Grant Number:	5R01CA088828-05 Interpret this number
Primary Investigator:	Kazak, Anne
Organization:	Children'S Hosp Of Philadelphia
Project Title:	Changing Parental Beliefs in Pediatrics Oncology
Fiscal Year:	2005

The diagnosis of children cancer affects the family and continues to impact parental functioning after treatment ends. Our previous research showed the persistence of parents' distressing symptoms of posttraumatic stress and its association with anxiety. In this proposal, we focus on the identification of parental beliefs associated with anxiety and adaption during treatment for childhood cancer, and conduct a randomized clinical trial (RCT) of a cognitive-behavioral and family therapy intervention for parents of newly diagnosed children with cancer. The three session intervention, Surviving Cancer Competently Intervention Program, Revised (SCCIP-R) is an adaptation of our intervention protocol for survivors of childhood cancer and their families. The first step in the project is the systematic identification of mothers' and fathers' beliefs about the disease and the treatment in a sample of 120 families of children in families at diagnosis of childhood cancer, randomized to SCCIP-R intervention or an attention control condition. Baseline, 2 and 6 month data collections will include self-report measures of parental anxiety, psychological adjustment and family. Child quality of life will be assessed by parent and staff report. We will determine the affects of parental anxiety and its reduction on the child's quality of life. In a subsample of 62 patients with acute lymphoblastic (ALL), we will examine the associations of parental anxiety with parental neuroendocrine makers (DHEA-S/cortosol ratio, ACTH, Substance P) and explore the associations among lowered levels of parental levels of parental anxiety and medical outcomes. Finally, we will assess the long- term impact of SCCIP-R assessing parental and patient posttraumatic stress at two points after cancer treatment ends. To our knowledge, this project is unique in providing a RCT of an intervention to reduce parental distress after diagnosis of childhood cancer and in the integration of neuroendocrine makers and medical outcome. If effective, SCCIP-R would provide evidence for the feasibility and importance of providing systemic intervention with families of patients with cancer.




Conducting A Randomized Clinical Trial Of An Psychological Intervention For Parents/caregivers Of Children With Cancer Shortly After Diagnosis
Authors: Stehl M.L. , Kazak A.E. , Alderfer M.A. , Rodriguez A. , Hwang W.T. , Pai A.L. , Boeving A. , Reilly A. .
Source: Journal Of Pediatric Psychology, 2009 Sep; 34(8), p. 803-16.
PMID: 19091806
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Innate Immune Markers In Mothers And Fathers Of Children Newly Diagnosed With Cancer
Authors: Stehl M.J. , Kazak A.E. , Hwang W.T. , Pai A.L. , Reilly A.F. , Douglas S.D. .
Source: Neuroimmunomodulation, 2008; 15(2), p. 102-7.
PMID: 18679048
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Families of infants and young children with cancer: a post-traumatic stress framework.
Authors: Kazak A.E. , Baxt C. .
Source: Pediatric Blood & Cancer, 2007 Dec; 49(7 Suppl), p. 1109-13.
PMID: 17943959
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Evidence-based assessment, intervention and psychosocial care in pediatric oncology: a blueprint for comprehensive services across treatment.
Authors: Kazak A.E. , Rourke M.T. , Alderfer M.A. , Pai A. , Reilly A.F. , Meadows A.T. .
Source: Journal Of Pediatric Psychology, 2007 Oct; 32(9), p. 1099-110.
PMID: 17626069
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Feasibility And Preliminary Outcomes From A Pilot Study Of A Brief Psychological Intervention For Families Of Children Newly Diagnosed With Cancer
Authors: Kazak A.E. , Simms S. , Alderfer M.A. , Rourke M.T. , Crump T. , McClure K. , Jones P. , Rodriguez A. , Boeving A. , Hwang W.T. , et al. .
Source: Journal Of Pediatric Psychology, 2005 Dec; 30(8), p. 644-55.
PMID: 16260434
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Posttraumatic Stress Symptoms During Treatment In Parents Of Children With Cancer
Authors: Kazak A.E. , Boeving C.A. , Alderfer M.A. , Hwang W.T. , Reilly A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-10-20 00:00:00.0; 23(30), p. 7405-10.
PMID: 16157936
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Patterns Of Posttraumatic Stress Symptoms In Parents Of Childhood Cancer Survivors
Authors: Alderfer,M.A. , Cnaan,A. , Annunziato,R.A. , Kazak,A.E. .
Source: Journal Of Family Psychology : Jfp : Journal Of The Division Of Family Psychology Of The American Psychological Association (division 43), 2005 Sep; 19(3), p. 430-40.
PMID: 16221023
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Cancer-related Parental Beliefs: The Family Illness Beliefs Inventory (fibi)
Authors: Kazak A.E. , McClure K.S. , Alderfer M.A. , Hwang W.T. , Crump T.A. , Le L.T. , Deatrick J. , Simms S. , Rourke M.T. .
Source: Journal Of Pediatric Psychology, 2004 Oct; 29(7), p. 531-42.
PMID: 15347701
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Posttraumatic Stress Disorder (ptsd) And Posttraumatic Stress Symptoms (ptss) In Families Of Adolescent Childhood Cancer Survivors
Authors: Kazak,A.E. , Alderfer,M. , Rourke,M.T. , Simms,S. , Streisand,R. , Grossman,J.R. .
Source: Journal Of Pediatric Psychology, 2004 Apr-May; 29(3), p. 211-9.
PMID: 15131138
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Brief Report: Does Posttraumatic Stress Apply To Siblings Of Childhood Cancer Survivors?
Authors: Alderfer,M.A. , Labay,L.E. , Kazak,A.E. .
Source: Journal Of Pediatric Psychology, 2003 Jun; 28(4), p. 281-6.
PMID: 12730285
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