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Grant Details

Grant Number: 5R01CA090974-05 Interpret this number
Primary Investigator: Glasgow, Russell
Organization: Kaiser Foundation Research Institute
Project Title: Re-Aim Evaluation of Tailored Smoking Harm Reduction
Fiscal Year: 2007


DESCRIPTION (provided by applicant): This revised proposal will address several limitations of existing programs to help hospitalized smokers, including reach and exportability. We will use the RE-AIM evaluation model to investigate an innovative intervention for reaching and involving smokers about to have out-patient surgery or an invasive endoscopic medical procedure (sigmoidoscopy/colonoscopy) in Kaiser Permanente-Colorado, but who decline to participate in cessation-based smoking activities. Based upon preliminary work and previous experience with harm reduction interventions with smokers, we will offer a harm reduction program with the goal of helping smokers achieve a 2/3 reduction in daily cigarette intake. The theory-based intervention will include goal setting and frequent feedback, barriers-based problem-solving, and other social-cognitive procedures tailored to the smoker and his or her social environment. It will be delivered both before surgery (or endoscopic procedures) and after, by a combination of phone counseling and tailored mailings, similar to that of the smoking cessation program (Project 1) proposed as part of this Interactive RO1 application. Previous work in our lab and by other investigators indicates that 50-75 percent reduction in number of cigarettes smoked is achievable and can be done in a way that does not result in compensatory smoking, so that reductions in biochemical exposures are achieved and maintained.Following a year of developmental work, we will conduct a randomized trial with 340 smokers to compare the harm reduction program to a control condition that will receive generic mailings. Following the RE-AIM model, key outcomes of the project will be 1) Reach (percent and representativeness of smokers who participate in this program); 2) Effectiveness: reductions in number of cigarettes, cotinine, and CO levels at 3 months follow-up; 3) Adoption: the percent of physicians who participate in the program; 4) Implementation: the percent of participants who receive and use each of several intervention components; and 5) Maintenance: the cessation rate, reduction in number of cigarettes and saliva cotinine, and CO levels at one-year follow-up.This is one of two projects being submitted using the Interactive Research Project Grant funding mechanism. Crossproject analyses will be conducted on various RE-AIM dimensions related to dissemination and economic outcomes. Taken together, both projects will provide an important test of an integrated program for an underserved population (patients in the hospital setting) that recognizes cessation and harm reduction as complementary strategies.


Defining and understanding success at smoking reduction: a mixed-methods study.
Authors: Estabrooks P.A. , Gaglio B. , Morse E.F. , Smith T. , Edwards A. , Glasgow R.E. .
Source: Addictive behaviors, 2010 Dec; 35(12), p. 1113-9.
EPub date: 2010-08-11.
PMID: 20807674
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Using theory and technology to design a practical and generalizable smoking reduction intervention.
Authors: Gaglio B. , Smith T.L. , Estabrooks P.A. , Ritzwoller D.P. , Ferro E.F. , Glasgow R.E. .
Source: Health promotion practice, 2010 Sep; 11(5), p. 675-84.
EPub date: 2008-12-30.
PMID: 19116418
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Costing behavioral interventions: a practical guide to enhance translation.
Authors: Ritzwoller D.P. , Sukhanova A. , Gaglio B. , Glasgow R.E. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2009 Apr; 37(2), p. 218-27.
EPub date: 2009-03-17.
PMID: 19291342
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Long-term results of a smoking reduction program.
Authors: Glasgow R.E. , Gaglio B. , Estabrooks P.A. , Marcus A.C. , Ritzwoller D.P. , Smith T.L. , Levinson A.H. , Sukhanova A. , O'Donnell C. , Ferro E.F. , et al. .
Source: Medical care, 2009 Jan; 47(1), p. 115-20.
PMID: 19106739
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Evaluating initial reach and robustness of a practical randomized trial of smoking reduction.
Authors: Glasgow R.E. , Estabrooks P.A. , Marcus A.C. , Smith T.L. , Gaglio B. , Levinson A.H. , Tong S. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2008 Nov; 27(6), p. 780-8.
PMID: 19025274
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Tailored behavioral support for smoking reduction: development and pilot results of an innovative intervention.
Authors: Levinson A.H. , Glasgow R.E. , Gaglio B. , Smith T.L. , Cahoon J. , Marcus A.C. .
Source: Health education research, 2008 Apr; 23(2), p. 335-46.
EPub date: 2007-09-19.
PMID: 17884837
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Applying the RE-AIM framework to assess the public health impact of policy change.
Authors: Jilcott S. , Ammerman A. , Sommers J. , Glasgow R.E. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2007 Oct; 34(2), p. 105-14.
PMID: 17927550
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Evaluating the relevance, generalization, and applicability of research: issues in external validation and translation methodology.
Authors: Green L.W. , Glasgow R.E. .
Source: Evaluation & the health professions, 2006 Mar; 29(1), p. 126-53.
PMID: 16510882
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Do behavioral smoking reduction approaches reach more or different smokers? Two studies; similar answers.
Authors: Glasgow R.E. , Gaglio B. , France E.K. , Marcus A. , Riley K.M. , Levinson A. , Bischoff K. .
Source: Addictive behaviors, 2006 Mar; 31(3), p. 509-18.
EPub date: 2005-06-24.
PMID: 15979815
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