Grant Number:	5R01CA090792-05 Interpret this number
Primary Investigator:	Garshick, Eric
Organization:	Brigham And Women'S Hospital
Project Title:	Diesel Particle Exposure and Lung Cancer
Fiscal Year:	2005

DESCRIPTION: Diesel exhaust particles are highly respirable with mutagenic and carcinogenic compounds adsorbed on their surface. Based on results from laboratory studies in rats and limited evidence in humans, the International Agency for Research on Cancer classified diesel exhaust as a probable human carcinogen in 1989. However, the interpretation of past epidemiologic studies has been limited due to lack of direct measures of diesel exposure and insufficient years of follow-up. We have identified a unique national cohort of 55,750 long-term trucking company workers employed in 1985. We propose to conduct an extensive exposure assessment and assess the association of exposure to diesel exhaust with lung cancer mortality through 2000. The US trucking fleet has included diesel vehicles since the early 1950s. Therefore, there are trucking company workers with long duration of exposure and at least 20 years since first exposure. We will use the results from the exposure assessment, along with external databases of pollution and truck registrations, to develop a prediction model for diesel exhaust exposure and form categorical groupings of exposure levels. The model will include factors that are readily available in company personnel records such as job title and terminal characteristics so that exposure levels can be linked to the individual employees. We will assess ever-exposure, cumulative and duration of exposure. We will use the results from a questionnaire mailed to all current workers to control for potential confounding by smoking. In this retrospective follow-up, we will have 80 percent power to detect a relative risk of 1.25. This large cohort provides a unique opportunity to detect (or refute) suggested carcinogenic effects of diesel exhaust based on animal toxicology and limited epidemiologic studies. Furthermore, since the range of exposure in these workers includes levels similar to the general population, the findings will be relevant to understanding general population risk of lung cancer from diesel emissions and other fine particulate air pollution.




Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry.
Authors: Walker D.I. , Hart J.E. , Patel C.J. , Rudel R. , Chu J.H. , Garshick E. , Pennell K.D. , Laden F. , Jones D.P. .
Source: Environment International, 2022 01; 158, p. 106957.
EPub date: 2021-10-28 00:00:00.0.
PMID: 34737152
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The Characterization of Polycyclic Aromatic Hydrocarbons in Northeastern US Trucking Terminals.
Authors: Walker E.D. , Hart J.E. , Garshick E. , Cavallari J.M. , Davis M.E. , Smith T.J. , Laden F. .
Source: Annals Of Work Exposures And Health, 2017-08-01 00:00:00.0; 61(7), p. 844-853.
PMID: 28810687
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A structural approach to address the healthy-worker survivor effect in occupational cohorts: an application in the trucking industry cohort.
Authors: Neophytou A.M. , Picciotto S. , Hart J.E. , Garshick E. , Eisen E.A. , Laden F. .
Source: Occupational And Environmental Medicine, 2014 Jun; 71(6), p. 442-7.
PMID: 24727736
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Ischaemic heart disease mortality and years of work in trucking industry workers.
Authors: Hart J.E. , Garshick E. , Smith T.J. , Davis M.E. , Laden F. .
Source: Occupational And Environmental Medicine, 2013 Aug; 70(8), p. 523-8.
PMID: 22992341
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A cross-sectional study of secondhand smoke exposure and respiratory symptoms in non-current smokers in the U.S. trucking industry: SHS exposure and respiratory symptoms.
Authors: Laden F. , Chiu Y.H. , Garshick E. , Hammond S.K. , Hart J.E. .
Source: Bmc Public Health, 2013-02-01 00:00:00.0; 13, p. 93.
EPub date: 2013-02-01 00:00:00.0.
PMID: 23368999
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Potential air toxics hot spots in truck terminals and cabs.
Authors: Smith T.J. , Davis M.E. , Hart J.E. , Blicharz A. , Laden F. , Garshick E. , HEI Health Review Committee .
