Grant Details
Grant Number: |
5R01CA072520-09 Interpret this number |
Primary Investigator: |
Le Marchand, Loic |
Organization: |
University Of Hawaii At Manoa |
Project Title: |
Diet, Genetic Susceptibility and Colorectal Neoplasia |
Fiscal Year: |
2006 |
Abstract
DESCRIPTION (provided by applicant): Smoking, overnutrition and a high red meat and low folate and calcium diet have been associated with colorectal cancer (CRC) and adenoma. The epidemiologic features of CRC among migrants and native populations in Hawaii suggest the modifying effects of genetic susceptibility factors on most of these associations. Taking advantage of the genetic and dietary diversity of our population, we have made good progress in investigating specific gene variants that affect one's capacity to bioactivate dietary carcinogens or utilize one-carbon groups for DNA synthesis or methylation. We also showed that a genetic variant associated with lower circulating IGF-I hormones may protect against colorectal neoplasia. We seek to renew grant 1 -R01-CA72520 to extend a case-control study of colorectal adenoma in order to test these gene-diet interactions in a large series of adenoma cases and controls, as well as to examine several new variants in these pathways in relation to adenoma, as well as CRC using existing samples/data from a companion study. New aims also include discovering new SNPs and mapping haplotypes in major genes related to the activation of heterocyclic amines and assessing population stratification in our subjects using random genetic markers.
A diet and lifestyle questionnaire will be administered in person to another 904 new adenoma cases and 904 endoscopically normal controls (for a total study sample of 1,204 adenoma cases and 1,404 controls) frequency-matched on age, sex, race/ethnicity, date and mode of endoscopy. Usual consumption of meat and fish items prepared by high-temperature methods and doneness of meats will be assessed, in addition to estimating the total intake of energy, nutrients, and other dietary components. Subjects will be phenotyped for several P450 enzymes by caffeine challenge. A blood sample will also be collected to genotype subjects for variants in a number of genes related to growth hormones, carcinogen activation and folate metabolism. Sequencing of genes related to heterocyclic amine activation in colorectal cancer patients of Japanese, Caucasian, African American, Latino or Native Hawaiian origin will allow for the construction of haplotypes. Correlations with CYP1A2 phenotype will help to select functional haplotypes which will then be tested for associations with adenoma and colorectal cancer. Genotyping for random markers will permit to exclude residual confounding by ethnicity.
Publications
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction.
Authors: Gauderman W.J.
, Fu Y.
, Queme B.
, Kawaguchi E.
, Wang Y.
, Morrison J.
, Brenner H.
, Chan A.
, Gruber S.B.
, Keku T.
, et al.
.
Source: Biorxiv : The Preprint Server For Biology, 2024-12-19 00:00:00.0; , .
EPub date: 2024-12-19 00:00:00.0.
PMID: 39763728
Related Citations
Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis.
Authors: Hazelwood E.
, Lopez Manzano C.
, Vincent E.E.
, Albanes D.
, Bishop D.T.
, Le Marchand L.
, Ulrich C.M.
, Peters U.
, Murphy G.
, Samadder N.J.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-12-02 00:00:00.0; 33(12), p. 1727-1732.
PMID: 39361354
Related Citations
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.
Authors: Denos M.
, Sun Y.Q.
, Brumpton B.
, Li Y.
, Albanes D.
, Burnett-Hartman A.
, Campbell P.T.
, Küry S.
, Li C.I.
, White E.
, et al.
.
Source: Research Square, 2024-04-10 00:00:00.0; , .
EPub date: 2024-04-10 00:00:00.0.
PMID: 38659935
Related Citations
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
Authors: Yarmolinsky J.
, Robinson J.W.
, Mariosa D.
, Karhunen V.
, Huang J.
, Dimou N.
, Murphy N.
, Burrows K.
, Bouras E.
, Smith-Byrne K.
, et al.
.
Source: Ebiomedicine, 2024 Feb; 100, p. 104991.
EPub date: 2024-02-01 00:00:00.0.
PMID: 38301482
Related Citations
Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes.
Authors: Mahmood K.
, Thomas M.
, Qu C.
, Gecco-Ccfr Consortium
, Hsu L.
