Grant Details
Grant Number: |
5R01AG023397-04 Interpret this number |
Primary Investigator: |
Buka, Stephen |
Organization: |
Harvard School Of Public Health |
Project Title: |
Pathways Linking Education/Health in Middle Adulthood |
Fiscal Year: |
2006 |
Abstract
DESCRIPTION (provided by applicant): Research on the association between education and health has not been able to escape the criticism that factors other than education are responsible for this repeatedly observed, but potentially spurious, association. If the association between education and health is causal, the pathways through which education impact health remain to be fully elucidated. This application seeks to 1) obtain an estimate of the effect of education on multiple adult health outcomes independent of several determinants of both schooling and later adult health, and 2) evaluate the contribution of several potential pathways hypothesized to account for the association between education and health. This proposal is submitted by investigators from developmental and social epidemiology, medicine, health education and literacy, economics, psychology and biostatistics, and is based on adult follow-up studies of the New England cohorts of the National Collaborative Perinatal Project. The first aim is to conduct analyses of data recently obtained from a family study of 2,000 subjects who have been followed from birth through age 40; these analyses will incorporate a
detailed measure of adult health status, prospective measures of social, familial, and individual determinants of education that were collected between 1959 and 1976, and a sibling design to account for potential unmeasured familial variables. In these analyses we will determine the 'adjusted' effects of education on the following health outcomes: diagnoses of cancer, cardiovascular disease, asthma and diabetes; self-rated health; and behavioral risk factors including current and lifetime indicators of tobacco use and substance abuse. We will also test the hypothesis that psychological processes (depression, anxiety, perceived social status, and perceived stress) mediate the association between education and health. The second and third aims of this study involve new data collection from 800 of these 2,000 subjects. Aim two focuses on elucidating the causal effects of education on biological precursors of cardiovascular disease and diabetes. The third aim will be to investigate the role of education in improving health through enhancement of functional literacy skills. The prospective nature of this study, the comprehensive assessment of parental and childhood variables, and the hypothesis-driven tests of causation and potential mechanisms make this project uniquely suited to evaluate the link between education and improved health outcomes.
Publications
Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood.
Authors: Huang G.
, Aroner S.A.
, Bay C.P.
, Gilman S.E.
, Ghassabian A.
, Loucks E.B.
, Buka S.L.
, Handa R.J.
, Lasley B.L.
, Bhasin S.
, et al.
.
Source: Journal Of Endocrinological Investigation, 2020-08-10 00:00:00.0; , .
EPub date: 2020-08-10 00:00:00.0.
PMID: 32776198
Related Citations
Associations of types of green space across the life-course with blood pressure and body mass index.
Authors: Jimenez M.P.
, Wellenius G.A.
, James P.
, Subramanian S.V.
, Buka S.
, Eaton C.
, Gilman S.E.
, Loucks E.B.
.
Source: Environmental Research, 2020 06; 185, p. 109411.
EPub date: 2020-03-26 00:00:00.0.
PMID: 32240843
Related Citations
Optimism and Social Support Predict Healthier Adult Behaviors Despite Socially Disadvantaged Childhoods.
Authors: Non A.L.
, Román J.C.
, Clausing E.S.
, Gilman S.E.
, Loucks E.B.
, Buka S.L.
, Appleton A.A.
, Kubzansky L.D.
.
Source: International Journal Of Behavioral Medicine, 2020-01-13 00:00:00.0; , .
EPub date: 2020-01-13 00:00:00.0.
PMID: 31933126
Related Citations
Longitudinal associations of neighborhood socioeconomic status with cardiovascular risk factors: A 46-year follow-up study.
Authors: Jimenez M.P.
, Wellenius G.A.
, Subramanian S.V.
, Buka S.
, Eaton C.
, Gilman S.E.
, Loucks E.B.
.
Source: Social Science & Medicine (1982), 2019 Nov; 241, p. 112574.
