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Grant Details

Grant Number: 5R01CA103827-05 Interpret this number
Primary Investigator: Eissenberg, Thomas
Organization: Virginia Commonwealth University
Project Title: Clinical Models for Evaluating Preps for Tobacco Users
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Use of cigarettes and smokeless tobacco (SLT) in the U.S. costs over 400,000 lives and $100 billion annually. These tobacco-related deaths and health care costs are due to tobacco-delivered toxicants, especially carcinogens. Tobacco cessation is the most effective way of reducing toxicant exposure, though relapse rates are high. High relapse rates and continued tobacco use have provoked interest in harm reduction for people who continue to use tobacco. Harm reduction for tobacco users can involve lowering the total adverse health consequences of continued tobacco use by reducing toxicant exposure. The tobacco industry appears to embrace this type of harm reduction, and markets several potential reduced exposure products (PREPs) for smokers and SLT users. The National Cancer Institute and Institute of Medicine argue for objective testing of these PREPs. No accepted testing method exists, though we have had success using a short-term clinical model for evaluating cigarette-like PREPs for smokers. This short-term model could be improved and must be adapted to evaluate oral PREPs for SLT users and smokers. A longer-term model is necessary to measure PREP-induced reductions in carcinogen exposure. The specific aims of this proposal are to: (1) Improve the short-term clinical model for evaluating cigarette-like PREPs by allowing ad libitum puffing so that PREP-induced changes in smoking behavior can be measured, and introducing pre- and post-exposure blood sampling so that PREP nicotine delivery can be assessed. (2) Adapt the short-term clinical model so that it can be used to evaluate oral products intended for SLT users and/or smokers, and (3) Develop a longer-term clinical model for evaluating PREP carcinogen delivery. This project's overarching goal is to establish a clinical model that can be used to evaluate the marketing claims and harm reduction potential of PREPs for tobacco users. The project is consistent with NCI's Plans and Priorities for Cancer Research in 2004: "Smokers may feel a false sense of security that they can significantly reduce their risk of disease by using these new products [PREPs], when no data exists to suggest that they are in fact less harmful. Scientists must examine the toxicity of these products as well as evaluate whether or not 'harm reduction' is a viable public health strategy." This proposal's clinical model will likely be an important component of a comprehensive approach to predict if PREPs for tobacco users increase, decrease, or fail to change tobacco's health risks.

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Publications

Measurement of smoking behavior: Comparison of self-reports, returned cigarette butts, and toxicant levels.
Authors: Blank M.D. , Breland A.B. , Enlow P.T. , Duncan C. , Metzger A. , Cobb C.O. .
Source: Experimental and clinical psychopharmacology, 2016 10; 24(5), p. 348-355.
EPub date: 2016-06-27.
PMID: 27347741
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Waterpipe tobacco products: nicotine labelling versus nicotine delivery.
Authors: Vansickel A.R. , Shihadeh A. , Eissenberg T. .
Source: Tobacco control, 2012 May; 21(3), p. 377-9.
EPub date: 2011-06-02.
PMID: 21636612
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Electronic nicotine delivery systems: a research agenda.
Authors: Etter J.F. , Bullen C. , Flouris A.D. , Laugesen M. , Eissenberg T. .
Source: Tobacco control, 2011 May; 20(3), p. 243-8.
EPub date: 2011-03-17.
PMID: 21415064
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Evaluating the acute effects of oral, non-combustible potential reduced exposure products marketed to smokers.
Authors: Cobb C.O. , Weaver M.F. , Eissenberg T. .
Source: Tobacco control, 2010 Oct; 19(5), p. 367-73.
EPub date: 2009-04-02.
PMID: 19346218
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A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects.
Authors: Vansickel A.R. , Cobb C.O. , Weaver M.F. , Eissenberg T.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Aug; 19(8), p. 1945-53.
EPub date: 2010-07-20.
PMID: 20647410
Related Citations

