Skip to main content
An official website of the United States government
Grant Details

Grant Number: 5R01CA090731-05 Interpret this number
Primary Investigator: Olshan, Andrew
Organization: Univ Of North Carolina Chapel Hill
Project Title: Gene Environment Interaction in Head and Neck Cancer
Fiscal Year: 2005


Abstract

DESCRIPTION: The major goal of the proposed study is to comprehensively evaluate the role of genetic susceptibility in the etiology of squamous cell carcinoma of the head and neck (SCCHN; including oral cavity, pharynx, and larynx). SCCHN provides an ideal model for the investigation of gene-environment interaction in cancer given its strong and highly prevalent risk factors, tobacco and alcohol. Polymorphisms in genes representing metabolism (activation and detoxification) of carcinogens, mediators of oxidative stress, and DNA repair may help to clarify dose-response relationships needed for risk assessment, elucidate low dose exposure effects, pinpoint specific carcinogens that act as part of complex mixtures, and to identify susceptible subgroups of individuals most likely to benefit from interventions to reduce exposure. The proposed North Carolina population-based case-control study including 1,700 cases and 1,700 controls will have the ability to more precisely define the nature of the gene-environment interactions related to the risk of SCCHN. This will be the largest study of head and neck cancer ever conducted in the United States. North Carolina is an excellent setting to conduct such a study given the large biracial population, relatively high prevalence of tobacco use, and the research team's experience with conducting population-based molecular epidemiologic studies of cancer. The previous gene-environment studies have yielded generally inconsistent results with respect to several metabolizing enzyme polymorphisms. These studies have been limited by their relatively small size (typically fewer than 200 cases), hospital-based design and examination of a small number of enzymes. The size and population-based design should allow us to more confidently confirm or reject associations raised in previous studies. Finally, the study size will permit us to consider selected gene-gene exposure interactions and examine important subgroups defined by age, gender, race, and tumor site. The systematic collection of tumor blocks will also facilitate future studies of "downstream" somatic alterations of tumor suppressor genes and oncogenes. The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology.



Publications

Partly linear single-index cure models with a nonparametric incidence link function.
Authors: Lee C.Y. , Wong K.Y. , Bandyopadhyay D. .
Source: Statistical Methods In Medical Research, 2024 Mar; 33(3), p. 498-514.
EPub date: 2024-02-23 00:00:00.0.
PMID: 38400526
Related Citations

Diagnostic accuracy of HPV16 early antigen serology for HPV-driven oropharyngeal cancer is independent of age and sex.
Authors: Kusters J.M.A. , Diergaarde B. , Ness A. , Schim van der Loeff M.F. , Heijne J.C.M. , Schroeder L. , Hueniken K. , McKay J.D. , Macfarlane G.J. , Lagiou P. , et al. .
Source: International Journal Of Cancer, 2024-01-15 00:00:00.0; 154(2), p. 389-402.
EPub date: 2023-09-11 00:00:00.0.
PMID: 37694289
Related Citations

Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies.
Authors: Chang K.W. , Mazul A.L. , Lander D.P. , Wahle B.M. , Yan E.Z. , Thorstad W.L. , Puram S.V. , Jackson R.S. , Pipkorn P. , Paniello R.C. , et al. .
Source: Otolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-head And Neck Surgery, 2024-01-14 00:00:00.0; , .
EPub date: 2024-01-14 00:00:00.0.
PMID: 38219743
Related Citations

A risk prediction model for head and neck cancers incorporating lifestyle factors, HPV serology and genetic markers.
Authors: Budhathoki S. , Diergaarde B. , Liu G. , Olshan A. , Ness A. , Waterboer T. , Virani S. , Basta P. , Bender N. , Brenner N. , et al. .
Source: International Journal Of Cancer, 2023-01-24 00:00:00.0; , .
EPub date: 2023-01-24 00:00:00.0.
PMID: 36694401
Related Citations

Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.
Authors: Liu H. , Li G. , Sturgis E.M. , Shete S. , Dahlstrom K.R. , Du M. , Amos C.I. , Christiani D.C. , Lazarus P. , Wei Q. .
Source: International Journal Of Cancer, 2022-04-11 00:00:00.0; , .
EPub date: 2022-04-11 00:00:00.0.
PMID: 35404482
Related Citations

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.
Authors: Gormley M. , Dudding T. , Kachuri L. , Burrows K. , Chong A.H.W. , Martin R.M. , Thomas S.J. , Tyrrell J. , Ness A.R. , Brennan P. , et al. .
Source: Bmc Medicine, 2022-01-31 00:00:00.0; 20(1), p. 40.
EPub date: 2022-01-31 00:00:00.0.
PMID: 35094705
Related Citations

Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients.
Authors: Emerson M.A. , Farquhar D.R. , Lenze N.R. , Sheth S. , Mazul A.L. , Zanation A.M. , Hackman T.G. , Weissler M.C. , Zevallos J.P. , Yarbrough W.G. , et al. .
Source: Head & Neck, 2022-01-19 00:00:00.0; , .
EPub date: 2022-01-19 00:00:00.0.
PMID: 35044015
Related Citations

Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer.
Authors: Ferreiro-Iglesias A. , McKay J.D. , Brenner N. , Virani S. , Lesseur C. , Gaborieau V. , Ness A.R. , Hung R.J. , Liu G. , Diergaarde B. , et al. .
Source: Nature Communications, 2021-10-12 00:00:00.0; 12(1), p. 5945.
EPub date: 2021-10-12 00:00:00.0.
PMID: 34642315
Related Citations

Prognostic impact of socioeconomic status compared to overall stage for HPV-negative head and neck squamous cell carcinoma.
Authors: Lenze N.R. , Farquhar D.R. , Sheth S. , Zevallos J.P. , Lumley C. , Blumberg J. , Patel S. , Hackman T. , Weissler M.C. , Yarbrough W.G. , et al. .
Source: Oral Oncology, 2021 08; 119, p. 105377.
EPub date: 2021-06-20 00:00:00.0.
PMID: 34161897
Related Citations

The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC.
Authors: Tasoulas J. , Lenze N.R. , Farquhar D. , P Schrank T. , Shen C. , Shazib M.A. , Singer B. , Patel S. , Grilley Olson J.E. , Hayes D.N. , et al. .
Source: Cancer Medicine, 2021-05-02 00:00:00.0; , .
EPub date: 2021-05-02 00:00:00.0.
PMID: 33934525
Related Citations

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
Authors: Gormley M. , Yarmolinsky J. , Dudding T. , Burrows K. , Martin R.M. , Thomas S. , Tyrrell J. , Brennan P. , Pring M. , Boccia S. , et al. .
Source: Plos Genetics, 2021 04; 17(4), p. e1009525.
EPub date: 2021-04-22 00:00:00.0.
PMID: 33886544
Related Citations

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.
Authors: Lesseur C. , Ferreiro-Iglesias A. , McKay J.D. , Bossé Y. , Johansson M. , Gaborieau V. , Landi M.T. , Christiani D.C. , Caporaso N.C. , Bojesen S.E. , et al. .
Source: Plos Genetics, 2021 03; 17(3), p. e1009254.
EPub date: 2021-03-05 00:00:00.0.
PMID: 33667223
Related Citations

Academic Affiliation and Surgical Volume Predict Survival in Head and Neck Cancer Patients Receiving Surgery.
Authors: Farquhar D.R. , Masood M.M. , Lenze N.R. , Sheth S. , Patel S.N. , Lumley C. , Zanation A.M. , Weissler M.C. , Olshan A.F. , Hackman T.G. .
Source: The Laryngoscope, 2021 02; 131(2), p. E479-E488.
EPub date: 2020-05-25 00:00:00.0.
PMID: 32449832
Related Citations

