Grant Details
Grant Number: |
5R01CA097397-05 Interpret this number |
Primary Investigator: |
Bernstein, Jonine |
Organization: |
Sloan-Kettering Inst Can Research |
Project Title: |
Interaction of Radiation, BRCA1/2, and Breast Cancer |
Fiscal Year: |
2006 |
Abstract
DESCRIPTION (provided by applicant): Deficiencies in cellular response to DNA damage can predispose to cancer. However, the gene-environment interactions that may be involved in the etiology of these cancers are poorly understood. One important environmental cause of DNA damage is exposure to ionizing radiation leading to the formation of DNA double-strand breaks (DSB). Recent evidence demonstrates that three genes in which mutations predispose to breast cancer, BRCA1/2 and ATM have complex interactions with each other and are essential for the normal cellular response to DSBs. Therefore, interaction between alleles at these loci may have important effects on breast cancer risk, in general, and radiation-induced breast cancer, in particular. To delineate the roles of radiation exposure and genetic predisposition in the etiology of breast cancer, we propose to determine the prevalence of BRCA1/2 mutations in a well characterized population-based sample of 2100 women with breast cancer for whom blood samples have already been obtained and ATM mutation status already determined. Our study hypothesis is that the incidence of contralateral breast cancer will be increased among women who are carriers of mutant BRCA1 or BRCA2 alleles and who received RT as part of treatment for first primary breast cancer. The 700 cases are women with bilateral breast cancer individually countermatched to two controls, women with unilateral breast cancer. Our specific aims are: Aim #1. To test for germline BRCA1/2 mutations in a population-based sample of young women with unilateral and bilateral breast cancer, using a staged approach with DHPLC screening followed by sequencing. Aim #2. To conduct analyses of gene-environment interactions for BRCA1/2 with a focus on radiation exposure. To achieve this aim, we will collect medical/treatment records and recreate the scatter radiation dose to the contralateral breast. Once our study has been completed, we will have established an outstanding resource for future studies of other putative breast cancer genes and environmental exposures, with a particular focus on radiation exposure.
Publications
Reply to "Critical analysis of Reiner et al.'s study on agreement of medical record abstraction and self-report of breast cancer treatment".
Authors: Reiner A.S.
, Knight J.A.
, John E.M.
, Lynch C.F.
, Malone K.E.
, Liang X.
, Woods M.
, Root J.C.
, Bernstein J.L.
.
Source: Cancer, 2024-09-04 00:00:00.0; , .
EPub date: 2024-09-04 00:00:00.0.
PMID: 39233462
Related Citations
Agreement of medical record abstraction and self-report of breast cancer treatment with an extended recall window.
Authors: Reiner A.S.
, Knight J.A.
, John E.M.
, Lynch C.F.
, Malone K.E.
, Liang X.
, Woods M.
, Root J.C.
, Bernstein J.L.
.
Source: Cancer, 2024-06-28 00:00:00.0; , .
EPub date: 2024-06-28 00:00:00.0.
PMID: 38941510
Related Citations
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer.
Authors: Sun X.
, Verma S.P.
, Jia G.
, Wang X.
, Ping J.
, Guo X.
, Shu X.O.
, Chen J.
, Derkach A.
, Cai Q.
, et al.
.
Source: Cancer Research, 2024-06-04 00:00:00.0; , .
EPub date: 2024-06-04 00:00:00.0.
PMID: 38832928
Related Citations
A genome-wide association study of contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study.
Authors: Sun X.
, Reiner A.S.
, Tran A.P.
, Watt G.P.
, Oh J.H.
, Mellemkjær L.
, Lynch C.F.
, Knight J.A.
, John E.M.
, Malone K.E.
, et al.
.
Source: Breast Cancer Research : Bcr, 2024-01-23 00:00:00.0; 26(1), p. 16.
EPub date: 2024-01-23 00:00:00.0.
PMID: 38263039
Related Citations
Trends in Radiation Dose to the Contralateral Breast During Breast Cancer Radiation Therapy.
Authors: Watt G.P.
, Smith S.A.
, Howell R.M.
, Pérez-Andújar A.
, Reiner A.S.
, Cerviño L.
, McCormick B.
, Hess D.
, Knight J.A.
, Malone K.E.
, et al.
.
Source: Radiation Research, 2023-10-01 00:00:00.0; 200(4), p. 331-339.
PMID: 37590492
Related Citations
The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2-Negative Women.
Authors: Larionov A.
, Fewings E.
, Redman J.
, Goldgraben M.
, Clark G.
, Boice J.
, Concannon P.
