Grant Number:	5R01CA042949-18 Interpret this number
Primary Investigator:	Langholz, Bryan
Organization:	University Of Southern California
Project Title:	Time Related Factors in Cancer Epidemiology
Fiscal Year:	2005

DESCRIPTION (provided by applicant): The long-term goals of this grant are to develop study designs and methods of statistical analysis for epidemiologic research of cancer and other chronic diseases. In this proposal, we focus on case-control studies in three broad aims: The first is to develop case-control design and analysis solutions to a number of important problems we have identified based on our applied work on "standard"' and counter matched case-control studies. These include appropriate analysis of case-control studies with random digit dial controls, Mantel-Haenszel and polytomous logistic regression estimators for studies with complex control selection, development of new population based case-control study designs that use inexpensive correlate exposure information to improve cost-efficiency, and analysis of case-control studies with missing covariate data. The second is to develop efficiency bound methods appropriate to case-control study designs as well as investigate estimation methods that make use of cohort or external information to improve case-control study efficiency. These results will clarify when auxiliary at-risk and covariate information can be used to improve efficiency in analysis of nested case-control studies and provide methods that exploit this information. The third aim is outreach to investigators interested in the methods including maintaining software and data examples on our website and limited consultation. The impact of these projects is to expand the design and analysis "tools"' available to epidemiologic research in a way that will improve validity and cost-efficiency.




A post-hoc Unweighted Analysis of Counter-Matched Case-Control Data.
Authors: Rakovski C. , Langholz B. .
Source: The International Journal Of Biostatistics, 2015 Nov; 11(2), p. 223-32.
PMID: 26351961
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A Semiparametric Missing-data-induced Intensity Method For Missing Covariate Data In Individually Matched Case-control Studies
Authors: Gebregziabher,M. , Langholz,B. .
Source: Biometrics, 2010 Sep; 66(3), p. 845-54.
PMID: 19751251
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Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study.
Authors: Figueiredo J.C. , Haile R.W. , Bernstein L. , Malone K.E. , Largent J. , Langholz B. , Lynch C.F. , Bertelsen L. , Capanu M. , Concannon P. , et al. .
Source: Breast Cancer Research And Treatment, 2010 Feb; 120(1), p. 175-83.
PMID: 19597986
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Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer.
Authors: Langholz B. , Thomas D.C. , Stovall M. , Smith S.A. , Boice J.D. , Shore R.E. , Bernstein L. , Lynch C.F. , Zhang X. , Bernstein J.L. .
Source: Biometrics, 2009 Jun; 65(2), p. 599-608.
PMID: 18647297
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Are Nested Case-control Studies Biased?
Authors: Langholz,B. , Richardson,D. .
Source: Epidemiology (cambridge, Mass.), 2009 May; 20(3), p. 321-9.
PMID: 19289963
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Using Tensor Product Splines In Modeling Exposure-time-response Relationships: Application To The Colorado Plateau Uranium Miners Cohort
Authors: Berhane,K. , Hauptmann,M. , Langholz,B. .
Source: Statistics In Medicine, 2008-11-20 00:00:00.0; 27(26), p. 5484-96.
PMID: 18613262
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Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study.
Authors: Stovall M. , Smith S.A. , Langholz B.M. , Boice J.D. , Shore R.E. , Andersson M. , Buchholz T.A. , Capanu M. , Bernstein L. , Lynch C.F. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2008-11-15 00:00:00.0; 72(4), p. 1021-30.
EPub date: 2008-11-15 00:00:00.0.
PMID: 18556141
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Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group.
Authors: Figueiredo J.C. , Bernstein L. , Capanu M. , Malone K.E. , Lynch C.F. , Anton-Culver H. , Stovall M. , Bertelsen L. , Haile R.W. , Bernstein J.L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-03-20 00:00:00.0; 26(9), p. 1411-8.
EPub date: 2008-03-20 00:00:00.0.
PMID: 18250348
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Toxicokinetic Genetics: An Approach To Gene-environment And Gene-gene Interactions In Complex Metabolic Pathways
Authors: Cortessis,V. , Thomas,D.C. .
Source: Iarc Scientific Publications, 2004; (157), p. 127-50.
PMID: 15055294
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Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.
Authors: Bernstein J.L. , Langholz B. , Haile R.W. , Bernstein L. , Thomas D.C. , Stovall M. , Malone K.E. , Lynch C.F. , Olsen J.H. , Anton-Culver H. , et al. .
Source: Breast Cancer Research : Bcr, 2004; 6(3), p. R199-214.
PMID: 15084244
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Selecting Controls For Assessing Interaction In Nested Case-control Studies
Authors: Cologne,J. , Langholz,B. .
Source: Journal Of Epidemiology / Japan Epidemiological Association, 2003 Jul; 13(4), p. 193-202.