EPub date: 2019-09-25 00:00:00.0.
PMID: 31593787
Related Citations
Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens.
Authors: Huang G.
, Cherkerzian S.
, Loucks E.B.
, Buka S.L.
, Handa R.J.
, Lasley B.L.
, Bhasin S.
, Goldstein J.M.
.
Source: The Journal Of Clinical Endocrinology And Metabolism, 2018-11-01 00:00:00.0; 103(11), p. 3945-3953.
PMID: 30113645
Related Citations
Maternal smoking during pregnancy and offspring antisocial behaviour: findings from a longitudinal investigation of discordant siblings.
Authors: Paradis A.D.
, Shenassa E.D.
, Papandonatos G.D.
, Rogers M.L.
, Buka S.L.
.
Source: Journal Of Epidemiology And Community Health, 2017 09; 71(9), p. 889-896.
EPub date: 2017-07-10 00:00:00.0.
PMID: 28696927
Related Citations
Impact of persistent and adolescent-limited antisocial behaviour on adult health outcomes.
Authors: Paradis A.D.
, Koenen K.C.
, Fitzmaurice G.M.
, Buka S.L.
.
Source: Journal Of Epidemiology And Community Health, 2016 10; 70(10), p. 1004-10.
EPub date: 2016-04-11 00:00:00.0.
PMID: 27069087
Related Citations
Early childhood social disadvantage is associated with poor health behaviours in adulthood.
Authors: Non A.L.
, Román J.C.
, Gross C.L.
, Gilman S.E.
, Loucks E.B.
, Buka S.L.
, Kubzansky L.D.
.
Source: Annals Of Human Biology, 2016; 43(2), p. 144-53.
PMID: 26727037
Related Citations
A prospective investigation of neurodevelopmental risk factors for adult antisocial behavior combining official arrest records and self-reports.
Authors: Paradis A.D.
, Fitzmaurice G.M.
, Koenen K.C.
, Buka S.L.
.
Source: Journal Of Psychiatric Research, 2015 Sep; 68, p. 363-70.
PMID: 26050211
Related Citations
Education and coronary heart disease risk: potential mechanisms such as literacy, perceived constraints, and depressive symptoms.
Authors: Loucks E.B.
, Gilman S.E.
, Howe C.J.
, Kawachi I.
, Kubzansky L.D.
, Rudd R.E.
, Martin L.T.
, Nandi A.
, Wilhelm A.
, Buka S.L.
.
Source: Health Education & Behavior : The Official Publication Of The Society For Public Health Education, 2015 Jun; 42(3), p. 370-9.
PMID: 25431228
Related Citations
Prospective evaluation of associations between prenatal cortisol and adulthood coronary heart disease risk: the New England family study.
Authors: Stinson L.J.
, Stroud L.R.
, Buka S.L.
, Eaton C.B.
, Lu B.
, Niaura R.
, Loucks E.B.
.
Source: Psychosomatic Medicine, 2015 Apr; 77(3), p. 237-45.
PMID: 25768844
Related Citations
Early origins of inflammation: An examination of prenatal and childhood social adversity in a prospective cohort study.
Authors: Slopen N.
, Loucks E.B.
, Appleton A.A.
, Kawachi I.
, Kubzansky L.D.
, Non A.L.
, Buka S.
, Gilman S.E.
.
Source: Psychoneuroendocrinology, 2015 Jan; 51, p. 403-13.
PMID: 25462912
Related Citations
Divergent associations of antecedent- and response-focused emotion regulation strategies with midlife cardiovascular disease risk.
Authors: Appleton A.A.
, Loucks E.B.
, Buka S.L.
, Kubzansky L.D.
.
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2014 Oct; 48(2), p. 246-55.
PMID: 24570218
Related Citations
Another casualty of sibling fixed-effects analysis of education and health: an informative null, or null information?
Authors: Gilman S.E.
, Loucks E.B.
.
