Grant Number:	1R03CA117350-01 Interpret this number
Primary Investigator:	Soliman, Amr
Organization:	University Of Michigan
Project Title:	Molecular Characterization of Inflammatory Breast Cancer
Fiscal Year:	2005

We seek to understand the differences between inflammatory breast cancer that arises in an area of surprisingly high proportion (Egypt) and in the U.S. where the proportion is 5 times lower. Egypt offers a unique setting for the comparative study of inflammatory breast cancer because: 1) Egypt has high proportion of IBC (10% of all breast cancers versus approximately 2-4% in the U.S.; 2) Extensive environmental exposures and documented high levels of markers of environmental exposures in breast cancer patients in Egypt; 3) Younger age of onset of both breast cancer in general and of IBC; 4) Our published research that showed clearly distinct molecular pathways in Egyptian colon tumors from the welldefined pathways of tumors of Western patients; and 5) Our recent research that showed alterations in two genes in 90 percent of IBC tumors: RhoC guanosine triphosphatase over-expression and WNT-1 induced secreted protein 3 (WISPS) as potential markers of IBC in the US. Our specific aims are: (1) To define the unique molecular genetic profile of IBC tumors from Egypt and to compare it with the profile of IBC tumors from the U.S., (2) to explore if specific molecular changes, such as, RhoC, p53, and Her-2/neu overexpression or loss of WISPS can predict phenotypic characteristics, such as age of disease-onset, rate of tumor progression, and family history of IBC in patients from Egypt and the U.S., and (3) to identify environmental or lifestyle-related factors that correlate with IBC profile in tumors from Egypt. We now propose to explore the epidemiologic and molecular profile of 100 IBC patients from Egypt and to compare them with 100 IBC patients from the U.S. We will compare the frequency of these molecular characteristics in IBC tumors from Egyptian versus U.S. IBC tumors. In addition, we will perform exploratory studies of cDNA expression profile 10 tumors from each geographic group, matched for severity of clinical symptoms at presentation and age, to expand our potential list of differentially expressed genes, besides those candidates derived from those derived from our previous work and that of others. With the large number of patients included in this study from Egypt and the U.S., we may be able develop a better idea about molecular pathways and prognostic factors in IBC pathogenesis.




Inflammatory Breast Cancer In North Africa: Comparison Of Clinical And Molecular Epidemiologic Characteristics Of Patients From Egypt, Tunisia, And Morocco
Authors: Soliman A.S. , Kleer C.G. , Mrad K. , Karkouri M. , Omar S. , Khaled H.M. , Benider A.L. , Ayed F.B. , Eissa S.S. , Eissa M.S. , et al. .
Source: Breast Disease, 2011-2012; 33(4), p. 159-69.
PMID: 23001584
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Urban-rural Differences In Breast Cancer Incidence In Egypt (1999-2006)
Authors: Dey S. , Soliman A.S. , Hablas A. , Seifeldein I.A. , Ismail K. , Ramadan M. , El-Hamzawy H. , Wilson M.L. , Banerjee M. , Boffetta P. , et al. .
Source: Breast (edinburgh, Scotland), 2010 Oct; 19(5), p. 417-23.
PMID: 20452771
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Lifestyle, Occupational, And Reproductive Factors And Risk Of Colorectal Cancer
Authors: Lo A.C. , Soliman A.S. , Khaled H.M. , Aboelyazid A. , Greenson J.K. .
Source: Diseases Of The Colon And Rectum, 2010 May; 53(5), p. 830-7.
PMID: 20389219
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Urban-rural Differences In Breast Cancer Incidence By Hormone Receptor Status Across 6 Years In Egypt
Authors: Dey S. , Soliman A.S. , Hablas A. , Seifeldin I.A. , Ismail K. , Ramadan M. , El-Hamzawy H. , Wilson M.L. , Banerjee M. , Boffetta P. , et al. .
Source: Breast Cancer Research And Treatment, 2010 Feb; 120(1), p. 149-60.
PMID: 19548084
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Urban-rural Differences Of Gynaecological Malignancies In Egypt (1999-2002)
Authors: Dey S. , Hablas A. , Seifeldin I.A. , Ismail K. , Ramadan M. , El-Hamzawy H. , Wilson M.L. , Banerjee M. , Boffetta P. , Harford J. , et al. .
Source: Bjog : An International Journal Of Obstetrics And Gynaecology, 2010 Feb; 117(3), p. 348-55.
PMID: 20015310
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High Proportion Of Inflammatory Breast Cancer In The Population-based Cancer Registry Of Gharbiah, Egypt
Authors: Soliman A.S. , Banerjee M. , Lo A.C. , Ismail K. , Hablas A. , Seifeldin I.A. , Ramadan M. , Omar H.G. , Fokuda A. , Harford J.B. , et al. .
Source: The Breast Journal, 2009 Jul-Aug; 15(4), p. 432-4.
PMID: 19601951
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Analysis Of Rhoc Expression And Lymphovascular Emboli In Inflammatory Vs Non-inflammatory Breast Cancers In Egyptian Patients
Authors: Lo A.C. , Georgopoulos A. , Kleer C.G. , Banerjee M. , Omar S. , Khaled H. , Eissa S. , Hablas A. , Omar H.G. , Douglas J.A. , et al. .
Source: Breast (edinburgh, Scotland), 2009 Feb; 18(1), p. 55-9.
PMID: 19157876
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Differences in Reliability of Reproductive History Recall Among Women in North Africa.
Authors: Soliman A. , Allen K. , Lo A.C. , Banerjee M. , Hablas A. , Benider A. , Benchekroun N. , Samir S. , Omar H.G. , Merajver S. , et al. .
Source: The International Electronic Journal Of Health Education, 2009 Jan; 12(1), p. 150-161.
PMID: 25620888
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Molecular Epidemiologic Features Of Inflammatory Breast Cancer: A Comparison Between Egyptian And Us Patients
Authors: Lo A.C. , Kleer C.G. , Banerjee M. , Omar S. , Khaled H. , Eissa S. , Hablas A. , Douglas J.A. , Alford S.H. , Merajver S.D. , et al. .
Source: Breast Cancer Research And Treatment, 2008 Nov; 112(1), p. 141-7.
PMID: 18058225
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