Grant Number:	5R01DA012697-05 Interpret this number
Primary Investigator:	Kandel, Denise
Organization:	Columbia University Health Sciences
Project Title:	The Transition to Nicotine Dependence in Adolescence
Fiscal Year:	2005

This revision of a proposal submitted initially on 10/1/98 requests five years of support (10/1/01-9/30/06) to investigate the transition from experimental smoking to daily smoking and nicotine dependence and the underlying risk and protective factors among white, African-American and Hispanic adolescents. The research has five major goals: (1) To identify the timing and sequence of the transition from experimental smoking to daily smoking and nicotine dependence among adolescents. (2) To identify the psychological, social and biological factors that promote the progression to daily smoking and dependence and reduce the risk. Special attention will be paid to (a) depressive symptoms, (b) conduct problems, (c) initial differences in sensitivity to tobacco, (d) cotinine levels, and (e) exposure to prenatal smoking. (3) To specify the comorbidity and sequencing between daily smoking, nicotine dependence and psychiatric disorders. (4) To identify pathways of progression from experimental smoking to nicotine dependence and the use of illicit drugs. (5) To identify gender and ethnic differences among white, African-American and Hispanic youths with respect to Aims number 1-number 4. These aims will be achieved by conducting a five-wave two-year longitudinal follow-up of 1,275 6th-10th graders and their mothers. A two-stage research design will be implemented. In Phase I, approximately 17,000 students in grades 6-10 from selected public schools will be administered a brief survey. Responses will be used to select a target sample of 1,300 experimental smokers and 200 non-smokers, evenly divided among the three ethnic groups. In Phase II, 3 annual computerized household interviews will be conducted with 1,275 participating youths and their mothers, and 2 telephone interviews with the youths six months after the first and second household interviews. At each annual interview, a psychiatric assessment will be administered to the youth and the parent about the child; a saliva sample will be collected to determine cotinine levels, validate self-reports of smoking and predict progression to daily smoking and nicotine dependence. This study represents a rare attempt to investigate prospectively the periods of risk for nicotine dependence in adolescence, the duration from onset to dependence, and the factors that explain the transition to dependence. The study is unique in focusing on the comorbidity between smoking, nicotine dependence, and psychiatric disorders among adolescents of different ethnicity. The study will generate a unique understanding of the natural history, etiology and consequences of nicotine dependence among young people.




Nicotine Dependence In Adolescence And Physical Health Symptoms In Early Adulthood
Authors: Griesler P.C. , Hu M.C. , Kandel D.B. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 May; 18(5), p. 950-8.
PMID: 26253615
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Reciprocal Associations Between Cigarette Consumption And Dsm-iv Nicotine Dependence Criteria In Adolescent Smokers
Authors: Hu M.C. , Griesler P.C. , Wall M.M. , Kandel D.B. .
Source: Addiction (abingdon, England), 2014 Sep; 109(9), p. 1518-28.
PMID: 24845775
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Trajectories Of Criteria Of Nicotine Dependence From Adolescence To Early Adulthood
Authors: Hu M.C. , Griesler P.C. , Schaffran C. , Wall M.M. , Kandel D.B. .
Source: Drug And Alcohol Dependence, 2012-10-01 00:00:00.0; 125(3), p. 283-9.
PMID: 22513378
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Linking Measures Of Adult Nicotine Dependence To A Common Latent Continuum And A Comparison With Adolescent Patterns
Authors: Strong,D.R. , Schonbrun,Y.C. , Schaffran,C. , Griesler,P.C. , Kandel,D. .
Source: Drug And Alcohol Dependence, 2012-01-01 00:00:00.0; 120(1-3), p. 88-98.
PMID: 21855236
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Risk And Protective Factors For Nicotine Dependence In Adolescence
Authors: Hu M.C. , Griesler P. , Schaffran C. , Kandel D. .
Source: Journal Of Child Psychology And Psychiatry, And Allied Disciplines, 2011 Oct; 52(10), p. 1063-72.
PMID: 21250992
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Comorbid Psychiatric Disorders And Nicotine Dependence In Adolescence
Authors: Griesler P.C. , Hu M.C. , Schaffran C. , Kandel D.B. .
Source: Addiction (abingdon, England), 2011 May; 106(5), p. 1010-20.
PMID: 21320229
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Educational Attainment And Smoking Among Women: Risk Factors And Consequences For Offspring
Authors: Kandel D.B. , Griesler P.C. , Schaffran C. .
Source: Drug And Alcohol Dependence, 2009-10-01 00:00:00.0; 104 Suppl 1, p. S24-33.
PMID: 19179020
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Sequencing Of Dsm-iv Criteria Of Nicotine Dependence
Authors: Kandel D.B. , Hu M.C. , Yamaguchi K. .
Source: Addiction (abingdon, England), 2009 Aug; 104(8), p. 1393-402.
PMID: 19489755
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Linking Measures Of Adolescent Nicotine Dependence To A Common Latent Continuum
Authors: Strong D.R. , Kahler C.W. , Colby S.M. , Griesler P.C. , Kandel D. .
Source: Drug And Alcohol Dependence, 2009-01-01 00:00:00.0; 99(1-3), p. 296-308.
PMID: 18938047
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Developmental Trajectories Of Criteria Of Nicotine Dependence In Adolescence
Authors: Hu M.C. , Muthén B. , Schaffran C. , Griesler P.C. , Kandel D.B. .
Source: Drug And Alcohol Dependence, 2008-11-01 00:00:00.0; 98(1-2), p. 94-104.
PMID: 18602225
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Comorbidity Of Psychiatric Disorders And Nicotine Dependence Among Adolescents: Findings From A Prospective, Longitudinal Study
Authors: Griesler P.C. , Hu M.C. , Schaffran C. , Kandel D.B. .
Source: Journal Of The American Academy Of Child And Adolescent Psychiatry, 2008 Nov; 47(11), p. 1340-50.
PMID: 18827718
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Adolescents' Inconsistency In Self-reported Smoking: A Comparison Of Reports In School And In Household Settings
Authors: Griesler P.C. , Kandel D.B. , Schaffran C. , Hu M.C. , Davies M. .
Source: Public Opinion Quarterly, 2008; 72(2), p. 260-290.
PMID: 18941620
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On The Development Of Nicotine Dependence In Adolescence
Authors: Kandel D.B. , Hu M.C. , Griesler P.C. , Schaffran C. .
Source: Drug And Alcohol Dependence, 2007-11-02 00:00:00.0; 91(1), p. 26-39.
PMID: 17553635
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Salivary Cotinine Concentration Versus Self-reported Cigarette Smoking: Three Patterns Of Inconsistency In Adolescence
Authors: Kandel D.B. , Schaffran C. , Griesler P.C. , Hu M.C. , Davies M. , Benowitz N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2006 Aug; 8(4), p. 525-37.
PMID: 16920650
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On The Measurement Of Nicotine Dependence In Adolescence: Comparisons Of The Mftq And A Dsm-iv-based Scale
Authors: Kandel D. , Schaffran C. , Griesler P. , Samuolis J. , Davies M. , Galanti R. .
Source: Journal Of Pediatric Psychology, 2005 Jun; 30(4), p. 319-32.
PMID: 15863429
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