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.
Authors: Gormley M. , Dudding T. , Sanderson E. , Martin R.M. , Thomas S. , Tyrrell J. , Ness A.R. , Brennan P. , Munafò M. , Pring M. , et al. .
Source: Nature Communications, 2020-11-27 00:00:00.0; 11(1), p. 6071.
EPub date: 2020-11-27 00:00:00.0.
PMID: 33247085
Related Citations

Socioeconomic Status Drives Racial Disparities in HPV-negative Head and Neck Cancer Outcomes.
Authors: Lenze N.R. , Farquhar D. , Sheth S. , Zevallos J.P. , Blumberg J. , Lumley C. , Patel S. , Hackman T. , Weissler M.C. , Yarbrough W.G. , et al. .
Source: The Laryngoscope, 2020-11-10 00:00:00.0; , .
EPub date: 2020-11-10 00:00:00.0.
PMID: 33170518
Related Citations

Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms.
Authors: Howe L.J. , Hemani G. , Lesseur C. , Gaborieau V. , Ludwig K.U. , Mangold E. , Brennan P. , Ness A.R. , St Pourcain B. , Davey Smith G. , et al. .
Source: Genetic Epidemiology, 2020 11; 44(8), p. 924-933.
EPub date: 2020-07-24 00:00:00.0.
PMID: 32710482
Related Citations

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.
Authors: Di Credico G. , Polesel J. , Dal Maso L. , Pauli F. , Torelli N. , Luce D. , Radoï L. , Matsuo K. , Serraino D. , Brennan P. , et al. .
Source: British Journal Of Cancer, 2020 10; 123(9), p. 1456-1463.
EPub date: 2020-08-24 00:00:00.0.
PMID: 32830199
Related Citations

Evaluation of pathologic staging using number of nodes in p16-negative head and neck cancer.
Authors: Farquhar D.R. , Coniglio A.J. , Masood M.M. , Lenze N. , Brennan P. , Anantharaman D. , Abedi-Ardekani B. , Zanation A.M. , Weissler M.C. , Olshan A.F. , et al. .
Source: Oral Oncology, 2020 Sep; 108, p. 104800.
EPub date: 2020-05-31 00:00:00.0.
PMID: 32492516
Related Citations

Access to preventive care services and stage at diagnosis in head and neck cancer.
Authors: Farquhar D.R. , Lenze N.R. , Masood M.M. , Divaris K. , Tasoulas J. , Blumberg J. , Lumley C. , Patel S. , Hackman T. , Weissler M.C. , et al. .
Source: Head & Neck, 2020-07-03 00:00:00.0; , .
EPub date: 2020-07-03 00:00:00.0.
PMID: 32618052
Related Citations

Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.
Authors: Bravi F. , Lee Y.A. , Hashibe M. , Boffetta P. , Conway D.I. , Ferraroni M. , La Vecchia C. , Edefonti V. , INHANCE Consortium investigators .
Source: Oral Diseases, 2020-06-22 00:00:00.0; , .
EPub date: 2020-06-22 00:00:00.0.
PMID: 32569410
Related Citations

A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.
Authors: Shete S. , Liu H. , Wang J. , Yu R. , Sturgis E.M. , Li G. , Dahlstrom K.R. , Liu Z. , Amos C.I. , Wei Q. .
Source: Cancer Research, 2020-06-15 00:00:00.0; 80(12), p. 2451-2460.
EPub date: 2020-04-10 00:00:00.0.
PMID: 32276964
Related Citations

Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.
Authors: Chang C.P. , La Vecchia C. , Serraino D. , Olshan A.F. , Zevallos J.P. , Morgenstern H. , Levi F. , Garavello W. , Kelsey K. , McClean M. , et al. .
Source: British Journal Of Cancer, 2020 Mar; 122(6), p. 745-748.
EPub date: 2020-01-13 00:00:00.0.
PMID: 31929514
Related Citations