, Bernstein J.
, Conti D.V.
, The Wecare Study Collaborative Group null
, et al.
.
Source: Cancers, 2023-01-08 00:00:00.0; 15(2), .
EPub date: 2023-01-08 00:00:00.0.
PMID: 36672364
Related Citations
Association of contralateral breast cancer risk with mammographic density defined at higher-than-conventional intensity thresholds.
Authors: Watt G.P.
, Knight J.A.
, Nguyen T.L.
, Reiner A.S.
, Malone K.E.
, John E.M.
, Lynch C.F.
, Brooks J.D.
, Woods M.
, Liang X.
, et al.
.
Source: International Journal Of Cancer, 2022-03-22 00:00:00.0; , .
EPub date: 2022-03-22 00:00:00.0.
PMID: 35315524
Related Citations
Mammographic texture features associated with contralateral breast cancer in the WECARE Study.
Authors: Watt G.P.
, Knight J.A.
, Lin C.
, Lynch C.F.
, Malone K.E.
, John E.M.
, Bernstein L.
, Brooks J.D.
, Reiner A.S.
, Liang X.
, et al.
.
Source: Npj Breast Cancer, 2021-11-29 00:00:00.0; 7(1), p. 146.
EPub date: 2021-11-29 00:00:00.0.
PMID: 34845211
Related Citations
Race, ethnicity and risk of second primary contralateral breast cancer in the United States.
Authors: Watt G.P.
, John E.M.
, Bandera E.V.
, Malone K.E.
, Lynch C.F.
, Palmer J.R.
, Knight J.A.
, Troester M.A.
, Bernstein J.L.
.
Source: International Journal Of Cancer, 2021-02-05 00:00:00.0; , .
EPub date: 2021-02-05 00:00:00.0.
PMID: 33544892
Related Citations
Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families.
Authors: Yang X.
, Leslie G.
, Doroszuk A.
, Schneider S.
, Allen J.
, Decker B.
, Dunning A.M.
, Redman J.
, Scarth J.
, Plaskocinska I.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2020-03-01 00:00:00.0; 38(7), p. 674-685.
EPub date: 2019-12-16 00:00:00.0.
PMID: 31841383
Related Citations
Machine learning on genome-wide association studies to predict the risk of radiation-associated contralateral breast cancer in the WECARE Study.
Authors: Lee S.
, Liang X.
, Woods M.
, Reiner A.S.
, Concannon P.
, Bernstein L.
, Lynch C.F.
, Boice J.D.
, Deasy J.O.
, Bernstein J.L.
, et al.
.
Source: Plos One, 2020; 15(2), p. e0226157.
EPub date: 2020-02-27 00:00:00.0.
PMID: 32106268
Related Citations
CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study.
Authors: Brooks J.D.
, Comen E.A.
, Reiner A.S.
, Orlow I.
, Leong S.F.
, Liang X.
, Mellemkjær L.
, Knight J.A.
, Lynch C.F.
, John E.M.
, et al.
.
Source: Breast Cancer Research : Bcr, 2018-12-10 00:00:00.0; 20(1), p. 149.
EPub date: 2018-12-10 00:00:00.0.
PMID: 30526633
Related Citations
Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study.
Authors: Reiner A.S.
, Sisti J.
, John E.M.
, Lynch C.F.
, Brooks J.D.
, Mellemkjær L.
, Boice J.D.
, Knight J.A.
, Concannon P.
, Capanu M.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2018-05-20 00:00:00.0; 36(15), p. 1513-1520.
EPub date: 2018-04-05 00:00:00.0.
PMID: 29620998
Related Citations
The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.
Authors: Knight J.A.
, Blackmore K.M.
, Fan J.
, Malone K.E.
, John E.M.
, Lynch C.F.
, Vachon C.M.
, Bernstein L.
, Brooks J.D.
, Reiner A.S.
, et al.
.
Source: Breast Cancer Research : Bcr, 2018-03-22 00:00:00.0; 20(1), p. 23.
EPub date: 2018-03-22 00:00:00.0.
PMID: 29566728
Related Citations
Agreement between self-reported and register-based cardiovascular events among Danish breast cancer survivors.
Authors: Langballe R.
, John E.M.
, Malone K.E.
, Bernstein L.
, Knight J.A.
, Lynch C.F.
, Howell R.M.
, Shore R.
, Woods M.
, Concannon P.
, et al.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2017-09-29 00:00:00.0; , .
EPub date: 2017-09-29 00:00:00.0.
PMID: 28963606
Related Citations
Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study.
Authors: Knight J.A.
, Fan J.
