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Grant Details

Grant Number: 5R01CA081310-07 Interpret this number
Primary Investigator: Giuliano, Anna
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Effect of Oxidant Load on HPV Persistence and Cin (SIL)
Fiscal Year: 2008
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Abstract

Preliminary analyses from the past three years of funding indicate that dietary and serum carotenoids, potent antioxidants, are independently associated with type-specific HPV persistence. Our observations of a reduced risk of persistent infection with compounds that quench reactive oxygen species combined with a growing literature demonstrating increased risk of cervical disease with factors that generate reactive oxygen species, lead us to hypothesize that the oxidant: antioxidant ratio may influence the natural history of HPV infections and hence disease progression. The overall goal of this application is to determine, using prospectively collected HPV and cytology data, the association between markers of oxidant load and cervical carcinogenesis among women in the Ludwig- McGill HPV Natural History Study. This project will provide the first prospective analysis of the association between markers of oxidant load [e.g., malondialdehyde and anti-5-hydroxymethyl-2'-deoxyuridine autoantibodies (anti-HMdU aAb)] and risk for persistent HPV infection that utilizes sensitive and specific methods for assessing type of HPV infection over a 36-month period. In addition, we will prospectively determine risk of progression to SIL over a 5-year period associated with markers of oxidant load. This study is unique in that it focuses on early events in cervical carcinogenesis: HPV infection, HPV persistence, and progression to SIL. It is cost effective utilizing previously collected serum samples and questionnaire and antioxidant nutrient data. The study utilizes state of the art methods for determining both HPV status and oxidant load status. Furthermore, it incorporates multiple measurements of HPV status, factors that contribute to oxidant load, and oxidant load, lessening the probability that measurement imprecision resulting from temporal fluctuations will obscure the total association.

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Publications

Biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response?
Authors: Siegel E.M. , Patel N. , Lu B. , Lee J.H. , Nyitray A.G. , Craft N.E. , Frenkel K. , Villa L.L. , Franco E.L. , Giuliano A.R. .
Source: International journal of cancer, 2012-07-01; 131(1), p. 219-28.
EPub date: 2011-11-28.
PMID: 21858808
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Circulating biomarkers of iron storage and clearance of incident human papillomavirus infection.
Authors: Siegel E.M. , Patel N. , Lu B. , Lee J.H. , Nyitray A.G. , Huang X. , Villa L.L. , Franco E.L. , Giuliano A.R. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012 May; 21(5), p. 859-65.
EPub date: 2012-03-16.
PMID: 22426142
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Optimizing technology for cervical cancer screening in high-resource settings.
Authors: Richardson L.A. , Tota J. , Franco E.L. .
Source: Expert review of obstetrics & gynecology, 2011 May; 6(3), p. 343-353.
PMID: 26617667
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Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.
Authors: Siegel E.M. , Salemi J.L. , Villa L.L. , Ferenczy A. , Franco E.L. , Giuliano A.R. .
Source: Gynecologic oncology, 2010 Sep; 118(3), p. 289-94.
EPub date: 2010-06-18.
PMID: 20691333
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No association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in Brazilian women.
Authors: Siegel E.M. , Salemi J.L. , Craft N.E. , Villa L.L. , Ferenczy A.S. , Franco E.L. , Giuliano A.R. .
Source: Cancer prevention research (Philadelphia, Pa.), 2010 Aug; 3(8), p. 1007-14.
EPub date: 2010-07-06.
PMID: 20606041
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Associations between serum carotenoids and tocopherols and type-specific HPV persistence: the Ludwig-McGill cohort study.
Authors: Siegel E.M. , Craft N.E. , Duarte-Franco E. , Villa L.L. , Franco E.L. , Giuliano A.R. .
Source: International journal of cancer, 2007-02-01; 120(3), p. 672-80.
PMID: 17096322
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Temporal variation and identification of factors associated with endogenous retinoic acid isomers in serum from Brazilian women.
Authors: Siegel E.M. , Craft N.E. , Roe D.J. , Duarte-Franco E. , Villa L.L. , Franco E.L. , Giuliano A.R. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004 Nov; 13(11 Pt 1), p. 1693-703.
PMID: 15533895
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Performance assessment of eight high-throughput PCR assays for viral load quantitation of oncogenic HPV types.
Authors: Flores-Munguia R. , Siegel E. , Klimecki W.T. , Giuliano A.R. .
Source: The Journal of molecular diagnostics : JMD, 2004 May; 6(2), p. 115-24.
PMID: 15096567
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Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study.
Authors: Giuliano A.R. , Siegel E.M. , Roe D.J. , Ferreira S. , Baggio M.L. , Galan L. , Duarte-Franco E. , Villa L.L. , Rohan T.E. , Marshall J.R. , et al. .
Source: The Journal of infectious diseases, 2003-11-15; 188(10), p. 1508-16.
EPub date: 2003-11-03.
PMID: 14624376
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