PMID: 12934962
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Stratified Case Sampling And The Use Of Family Controls
Authors: Siegmund K.D. , Langholz B. .
Source: Genetic Epidemiology, 2001 Apr; 20(3), p. 316-27.
PMID: 11255241
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Testing Linkage Disequilibrium In Sibships
Authors: Siegmund K.D. , Langholz B. , Kraft P. , Thomas D.C. .
Source: American Journal Of Human Genetics, 2000 Jul; 67(1), p. 244-8.
PMID: 10831398
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Exposure Stratified Case-cohort Designs
Authors: Borgan O. , Langholz B. , Samuelsen S.O. , Goldstein L. , Pogoda J. .
Source: Lifetime Data Analysis, 2000 Mar; 6(1), p. 39-58.
PMID: 10763560
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Application Of The Missing-indicator Method In Matched Case-control Studies With Incomplete Data
Authors: Huberman M. , Langholz B. .
Source: American Journal Of Epidemiology, 1999-12-15 00:00:00.0; 150(12), p. 1340-5.
PMID: 10604777
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Latency Analysis In Epidemiologic Studies Of Occupational Exposures: Application To The Colorado Plateau Uranium Miners Cohort
Authors: Langholz B. , Thomas D. , Xiang A. , Stram D. .
Source: American Journal Of Industrial Medicine, 1999 Mar; 35(3), p. 246-56.
PMID: 9987557
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New Techniques For The Analysis Of Cohort Studies
Authors: Thomas D. .
Source: Epidemiologic Reviews, 1998; 20(1), p. 122-34.
PMID: 9762515
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Estimation Of Excess Risk From Case-control Data Using Aalen's Linear Regression Model
Authors: Borgan O. , Langholz B. .
Source: Biometrics, 1997 Jun; 53(2), p. 690-7.
PMID: 9192457
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Estimation Of Absolute Risk From Nested Case-control Data
Authors: Langholz B. , Borgan O. .
Source: Biometrics, 1997 Jun; 53(2), p. 767-74.
PMID: 9192463
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Simultaneously Modelling Censored Survival Data And Repeatedly Measured Covariates: A Gibbs Sampling Approach
Authors: Faucett C.L. , Thomas D.C. .
Source: Statistics In Medicine, 1996-08-15 00:00:00.0; 15(15), p. 1663-85.
PMID: 8858789
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Temporal Modifiers Of The Radon-smoking Interaction
Authors: Thomas D. , Pogoda J. , Langholz B. , Mack W. .
Source: Health Physics, 1994 Mar; 66(3), p. 257-62.
PMID: 8106243
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Use Of External Rates In Nested Case-control Studies With Application To The International Radiation Study Of Cervical Cancer Patients
Authors: Thomas D.C. , Blettner M. , Day N.E. .
Source: Biometrics, 1992 Sep; 48(3), p. 781-94.
PMID: 1420841
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Definition And Estimation Of Lifetime Detriment From Radiation Exposures: Principles And Methods
Authors: Thomas D. , Darby S. , Fagnani F. , Hubert P. , Vaeth M. , Weiss K. .
Source: Health Physics, 1992 Sep; 63(3), p. 259-72.
PMID: 1644562
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A Gibbs Sampling Approach To Linkage Analysis
Authors: Thomas D.C. , Cortessis V. .
Source: Human Heredity, 1992; 42(1), p. 63-76.
PMID: 1555847
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Fitting Genetic Data Using Gibbs Sampling: An Application To Nevus Counts In 38 Utah Kindreds
Authors: Thomas D.C. .
Source: Cytogenetics And Cell Genetics, 1992; 59(2-3), p. 228-30.
PMID: 1737510
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Efficiency Of Cohort Sampling Designs: Some Surprising Results
Authors: Langholz B. , Thomas D.C. .
Source: Biometrics, 1991 Dec; 47(4), p. 1563-71.
PMID: 1786329
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A Model For Dose Rate And Duration Of Exposure Effects In Radiation Carcinogenesis
Authors: Thomas D.C. .
Source: Environmental Health Perspectives, 1990 Jul; 87, p. 163-71.
PMID: 2269222
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Survival Models For Familial Aggregation Of Cancer
Authors: Mack W. , Langholz B. , Thomas D.C. .
Source: Environmental Health Perspectives, 1990 Jul; 87, p. 27-35.
PMID: 2269231
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Bivariate Survival Models For Analysis Of Genetic And Environmental Effects In Twins
Authors: Thomas D.C. , Langholz B. , Mack W. , Floderus B. .
Source: Genetic Epidemiology, 1990; 7(2), p. 121-35.
PMID: 2338229
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Nested Case-control And Case-cohort Methods Of Sampling From A Cohort: A Critical Comparison
Authors: Langholz B. , Thomas D.C. .
Source: American Journal Of Epidemiology, 1990 Jan; 131(1), p. 169-76.
PMID: 2403467
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