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Grant Details

Grant Number: 5R01CA081191-05 Interpret this number
Primary Investigator: Demark-Wahnefried, Wendy
Organization: Duke University
Project Title: Promoting Health in Prostate & Breast Cancer
Fiscal Year: 2005


Abstract

This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.



Publications

Rural-urban differences in health behaviors and outcomes among older, overweight, long-term cancer survivors in the RENEW randomized control trial.
Authors: Gray M.S. , Judd S.E. , Sloane R. , Snyder D.C. , Miller P.E. , Demark-Wahnefried W. .
Source: Cancer Causes & Control : Ccc, 2019 Apr; 30(4), p. 301-309.
EPub date: 2019-02-19 00:00:00.0.
PMID: 30783858
Related Citations

Cancer survivors' uptake and adherence in diet and exercise intervention trials: an integrative data analysis.
Authors: Adams R.N. , Mosher C.E. , Blair C.K. , Snyder D.C. , Sloane R. , Demark-Wahnefried W. .
Source: Cancer, 2015-01-01 00:00:00.0; 121(1), p. 77-83.
EPub date: 2015-01-01 00:00:00.0.
PMID: 25155573
Related Citations

Cancer-specific concerns and physical activity among recently diagnosed breast and prostate cancer survivors.
Authors: Ottenbacher A. , Sloane R. , Snyder D.C. , Kraus W. , Sprod L. , Demark-Wahnefried W. .
Source: Integrative Cancer Therapies, 2013 May; 12(3), p. 206-12.
PMID: 22879576
Related Citations

Long-term outcomes of the FRESH START trial: exploring the role of self-efficacy in cancer survivors' maintenance of dietary practices and physical activity.
Authors: Mosher C.E. , Lipkus I. , Sloane R. , Snyder D.C. , Lobach D.F. , Demark-Wahnefried W. .
Source: Psycho-oncology, 2013 Apr; 22(4), p. 876-85.
PMID: 22544562
Related Citations

Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.
Authors: Rock C.L. , Byers T.E. , Colditz G.A. , Demark-Wahnefried W. , Ganz P.A. , Wolin K.Y. , Elias A. , Krontiras H. , Liu J. , Naughton M. , et al. .
Source: Contemporary Clinical Trials, 2013 Mar; 34(2), p. 282-95.
PMID: 23266440
Related Citations

Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors.
Authors: Ottenbacher A.J. , Day R.S. , Taylor W.C. , Sharma S.V. , Sloane R. , Snyder D.C. , Lipkus I.M. , Jones L.W. , Demark-Wahnefried W. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2012 Oct; 20(10), p. 2483-9.
PMID: 22249915
Related Citations

Nutrition And Physical Activity Guidelines For Cancer Survivors
Authors: Rock,C.L. , Doyle,C. , Demark-Wahnefried,W. , Meyerhardt,J. , Courneya,K.S. , Schwartz,A.L. , Bandera,E.V. , Hamilton,K.K. , Grant,B. , McCullough,M. , et al. .
Source: Ca: A Cancer Journal For Clinicians, 2012 Jul-Aug; 62(4), p. 243-74.
PMID: 22539238
Related Citations

Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists.
Authors: Wilkinson A.V. , Barrera S.L. , McBride C.M. , Snyder D.C. , Sloane R. , Meneses K.M. , Pekmezi D. , Kraus W.E. , Demark-Wahnefried W. .
Source: Psycho-oncology, 2012 Jan; 21(1), p. 108-13.
PMID: 21061408
Related Citations

Exercise among breast and prostate cancer survivors--what are their barriers?
Authors: Ottenbacher A.J. , Day R.S. , Taylor W.C. , Sharma S.V. , Sloane R. , Snyder D.C. , Kraus W.E. , Demark-Wahnefried W. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2011 Dec; 5(4), p. 413-9.
PMID: 21598023
Related Citations

Long-term dietary outcomes of the FRESH START intervention for breast and prostate cancer survivors.
Authors: Christy S.M. , Mosher C.E. , Sloane R. , Snyder D.C. , Lobach D.F. , Demark-Wahnefried W. .
Source: Journal Of The American Dietetic Association, 2011 Dec; 111(12), p. 1844-51.
PMID: 22117660
Related Citations

Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.
Authors: Sloane R. , Snyder D.C. , Demark-Wahnefried W. , Lobach D. , Kraus W.E. .
Source: Medicine And Science In Sports And Exercise, 2009 Jun; 41(6), p. 1334-40.
PMID: 19461530
Related Citations

Cancer Survivors' Health Worries And Associations With Lifestyle Practices
Authors: Mosher C.E. , Lipkus I.M. , Sloane R. , Kraus W.E. , Snyder D.C. , Peterson B. , Jones L.W. , Demark-Wahnefried W. .
Source: Journal Of Health Psychology, 2008 Nov; 13(8), p. 1105-12.
PMID: 18987083
Related Citations

Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.
Authors: Mosher C.E. , Fuemmeler B.F. , Sloane R. , Kraus W.E. , Lobach D.F. , Snyder D.C. , Demark-Wahnefried W. .
Source: Psycho-oncology, 2008 Oct; 17(10), p. 1014-23.
PMID: 18300337
Related Citations

Nutrition and the cancer survivor: evidence to guide oncology nursing practice.
Authors: Toles M. , Demark-Wahnefried W. .
Source: Seminars In Oncology Nursing, 2008 Aug; 24(3), p. 171-9.
PMID: 18687263
Related Citations

Differences in baseline characteristics and outcomes at 1- and 2-year follow-up of cancer survivors accrued via self-referral versus cancer registry in the FRESH START Diet and exercise trial.
Authors: Snyder D.C. , Sloane R. , Lobach D. , Lipkus I.M. , Peterson B. , Kraus W. , Demark-Wahnefried W. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 May; 17(5), p. 1288-94.
PMID: 18483353
Related Citations

Move onward, press forward, and take a deep breath: can lifestyle interventions improve the quality of life of women with breast cancer, and how can we be sure?
Authors: Demark-Wahnefried W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-10-01 00:00:00.0; 25(28), p. 4344-5.
EPub date: 2007-10-01 00:00:00.0.
PMID: 17785702
Related Citations

Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors.
Authors: Demark-Wahnefried W. , Clipp E.C. , Lipkus I.M. , Lobach D. , Snyder D.C. , Sloane R. , Peterson B. , Macri J.M. , Rock C.L. , McBride C.M. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-07-01 00:00:00.0; 25(19), p. 2709-18.
PMID: 17602076
Related Citations

Dietary intervention in the management of prostate cancer.
Authors: Demark-Wahnefried W. , Moyad M.A. , Moyad M.M. .
Source: Current Opinion In Urology, 2007 May; 17(3), p. 168-74.
PMID: 17414514
Related Citations

Print-to-practice: Designing Tailored Print Materials To Improve Cancer Survivors' Dietary And Exercise Practices In The Fresh Start Trial
Authors: Demark-Wahnefried W. .
Source: Nutrition Today, 2007 May; 42(3), p. 131-138.
PMID: 19081749
Related Citations

Lifestyle interventions in cancer survivors: designing programs that meet the needs of this vulnerable and growing population.
Authors: Stull V.B. , Snyder D.C. , Demark-Wahnefried W. .
Source: The Journal Of Nutrition, 2007 Jan; 137(1 Suppl), p. 243S-248S.
PMID: 17182834
Related Citations

Promoting health and physical function among cancer survivors: potential for prevention and questions that remain.
Authors: Demark-Wahnefried W. , Pinto B.M. , Gritz E.R. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2006-11-10 00:00:00.0; 24(32), p. 5125-31.
PMID: 17093274
Related Citations

The older cancer survivor.
Authors: Rao A.V. , Demark-Wahnefried W. .
Source: Critical Reviews In Oncology/hematology, 2006 Nov; 60(2), p. 131-43.
PMID: 16965920
Related Citations

Cancer survival: time to get moving? Data accumulate suggesting a link between physical activity and cancer survival.
Authors: Demark-Wahnefried W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2006-08-01 00:00:00.0; 24(22), p. 3517-8.
EPub date: 2006-08-01 00:00:00.0.
PMID: 16822842
Related Citations

