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Grant Details

Grant Number: 5R01CA097386-05 Interpret this number
Primary Investigator: Zheng, Wei
Organization: Vanderbilt University
Project Title: Tumor Markers and Recurrent Adenomas: a Follow-Up Study
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): Most colorectal cancers arise from adenomatous polyps, and a large proportion of patients with adenomas will develop recurrent adenomas. There is considerable controversy regarding the appropriate surveillance interval following initial colonoscopy. Studies assessing predictors for recurrent adenomas will provide valuable information for designing individualized surveillance strategies, particularly for patients with either multiple adenomas or pathologically advanced adenoma. We propose in this application to recruit and follow 2000 patients diagnosed in 1996 to 2001 with incident multiple or advanced adenomas to evaluate the utility of a panel of promising tumor markers in predicting the risk of adenoma recurrence. The tumor markers proposed for this study reflect major events that occur during the formation and progression of adenomas. Specifically, we will evaluate the following four groups of tumor markers in relation to the risk of adenoma recurrence: 1) proliferation and apoptosis, including the apoptosis index (TUNEL assay) and the expression of Ki-67 (Mibl), epidermal growth factor receptor (EGFR), and transforming growth factor B receptor type II (TGF-J3 RI]); 2) genomic instability - loss of heterozygosity (LOH) events on chromosomes 5q, l7p, 15q, ip, and 18q; 3) Wingless/Writ signaling pathway - expression of the CTTNB1 (Beta-catenin gene), Cyclin D1 CMYC, and COX2 gene products; and 4) DNA methylation - methylation status of the promoters of the MLH1, MGMT, CDKN2A/P16, and APC. Study patients will be followed through a combination of telephone interviews and medical chart reviews. Paraffin-embedded blocks of initial adenomas will be retrieved for bioassays of tumor markers. The diagnosis of initial and recurrent adenomas will be reviewed and confirmed by study pathologists. This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention.

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Publications

Effects of fish oil supplementation on eicosanoid production in patients at higher risk for colorectal cancer.
Authors: White M.N. , Shrubsole M.J. , Cai Q. , Su T. , Hardee J. , Coppola J.A. , Cai S.S. , Martin S.M. , Motley S. , Swift L.L. , et al. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2019 05; 28(3), p. 188-195.
PMID: 30640206
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PUFA levels in erythrocyte membrane phospholipids are differentially associated with colorectal adenoma risk.
Authors: Rifkin S.B. , Shrubsole M.J. , Cai Q. , Smalley W.E. , Ness R.M. , Swift L.L. , Zheng W. , Murff H.J. .
Source: The British journal of nutrition, 2017 Jun; 117(11), p. 1615-1622.
EPub date: 2017-06-29.
PMID: 28660850
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Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps.
Authors: Davenport J.R. , Su T. , Zhao Z. , Coleman H.G. , Smalley W.E. , Ness R.M. , Zheng W. , Shrubsole M.J. .
Source: Gut, 2018 03; 67(3), p. 456-465.
EPub date: 2016-11-15.
PMID: 27852795
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Smoking and red blood cell phospholipid membrane fatty acids.
Authors: Murff H.J. , Tindle H.A. , Shrubsole M.J. , Cai Q. , Smalley W. , Milne G.L. , Swift L.L. , Ness R.M. , Zheng W. .
Source: Prostaglandins, leukotrienes, and essential fatty acids, 2016 09; 112, p. 24-31.
EPub date: 2016-08-16.
PMID: 27637337
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Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study.
Authors: Su T. , Washington M.K. , Ness R.M. , Rex D.K. , Smalley W.E. , Ulbright T.M. , Cai Q. , Zheng W. , Shrubsole M.J. .
Source: Molecular carcinogenesis, 2017 02; 56(2), p. 761-773.
EPub date: 2016-08-11.
PMID: 27479195
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Evaluation of pro-inflammatory markers plasma C-reactive protein and urinary prostaglandin-E2 metabolite in colorectal adenoma risk.