, Buchanan D.D.
, Peters U.
.
Source: Gastroenterology, 2023 Oct; 165(4), p. 1070-1076.e3.
EPub date: 2023-07-14 00:00:00.0.
PMID: 37453563
Related Citations
A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.
Authors: Aglago E.K.
, Kim A.
, Lin Y.
, Qu C.
, Evangelou M.
, Ren Y.
, Morrison J.
, Albanes D.
, Arndt V.
, Barry E.L.
, et al.
.
Source: Cancer Research, 2023-08-01 00:00:00.0; 83(15), p. 2572-2583.
PMID: 37249599
Related Citations
Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Authors: Bull C.J.
, Hazelwood E.
, Bell J.A.
, Tan V.Y.
, Constantinescu A.E.
, Borges M.C.
, Legge D.N.
, Burrows K.
, Huyghe J.R.
, Brenner H.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-07-17 00:00:00.0; , .
EPub date: 2023-07-17 00:00:00.0.
PMID: 36945480
Related Citations
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
Authors: Dimou N.
, Kim A.E.
, Flanagan O.
, Murphy N.
, Diez-Obrero V.
, Shcherbina A.
, Aglago E.K.
, Bouras E.
, Campbell P.T.
, Casey G.
, et al.
.
Source: British Journal Of Cancer, 2023-06-26 00:00:00.0; , .
EPub date: 2023-06-26 00:00:00.0.
PMID: 37365285
Related Citations
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
Authors: Yarmolinsky J.
, Robinson J.W.
, Mariosa D.
, Karhunen V.
, Huang J.
, Dimou N.
, Murphy N.
, Burrows K.
, Bouras E.
, Smith-Byrne K.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-05-05 00:00:00.0; , .
EPub date: 2023-05-05 00:00:00.0.
PMID: 37205426
Related Citations
The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
Authors: Haycock P.C.
, Borges M.C.
, Burrows K.
, Lemaitre R.N.
, Burgess S.
, Khankari N.K.
, Tsilidis K.K.
, Gaunt T.R.
, Hemani G.
, Zheng J.
, et al.
.
Source: Ebiomedicine, 2023 May; 91, p. 104510.
EPub date: 2023-04-20 00:00:00.0.
PMID: 37086649
Related Citations
Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response.
Authors: Carreras-Torres R.
, Kim A.E.
, Lin Y.
, Díez-Obrero V.
, Bien S.A.
, Qu C.
, Wang J.
, Dimou N.
, Aglago E.K.
, Albanes D.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-12-28 00:00:00.0; , .
EPub date: 2022-12-28 00:00:00.0.
PMID: 36576985
Related Citations
Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis.
Authors: Lu Y.
, Zhao Y.C.
, Chang-Claude J.
, Gruber S.B.
, Gsur A.
, Offit K.
, Vodickova L.
, Woods M.O.
, Nguyen L.H.
, Wade K.H.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-12-13 00:00:00.0; , .
EPub date: 2022-12-13 00:00:00.0.
PMID: 36512731
Related Citations
Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation.
Authors: Martin S.
, Tyrrell J.
, Thomas E.L.
, Bown M.J.
, Wood A.R.
, Beaumont R.N.
, Tsoi L.C.
, Stuart P.E.
, Elder J.T.
, Law P.
, et al.
.
Source: Elife, 2022-01-25 00:00:00.0; 11, .
EPub date: 2022-01-25 00:00:00.0.
PMID: 35074047
Related Citations
Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses.
Authors: Dimou N.
, Mori N.
, Harlid S.
, Harbs J.
, Martin R.M.
, Smith-Byrne K.
, Papadimitriou N.
, Bishop D.T.
, Casey G.
, Colorado-Yohar S.M.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021 07; 30(7), p. 1336-1348.
EPub date: 2021-04-20 00:00:00.0.
PMID: 33879453
Related Citations
Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study.
Authors: Dimou N.
, Yarmolinsky J.
, Bouras E.
, Tsilidis K.K.
, Martin R.M.
, Lewis S.J.
, Gram I.T.
, Bakker M.F.
, Brenner H.
, Figueiredo J.C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021 May; 30(5), p. 953-964.
