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Grant Details

Grant Number: 7R01CA047473-13 Interpret this number
Primary Investigator: Grufferman, Seymour
Organization: University Of New Mexico
Project Title: Case-Control Study of Hodgkin's Disease in Children
Fiscal Year: 2003
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Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a competing renewal application for a case-control study of childhood Hodgkin's disease (HD) with epidemiologic, genetic and virologic components. Cases are from the Children's Cancer and Pediatric Oncology Groups with individually matched controls selected by random digit dialing (RDD). Epidemiologic data for 480 cases and 726 matching controls have been collected by telephone interviews of parents. Tumor specimens have been collected for 321 cases and blood samples for 234 cases for Epstein-Barr virus (EBV) studies. In the new phase of this study, emphasis will be placed on genetic factors in the etiology of HD. Thus far, 186 case and 79 control families have been re-interviewed. Complex segregation analyses of the family data have been performed and the best fit is with an environmental rather than a Mendelian inheritance model of HD using two approaches. DNA microsatellite markers will be used to test for the association between HD and candidate HLA regions and non-HLA regions. The second approach will perform high resolution molecular typing HLA Class I (HLA-A,B,C) and II (HLA-DR, DQA1, D1B1 and DP) alleles. The proposed HLA studies will allow for analyses of the relationship between EBV-status and subject's HLA type. The proposed new studies will also include statistical assessment of time-space clustering of cases and controls, an evaluation of the introduction of socioeconomic status bias by RDD and the performance of a second follow-up interview of subjects' families. The study will focus on Hispanic cases since they differ significantly from other cases in EBV-positivity of their tumors and other epidemiologic features.

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Publications

Family history of cancer and risk of pediatric and adolescent Hodgkin lymphoma: A Children's Oncology Group study.
Authors: Linabery A.M. , Erhardt E.B. , Richardson M.R. , Ambinder R.F. , Friedman D.L. , Glaser S.L. , Monnereau A. , Spector L.G. , Ross J.A. , Grufferman S. .
Source: International journal of cancer, 2015-11-01; 137(9), p. 2163-74.
EPub date: 2015-05-19.
PMID: 25940226
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Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: a Children's Oncology Group study.
Authors: Linabery A.M. , Erhardt E.B. , Fonstad R.K. , Ambinder R.F. , Bunin G.R. , Ross J.A. , Spector L.G. , Grufferman S. .
Source: International journal of cancer, 2014-09-15; 135(6), p. 1454-69.
EPub date: 2014-03-18.
PMID: 24523151
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Antibody responses to Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) and expression of LMP1 in juvenile Hodgkin's disease.
Authors: Meij P. , Vervoort M.B. , Bloemena E. , Schouten T.E. , Schwartz C. , Grufferman S. , Ambinder R.F. , Middeldorp J.M. .
Source: Journal of medical virology, 2002 Nov; 68(3), p. 370-7.
PMID: 12226824
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Anticipation in familial Hodgkin lymphoma.
Authors: Shugart Y.Y. .
Source: American journal of human genetics, 1998 Jul; 63(1), p. 270-2.
PMID: 9634521
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Methodologic approaches to studying environmental factors in childhood cancer.
Authors: Grufferman S. .
Source: Environmental health perspectives, 1998 Jun; 106 Suppl 3, p. 881-6.
PMID: 9646052
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Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies.
Authors: Macfarlane G.J. , Zheng T. , Marshall J.R. , Boffetta P. , Niu S. , Brasure J. , Merletti F. , Boyle P. .
Source: European journal of cancer. Part B, Oral oncology, 1995 May; 31B(3), p. 181-7.
PMID: 7549758
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International patterns in the occurrence of Hodgkin's disease in children and young adult males.
Authors: Macfarlane G.J. , Evstifeeva T. , Boyle P. , Grufferman S. .
Source: International journal of cancer, 1995-04-10; 61(2), p. 165-9.
PMID: 7705942
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Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States.
Authors: Ambinder R.F. , Browning P.J. , Lorenzana I. , Leventhal B.G. , Cosenza H. , Mann R.B. , MacMahon E.M. , Medina R. , Cardona V. , Grufferman S. .
Source: Blood, 1993-01-15; 81(2), p. 462-7.
PMID: 8380725
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