Source: Social Science & Medicine (1982), 2014 Oct; 118, p. 191-3.
PMID: 25138687
Related Citations
Childhood social disadvantage, cardiometabolic risk, and chronic disease in adulthood.
Authors: Non A.L.
, Rewak M.
, Kawachi I.
, Gilman S.E.
, Loucks E.B.
, Appleton A.A.
, Román J.C.
, Buka S.L.
, Kubzansky L.D.
.
Source: American Journal Of Epidemiology, 2014-08-01 00:00:00.0; 180(3), p. 263-71.
EPub date: 2014-08-01 00:00:00.0.
PMID: 24970845
Related Citations
Race-related health disparities and biological aging: does rate of telomere shortening differ across blacks and whites?
Authors: Rewak M.
, Buka S.
, Prescott J.
, De Vivo I.
, Loucks E.B.
, Kawachi I.
, Non A.L.
, Kubzansky L.D.
.
Source: Biological Psychology, 2014 May; 99, p. 92-9.
PMID: 24686071
Related Citations
Divergent associations of adaptive and maladaptive emotion regulation strategies with inflammation.
Authors: Appleton A.A.
, Buka S.L.
, Loucks E.B.
, Gilman S.E.
, Kubzansky L.D.
.
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2013 Jul; 32(7), p. 748-56.
PMID: 23815767
Related Citations
Childhood emotional functioning and the developmental origins of cardiovascular disease risk.
Authors: Appleton A.A.
, Loucks E.B.
, Buka S.L.
, Rimm E.
, Kubzansky L.D.
.
Source: Journal Of Epidemiology And Community Health, 2013 May; 67(5), p. 405-11.
PMID: 23322856
Related Citations
Sheepskin effects of education in the 10-year Framingham risk of coronary heart disease.
Authors: Liu S.Y.
, Buka S.L.
, Kubzansky L.D.
, Kawachi I.
, Gilman S.E.
, Loucks E.B.
.
Source: Social Science & Medicine (1982), 2013 Mar; 80, p. 31-6.
PMID: 23415589
Related Citations
A prospective study of positive early-life psychosocial factors and favorable cardiovascular risk in adulthood.
Authors: Appleton A.A.
, Buka S.L.
, Loucks E.B.
, Rimm E.B.
, Martin L.T.
, Kubzansky L.D.
.
Source: Circulation, 2013-02-26 00:00:00.0; 127(8), p. 905-12.
EPub date: 2013-02-26 00:00:00.0.
PMID: 23339873
Related Citations
Invited commentary: does the childhood environment influence the association between every x and every y in adulthood?
Authors: Gilman S.E.
, Loucks E.B.
.
Source: American Journal Of Epidemiology, 2012-10-15 00:00:00.0; 176(8), p. 684-8.
EPub date: 2012-10-15 00:00:00.0.
PMID: 23024136
Related Citations
The association between childhood emotional functioning and adulthood inflammation is modified by early-life socioeconomic status.
Authors: Appleton A.A.
, Buka S.L.
, McCormick M.C.
, Koenen K.C.
, Loucks E.B.
, Kubzansky L.D.
.
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2012 Jul; 31(4), p. 413-22.
PMID: 22329424
Related Citations
Education and coronary heart disease risk associations may be affected by early-life common prior causes: a propensity matching analysis.
Authors: Loucks E.B.
, Buka S.L.
, Rogers M.L.
, Liu T.
, Kawachi I.
, Kubzansky L.D.
, Martin L.T.
, Gilman S.E.
.
Source: Annals Of Epidemiology, 2012 Apr; 22(4), p. 221-32.
PMID: 22463841
Related Citations
Maternal smoking during pregnancy and criminal offending among adult offspring.
Authors: Paradis A.D.
, Fitzmaurice G.M.
, Koenen K.C.
, Buka S.L.
.
Source: Journal Of Epidemiology And Community Health, 2011 Dec; 65(12), p. 1145-50.