Source: Research Report (health Effects Institute), 2012 Dec; (172), p. 5-82.
PMID: 23409510
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Lung cancer and elemental carbon exposure in trucking industry workers.
Authors: Garshick E. , Laden F. , Hart J.E. , Davis M.E. , Eisen E.A. , Smith T.J. .
Source: Environmental Health Perspectives, 2012 Sep; 120(9), p. 1301-6.
PMID: 22739103
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Structural equation models in occupational health: an application to exposure modelling.
Authors: Davis M.E. .
Source: Occupational And Environmental Medicine, 2012 Mar; 69(3), p. 184-90.
PMID: 21680563
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Comparing gravimetric and real-time sampling of PM(2.5) concentrations inside truck cabins.
Authors: Zhu Y. , Smith T.J. , Davis M.E. , Levy J.I. , Herrick R. , Jiang H. .
Source: Journal Of Occupational And Environmental Hygiene, 2011 Nov; 8(11), p. 662-72.
PMID: 21991940
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A retrospective assessment of occupational exposure to elemental carbon in the U.S. trucking industry.
Authors: Davis M.E. , Hart J.E. , Laden F. , Garshick E. , Smith T.J. .
Source: Environmental Health Perspectives, 2011 Jul; 119(7), p. 997-1002.
PMID: 21447452
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Long-term ambient multipollutant exposures and mortality.
Authors: Hart J.E. , Garshick E. , Dockery D.W. , Smith T.J. , Ryan L. , Laden F. .
Source: American Journal Of Respiratory And Critical Care Medicine, 2011-01-01 00:00:00.0; 183(1), p. 73-8.
EPub date: 2011-01-01 00:00:00.0.
PMID: 20656944
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Economic activity and trends in ambient air pollution.
Authors: Davis M.E. , Laden F. , Hart J.E. , Garshick E. , Smith T.J. .
Source: Environmental Health Perspectives, 2010 May; 118(5), p. 614-9.
PMID: 20056563
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Workplace secondhand smoke exposure in the U.S. trucking industry.
Authors: Chiu Y.H. , Hart J.E. , Spiegelman D. , Garshick E. , Smith T.J. , Dockery D.W. , Hammond S.K. , Laden F. .
Source: Environmental Health Perspectives, 2010 Feb; 118(2), p. 216-21.
PMID: 20123606
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Spatial modeling of PM10 and NO2 in the continental United States, 1985-2000.
Authors: Hart J.E. , Yanosky J.D. , Puett R.C. , Ryan L. , Dockery D.W. , Smith T.J. , Garshick E. , Laden F. .
Source: Environmental Health Perspectives, 2009 Nov; 117(11), p. 1690-6.
PMID: 20049118
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Predicting changes in PM exposure over time at U.S. trucking terminals using structural equation modeling techniques.
Authors: Davis M.E. , Laden F. , Hart J.E. , Garshick E. , Blicharz A. , Smith T.J. .
Source: Journal Of Occupational And Environmental Hygiene, 2009 Jul; 6(7), p. 396-403.
PMID: 19367483
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Tracking personal exposure to particulate diesel exhaust in a diesel freight terminal using organic tracer analysis.
Authors: Sheesley R.J. , Schauer J.J. , Garshick E. , Laden F. , Smith T.J. , Blicharz A.P. , Deminter J.T. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2009 Feb; 19(2), p. 172-86.
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Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.
Authors: Sobus J.R. , Waidyanatha S. , McClean M.D. , Herrick R.F. , Smith T.J. , Garshick E. , Laden F. , Hart J.E. , Zheng Y. , Rappaport S.M. .
Source: Occupational And Environmental Medicine, 2009 Feb; 66(2), p. 99-104.
PMID: 19017700
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Nicotine contamination in particulate matter sampling.
Authors: Chiu Y.H. , Hart J.E. , Smith T.J. , Hammond S.K. , Garshick E. , Laden F. .