, Malone K.E.
, John E.M.
, Lynch C.F.
, Langballe R.
, Bernstein L.
, Shore R.E.
, Brooks J.D.
, Reiner A.S.
, et al.
.
Source: International Journal Of Cancer, 2017-09-01 00:00:00.0; 141(5), p. 916-924.
EPub date: 2017-05-31 00:00:00.0.
PMID: 28524234
Related Citations
ATM, radiation, and the risk of second primary breast cancer.
Authors: Bernstein J.L.
, WECARE Study Collaborative Group
, Concannon P.
.
Source: International Journal Of Radiation Biology, 2017-07-27 00:00:00.0; , p. 1-7.
EPub date: 2017-07-27 00:00:00.0.
PMID: 28627265
Related Citations
Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population.
Authors: Reiner A.S.
, Lynch C.F.
, Sisti J.S.
, John E.M.
, Brooks J.D.
, Bernstein L.
, Knight J.A.
, Hsu L.
, Concannon P.
, Mellemkjær L.
, et al.
.
Source: Breast Cancer Research : Bcr, 2017-07-19 00:00:00.0; 19(1), p. 83.
EPub date: 2017-07-19 00:00:00.0.
PMID: 28724391
Related Citations
Body Mass Index, Weight Change, And Risk Of Second Primary Breast Cancer In The Wecare Study: Influence Of Estrogen Receptor Status Of The First Breast Cancer
Authors: Brooks J.D.
, John E.M.
, Mellemkjaer L.
, Lynch C.F.
, Knight J.A.
, Malone K.E.
, Reiner A.S.
, Bernstein L.
, Liang X.
, Shore R.E.
, et al.
.
Source: Cancer Medicine, 2016 Nov; 5(11), p. 3282-3291.
PMID: 27700016
Related Citations
Systemic Therapy For Breast Cancer And Risk Of Subsequent Contralateral Breast Cancer In The Wecare Study
Authors: Langballe R.
, Mellemkjær L.
, Malone K.E.
, Lynch C.F.
, John E.M.
, Knight J.A.
, Bernstein L.
, Brooks J.
, Andersson M.
, Reiner A.S.
, et al.
.
Source: Breast Cancer Research : Bcr, 2016-07-12 00:00:00.0; 18(1), p. 65.
PMID: 27400983
Related Citations
A post-hoc Unweighted Analysis of Counter-Matched Case-Control Data.
Authors: Rakovski C.
, Langholz B.
.
Source: The International Journal Of Biostatistics, 2015 Nov; 11(2), p. 223-32.
PMID: 26351961
Related Citations
Reproductive Factors, Tumor Estrogen Receptor Status And Contralateral Breast Cancer Risk: Results From The Wecare Study
Authors: Sisti J.S.
, Bernstein J.L.
, Lynch C.F.
, Reiner A.S.
, Mellemkjaer L.
, Brooks J.D.
, Knight J.A.
, Bernstein L.
, Malone K.E.
, Woods M.
, et al.
.
Source: Springerplus, 2015; 4, p. 825.
PMID: 26751177
Related Citations
Breast-cancer risk in families with mutations in PALB2.
Authors: Antoniou A.C.
, Casadei S.
, Heikkinen T.
, Barrowdale D.
, Pylkäs K.
, Roberts J.
, Lee A.
, Subramanian D.
, De Leeneer K.
, Fostira F.
, et al.
.
Source: The New England Journal Of Medicine, 2014-08-07 00:00:00.0; 371(6), p. 497-506.
PMID: 25099575
Related Citations
Breast cancer after chest radiation therapy for childhood cancer.
Authors: Moskowitz C.S.
, Chou J.F.
, Wolden S.L.
, Bernstein J.L.
, Malhotra J.
, Novetsky Friedman D.
, Mubdi N.Z.
, Leisenring W.M.
, Stovall M.
, Hammond S.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-07-20 00:00:00.0; 32(21), p. 2217-23.
EPub date: 2014-07-20 00:00:00.0.
PMID: 24752044
Related Citations
Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report.
Authors: Bernstein J.L.
, Thomas D.C.
, Shore R.E.
, Robson M.
, Boice J.D.
, Stovall M.
, Andersson M.
, Bernstein L.
, Malone K.E.
, Reiner A.S.
, et al.
.
Source: European Journal Of Cancer (oxford, England : 1990), 2013 Sep; 49(14), p. 2979-85.
PMID: 23706288
Related Citations
Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case-control study of contralateral breast cancer risk in the WECARE Study.
Authors: Brooks J.D.
, Teraoka S.N.
, Bernstein L.
