Grant Number:	1R21CA118703-01A1 Interpret this number
Primary Investigator:	Erblich, Joel
Organization:	Icahn School Of Medicine At Mount Sinai
Project Title:	Dopamine Genotypes, Experimentally-Induced Craving, & Cessation in Female Smokers
Fiscal Year:	2007

DESCRIPTION (provided by applicant): Project Summary: The objective of this exploratory/developmental R21 application is to characterize and better understand the effects of genetic polymorphisms in the dopamine system on stress- & smoking cue- induced cigarette cravings and smoking cessation among women who smoke. Grounded in a diverse literature, the proposed multidisciplinary prospective study of women interested in making an untreated, 'cold turkey' smoking cessation attempt will provide a naturalistic look at potential effects of dopamine-related genotypes and stress- & cue-induced cravings elicited under laboratory conditions, on abstinence. To that end, 250 women will be genotyped for dopamine-related polymorphisms, participate in laboratory stress and cue-exposure tasks the day before their target quit date, and will be assessed for abstinence at 8 time points during a 6-month follow-up interval. By closely examining relations between experimentally-induced craving reactions and cessation, the study will attempt to better characterize mechanisms underlying the effects of dopamine genotypes. This first study will lay the groundwork for larger-scale investigations aimed at determining the beneficial effects of tailored treatments (e.g., cue-exposure, stress management, nicotine replacement) in the context of genetic (e.g., dopamine polymorphisms) and psychobiological (e.g., cue- and stress-induced craving reactions) characteristics in samples of both men and women, with an eye toward yielding a better undestanding of the unique challenges experienced by women trying to quit smoking. Relevance: Smoking is the single most preventable cause of morbidity and mortality in the United States. Indeed, smoking has been implicated in at least 30 percent of all cancer deaths in the U.S. and an estimated three million deaths per year worldwide. In spite of the clear negative consequences of smoking, a significant subset of the population continues to smoke. Moreover, although most smokers express a strong interest in quitting, few are successful at maintaining abstinence, a problem that is even more pronounced among women. Persistent smoking behavior (i.e., failure or difficulty in remaining abstinent) thus continues to be a major public health problem. Understanding the genetic and psychobiological determinants of smoking cessation success is a critical first step in developing novel approaches to promote cessation, so necessary to reduce the alarming rates of cancer and other smoking-related chronic diseases.




Reward dependence moderates smoking-cue- and stress-induced cigarette cravings.
Authors: Michalowski A. , Erblich J. .
Source: Addictive Behaviors, 2014 Dec; 39(12), p. 1879-83.
PMID: 25133977
Related Citations

Cue-induced cigarette and food craving: a common effect?
Authors: Styn M.A. , Bovbjerg D.H. , Lipsky S. , Erblich J. .
Source: Addictive Behaviors, 2013 Mar; 38(3), p. 1840-3.
PMID: 23262259
Related Citations

Cue-induced cigarette cravings and smoking cessation: the role of expectancies.
Authors: Erblich J. , Montgomery G.H. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2012 Jul; 14(7), p. 809-15.
PMID: 22218404
Related Citations

Genetic predictors of cue- and stress-induced cigarette craving: an exploratory study.
Authors: Erblich J. , Bovbjerg D.H. , Diaz G.A. .
Source: Experimental And Clinical Psychopharmacology, 2012 Feb; 20(1), p. 40-6.
PMID: 21910549
Related Citations

Exposure to smoking cues: cardiovascular and autonomic effects.
Authors: Erblich J. , Bovbjerg D.H. , Sloan R.P. .
Source: Addictive Behaviors, 2011 Jul; 36(7), p. 737-42.
PMID: 21419576
Related Citations

Script-guided imagery of social drinking induces both alcohol and cigarette craving in a sample of nicotine-dependent smokers.
Authors: Erblich J. , Montgomery G.H. , Bovbjerg D.H. .
Source: Addictive Behaviors, 2009 Feb; 34(2), p. 164-70.
PMID: 18977604
Related Citations