Source: International Journal Of Environmental Research And Public Health, 2009 Feb; 6(2), p. 601-7.
PMID: 19440403
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Lung cancer and vehicle exhaust in trucking industry workers.
Authors: Garshick E. , Laden F. , Hart J.E. , Rosner B. , Davis M.E. , Eisen E.A. , Smith T.J. .
Source: Environmental Health Perspectives, 2008 Oct; 116(10), p. 1327-32.
PMID: 18941573
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Assessment of diesel particulate matter exposure in the workplace: freight terminals.
Authors: Sheesley R.J. , Schauer J.J. , Smith T.J. , Garshick E. , Laden F. , Marr L.C. , Molina L.T. .
Source: Journal Of Environmental Monitoring : Jem, 2008 Mar; 10(3), p. 305-14.
PMID: 18392272
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Driver exposure to combustion particles in the U.S. Trucking industry.
Authors: Davis M.E. , Smith T.J. , Laden F. , Hart J.E. , Blicharz A.P. , Reaser P. , Garshick E. .
Source: Journal Of Occupational And Environmental Hygiene, 2007 Nov; 4(11), p. 848-54.
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Occupational exposure to volatile organic compounds and aldehydes in the U.S. trucking industry.
Authors: Davis M.E. , Blicharz A.P. , Hart J.E. , Laden F. , Garshick E. , Smith T.J. .
Source: Environmental Science & Technology, 2007-10-15 00:00:00.0; 41(20), p. 7152-8.
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Cause-specific mortality in the unionized U.S. trucking industry.
Authors: Laden F. , Hart J.E. , Smith T.J. , Davis M.E. , Garshick E. .
Source: Environmental Health Perspectives, 2007 Aug; 115(8), p. 1192-6.
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Effects of wind on background particle concentrations at truck freight terminals.
Authors: Garcia R. , Hart J.E. , Davis M.E. , Reaser P. , Natkin J. , Laden F. , Garshick E. , Smith T.J. .
Source: Journal Of Occupational And Environmental Hygiene, 2007 Jan; 4(1), p. 36-48.
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Smoking behavior in trucking industry workers.
Authors: Jain N.B. , Hart J.E. , Smith T.J. , Garshick E. , Laden F. .
Source: American Journal Of Industrial Medicine, 2006 Dec; 49(12), p. 1013-20.
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Overview of particulate exposures in the US trucking industry.
Authors: Smith T.J. , Davis M.E. , Reaser P. , Natkin J. , Hart J.E. , Laden F. , Heff A. , Garshick E. .
Source: Journal Of Environmental Monitoring : Jem, 2006 Jul; 8(7), p. 711-20.
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Modeling particle exposure in U.S. trucking terminals.
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Exposure of trucking company workers to particulate matter during the winter.
Authors: Lee B.K. , Smith T.J. , Garshick E. , Natkin J. , Reaser P. , Lane K. , Lee H.K. .
Source: Chemosphere, 2005 Dec; 61(11), p. 1677-90.
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Respiratory symptoms and intensity of occupational dust exposure.
Authors: Garshick E. , Laden F. , Hart J.E. , Moy M.L. .
Source: International Archives Of Occupational And Environmental Health, 2004 Oct; 77(7), p. 515-20.
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Vehicle traffic as a source of particulate polycyclic aromatic hydrocarbon exposure in the Mexico City metropolitan area.
Authors: Marr L.C. , Grogan L.A. , Wöhrnschimmel H. , Molina L.T. , Molina M.J. , Smith T.J. , Garshick E. .
Source: Environmental Science & Technology, 2004-05-01 00:00:00.0; 38(9), p. 2584-92.
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Residence near a major road and respiratory symptoms in U.S. Veterans.
Authors: Garshick E. , Laden F. , Hart J.E. , Caron A. .
Source: Epidemiology (cambridge, Mass.), 2003 Nov; 14(6), p. 728-36.
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