, Mellemkjær L.
, Malone K.E.
, Lynch C.F.
, Haile R.W.
, Concannon P.
, Reiner A.S.
, Duggan D.J.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2013 Aug; 24(8), p. 1605-14.
PMID: 23775025
Related Citations
Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study.
Authors: Reiner A.S.
, John E.M.
, Brooks J.D.
, Lynch C.F.
, Bernstein L.
, Mellemkjær L.
, Malone K.E.
, Knight J.A.
, Capanu M.
, Teraoka S.N.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-02-01 00:00:00.0; 31(4), p. 433-9.
EPub date: 2013-02-01 00:00:00.0.
PMID: 23269995
Related Citations
Variants In Tamoxifen Metabolizing Genes: A Case-control Study Of Contralateral Breast Cancer Risk In The Wecare Study
Authors: Brooks J.D.
, Teraoka S.N.
, Malone K.E.
, Haile R.W.
, Bernstein L.
, Lynch C.F.
, Mellemkjær L.
, Duggan D.J.
, Reiner A.S.
, Concannon P.
, et al.
.
Source: International Journal Of Molecular Epidemiology And Genetics, 2013; 4(1), p. 35-48.
PMID: 23565321
Related Citations
Rare germline mutations in PALB2 and breast cancer risk: a population-based study.
Authors: Tischkowitz M.
, Capanu M.
, Sabbaghian N.
, Li L.
, Liang X.
, Vallée M.P.
, Tavtigian S.V.
, Concannon P.
, Foulkes W.D.
, Bernstein L.
, et al.
.
Source: Human Mutation, 2012 Apr; 33(4), p. 674-80.
PMID: 22241545
Related Citations
Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.
Authors: Brooks J.D.
, Teraoka S.N.
, Reiner A.S.
, Satagopan J.M.
, Bernstein L.
, Thomas D.C.
, Capanu M.
, Stovall M.
, Smith S.A.
, Wei S.
, et al.
.
Source: Human Mutation, 2012 Jan; 33(1), p. 158-64.
PMID: 21898661
Related Citations
Incorporating prior biologic information for high-dimensional rare variant association studies.
Authors: Quintana M.A.
, Schumacher F.R.
, Casey G.
, Bernstein J.L.
, Li L.
, Conti D.V.
.
Source: Human Heredity, 2012; 74(3-4), p. 184-95.
PMID: 23594496
Related Citations
Incorporating model uncertainty in detecting rare variants: the Bayesian risk index.
Authors: Quintana M.A.
, Berstein J.L.
, Thomas D.C.
, Conti D.V.
.
Source: Genetic Epidemiology, 2011 Nov; 35(7), p. 638-49.
PMID: 22009789
Related Citations
Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling.
Authors: Capanu M.
, Concannon P.
, Haile R.W.
, Bernstein L.
, Malone K.E.
, Lynch C.F.
, Liang X.
, Teraoka S.N.
, Diep A.T.
, Thomas D.C.
, et al.
.
Source: Genetic Epidemiology, 2011 Jul; 35(5), p. 389-97.
PMID: 21520273
Related Citations
Hierarchical modeling for estimating relative risks of rare genetic variants: properties of the pseudo-likelihood method.
Authors: Capanu M.
, Begg C.B.
.
Source: Biometrics, 2011 Jun; 67(2), p. 371-80.
PMID: 20707869
Related Citations
Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.
Authors: Figueiredo J.C.
, Brooks J.D.
, Conti D.V.
, Poynter J.N.
, Teraoka S.N.
, Malone K.E.
, Bernstein L.
, Lee W.D.
, Duggan D.J.
, Siniard A.
, et al.
.
Source: Breast Cancer Research And Treatment, 2011 Jun; 127(3), p. 819-29.
PMID: 21161372
Related Citations
Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study.
Authors: Teraoka S.N.
, Bernstein J.L.
, Reiner A.S.
, Haile R.W.
, Bernstein L.
, Lynch C.F.
, Malone K.E.
, Stovall M.
, Capanu M.
, Liang X.
, et al.
.
Source: Breast Cancer Research : Bcr, 2011; 13(6), p. R114.
PMID: 22087758
Related Citations
Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer.
Authors: Reding K.W.
, Bernstein J.L.
, Langholz B.M.
, Bernstein L.
, Haile R.W.
, Begg C.B.
, Lynch C.F.
, Concannon P.
, Borg A.
, Teraoka S.N.
, et al.
.
Source: Breast Cancer Research And Treatment, 2010 Sep; 123(2), p. 491-8.
PMID: 20135344
Related Citations
Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study.
