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Grant Details

Grant Number: 5R03CA123546-02 Interpret this number
Primary Investigator: Brennan, Paul
Organization: International Agency For Res On Cancer
Project Title: Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk R*
Fiscal Year: 2007


Abstract

DESCRIPTION (provided by applicant): On an international level, the highest incidence rates for pancreatic cancer occur among US blacks and among Caucasian populations in Central Europe, in particular in Czech Republic and Slovakia. The reason for this high incidence is not known. We will conduct a pilot for a multicentre case-control study of pancreatic cancer in 5 centers within the high risk region of Czech Republic and Slovakia in order to investigate the role of established and potential risk factors, as well as to generate a biorepository for future molecular and genetic epidemiology studies. This pilot study will build on previous large case- control studies that were successfully conducted in these centres on lung and kidney cancer. Our proposed study will have a strong focus on the role of lifestyle and occupational risk factors including tobacco and alcohol, as well as exposure to specific metals, solvents and pesticides. It will also incorporate the following important characteristics: Ultra rapid case identification (i.e. identify and interview cases within weeks of initial diagnosis); Population based case identification (i.e. try to recruit all cases occurring in a particular geographical region) and recruitment of population controls, as well as a high response rate for both; Extensive collection of biological samples including blood samples, viable lymphocytes, pancreatic juice and tumor tissue. The long term aim is to establish the foundation for a population based case-control study in this region, which will be conducted in collaboration with other similar initiatives in the US and elsewhere, and contribute to any future consortium of pancreatic cancer studies. Public health relevance: The causes of pancreatic cancer remain largely unknown. This pilot study of pancreatic cancer in this high risk population is a necessary step before a full study can be undertaken. The results of a full study have the potential to identify important lifestyle and occupational risk factors for pancreatic cancer and inform future prevention efforts against pancreatic cancer.



Publications

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.
Authors: Julián-Serrano S. , Yuan F. , Wheeler W. , Benyamin B. , Machiela M.J. , Arslan A.A. , Beane-Freeman L.E. , Bracci P.M. , Duell E.J. , Du M. , et al. .
Source: The American journal of clinical nutrition, 2021-10-04; 114(4), p. 1408-1417.
PMID: 34258619
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Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
Authors: Chen H. , Majumdar A. , Wang L. , Kar S. , Brown K.M. , Feng H. , Turman C. , Dennis J. , Easton D. , Michailidou K. , et al. .
Source: HGG advances, 2021-07-08; 2(3), .
EPub date: 2021-06-12.
PMID: 34355204
Related Citations

Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3.
Authors: Mocci E. , Kundu P. , Wheeler W. , Arslan A.A. , Beane-Freeman L.E. , Bracci P.M. , Brennan P. , Canzian F. , Du M. , Gallinger S. , et al. .
Source: Cancer research, 2021-06-01; 81(11), p. 3134-3143.
EPub date: 2021-02-11.
PMID: 33574088
Related Citations

Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk.
Authors: Yuan F. , Hung R.J. , Walsh N. , Zhang H. , Platz E.A. , Wheeler W. , Song L. , Arslan A.A. , Beane Freeman L.E. , Bracci P. , et al. .
Source: Cancer research, 2020-09-15; 80(18), p. 4004-4013.
EPub date: 2020-07-08.
PMID: 32641412
Related Citations

Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia.
Authors: Tang H. , Jiang L. , Stolzenberg-Solomon R.Z. , Arslan A.A. , Beane Freeman L.E. , Bracci P.M. , Brennan P. , Canzian F. , Du M. , Gallinger S. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020 09; 29(9), p. 1784-1791.
EPub date: 2020-06-16.
PMID: 32546605
Related Citations

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study.
Authors: Chen F. , Childs E.J. , Mocci E. , Bracci P. , Gallinger S. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , Bamlet W.R. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 07; 28(7), p. 1238-1245.
EPub date: 2019-04-23.
PMID: 31015203
Related Citations

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Authors: Childs E.J. , Mocci E. , Campa D. , Bracci P.M. , Gallinger S. , Goggins M. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , et al. .
Source: Nature genetics, 2015 Aug; 47(8), p. 911-6.
EPub date: 2015-06-22.
PMID: 26098869
Related Citations

Physical activity and risk of pancreatic cancer in a central European multicenter case-control study.
Authors: Brenner D.R. , Wozniak M.B. , Feyt C. , Holcatova I. , Janout V. , Foretova L. , Fabianova E. , Shonova O. , Martinek A. , Ryska M. , et al. .
Source: Cancer causes & control : CCC, 2014 Jun; 25(6), p. 669-81.
EPub date: 2014-04-03.
PMID: 24695987
Related Citations

Body mass index and body size in early adulthood and risk of pancreatic cancer in a central European multicenter case-control study.
Authors: Urayama K.Y. , Holcatova I. , Janout V. , Foretova L. , Fabianova E. , Adamcakova Z. , Ryska M. , Martinek A. , Shonova O. , Brennan P. , et al. .
Source: International journal of cancer, 2011-12-15; 129(12), p. 2875-84.
EPub date: 2011-04-25.
PMID: 21520034
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