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Grant Details

Grant Number: 5R44CA092807-03 Interpret this number
Primary Investigator: Goovaerts, Pierre
Organization: Biomedware
Project Title: Simulation Algorithms for Spatial Pattern Recognition
Fiscal Year: 2006


Abstract

DESCRIPTION (provided by applicant): This SBIR project is developing methods and software for the specification, construction and simulation of neutral spatial models, and for applying these neutral models within the framework of probabilistic pattern recognition. Results will allow epidemiologists, environmental scientists and image analysts across a broad range of commercial disciplines to more accurately identify patterns in spatial data by removing the bias towards false positives that is caused by unrealistic null hypotheses such as "complete spatial randomness" (CSR). This project will accomplish 5 aims: 1. Conduct a requirements analysis to specify the neutral models and functionality to incorporate in the software. 2. Develop and test a software prototype to evaluate feasibility of the proposed models. 3. Propose a topology of neutral models and develop strategies to generate them and to conduct sensitivity analysis for investigating the impact of implicit assumptions (i.e. spatial autocorrelation or non-uniform risk) and number of realizations on test results. 4. Incorporate the neutral models in the first commercially established software package that allows for user-specified alternate hypothesis in spatial statistical tests. 5. Apply the software and methods to demonstrate the approach and its unique benefits for exposure and health risk assessment. Feasibility of this project was demonstrated in the Phase I. This Phase II project will accomplish aims three through five. These technologic, scientific and commercial innovations will revolutionize our ability to identify, document and assess the probability of spatial patterns relative to neutral models that incorporate realistic local, spatial and multivariate dependencies. The neutral models and methods in this proposal make possible, for the first time ever, evaluation of the sensitivity of the results of cluster or boundary analyses to specification of the null hypothesis.



Publications

Accounting for rate instability and spatial patterns in the boundary analysis of cancer mortality maps.
Authors: Goovaerts P. .
Source: Environmental and ecological statistics, 2008 Dec; 15(4), p. 421-446.
PMID: 19023455
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Space-time clustering of case-control data with residential histories: insights into empirical induction periods, age-specific susceptibility, and calendar year-specific effects.
Authors: Meliker J.R. , Jacquez G.M. .
Source: Stochastic environmental research and risk assessment : research journal, 2007 Aug; 21(5), p. 625-634.
PMID: 18560470
Related Citations

Case-control geographic clustering for residential histories accounting for risk factors and covariates.
Authors: Jacquez G.M. , Meliker J.R. , Avruskin G.A. , Goovaerts P. , Kaufmann A. , Wilson M.L. , Nriagu J. .
Source: International journal of health geographics, 2006-08-03; 5, p. 32.
EPub date: 2006-08-03.
PMID: 16887016
Related Citations

Geostatistical analysis of disease data: visualization and propagation of spatial uncertainty in cancer mortality risk using Poisson kriging and p-field simulation.
Authors: Goovaerts P. .
Source: International journal of health geographics, 2006-02-09; 5, p. 7.
EPub date: 2006-02-09.
PMID: 16469095
Related Citations

Geostatistical analysis of disease data: estimation of cancer mortality risk from empirical frequencies using Poisson kriging.
Authors: Goovaerts P. .
Source: International journal of health geographics, 2005-12-14; 4, p. 31.
EPub date: 2005-12-14.
PMID: 16354294
Related Citations

Detection of temporal changes in the spatial distribution of cancer rates using local Moran's I and geostatistically simulated spatial neutral models.
Authors: Goovaerts P. , Jacquez G.M. .
Source: Journal of geographical systems, 2005 May; 7(1), p. 137-159.
PMID: 16710441
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Accounting for regional background and population size in the detection of spatial clusters and outliers using geostatistical filtering and spatial neutral models: the case of lung cancer in Long Island, New York.
Authors: Goovaerts P. , Jacquez G.M. .
Source: International journal of health geographics, 2004-07-23; 3(1), p. 14.
EPub date: 2004-07-23.
PMID: 15272930
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