Authors: Davenport J.R. , Cai Q. , Ness R.M. , Milne G. , Zhao Z. , Smalley W.E. , Zheng W. , Shrubsole M.J. .
Source: Molecular carcinogenesis, 2016 08; 55(8), p. 1251-61.
EPub date: 2015-08-31.
PMID: 26333108
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Aspects of dietary carbohydrate intake are not related to risk of colorectal polyps in the Tennessee Colorectal Polyp Study.
Authors: Coleman H.G. , Ness R.M. , Smalley W.E. , Zheng W. , Shrubsole M.J. .
Source: Cancer causes & control : CCC, 2015 Aug; 26(8), p. 1197-202.
EPub date: 2015-06-09.
PMID: 26054912
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Plasma lipid levels and colorectal adenoma risk.
Authors: Coppola J.A. , Shrubsole M.J. , Cai Q. , Smalley W.E. , Dai Q. , Ness R.M. , Fazio S. , Zheng W. , Murff H.J. .
Source: Cancer causes & control : CCC, 2015 Apr; 26(4), p. 635-43.
EPub date: 2015-03-12.
PMID: 25761410
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12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Authors: Chang J. , Jiang L. , Wang Y. , Yao B. , Yang S. , Zhang B. , Zhang M.Z. .
Source: Oncotarget, 2015-02-20; 6(5), p. 2879-88.
PMID: 25576922
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Associations between S-adenosylmethionine, S-adenosylhomocysteine, and colorectal adenoma risk are modified by sex.
Authors: Shrubsole M.J. , Wagner C. , Zhu X. , Hou L. , Loukachevitch L.V. , Ness R.M. , Zheng W. .
Source: American journal of cancer research, 2015; 5(1), p. 458-65.
EPub date: 2014-12-15.
PMID: 25628954
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Associations between dietary fiber and colorectal polyp risk differ by polyp type and smoking status.
Authors: Fu Z. , Shrubsole M.J. , Smalley W.E. , Ness R.M. , Zheng W. .
Source: The Journal of nutrition, 2014 May; 144(5), p. 592-8.
EPub date: 2014-02-26.
PMID: 24572038
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Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.
Authors: Fu Z. , Shrubsole M.J. , Li G. , Smalley W.E. , Hein D.W. , Cai Q. , Ness R.M. , Zheng W. .
Source: Carcinogenesis, 2013 Apr; 34(4), p. 779-86.
EPub date: 2013-01-08.
PMID: 23299405
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Association of genetic variants for colorectal cancer differs by subtypes of polyps in the colorectum.
Authors: Zhang B. , Shrubsole M.J. , Li G. , Cai Q. , Edwards T. , Smalley W.E. , Ness R.M. , Zheng W. .
Source: Carcinogenesis, 2012 Dec; 33(12), p. 2417-23.
EPub date: 2012-10-01.
PMID: 23027627
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Lifestyle factors and their combined impact on the risk of colorectal polyps.
Authors: Fu Z. , Shrubsole M.J. , Smalley W.E. , Wu H. , Chen Z. , Shyr Y. , Ness R.M. , Zheng W. .
Source: American journal of epidemiology, 2012-11-01; 176(9), p. 766-76.
EPub date: 2012-10-18.
PMID: 23079606
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Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.
Authors: Fu Z. , Shrubsole M.J. , Li G. , Smalley W.E. , Hein D.W. , Chen Z. , Shyr Y. , Cai Q. , Ness R.M. , Zheng W. .
Source: The American journal of clinical nutrition, 2012 Nov; 96(5), p. 1119-28.
EPub date: 2012-09-26.
PMID: 23015320
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Dietary intake of PUFAs and colorectal polyp risk.
Authors: Murff H.J. , Shrubsole M.J. , Cai Q. , Smalley W.E. , Dai Q. , Milne G.L. , Ness R.M. , Zheng W. .
Source: The American journal of clinical nutrition, 2012 Mar; 95(3), p. 703-12.
EPub date: 2012-01-25.
PMID: 22277551
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Urinary prostaglandin E2 metabolite and risk for colorectal adenoma.