EPub date: 2021-03-02 00:00:00.0.
PMID: 33653810
Related Citations
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.
Authors: Nounu A.
, Greenhough A.
, Heesom K.J.
, Richmond R.C.
, Zheng J.
, Weinstein S.J.
, Albanes D.
, Baron J.A.
, Hopper J.L.
, Figueiredo J.C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-12-14 00:00:00.0; , .
EPub date: 2020-12-14 00:00:00.0.
PMID: 33318029
Related Citations
Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.
Authors: Guo X.
, Lin W.
, Wen W.
, Huyghe J.
, Bien S.
, Cai Q.
, Harrison T.
, Chen Z.
, Qu C.
, Bao J.
, et al.
.
Source: Gastroenterology, 2020-10-12 00:00:00.0; , .
EPub date: 2020-10-12 00:00:00.0.
PMID: 33058866
Related Citations
Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.
Authors: Lu Y.
, Kweon S.S.
, Cai Q.
, Tanikawa C.
, Shu X.O.
, Jia W.H.
, Xiang Y.B.
, Huyghe J.R.
, Harrison T.A.
, Kim J.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020 02; 29(2), p. 477-486.
EPub date: 2019-12-11 00:00:00.0.
PMID: 31826910
Related Citations
Heterocyclic Amine Intake, Smoking, Cytochrome P450 1a2 And N-acetylation Phenotypes, And Risk Of Colorectal Adenoma In A Multiethnic Population
Authors: Voutsinas J.
, Wilkens L.R.
, Franke A.
, Vogt T.M.
, Yokochi L.A.
, Decker R.
, Le Marchand L.
.
Source: Gut, 2013 Mar; 62(3), p. 416-22.
PMID: 22628494
Related Citations
Variations In Bitter-taste Receptor Genes, Dietary Intake, And Colorectal Adenoma Risk
Authors: Schembre S.M.
, Cheng I.
, Wilkens L.R.
, Albright C.L.
, Marchand L.
.
Source: Nutrition And Cancer, 2013; 65(7), p. 982-90.
PMID: 24083639
Related Citations
Metabolism And Biomarkers Of Heterocyclic Aromatic Amines In Molecular Epidemiology Studies: Lessons Learned From Aromatic Amines
Authors: Turesky R.J.
, Le Marchand L.
.
Source: Chemical Research In Toxicology, 2011-08-15 00:00:00.0; 24(8), p. 1169-214.
PMID: 21688801
Related Citations
Association Of Plasma Vitamin B6 With Risk Of Colorectal Adenoma In A Multiethnic Case-control Study
Authors: Le Marchand L.
, Wang H.
, Selhub J.
, Vogt T.M.
, Yokochi L.
, Decker R.
.
Source: Cancer Causes & Control : Ccc, 2011 Jun; 22(6), p. 929-36.
PMID: 21437631
Related Citations
Genetic Variation In The Bioactivation Pathway For Polycyclic Hydrocarbons And Heterocyclic Amines In Relation To Risk Of Colorectal Neoplasia
Authors: Wang H.
, Yamamoto J.F.
, Caberto C.
, Saltzman B.
, Decker R.
, Vogt T.M.
, Yokochi L.
, Chanock S.
, Wilkens L.R.
, Le Marchand L.
.
Source: Carcinogenesis, 2011 Feb; 32(2), p. 203-9.
PMID: 21081473
Related Citations
Generalizability And Epidemiologic Characterization Of Eleven Colorectal Cancer Gwas Hits In Multiple Populations
Authors: He J.
, Wilkens L.R.
, Stram D.O.
, Kolonel L.N.
, Henderson B.E.
, Wu A.H.
, Le Marchand L.
, Haiman C.A.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2011 Jan; 20(1), p. 70-81.
PMID: 21071539
Related Citations
Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population.
Authors: Ognjanovic S.
, Yamamoto J.
, Saltzman B.
, Franke A.
, Ognjanovic M.
, Yokochi L.
, Vogt T.
, Decker R.
, Le Marchand L.
.
Source: Cancer Causes & Control : Ccc, 2010 Jul; 21(7), p. 1131-8.