The association between diet quality and cancer incidence of the head and neck.
Authors: Saraiya V. , Bradshaw P. , Meyer K. , Gammon M. , Slade G. , Brennan P. , Abedi-Ardekani B. , Olshan A. .
Source: Cancer Causes & Control : Ccc, 2020-01-01 00:00:00.0; , .
EPub date: 2020-01-01 00:00:00.0.
PMID: 31894494
Related Citations

Head and Neck Cancer Risk Prediction Models for the US Population from the INHANCE Consortium.
Authors: Lee Y.A. , Al-Temimi M. , Ying J. , Muscat J. , Olshan A.F. , Zevallos J.P. , Winn D.M. , Li G. , Sturgis E.M. , Morgenstern H. , et al. .
Source: American Journal Of Epidemiology, 2019-11-29 00:00:00.0; , .
EPub date: 2019-11-29 00:00:00.0.
PMID: 31781743
Related Citations

A Bayesian Sensitivity Analysis to Partition Body Mass Index Into Components of Body Composition: An Application to Head and Neck Cancer Survival.
Authors: Bradshaw P.T. , Zevallos J.P. , Wisniewski K. , Olshan A.F. .
Source: American Journal Of Epidemiology, 2019-11-01 00:00:00.0; 188(11), p. 2031-2039.
PMID: 31504108
Related Citations

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.
Authors: Di Credico G. , Edefonti V. , Polesel J. , Pauli F. , Torelli N. , Serraino D. , Negri E. , Luce D. , Stucker I. , Matsuo K. , et al. .
Source: Oral Oncology, 2019 Jul; 94, p. 47-57.
EPub date: 2019-05-17 00:00:00.0.
PMID: 31178212
Related Citations

Travel time to provider is associated with advanced stage at diagnosis among low income head and neck squamous cell carcinoma patients in North Carolina.
Authors: Farquhar D.R. , Masood M.M. , Lenze N.R. , McDaniel P. , Mazul A. , Sheth S. , Zanation A.M. , Hackman T.G. , Weissler M. , Zevallos J.P. , et al. .
Source: Oral Oncology, 2019 Feb; 89, p. 115-120.
EPub date: 2019-01-02 00:00:00.0.
PMID: 30732948
Related Citations

Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature Communications, 2019-01-25 00:00:00.0; 10(1), p. 431.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30683880
Related Citations

Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status.
Authors: Du E. , Mazul A.L. , Farquhar D. , Brennan P. , Anantharaman D. , Abedi-Ardekani B. , Weissler M.C. , Hayes D.N. , Olshan A.F. , Zevallos J.P. .
Source: The Laryngoscope, 2019-01-13 00:00:00.0; , .
EPub date: 2019-01-13 00:00:00.0.
PMID: 30637762
Related Citations

Interaction between known risk factors for head and neck cancer and socioeconomic status: the Carolina Head and Neck Cancer Study.
Authors: Stanford-Moore G. , Bradshaw P.T. , Weissler M.C. , Zevallos J.P. , Brennan P. , Anantharaman D. , Abedi-Ardekani B. , Olshan A.F. .
Source: Cancer Causes & Control : Ccc, 2018-08-01 00:00:00.0; , .
EPub date: 2018-08-01 00:00:00.0.
PMID: 30069657
Related Citations

Shared and study-specific dietary patterns and head and neck cancer risk in an international consortium.
Authors: De Vito R. , Lee Y.C.A. , Parpinel M. , Serraino D. , Olshan A.F. , Zevallos J.P. , Levi F. , Zhang Z.F. , Morgenstern H. , Garavello W. , et al. .
Source: Epidemiology (cambridge, Mass.), 2018-07-30 00:00:00.0; , .
EPub date: 2018-07-30 00:00:00.0.
PMID: 30063539
Related Citations

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.
Authors: Kachuri L. , Saarela O. , Bojesen S.E. , Davey Smith G. , Liu G. , Landi M.T. , Caporaso N.E. , Christiani D.C. , Johansson M. , Panico S. , et al. .
Source: International Journal Of Epidemiology, 2018-07-28 00:00:00.0; , .
EPub date: 2018-07-28 00:00:00.0.
PMID: 30059977
Related Citations

Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium.
Authors: Voltzke K.J. , Lee Y.A. , Zhang Z.F. , Zevallos J.P. , Yu G.P. , Winn D.M. , Vaughan T.L. , Sturgis E.M. , Smith E. , Schwartz S.M. , et al. .
Source: Cancer Causes & Control : Ccc, 2018-05-14 00:00:00.0; , .
EPub date: 2018-05-14 00:00:00.0.
PMID: 29761303
Related Citations

Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer.
Authors: Mazul A.L. , Shivappa N. , Hébert J.R. , Steck S.E. , Rodriguez-Ormaza N. , Weissler M. , Olshan A.F. , Zevallos J.P. .
Source: International Journal Of Cancer, 2018-04-26 00:00:00.0; , .
EPub date: 2018-04-26 00:00:00.0.
PMID: 29696631
Related Citations

Fish/shellfish intake and the risk of head and neck cancer.
Authors: McClain K.M. , Bradshaw P.T. , Khankari N.K. , Gammon M.D. , Olshan A.F. .
Source: European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ecp), 2018-02-05 00:00:00.0; , .
EPub date: 2018-02-05 00:00:00.0.
PMID: 29406335
Related Citations

Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
Authors: Kawakita D. , Lee Y.A. , Turati F. , Parpinel M. , Decarli A. , Serraino D. , Matsuo K. , Olshan A.F. , Zevallos J.P. , Winn D.M. , et al. .
Source: International Journal Of Cancer, 2017-11-01 00:00:00.0; 141(9), p. 1811-1821.
EPub date: 2017-07-27 00:00:00.0.
PMID: 28710831
Related Citations

Poor oral health affects survival in head and neck cancer.
Authors: Farquhar D.R. , Divaris K. , Mazul A.L. , Weissler M.C. , Zevallos J.P. , Olshan A.F. .
Source: Oral Oncology, 2017 Oct; 73, p. 111-117.
PMID: 28939062
Related Citations

Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer.
Authors: Anantharaman D. , Abedi-Ardekani B. , Beachler D.C. , Gheit T. , Olshan A.F. , Wisniewski K. , Wunsch-Filho V. , Toporcov T.N. , Tajara E.H. , Levi J.E. , et al. .
Source: International Journal Of Cancer, 2017-05-01 00:00:00.0; 140(9), p. 1968-1975.
EPub date: 2017-02-14 00:00:00.0.
PMID: 28108990
Related Citations

Corrigendum to 'Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents' [Oral Oncol. 62 (2016) 20-27].
Authors: D'Souza G. , Anantharaman D. , Gheit T. , Abedi-Ardekani B. , Beachler D.C. , Conway D.I. , Olshan A.F. , Wunsch-Filho V. , Toporcov T.N. , Ahrens W. , et al. .
Source: Oral Oncology, 2017 Feb; 65, p. e1.
EPub date: 2016-12-30 00:00:00.0.
PMID: 28043765
Related Citations

Factors that impact health-related quality of life over time for individuals with head and neck cancer.
Authors: Reeve B.B. , Cai J. , Zhang H. , Weissler M.C. , Wisniewski K. , Gross H. , Olshan A.F. .
Source: The Laryngoscope, 2016 12; 126(12), p. 2718-2725.
EPub date: 2016-05-25 00:00:00.0.
PMID: 27224024
Related Citations

Genome-wide Association Analyses Identify New Susceptibility Loci For Oral Cavity And Pharyngeal Cancer
Authors: Lesseur C. , Diergaarde B. , Olshan A.F. , Wünsch-Filho V. , Ness A.R. , Liu G. , Lacko M. , Eluf-Neto J. , Franceschi S. , Lagiou P. , et al. .
Source: Nature Genetics, 2016 Dec; 48(12), p. 1544-1550.
PMID: 27749845
Related Citations