PMID: 21081311
Related Citations
Maternal smoking during pregnancy and anger temperament among adult offspring.
Authors: Liu T.
, Gatsonis C.A.
, Baylin A.
, Kubzansky L.D.
, Loucks E.B.
, Buka S.L.
.
Source: Journal Of Psychiatric Research, 2011 Dec; 45(12), p. 1648-54.
PMID: 21890149
Related Citations
Childhood family psychosocial environment and coronary heart disease risk.
Authors: Loucks E.B.
, Almeida N.D.
, Taylor S.E.
, Matthews K.A.
.
Source: Psychosomatic Medicine, 2011 Sep; 73(7), p. 563-71.
PMID: 21810898
Related Citations
Emotional functioning at age 7 years is associated with C-reactive protein in middle adulthood.
Authors: Appleton A.A.
, Buka S.L.
, McCormick M.C.
, Koenen K.C.
, Loucks E.B.
, Gilman S.E.
, Kubzansky L.D.
.
Source: Psychosomatic Medicine, 2011 May; 73(4), p. 295-303.
PMID: 21536835
Related Citations
Maternal smoking during pregnancy and risk of alcohol use disorders among adult offspring.
Authors: Nomura Y.
, Gilman S.E.
, Buka S.L.
.
Source: Journal Of Studies On Alcohol And Drugs, 2011 Mar; 72(2), p. 199-209.
PMID: 21388593
Related Citations
The association between blood pressure and years of schooling versus educational credentials: test of the sheepskin effect.
Authors: Liu S.Y.
, Buka S.L.
, Linkletter C.D.
, Kawachi I.
, Kubzansky L.
, Loucks E.B.
.
Source: Annals Of Epidemiology, 2011 Feb; 21(2), p. 128-38.
PMID: 21184953
Related Citations
Beyond reading alone: the relationship between aural literacy and asthma management.
Authors: Rosenfeld L.
, Rudd R.
, Emmons K.M.
, Acevedo-García D.
, Martin L.
, Buka S.
.
Source: Patient Education And Counseling, 2011 Jan; 82(1), p. 110-6.
PMID: 20399060
Related Citations
Maternal pregnancy-related hypertension and risk for hypertension in offspring later in life.
Authors: Palmsten K.
, Buka S.L.
, Michels K.B.
.
Source: Obstetrics And Gynecology, 2010 Oct; 116(4), p. 858-64.
PMID: 20859149
Related Citations
Quality of parental emotional care and calculated risk for coronary heart disease.
Authors: Almeida N.D.
, Loucks E.B.
, Kubzansky L.
, Pruessner J.
, Maselko J.
, Meaney M.J.
, Buka S.L.
.
Source: Psychosomatic Medicine, 2010 Feb; 72(2), p. 148-55.
PMID: 20064905
Related Citations
Educational attainment and cigarette smoking: a causal association?
Authors: Gilman S.E.
, Martin L.T.
, Abrams D.B.
, Kawachi I.
, Kubzansky L.
, Loucks E.B.
, Rende R.
, Rudd R.
, Buka S.L.
.
Source: International Journal Of Epidemiology, 2008 Jun; 37(3), p. 615-24.
PMID: 18180240
Related Citations
Childhood cognitive performance and risk of generalized anxiety disorder.
Authors: Martin L.T.
, Kubzansky L.D.
, LeWinn K.Z.
, Lipsitt L.P.
, Satz P.
, Buka S.L.
.
Source: International Journal Of Epidemiology, 2007 Aug; 36(4), p. 769-75.
PMID: 17470490
Related Citations
Childhood cognitive performance and risk of mortality: a prospective cohort study of gifted individuals.
Authors: Martin L.T.
, Kubzansky L.D.
.
Source: American Journal Of Epidemiology, 2005-11-01 00:00:00.0; 162(9), p. 887-90.
EPub date: 2005-11-01 00:00:00.0.
PMID: 16150888
Related Citations