Grant Number:	2R01CA077318-06A2 Interpret this number
Primary Investigator:	Goodman, Marc
Organization:	University Of Hawaii At Manoa
Project Title:	Diet and Duration of Cervical HPV Infection
Fiscal Year:	2005

DESCRIPTION (provided by applicant): During the past five years, we have established a multiethnic cohort of women for long-term follow-up to identify factors that influence the persistence of human papillomavirus (HPV) infection of the uterine cervix. Preliminary analyses of our data suggest that reduced dietary and plasma levels of certain micronutrients, such as carotenoids, may enhance the persistence of oncogenic HPV infection. Although the precise mechanism for this inverse association is unknown, failure to clear the virus results in the induction of proinflammatory cytokines, such as interleukin (IL)-1, which increases cellular vulnerability to DNA, protein and lipid damage. We hypothesize that dietary components that possess antioxidant and DNA repair properties will protect immune cells from oxidative damage and reduce HPV persistence. Our specific aims are to 1) evaluate the effect of dietary and/or plasma concentrations of carotenoids, tocopherols, vitamin C and B complex vitamins on incident oncogenic HPV infection, oncogenic HPV persistence, and SIL of the cervix; 2) examine the influence of local cervical mRNA levels of IL-1alpha, IL-1beta, and tumor necrosis factor (TNF)-alpha on the persistence of oncogenic HPV infection; and 3) examine the joint association of dietary and immunological markers on the persistence of oncogenic HPV infections of the cervix. A multiethnic cohort of 751 oncogenic HPV DMA-positive women will be followed during a five year period. Interviews and biological specimens will be collected at baseline and at four month intervals for a minimum of four visits in one year and a maximum of 16 visits in five years. At each visit a gynecologic examination will be performed and the following specimens will be collected: a) endocervical specimens for cytokine mRNA detection, HPV DNA analysis, a cytological (Pap) smear, and future detection of C. trachomatis and Herpes Simplex Virus-2; b) a fasting blood sample to measure micronutrient levels; c) an endocervical specimen by Merocel ophthalmic sponge for future cytokine protein detection; and d) an anal sample for future detection of HPV. A follow-up interview will be conducted at each visit; a diet history will be repeated annually. Statistical analyses of data collected in both grant cycles will focus primarily on the evaluation of dietary and plasma micronutrient levels and immune characteristics that influence the persistence of HPV infection. Increased knowledge of the role of nutrition and the inflammatory response in HPV persistence will help us to better understand the responsiveness to HPV vaccines, may assist in the development of novel therapies, and may provide a fuller picture of the host's reaction to HPV infection.




Human Papillomavirus Genotype And Oropharynx Cancer Survival In The United States Of America
Authors: Goodman M.T. , Saraiya M. , Thompson T.D. , Steinau M. , Hernandez B.Y. , Lynch C.F. , Lyu C.W. , Wilkinson E.J. , Tucker T. , Copeland G. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2015 Dec; 51(18), p. 2759-67.
PMID: 26602016
Related Citations

Cervical cytokines and clearance of incident human papillomavirus infection: Hawaii HPV cohort study.
Authors: Scott M.E. , Shvetsov Y.B. , Thompson P.J. , Hernandez B.Y. , Zhu X. , Wilkens L.R. , Killeen J. , Vo D.D. , Moscicki A.B. , Goodman M.T. .
Source: International Journal Of Cancer, 2013-09-01 00:00:00.0; 133(5), p. 1187-96.
EPub date: 2013-09-01 00:00:00.0.
PMID: 23436563
Related Citations

Updating the natural history of human papillomavirus and anogenital cancers.
Authors: Moscicki A.B. , Schiffman M. , Burchell A. , Albero G. , Giuliano A.R. , Goodman M.T. , Kjaer S.K. , Palefsky J. .
Source: Vaccine, 2012-11-20 00:00:00.0; 30 Suppl 5, p. F24-33.
PMID: 23199964
Related Citations

A Community-based Approach To Enhancing Anal Cancer Screening In Hawaii's Hiv-infected Ethnic Minorities
Authors: Shiramizu B. , Milne C. , Terada K. , Cassel K. , Matsuno R.K. , Killeen J. , Liang C.Y. , Tachibana F. , Sheeran T. , Weihe J. , et al. .
Source: Journal Of Aids & Clinical Research, 2012-08-01 00:00:00.0; 3(6), .
PMID: 23560244
Related Citations

The Influence Of Multiple Human Papillomavirus Types On The Risk Of Genotype-concordant Incident Infections Of The Anus And Cervix: The Hawaii Hpv Cohort Study
Authors: Goodman,M.T. , McDuffie,K. , Hernandez,B.Y. , Wilkens,L.R. , Zhu,X. , Thompson,P.J. , Killeen,J. , Kamemoto,L. , Shvetsov,Y.B. .
Source: The Journal Of Infectious Diseases, 2011-02-01 00:00:00.0; 203(3), p. 335-40.
PMID: 21208924
Related Citations