Effect Of Hpv On Head And Neck Cancer Patient Survival, By Region And Tumor Site: A Comparison Of 1362 Cases Across Three Continents
Authors: D'Souza G. , Anantharaman D. , Gheit T. , Abedi-Ardekani B. , Beachler D.C. , Conway D.I. , Olshan A.F. , Wunsch-Filho V. , Toporcov T.N. , Ahrens W. , et al. .
Source: Oral Oncology, 2016 Nov; 62, p. 20-27.
PMID: 27865368
Related Citations

Smokeless Tobacco Use And The Risk Of Head And Neck Cancer: Pooled Analysis Of Us Studies In The Inhance Consortium
Authors: Wyss A.B. , Hashibe M. , Lee Y.A. , Chuang S.C. , Muscat J. , Chen C. , Schwartz S.M. , Smith E. , Zhang Z.F. , Morgenstern H. , et al. .
Source: American Journal Of Epidemiology, 2016-10-15 00:00:00.0; , .
PMID: 27744388
Related Citations

Prognostic Significance Of Non-hpv16 Genotypes In Oropharyngeal Squamous Cell Carcinoma
Authors: Mazul A.L. , Rodriguez-Ormaza N. , Taylor J.M. , Desai D.D. , Brennan P. , Anantharaman D. , Gheit T. , Tommasino M. , Abedi-Ardekani B. , Olshan A.F. , et al. .
Source: Oral Oncology, 2016 Oct; 61, p. 98-103.
PMID: 27688111
Related Citations

Oral Health And Human Papillomavirus-associated Head And Neck Squamous Cell Carcinoma
Authors: Mazul A.L. , Taylor J.M. , Divaris K. , Weissler M.C. , Brennan P. , Anantharaman D. , Abedi-Ardekani B. , Olshan A.F. , Zevallos J.P. .
Source: Cancer, 2016-08-29 00:00:00.0; , .
PMID: 27571516
Related Citations

Gastroesophageal reflux disease and odds of head and neck squamous cell carcinoma in North Carolina.
Authors: Busch E.L. , Zevallos J.P. , Olshan A.F. .
Source: The Laryngoscope, 2016 05; 126(5), p. 1091-6.
EPub date: 2015-10-09 00:00:00.0.
PMID: 26451875
Related Citations

Previous Tonsillectomy Modifies Odds Of Tonsil And Base Of Tongue Cancer
Authors: Zevallos J.P. , Mazul A.L. , Rodriguez N. , Weissler M.C. , Brennan P. , Anantharaman D. , Abedi-Ardekani B. , Neil Hayes D. , Olshan A.F. .
Source: British Journal Of Cancer, 2016-03-29 00:00:00.0; 114(7), p. 832-8.
PMID: 26977858
Related Citations

Joint Analysis Of Survival Time And Longitudinal Categorical Outcomes
Authors: Choi J. , Cai J. , Zeng D. , Olshan A.F. .
Source: Statistics In Biosciences, 2015 May; 7(1), p. 19-47.
PMID: 26052353
Related Citations

Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.
Authors: Conway D.I. , Brenner D.R. , McMahon A.D. , Macpherson L.M. , Agudo A. , Ahrens W. , Bosetti C. , Brenner H. , Castellsague X. , Chen C. , et al. .
Source: International Journal Of Cancer, 2015-03-01 00:00:00.0; 136(5), p. 1125-39.
EPub date: 2015-03-01 00:00:00.0.
PMID: 24996155
Related Citations

Single Nucleotide Polymorphisms In Nucleotide Excision Repair Genes, Cancer Treatment, And Head And Neck Cancer Survival
Authors: Wyss A.B. , Weissler M.C. , Avery C.L. , Herring A.H. , Bensen J.T. , Barnholtz-Sloan J.S. , Funkhouser W.K. , Olshan A.F. .
Source: Cancer Causes & Control : Ccc, 2014 Apr; 25(4), p. 437-50.
PMID: 24487794
Related Citations



Back to Top