Waterpipe tobacco smoking: an emerging health crisis in the United States.
Authors: Cobb C. , Ward K.D. , Maziak W. , Shihadeh A.L. , Eissenberg T. .
Source: American journal of health behavior, 2010 May-Jun; 34(3), p. 275-85.
PMID: 20001185
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Evaluating oral noncombustible potential-reduced exposure products for smokers.
Authors: Blank M.D. , Eissenberg T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010 Apr; 12(4), p. 336-43.
EPub date: 2010-02-16.
PMID: 20159791
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Electronic nicotine delivery devices: ineffective nicotine delivery and craving suppression after acute administration.
Authors: Eissenberg T. .
Source: Tobacco control, 2010 Feb; 19(1), p. 87-8.
PMID: 20154061
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Criteria for evaluating tobacco control research funding programs and their application to models that include financial support from the tobacco industry.
Authors: Cohen J.E. , Zeller M. , Eissenberg T. , Parascandola M. , O'Keefe R. , Planinac L. , Leischow S. .
Source: Tobacco control, 2009 Jun; 18(3), p. 228-34.
EPub date: 2009-02-24.
PMID: 19240229
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Water-pipe tobacco smoking among middle and high school students in Arizona.
Authors: Primack B.A. , Walsh M. , Bryce C. , Eissenberg T. .
Source: Pediatrics, 2009 Feb; 123(2), p. e282-8.
PMID: 19171581
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Potential reduced exposure products (PREPs) for smokeless tobacco users: clinical evaluation methodology.
Authors: Gray J.N. , Breland A.B. , Weaver M. , Eissenberg T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008 Sep; 10(9), p. 1441-8.
PMID: 19023835
Related Citations

Prevalence of and associations with waterpipe tobacco smoking among U.S. university students.
Authors: Primack B.A. , Sidani J. , Agarwal A.A. , Shadel W.G. , Donny E.C. , Eissenberg T.E. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2008 Aug; 36(1), p. 81-6.
EPub date: 2008-08-22.
PMID: 18719977
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Waterpipe tobacco smoking on a U.S. College campus: prevalence and correlates.
Authors: Eissenberg T. , Ward K.D. , Smith-Simone S. , Maziak W. .
Source: The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2008 May; 42(5), p. 526-9.
EPub date: 2007-12-21.
PMID: 18407049
Related Citations

Nicotine delivery, cardiovascular profile, and subjective effects of an oral tobacco product for smokers.
Authors: Blank M.D. , Sams C. , Weaver M.F. , Eissenberg T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008 Mar; 10(3), p. 417-21.
PMID: 18324559
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Waterpipe tobacco smoking: knowledge, attitudes, beliefs, and behavior in two U.S. samples.
Authors: Smith-Simone S. , Maziak W. , Ward K.D. , Eissenberg T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008 Feb; 10(2), p. 393-8.
PMID: 18236304
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Exposure to secondhand smoke at home and in public places in Syria: a developing country's perspective.
Authors: Maziak W. , Ali R.A. , Fouad M.F. , Rastam S. , Wipfli H. , Travers M.J. , Ward K.D. , Eissenberg T. .
Source: Inhalation toxicology, 2008 Jan; 20(1), p. 17-24.
PMID: 18236217
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Characteristics of U.S. waterpipe users: a preliminary report.
Authors: Ward K.D. , Eissenberg T. , Gray J.N. , Srinivas V. , Wilson N. , Maziak W. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007 Dec; 9(12), p. 1339-46.
PMID: 18058352
Related Citations

Caffeine's influence on nicotine's effects in nonsmokers.
Authors: Blank M.D. , Kleykamp B.A. , Jennings J.M. , Eissenberg T. .
Source: American journal of health behavior, 2007 Sep-Oct; 31(5), p. 473-83.
PMID: 17555378
Related Citations

Clinical laboratory evaluation of potential reduced exposure products for smokers.
Authors: Breland A.B. , Kleykamp B.A. , Eissenberg T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006 Dec; 8(6), p. 727-38.
PMID: 17132520
Related Citations

The time for tobacco industry sponsored PREP evaluation has arrived.
Authors: Eissenberg T. .
Source: Tobacco control, 2006 Feb; 15(1), p. 1-2.
PMID: 16436389
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Tobacco smoking using a waterpipe: a re-emerging strain in a global epidemic.
Authors: Maziak W. , Ward K.D. , Afifi Soweid R.A. , Eissenberg T. .
Source: Tobacco control, 2004 Dec; 13(4), p. 327-33.
PMID: 15564614
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