Authors: Poynter J.N.
, Langholz B.
, Largent J.
, Mellemkjaer L.
, Bernstein L.
, Malone K.E.
, Lynch C.F.
, Borg A.
, Concannon P.
, Teraoka S.N.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2010 Jun; 21(6), p. 839-46.
PMID: 20130978
Related Citations
Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2.
Authors: Malone K.E.
, Begg C.B.
, Haile R.W.
, Borg A.
, Concannon P.
, Tellhed L.
, Xue S.
, Teraoka S.
, Bernstein L.
, Capanu M.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2010-05-10 00:00:00.0; 28(14), p. 2404-10.
EPub date: 2010-05-10 00:00:00.0.
PMID: 20368571
Related Citations
Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.
Authors: Bernstein J.L.
, Haile R.W.
, Stovall M.
, Boice J.D.
, Shore R.E.
, Langholz B.
, Thomas D.C.
, Bernstein L.
, Lynch C.F.
, Olsen J.H.
, et al.
.
Source: Journal Of The National Cancer Institute, 2010-04-07 00:00:00.0; 102(7), p. 475-83.
EPub date: 2010-04-07 00:00:00.0.
PMID: 20305132
Related Citations
Characterization Of Brca1 And Brca2 Deleterious Mutations And Variants Of Unknown Clinical Significance In Unilateral And Bilateral Breast Cancer: The Wecare Study
Authors: Borg A.
, Haile R.W.
, Malone K.E.
, Capanu M.
, Diep A.
, Törngren T.
, Teraoka S.
, Begg C.B.
, Thomas D.C.
, Concannon P.
, et al.
.
Source: Human Mutation, 2010 Mar; 31(3), p. E1200-40.
PMID: 20104584
Related Citations
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study.
Authors: Figueiredo J.C.
, Haile R.W.
, Bernstein L.
, Malone K.E.
, Largent J.
, Langholz B.
, Lynch C.F.
, Bertelsen L.
, Capanu M.
, Concannon P.
, et al.
.
Source: Breast Cancer Research And Treatment, 2010 Feb; 120(1), p. 175-83.
PMID: 19597986
Related Citations
Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer.
Authors: Langholz B.
, Thomas D.C.
, Stovall M.
, Smith S.A.
, Boice J.D.
, Shore R.E.
, Bernstein L.
, Lynch C.F.
, Zhang X.
, Bernstein J.L.
.
Source: Biometrics, 2009 Jun; 65(2), p. 599-608.
PMID: 18647297
Related Citations
Alcohol intake and cigarette smoking and risk of a contralateral breast cancer: The Women's Environmental Cancer and Radiation Epidemiology Study.
Authors: Knight J.A.
, Bernstein L.
, Largent J.
, Capanu M.
, Begg C.B.
, Mellemkjaer L.
, Lynch C.F.
, Malone K.E.
, Reiner A.S.
, Liang X.
, et al.
.
Source: American Journal Of Epidemiology, 2009-04-15 00:00:00.0; 169(8), p. 962-8.
EPub date: 2009-04-15 00:00:00.0.
PMID: 19211621
Related Citations
Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study.
Authors: Stovall M.
, Smith S.A.
, Langholz B.M.
, Boice J.D.
, Shore R.E.
, Andersson M.
, Buchholz T.A.
, Capanu M.
, Bernstein L.
, Lynch C.F.
, et al.
.
Source: International Journal Of Radiation Oncology, Biology, Physics, 2008-11-15 00:00:00.0; 72(4), p. 1021-30.
EPub date: 2008-11-15 00:00:00.0.
PMID: 18556141
Related Citations
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Authors: Concannon P.
, Haile R.W.
, Børresen-Dale A.L.
, Rosenstein B.S.
, Gatti R.A.
, Teraoka S.N.
, Diep T.A.
, Jansen L.
, Atencio D.P.
, Langholz B.
, et al.
.
Source: Cancer Research, 2008-08-15 00:00:00.0; 68(16), p. 6486-91.
PMID: 18701470
Related Citations
Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group.
Authors: Figueiredo J.C.
, Bernstein L.
, Capanu M.
, Malone K.E.
, Lynch C.F.
, Anton-Culver H.
, Stovall M.
, Bertelsen L.
, Haile R.W.
, Bernstein J.L.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-03-20 00:00:00.0; 26(9), p. 1411-8.
EPub date: 2008-03-20 00:00:00.0.
PMID: 18250348
Related Citations
Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study.
Authors: Mellemkjaer L.
, Dahl C.
, Olsen J.H.
, Bertelsen L.
, Guldberg P.
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