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Grant Details

Grant Number: 5R01CA106668-05 Interpret this number
Primary Investigator: Williams, Geoffrey
Organization: University Of Rochester
Project Title: Self-Determination and Maintaining Tobacco Abstinence
Fiscal Year: 2008


DESCRIPTION (provided by applicant): This application (RFA # OB-03-003) extends our examination of self-determination theory (SDT) based counseling interventions to the issue of maintained abstinence from tobacco use. Two projects are proposed, both of which build on the results of our current trial. The first is a 32-month follow-up of the smoking status of patients in the current trial. The SDT intervention was effective at 6 months relative to community care, and, according to preliminary analyses, was also effective for maintenance at 18 months, but long-term (32-month) follow-up data are needed. The second project is a 3-cell clinical trial. The current results show that patients were four times more likely to quit by 6 months if they used medications known to be efficacious for cessation, so the trial will examine two extensions of the current intervention, both of which place greater emphasis on use of, and adherence to, cessation medications. The two arms will be compared to community care. Both arms involve two visits with a physician to discuss medications and side effects. In both interventions, counselors will address medication adherence. The two arms differ in that patients not ready to quit in one arm will receive a smoking reduction approach (with medications) in which they first try to reduce their smoking to half and then attempt cessation. In addition to greater emphasis on medications and examination of medication adherence as a mediator of maintained cessation, there will be two major changes in the intervention intended to facilitate long-term maintenance. First, the intervention will extend over 12 months (whereas the current one lasts only 6 months) with meetings during the additional time focusing on maintenance and relapse prevention. Second, at least one family member or best friend of each patient will be encouraged to meet with a counselor to learn how to be more autonomy supportive with the patient around issues related to tobacco. Our current results show that family autonomy support predicts cessation, and family members represent an important source of support for long-term maintenance of abstinence. Cessation and maintained abstinence will be examined with logistic regression and survival curve analyses. The SDT process model of maintained cessation will be tested using structural equation modeling, and cost-effectiveness analyses will be done for the interventions.


Self-determination theory and the smoking cessation process: Daily electronic self-reports can identify the initiation of quit attempts.
Authors: Niemiec C.P. , Ivarsson A. , Weman K. , Smit E. , Williams G.C. .
Source: Patient education and counseling, 2023 Oct; 115, p. 107886.
EPub date: 2023-07-07.
PMID: 37567038
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Study of monotherapy versus combination therapy for tobacco dependence among heavily addicted smokers.
Authors: Ternullo S.R. , Abdolahi A. , Williams G.C. .
Source: Journal of the American Pharmacists Association : JAPhA, 2017 Jan-Feb; 57(1), p. 77-81.e1.
EPub date: 2016-11-11.
PMID: 27839954
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Outcomes of the Smoker's Health Project: a pragmatic comparative effectiveness trial of tobacco-dependence interventions based on self-determination theory.
Authors: Williams G.C. , Niemiec C.P. , Patrick H. , Ryan R.M. , Deci E.L. .
Source: Health education research, 2016 Dec; 31(6), p. 749-759.
EPub date: 2016-10-22.
PMID: 27923864
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Cost-effectiveness of intensive tobacco dependence intervention based on self-determination theory.
Authors: Pesis-Katz I. , Williams G.C. , Niemiec C.P. , Fiscella K. .
Source: The American journal of managed care, 2011-10-01; 17(10), p. e393-8.
EPub date: 2011-10-01.
PMID: 21999719
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The smoker's health project: a self-determination theory intervention to facilitate maintenance of tobacco abstinence.
Authors: Williams G.C. , Patrick H. , Niemiec C.P. , Ryan R.M. , Deci E.L. , Lavigne H.M. .
Source: Contemporary clinical trials, 2011 Jul; 32(4), p. 535-43.
EPub date: 2011-03-05.
PMID: 21382516
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The importance of supporting autonomy and perceived competence in facilitating long-term tobacco abstinence.
Authors: Williams G.C. , Niemiec C.P. , Patrick H. , Ryan R.M. , Deci E.L. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2009 Jun; 37(3), p. 315-24.
EPub date: 2009-04-17.
PMID: 19373517
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Aspiring to physical health: the role of aspirations for physical health in facilitating long-term tobacco abstinence.
Authors: Niemiec C.P. , Ryan R.M. , Deci E.L. , Williams G.C. .
Source: Patient education and counseling, 2009 Feb; 74(2), p. 250-7.
EPub date: 2008-10-05.
PMID: 18838243
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Self-regulation and the problem of human autonomy: does psychology need choice, self-determination, and will?
Authors: Ryan R.M. , Deci E.L. .
Source: Journal of personality, 2006 Dec; 74(6), p. 1557-85.
PMID: 17083658
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