A Simple, Flexible And Scalable Approach For Generating Tailored Questionnaires And Health Education Messages
Authors: Macri,J.M. , Downs,S.M. , Demark-Wahnefried,W. , Snyder,D.C. , Lobach,D.F. .
Source: Computers, Informatics, Nursing : Cin, 2005 Nov-Dec; 23(6), p. 316-21.
PMID: 16292046
Related Citations

Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer.
Authors: Demark-Wahnefried W. , Aziz N.M. , Rowland J.H. , Pinto B.M. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-08-20 00:00:00.0; 23(24), p. 5814-30.
EPub date: 2005-08-20 00:00:00.0.
PMID: 16043830
Related Citations

Supplement Use Among Men With Prostate Cancer
Authors: Wiygul J.B. , Evans B.R. , Peterson B.L. , Polascik T.J. , Walther P.J. , Robertson C.N. , Albala D.M. , Demark-Wahnefried W. .
Source: Urology, 2005 Jul; 66(1), p. 161-6.
PMID: 15992901
Related Citations

Physical function and associations with diet and exercise: Results of a cross-sectional survey among elders with breast or prostate cancer.
Authors: Demark-Wahnefried W. , Clipp E.C. , Morey M.C. , Pieper C.F. , Sloane R. , Snyder D.C. , Cohen H.J. .
Source: The International Journal Of Behavioral Nutrition And Physical Activity, 2004-10-29 00:00:00.0; 1(1), p. 16.
EPub date: 2004-10-29 00:00:00.0.
PMID: 15516261
Related Citations

Agreement Between A Brief Mailed Screener And An In-depth Telephone Survey: Observations From The Fresh Start Study
Authors: Snyder,D.C. , Sloane,R. , Lobach,D. , Lipkus,I. , Clipp,E. , Kraus,W.E. , Demark-Wahnefried,W. , Fresh Start study .
Source: Journal Of The American Dietetic Association, 2004 Oct; 104(10), p. 1593-6.
PMID: 15389420
Related Citations

Age-related Vulnerabilities Of Older Adults With Colon Adenomas: Evidence From Project Prevent
Authors: Clipp E.C. , Carver E.H. , Pollak K.I. , Puleo E. , Emmons K.M. , Onken J. , Farraye F.A. , McBride C.M. .
Source: Cancer, 2004-03-01 00:00:00.0; 100(5), p. 1085-94.
PMID: 14983506
Related Citations

Nutrition-related issues for the breast cancer survivor.
Authors: Demark-Wahnefried W. , Rock C.L. .
Source: Seminars In Oncology, 2003 Dec; 30(6), p. 789-98.
PMID: 14663779
Related Citations

Teachable moments for promoting smoking cessation: the context of cancer care and survivorship.
Authors: McBride C.M. , Ostroff J.S. .
Source: Cancer Control : Journal Of The Moffitt Cancer Center, 2003 Jul-Aug; 10(4), p. 325-33.
PMID: 12915811
Related Citations

Design of FRESH START: a randomized trial of exercise and diet among cancer survivors.
Authors: Demark-Wahnefried W. , Clipp E.C. , McBride C. , Lobach D.F. , Lipkus I. , Peterson B. , Clutter Snyder D. , Sloane R. , Arbanas J. , Kraus W.E. .
Source: Medicine And Science In Sports And Exercise, 2003 Mar; 35(3), p. 415-24.
PMID: 12618570
Related Citations

Can lifestyle modification increase survival in women diagnosed with breast cancer?
Authors: Rock C.L. , Demark-Wahnefried W. .
Source: The Journal Of Nutrition, 2002 Nov; 132(11 Suppl), p. 3504S-3507S.
PMID: 12421877
Related Citations

Nutrition and survival after the diagnosis of breast cancer: a review of the evidence.
Authors: Rock C.L. , Demark-Wahnefried W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2002-08-01 00:00:00.0; 20(15), p. 3302-16.
PMID: 12149305
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