PMID: 20333461
Related Citations
Associations Of Plasma C-peptide And Igfbp-1 Levels With Risk Of Colorectal Adenoma In A Multiethnic Population
Authors: Le Marchand L.
, Wang H.
, Rinaldi S.
, Kaaks R.
, Vogt T.M.
, Yokochi L.
, Decker R.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Jun; 19(6), p. 1471-7.
PMID: 20501760
Related Citations
Association Of Genetic Variation In The Transforming Growth Factor Beta-1 Gene With Serum Levels And Risk Of Colorectal Neoplasia
Authors: Saltzman B.S.
, Yamamoto J.F.
, Decker R.
, Yokochi L.
, Theriault A.G.
, Vogt T.M.
, Le Marchand L.
.
Source: Cancer Research, 2008-02-15 00:00:00.0; 68(4), p. 1236-44.
PMID: 18281501
Related Citations
Design considerations for genomic association studies: importance of gene-environment interactions.
Authors: Le Marchand L.
, Wilkens L.R.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Feb; 17(2), p. 263-7.
PMID: 18268108
Related Citations
A Common Genetic Risk Factor For Colorectal And Prostate Cancer
Authors: Haiman C.A.
, Le Marchand L.
, Yamamato J.
, Stram D.O.
, Sheng X.
, Kolonel L.N.
, Wu A.H.
, Reich D.
, Henderson B.E.
.
Source: Nature Genetics, 2007 Aug; 39(8), p. 954-6.
PMID: 17618282
Related Citations
Smoking And Colorectal Cancer: Different Effects By Type Of Cigarettes?
Authors: Lüchtenborg M.
, White K.K.
, Wilkens L.
, Kolonel L.N.
, Le Marchand L.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Jul; 16(7), p. 1341-7.
PMID: 17626999
Related Citations
Nat2, Meat Consumption And Colorectal Cancer Incidence: An Ecological Study Among 27 Countries
Authors: Ognjanovic S.
, Yamamoto J.
, Maskarinec G.
, Le Marchand L.
.
Source: Cancer Causes & Control : Ccc, 2006 Nov; 17(9), p. 1175-82.
PMID: 17006723
Related Citations
The Predominance Of The Environment Over Genes In Cancer Causation: Implications For Genetic Epidemiology
Authors: Le Marchand L.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2005 May; 14(5), p. 1037-9.
PMID: 15894649
Related Citations
Association Of The Cyclin D1 A870g Polymorphism With Advanced Colorectal Cancer
Authors: Le Marchand L.
, Seifried A.
, Lum-Jones A.
, Donlon T.
, Wilkens L.R.
.
Source: Jama, 2003-12-03 00:00:00.0; 290(21), p. 2843-8.
PMID: 14657069
Related Citations
Association Of A Common Polymorphism In The Human Gh1 Gene With Colorectal Neoplasia
Authors: Le Marchand L.
, Donlon T.
, Seifried A.
, Kaaks R.
, Rinaldi S.
, Wilkens L.R.
.
Source: Journal Of The National Cancer Institute, 2002-03-20 00:00:00.0; 94(6), p. 454-60.
PMID: 11904318
Related Citations
Feasibility Of Collecting Buccal Cell Dna By Mail In A Cohort Study
Authors: Le Marchand L.
, Lum-Jones A.
, Saltzman B.
, Visaya V.
, Nomura A.M.
, Kolonel L.N.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Jun; 10(6), p. 701-3.
PMID: 11401922
Related Citations
Cyp1a1, Gstm1, And Gstp1 Genetic Polymorphisms And Urinary 1-hydroxypyrene Excretion In Non-occupationally Exposed Individuals
Authors: Nerurkar P.V.
, Okinaka L.
, Aoki C.
, Seifried A.
, Lum-Jones A.
, Wilkens L.R.
, Le Marchand L.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2000 Oct; 9(10), p. 1119-22.
PMID: 11045797
Related Citations
Effects Of Marinating With Asian Marinades Or Western Barbecue Sauce On Phip And Meiqx Formation In Barbecued Beef
Authors: Nerurkar P.V.
, Le Marchand L.
, Cooney R.V.
.
Source: Nutrition And Cancer, 1999; 34(2), p. 147-52.
PMID: 10578481
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