Grant Number:	5R01CA096789-03 Interpret this number
Primary Investigator:	Neuhouser, Marian
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Diet and Genetic Risks for Prostate Cancer
Fiscal Year:	2005

DESCRIPTION (provided by applicant): Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths among American men. Prostate cancer etiology remains elusive but there is growing evidence that dietary patterns are associated with prostate carcinogenesis. The most consistent dietary finding is that diets high in fat or high-fat foods increase risk and there is increasing evidence that compounds found in vegetables (e.g., lycopene, glucosinolates) decrease risk. However, results are not consistent across studies and there is no scientific consensus for specific dietary recommendations to reduce prostate cancer risk. Non-dietary factors associated with risk include age, race and family history. These and other risk factors may interact with dietary components and alter the prooxidant-antioxidant balance in the prostate. This proposal is for a comprehensive investigation into the associations of dietary fat, fruit and vegetable intakes and polymorphisms in genes that encode oxidative stress regulatory enzymes with the risk of prostate cancer. Our hypothesis is that dietary and other factors that increase oxidative stress (e.g., dietary fat, smoking) are associated with increased risk of prostate cancer; dietary factors that decrease oxidative stress are associated with decreased risk of prostate cancer; and the magnitude of these risks will vary by cancer susceptibility genetic profile. We will test whether polymorphisms in genes whose products affect tissue responses to oxidative stress influence prostate cancer risk, and whether there are interactions of these polymorphisms with dietary factors related to oxidative stress. Our study sample is the 12,025 male participants in CARET (The Beta-Carotene and Retinol Efficacy Trial). To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control.




Body mass index and prostate cancer risk in the Carotene and Retinol Efficacy Trial.
Authors: Bonn S.E. , Barnett M.J. , Thornquist M. , Goodman G. , Neuhouser M.L. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2019 May; 28(3), p. 212-219.
PMID: 29521683
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Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.
Authors: Key T.J. , Appleby P.N. , Travis R.C. , Albanes D. , Alberg A.J. , Barricarte A. , Black A. , Boeing H. , Bueno-de-Mesquita H.B. , Chan J.M. , et al. .
Source: The American journal of clinical nutrition, 2015 Nov; 102(5), p. 1142-57.
EPub date: 2015-10-07.
PMID: 26447150
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Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies.
Authors: Crowe F.L. , Appleby P.N. , Travis R.C. , Barnett M. , Brasky T.M. , Bueno-de-Mesquita H.B. , Chajes V. , Chavarro J.E. , Chirlaque M.D. , English D.R. , et al. .
Source: Journal of the National Cancer Institute, 2014 Sep; 106(9), .
EPub date: 2014-09-10.
PMID: 25210201
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Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial.
Authors: Cheng T.Y. , King I.B. , Barnett M.J. , Ambrosone C.B. , Thornquist M.D. , Goodman G.E. , Neuhouser M.L. .
Source: American journal of epidemiology, 2013-05-15; 177(10), p. 1106-17.
EPub date: 2013-03-27.
PMID: 23535901
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Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers.
Authors: Cheng T.Y. , Barnett M.J. , Kristal A.R. , Ambrosone C.B. , King I.B. , Thornquist M.D. , Goodman G.E. , Neuhouser M.L. .
Source: The Journal of nutrition, 2011 Sep; 141(9), p. 1731-7.
EPub date: 2011-07-27.
PMID: 21795425
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Dietary supplement use and prostate cancer risk in the Carotene and Retinol Efficacy Trial.
Authors: Neuhouser M.L. , Barnett M.J. , Kristal A.R. , Ambrosone C.B. , King I.B. , Thornquist M. , Goodman G.G. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 Aug; 18(8), p. 2202-6.
PMID: 19661078
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Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.
Authors: Choi J.Y. , Neuhouser M.L. , Barnett M.J. , Hong C.C. , Kristal A.R. , Thornquist M.D. , King I.B. , Goodman G.E. , Ambrosone C.B. .
Source: Carcinogenesis, 2008 May; 29(5), p. 964-70.
EPub date: 2008-02-22.
PMID: 18296681
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(n-6) PUFA increase and dairy foods decrease prostate cancer risk in heavy smokers.
Authors: Neuhouser M.L. , Barnett M.J. , Kristal A.R. , Ambrosone C.B. , King I. , Thornquist M. , Goodman G. .
Source: The Journal of nutrition, 2007 Jul; 137(7), p. 1821-7.
PMID: 17585037
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Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers.
Authors: Choi J.Y. , Neuhouser M.L. , Barnett M. , Hudson M. , Kristal A.R. , Thornquist M. , King I.B. , Goodman G.E. , Ambrosone C.B. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 Jun; 16(6), p. 1115-20.
PMID: 17548672
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Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk.
Authors: Joseph M.A. , Moysich K.B. , Freudenheim J.L. , Shields P.G. , Bowman E.D. , Zhang Y. , Marshall J.R. , Ambrosone C.B. .
Source: Nutrition and cancer, 2004; 50(2), p. 206-13.
PMID: 15623468
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