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Grant Details

Grant Number: 5R01CA095415-03 Interpret this number
Primary Investigator: Joffe, Marshall
Organization: University Of Pennsylvania
Project Title: Analysis of Case-Control Follow-Up Studies
Fiscal Year: 2006


DESCRIPTION (provided by applicant): The case-control follow-up (CCFU) study is a hybrid design, a combination of case control and cohort or follow-up studies. In such studies, a cohort is monitored for early or sentinels events, which are closely associated with some outcome of interest (e.g., diagnosis of breast cancer); information is obtained on all subjects developing the sentinel events, and on a sample of the remaining subjects. Subjects developing the sentinel event (and sometimes other subjects) are then followed prospectively for an event of interest (e.g., death from breast cancer). The design has been employed in studies of the efficacy of cancer screening and of spontaneous abortion but has generally been mistaken for a case-control design. The purpose of this project is to advance understanding of the design and improve inference derived from it. This will be done by 1) developing a general notation and theory for describing these studies; 2) applying and developing appropriate statistical methods for analyzing data arising from these studies; and 3) comparing various approaches for analyzing these studies. We have identified two main general statistical approaches for these studies: one we term the direct approach and the other we call the synthetic approach. We propose to elaborate these approaches, and then consider how to deal with biases that may arise in each of them. New and familiar methods will be assessed through simulation, through application to several CCFU studies, and through artificial generation of CCFU studies by sampling from cohort studies.


A review of causal estimation of effects in mediation analyses.
Authors: Ten Have T.R. , Joffe M.M. .
Source: Statistical methods in medical research, 2012 Feb; 21(1), p. 77-107.
EPub date: 2010-12-16.
PMID: 21163849
Related Citations

Authors: Zhang M. , Joffe M.M. , Small D.S. .
Source: Annals of statistics, 2011 Feb; 39(1), .
PMID: 24339454
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Design and analysis of multiple events case-control studies.
Authors: Sun W. , Joffe M.M. , Chen J. , Brunelli S.M. .
Source: Biometrics, 2010 Dec; 66(4), p. 1220-9.
PMID: 20002403
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Related causal frameworks for surrogate outcomes.
Authors: Joffe M.M. , Greene T. .
Source: Biometrics, 2009 Jun; 65(2), p. 530-8.
PMID: 18759836
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Extended instrumental variables estimation for overall effects.
Authors: Joffe M.M. , Small D. , Ten Have T. , Brunelli S. , Feldman H.I. .
Source: The international journal of biostatistics, 2008-04-07; 4(1), p. Article 4.
EPub date: 2008-04-07.
PMID: 20231915
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Causal Mediation Analyses for Randomized Trials.
Authors: Lynch K.G. , Cary M. , Gallop R. , Ten Have T.R. .
Source: Health services & outcomes research methodology, 2008; 8(2), p. 57-76.
PMID: 19484136
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Empirical efficiency maximization: improved locally efficient covariate adjustment in randomized experiments and survival analysis.
Authors: Rubin D.B. , van der Laan M.J. .
Source: The international journal of biostatistics, 2008; 4(1), p. Article 5.
PMID: 19381345
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Causal mediation analyses with rank preserving models.
Authors: Have T.R. , Joffe M.M. , Lynch K.G. , Brown G.K. , Maisto S.A. , Beck A.T. .
Source: Biometrics, 2007 Sep; 63(3), p. 926-34.
PMID: 17825022
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On the estimation and use of propensity scores in case-control and case-cohort studies.
Authors: MÃ¥nsson R. , Joffe M.M. , Sun W. , Hennessy S. .
Source: American journal of epidemiology, 2007-08-01; 166(3), p. 332-9.
EPub date: 2007-05-15.
PMID: 17504780
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