Color On 15q Using Comparative Ratings Of Sibling Pairs
Authors: Posthuma D.
, Visscher P.M.
, Willemsen G.
, Zhu G.
, Martin N.G.
, Slagboom P.E.
, de Geus E.J.
, Boomsma D.I.
.
Source: Behavior Genetics, 2006 Jan; 36(1), p. 12-7.
PMID: 16341609
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