Skip to main content

COVID-19 Resources

What people with cancer should know:

Guidance for cancer researchers:

Get the latest public health information from CDC:

Get the latest research information from NIH:

Grant Details

Grant Number: 5R01CA093817-05 Interpret this number
Primary Investigator: Kato, Ikuko
Organization: Wayne State University
Project Title: Luminal Lipid Exposure, Genetics and Colon Cancer Risk
Fiscal Year: 2006


DESCRIPTION (provided by applicant): The long-term goal of the proposed study is to provide the scientific basis for public health strategies to reduce incidence of and mortality from colorectal cancer. Several lines of evidence suggest that a high fat diet increases the risk of colorectal cancer. While ecologic studies and earlier case-control studies demonstrated a strong association with high fat intake, the results from cohort studies and recent case-control studies have rather been inconsistent. These discrepancies may indicate some genetic susceptibility that modify the effects of a high fat diet. One of the major mechanistic bases for the roles of fat in colorectal carcinogenesis is intracolonic exposure to potentially carcinogenic substances which are generated from lipid and its metabolites with fecal bacterial activities. In this context fat absorption may play a key role in determining the effects of a high fat diet on colorectal cancer risk via modifying the levels of luminal exposure to potentially carcinogenic metabolites. Recently, two common genetic polymorphisms (FABP2 and Apo E) that affect intestinal fat absorption and bile acid secretion have been reported and associated with risks of cardiovascular diseases, diabetes and dementia. We hypothesize that individuals with genotypes for lower intestinal absorption, which results in more intracolonic exposure to potentially carcinogenic substances, have a higher risk of developing colorectal cancer in relation to a high fat diet. To test this hypothesis, we propose to conduct a population-based case-control study in Metropolitan Detroit taking an advantage of the SEER Cancer Registry. We plan to interview 2000 cases and 2000 controls for their usual diet to estimate fat and other nutrient intake and collect blood or buccal cell specimens for genotyping assays. Specific aims of the study are (1) To determine whether the genotype, FABP2 A54, Apo E2/E3 or a combination of these, is associated with risk of colorectal cancer; (2) To determine whether the effect of a high fat diet on colorectal cancer risk is more pronounced in the subjects with these genotypes; and (3) To determine if the above interactions are modified by intake of other dietary components, such as fiber, calcium and iron, which affect luminal lipid metabolism. The results from the proposed study would provide useful information for effective dietary modification in primary prevention for colorectal cancer. In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions.


Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer.
Authors: Butt J. , Fernández de Larrea N. , Tjalsma H. , Roelofs R. , Kato I. , Martín V. , Pérez-Gómez B. , Moreno V. , Dierssen-Sotos T. , Castilla J. , et al. .
Source: Scientific reports, 2019-07-26; 9(1), p. 10847.
EPub date: 2019-07-26.
PMID: 31350458
Related Citations

Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
Authors: Wang H. , Schmit S.L. , Haiman C.A. , Keku T.O. , Kato I. , Palmer J.R. , van den Berg D. , Wilkens L.R. , Burnett T. , Conti D.V. , et al. .
Source: International journal of cancer, 2017-06-15; 140(12), p. 2728-2733.
EPub date: 2017-03-28.
PMID: 28295283
Related Citations

Nutritional Correlates of Human Oral Microbiome.
Authors: Kato I. , Vasquez A. , Moyerbrailean G. , Land S. , Djuric Z. , Sun J. , Lin H.S. , Ram J.L. .
Source: Journal of the American College of Nutrition, 2017 02; 36(2), p. 88-98.
EPub date: 2016-10-31.
PMID: 27797671
Related Citations

Oral microbiome and history of smoking and colorectal cancer.
Authors: Kato I. , Vasquez A.A. , Moyerbrailean G. , Land S. , Sun J. , Lin H.S. , Ram J.L. .
Source: Journal of epidemiological research, 2016 Oct; 2(2), p. 92-101.
PMID: 28111632
Related Citations

Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer.
Authors: Kato I. , Dyson G. , Snyder M. , Kim H.R. , Severson R.K. .
Source: Journal of radiation oncology, 2016 Sep; 5(3), p. 279-286.
EPub date: 2016-01-27.
PMID: 27746859
Related Citations

Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk.
Authors: Kato I. , Boleij A. , Kortman G.A. , Roelofs R. , Djuric Z. , Severson R.K. , Tjalsma H. .
Source: Nutrition and cancer, 2013; 65(2), p. 169-77.
PMID: 23441604
Related Citations

Association of dietary quercetin with reduced risk of proximal colon cancer.
Authors: Djuric Z. , Severson R.K. , Kato I. .
Source: Nutrition and cancer, 2012 Apr; 64(3), p. 351-60.
EPub date: 2012-03-19.
PMID: 22429001
Related Citations

Selective antibody response to Streptococcus gallolyticus pilus proteins in colorectal cancer patients.
Authors: Boleij A. , Roelofs R. , Danne C. , Bellais S. , Dramsi S. , Kato I. , Tjalsma H. .
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Feb; 5(2), p. 260-5.
EPub date: 2011-10-19.
PMID: 22012878
Related Citations

Plasma levels of resistin-like molecule beta in humans.
Authors: Neilson A.P. , Djuric Z. , Land S. , Kato I. .
Source: Cancer epidemiology, 2011 Oct; 35(5), p. 485-9.
EPub date: 2010-11-19.
PMID: 21094111
Related Citations

APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease.
Authors: Kato I. , Land S. , Barnholtz-Sloan J. , Severson R.K. .
Source: Cholesterol, 2011; 2011, p. 896360.
EPub date: 2011-09-18.
PMID: 21941641
Related Citations

Increased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients.
Authors: Boleij A. , Roelofs R. , Schaeps R.M. , Schülin T. , Glaser P. , Swinkels D.W. , Kato I. , Tjalsma H. .
Source: Cancer, 2010-09-01; 116(17), p. 4014-22.
PMID: 20564125
Related Citations

Dietary fatty acids, luminal modifiers, and risk of colorectal cancer.
Authors: Kato I. , Majumdar A.P. , Land S.J. , Barnholtz-Sloan J.S. , Severson R.K. .
Source: International journal of cancer, 2010-08-15; 127(4), p. 942-51.
PMID: 19998336
Related Citations

Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer.
Authors: Kato I. , Land S. , Majumdar A.P. , Barnholtz-Sloan J. , Severson R.K. .
Source: Cancer epidemiology, 2010 Jun; 34(3), p. 291-7.
EPub date: 2010-03-21.
PMID: 20308031
Related Citations

African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.
Authors: Kato I. , Cichon M. , Yee C.L. , Land S. , Korczak J.F. .
Source: Cancer epidemiology, 2009 Jul; 33(1), p. 24-30.
EPub date: 2009-05-14.
PMID: 19679043
Related Citations

Non-steroidal anti-inflammatory drug (NSAID) use and levels of a lipid oxidation marker in plasma and nipple aspirate fluids.
Authors: Kato I. , Chen G. , Djuric Z. .
Source: Breast cancer research and treatment, 2006 May; 97(2), p. 145-8.
EPub date: 2005-12-02.
PMID: 16322889
Related Citations

Nutritional predictors for cellular nipple aspirate fluid: Nutrition and Breast Health Study.
Authors: Kato I. , Ren J. , Visscher D.W. , Djuric Z. .
Source: Breast cancer research and treatment, 2006 May; 97(1), p. 33-9.
EPub date: 2005-11-30.
PMID: 16317581
Related Citations

Intra- and inter-individual variability in measurements of biomarkers for oxidative damage in vivo: Nutrition and Breast Health Study.
Authors: Kato I. , Ren J. , Heilbrun L.K. , Djuric Z. .
Source: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2006 Mar-Apr; 11(2), p. 143-52.
PMID: 16766390
Related Citations

Back to Top