Authors: Shrubsole M.J. , Cai Q. , Wen W. , Milne G. , Smalley W.E. , Chen Z. , Ness R.M. , Zheng W. .
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Feb; 5(2), p. 336-42.
EPub date: 2011-12-13.
PMID: 22166248
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Nonsteroidal anti-inflammatory drug use and risk of adenomatous and hyperplastic polyps.
Authors: Murff H.J. , Shrubsole M.J. , Chen Z. , Smalley W.E. , Chen H. , Shyr Y. , Ness R.M. , Zheng W. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Nov; 4(11), p. 1799-807.
EPub date: 2011-07-15.
PMID: 21764857
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Association of meat intake and meat-derived mutagen exposure with the risk of colorectal polyps by histologic type.
Authors: Fu Z. , Shrubsole M.J. , Smalley W.E. , Wu H. , Chen Z. , Shyr Y. , Ness R.M. , Zheng W. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Oct; 4(10), p. 1686-97.
EPub date: 2011-07-29.
PMID: 21803984
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Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans.
Authors: Zhang M.Z. , Xu J. , Yao B. , Yin H. , Cai Q. , Shrubsole M.J. , Chen X. , Kon V. , Zheng W. , Pozzi A. , et al. .
Source: The Journal of clinical investigation, 2009 Apr; 119(4), p. 876-85.
EPub date: 2009-03-23.
PMID: 19307727
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Fruit and vegetable intakes are associated with lower risk of colorectal adenomas.
Authors: Wu H. , Dai Q. , Shrubsole M.J. , Ness R.M. , Schlundt D. , Smalley W.E. , Chen H. , Li M. , Shyr Y. , Zheng W. .
Source: The Journal of nutrition, 2009 Feb; 139(2), p. 340-4.
EPub date: 2008-12-17.
PMID: 19091801
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Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps.
Authors: Shrubsole M.J. , Wu H. , Ness R.M. , Shyr Y. , Smalley W.E. , Zheng W. .
Source: American journal of epidemiology, 2008-05-01; 167(9), p. 1050-8.
EPub date: 2008-02-27.
PMID: 18304959
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Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
Authors: Shin A. , Shrubsole M.J. , Rice J.M. , Cai Q. , Doll M.A. , Long J. , Smalley W.E. , Shyr Y. , Sinha R. , Ness R.M. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Feb; 17(2), p. 320-9.
PMID: 18268115
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The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk.
Authors: Dai Q. , Shrubsole M.J. , Ness R.M. , Schlundt D. , Cai Q. , Smalley W.E. , Li M. , Shyr Y. , Zheng W. .
Source: The American journal of clinical nutrition, 2007 Sep; 86(3), p. 743-51.
PMID: 17823441
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Meat and meat-mutagen intake, doneness preference and the risk of colorectal polyps: the Tennessee Colorectal Polyp Study.
Authors: Shin A. , Shrubsole M.J. , Ness R.M. , Wu H. , Sinha R. , Smalley W.E. , Shyr Y. , Zheng W. .
Source: International journal of cancer, 2007-07-01; 121(1), p. 136-42.
PMID: 17354224
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The interaction of age and hormone replacement therapy on colon adenoma risk.
Authors: Murff H.J. , Shrubsole M.J. , Smalley W.E. , Wu H. , Shyr Y. , Ness R.M. , Zheng W. .
Source: Cancer detection and prevention, 2007; 31(2), p. 161-5.
EPub date: 2007-04-11.
PMID: 17433566
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Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays.
Authors: Su Y. , Shrubsole M.J. , Ness R.M. , Cai Q. , Kataoka N. , Washington K. , Zheng W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006 Sep; 15(9), p. 1719-26.
PMID: 16985035
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Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas.
Authors: Ye C. , Shrubsole M.J. , Cai Q. , Ness R. , Grady W.M. , Smalley W. , Cai H. , Washington K. , Zheng W. .
Source: Oncology reports, 2006 Aug; 16(2), p. 429-35.
PMID: 16820927
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