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Grant Details

Grant Number: 5R03CA110851-02 Interpret this number
Primary Investigator: Boudreau, Denise
Organization: Group Health Cooperative
Project Title: Medication and Colorectal Cancer Risk
Fiscal Year: 2005


DESCRIPTION (provided by applicant): Colorectal carcinoma is one of the most prevalent cancers in the United States and one of the leading causes of cancer mortality. While diet, family history, and lifestyle factors have been proposed as risk factors for colorectal cancer, the etiology of the majority of colorectal cancers remains uncertain. Studies evaluating medication use and colorectal cancer risk have mainly focused on only a few drug classes. Experimental and observational studies support a potential role for a number of medications. The goal of this study is to evaluate the relationship between understudied but commonly prescribed medication use and colorectal cancer risk. To meet these aims, we plan to conduct a case-control study of colorectal cancer comprised of 675 cases and 675 controls in the defined population of Group Health Cooperative, a large health maintenance organization in western Washington State. Cancer outcomes will be identified through the western Washington Surveillance, Epidemiology, and End Results registry. Data on medication use, medical conditions, and covariates will be obtained from traditional medical records and automated data files, which include pharmacy records, laboratory values, hospitalizations, outpatient visits, and cause of death.


Colorectal cancer risk in relation to antidepressant medication use.
Authors: Chubak J. , Boudreau D.M. , Rulyak S.J. , Mandelson M.T. .
Source: International journal of cancer, 2011-01-01; 128(1), p. 227-32.
PMID: 20232382
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Colorectal cancer risk in relation to use of acid suppressive medications.
Authors: Chubak J. , Boudreau D.M. , Rulyak S.J. , Mandelson M.T. .
Source: Pharmacoepidemiology and drug safety, 2009 Jul; 18(7), p. 540-4.
PMID: 19367565
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Cardiovascular medication use and risk for colorectal cancer.
Authors: Boudreau D.M. , Koehler E. , Rulyak S.J. , Haneuse S. , Harrison R. , Mandelson M.T. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Nov; 17(11), p. 3076-80.
EPub date: 2008-10-28.
PMID: 18957524
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