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Grant Details

Grant Number: 5R01CA108634-02 Interpret this number
Primary Investigator: Bernstein, Leslie
Organization: University Of Southern California
Project Title: Exogenous Hormones, IL-6 and Nhl Risk in Women
Fiscal Year: 2005


Abstract

DESCRIPTION (provided by applicant): Non-Hodgkin's lymphoma (NHL) rates have been increasing since the 1940s. Incidence is lower among women than among men, yet few risk factors explain incidence patterns over time or by gender. One possible exposure that may explain differences in risk patterns of men and women is hormone therapy (HT). Our own prior research suggested HT and other exogenous estrogen exposures decrease women's risk of high and intermediate NHL, yet results of another study suggest HT increases risk of follicular NHL (a subtype we did not study). Both studies had limited information on potential confounders of an HT-NHL relationship; nevertheless these results are intriguing because the evolution of cell type may depend on B-cell maturation and differentiation which is influenced by levels of interleukin-6 (IL-6); these, in turn, are influenced by the individual's IL-6 genotype and may be impacted by estrogen and progesterone exposure. We propose to conduct a population-based case-control study of B-cell NHL among women 20- 79 years of age, living in Los Angeles County, who are English speaking. We will recruit 1173 cases and 1173 controls, who will provide information during an in-person interview and will provide a buccal cell sample. Cases will have a first primary NHL diagnosis that occurs between July 1, 2004 and December 31, 2007. Controls will be frequency matched to cases by age (5 year age groups) and race/ethnicity and will be identified by surveying the neighborhoods of cases. In this study we will address 1) whether HT use (including specific types, durations, ages and recency of use) affects NHL risk; 2) whether oral contraceptives (including types, durations, and ages of use), lactation suppressants or other exogenous hormones affect NHL risk; 3) whether NHL risk associated with use of exogenous hormones varies by histologic subtype; 4) whether IL-6 genotype (as defined by 4 polymorphisms) modifies any of these relationships; and 5) whether reproductive factors, medical exposures or lifestyle characteristics influence risk of NHL.



Publications

Assessing Cancer Treatment Information Using Medicare and Hospital Discharge Data among Women with Non-Hodgkin Lymphoma in a Los Angeles County Case-Control Study.
Authors: Zhong C. , Seibold P. , Chao C.R. , Cozen W. , Song J.Y. , Weisenburger D. , Bernstein L. , Wang S.S. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020 05; 29(5), p. 936-941.
EPub date: 2020-02-17.
PMID: 32066614
Related Citations

Follicular lymphoma polygenic risk score is associated with increased disease risk but improved overall survival among women in a population based case-control in Los Angeles County California.
Authors: Zhong C. , Chao C.R. , Song J.Y. , Weisenburger D.D. , Luo J. , Ding Y.C. , Neuhausen S.L. , Bernstein L. , Cozen W. , Wang S.S. .
Source: Cancer epidemiology, 2020 04; 65, p. 101688.
EPub date: 2020-02-21.
PMID: 32092486
Related Citations

Pregnancy-related factors and risk of B-cell non-Hodgkin lymphoma among women in Los Angeles.
Authors: Luo J. , Wang S.S. , Lu Y. , Sullivan-Halley J. , Cozen W. , Ma H. , Bernstein L. .
Source: British journal of haematology, 2019 07; 186(1), p. 133-137.
EPub date: 2018-11-29.
PMID: 30488431
Related Citations

Evaluating the use of friend or family controls in epidemiologic case-control studies.
Authors: Zhong C. , Cockburn M. , Cozen W. , Voutsinas J. , Lacey J.V. , Luo J. , Sullivan-Halley J. , Bernstein L. , Wang S.S. .
Source: Cancer epidemiology, 2017 02; 46, p. 9-13.
EPub date: 2016-11-18.
PMID: 27871006
Related Citations

Breast implants and anaplastic large cell lymphomas among females in the California Teachers Study cohort.
Authors: Wang S.S. , Deapen D. , Voutsinas J. , Lacey J.V. , Lu Y. , Ma H. , Clarke C.A. , Weisenburger D. , Forman S.J. , Bernstein L. .
Source: British journal of haematology, 2016 08; 174(3), p. 480-3.
EPub date: 2015-10-12.
PMID: 26456010
Related Citations




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