Plasma Micronutrients And The Acquisition And Clearance Of Anal Human Papillomavirus Infection: The Hawaii Hpv Cohort Study
Authors: Shvetsov,Y.B. , Hernandez,B.Y. , Wilkens,L.R. , Thompson,P.J. , Franke,A.A. , Zhu,X. , Goodman,M.T. .
Source: Cancer Research, 2010-12-01 00:00:00.0; 70(23), p. 9787-97.
PMID: 20935226
Related Citations

Acceptability Of Prophylactic Human Papillomavirus Vaccination Among Adult Men
Authors: Hernandez,B.Y. , Wilkens,L.R. , Thompson,P.J. , Shvetsov,Y.B. , Goodman,M.T. , Ning,L. , Kaopua,L. .
Source: Human Vaccines, 2010 Jun; 6(6), p. 467-75.
PMID: 20671442
Related Citations

Sequential Acquisition Of Human Papillomavirus (hpv) Infection Of The Anus And Cervix: The Hawaii Hpv Cohort Study
Authors: Goodman,M.T. , Shvetsov,Y.B. , McDuffie,K. , Wilkens,L.R. , Zhu,X. , Thompson,P.J. , Ning,L. , Killeen,J. , Kamemoto,L. , Hernandez,B.Y. .
Source: The Journal Of Infectious Diseases, 2010-05-01 00:00:00.0; 201(9), p. 1331-9.
PMID: 20307204
Related Citations

Duration And Clearance Of Anal Human Papillomavirus (hpv) Infection Among Women: The Hawaii Hpv Cohort Study
Authors: Shvetsov,Y.B. , Hernandez,B.Y. , McDuffie,K. , Wilkens,L.R. , Zhu,X. , Ning,L. , Killeen,J. , Kamemoto,L. , Goodman,M.T. .
Source: Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America, 2009-03-01 00:00:00.0; 48(5), p. 536-46.
PMID: 19191636
Related Citations

Intraindividual Variability In Serum Micronutrients: Effects On Reliability Of Estimated Parameters
Authors: Shvetsov,Y.B. , Hernandez,B.Y. , Wong,S.H. , Wilkens,L.R. , Franke,A.A. , Goodman,M.T. .
Source: Epidemiology (cambridge, Mass.), 2009 Jan; 20(1), p. 36-43.
PMID: 18813024
Related Citations

Prevalence, Acquisition, And Clearance Of Cervical Human Papillomavirus Infection Among Women With Normal Cytology: Hawaii Human Papillomavirus Cohort Study
Authors: Goodman,M.T. , Shvetsov,Y.B. , McDuffie,K. , Wilkens,L.R. , Zhu,X. , Thompson,P.J. , Ning,L. , Killeen,J. , Kamemoto,L. , Hernandez,B.Y. .
Source: Cancer Research, 2008-11-01 00:00:00.0; 68(21), p. 8813-24.
PMID: 18974124
Related Citations

Acquisition Of Anal Human Papillomavirus (hpv) Infection In Women: The Hawaii Hpv Cohort Study
Authors: Goodman,M.T. , Shvetsov,Y.B. , McDuffie,K. , Wilkens,L.R. , Zhu,X. , Ning,L. , Killeen,J. , Kamemoto,L. , Hernandez,B.Y. .
Source: The Journal Of Infectious Diseases, 2008-04-01 00:00:00.0; 197(7), p. 957-66.
PMID: 18429348
Related Citations

Anal Human Papillomavirus Infection In Women And Its Relationship With Cervical Infection
Authors: Hernandez,B.Y. , McDuffie,K. , Zhu,X. , Wilkens,L.R. , Killeen,J. , Kessel,B. , Wakabayashi,M.T. , Bertram,C.C. , Easa,D. , Ning,L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2005 Nov; 14(11 Pt 1), p. 2550-6.
PMID: 16284377
Related Citations

A Tailored Multi-media Campaign To Promote The Human Papillomavirus Cohort Study To Young Women
Authors: Bushley,A.W. , Cassel,K. , Hernandez,B.Y. , Robinett,H. , Goodman,M.T. .
Source: Preventive Medicine, 2005 Jul; 41(1), p. 98-101.
PMID: 15916999
Related Citations

Association Of Methylenetetrahydrofolate Reductase Polymorphism C677t And Dietary Folate With The Risk Of Cervical Dysplasia
Authors: Goodman M.T. , McDuffie K. , Hernandez B. , Wilkens L.R. , Bertram C.C. , Killeen J. , Le Marchand L. , Selhub J. , Murphy S. , Donlon T.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Dec; 10(12), p. 1275-80.
PMID: 11751445
Related Citations

Local Studies Address A Previously Hidden Sexually Transmitted Disease: Human Papillomavirus And Cervical Neoplasia
Authors: Goodman M.T. .
Source: Hawaii Medical Journal, 2001 Sep; 60(9), p. 236-8.
PMID: 11802562
Related Citations