Grant Number:	1R03CA108370-01A1 Interpret this number
Primary Investigator:	Holly, Elizabeth
Organization:	University Of California, San Francisco
Project Title:	Pancreas Cancer Analysis-Sf Bay Area Case-Control Study
Fiscal Year:	2004

DESCRIPTION (provided by applicant): Pancreas cancer analysis-SF Bay Area case-control study: Pancreatic cancer (PC) is the fourth most common cause of cancer death with the lowest 5-year survival rate (<5%) of all cancers. It has been designated as a high priority for NCI by the NCI-sponsored Progress Review Group and by Congress for FY 2004. The overall study goal is to continue data analyses for our large population-based case-control study of PC that was conducted between 1994 and 2002 (no proxy interviews, n=532 patients, 1701 controls). Using unconditional logistic regression, the specific aims are to: 1) perform data analyses of diet (energy-adjusted for nutrients), pancreatitis, diabetes, smoking, alcohol consumption, and hormone use in women in relation to PC; and 2) to evaluate the relationships between factors in Aim 1 and previously determined polymorphisms (GSTT1, GSTM1, CYPIA1, XRCC1). Detailed data were collected for this study about each factor of interest. Because the genes of interest play an important role in detoxification of carcinogenic polycyclic aromatic hydrocarbons and heterocyclic amines, estrogen metabolism and repair of DNA damaged by oxidative stress, it is plausible that the presence of polymorphisms in these genes will alter the association between pancreatic cancer and factors in Aim 1. Study strengths include: 1) already identified genetic polymorphisms; 2) extensive information on risk factors; 3) diet questionnaire developed by Dr. Walter Willett's group at Harvard University who have computed macro and micronutrients for this study; 4) large sample size allows combination of risk-factor and molecular data to determine possible interactions between genetic and environmental factors; 5) data were collected on food preparation methods and vitamins that may be relevant in PC etiology; 6) SEER registry provided complete case ascertainment; and 7) can evaluate potential confounding and effect modification. Data on modifiable risk factors may provide new and provocative results of 3ublic health importance for this devastating disease.




Pancreatic Cancer Risk is Modulated by Inflammatory Potential of Diet and ABO Genotype: A Consortia-based Evaluation and Replication Study.
Authors: Antwi S.O. , Bamlet W.R. , Pedersen K.S. , Chaffee K.G. , Risch H.A. , Shivappa N. , Steck S.E. , Anderson K.E. , Bracci P.M. , Polesel J. , et al. .
Source: Carcinogenesis, 2018-05-25 00:00:00.0; , .
EPub date: 2018-05-25 00:00:00.0.
PMID: 29800239
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Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Lujan-Barroso L. , Zhang W. , Olson S.H. , Gao Y.T. , Yu H. , Baghurst P.A. , Bracci P.M. , Bueno-de-Mesquita H.B. , Foretová L. , Gallinger S. , et al. .
Source: Pancreas, 2016 Nov; 45(10), p. 1401-1410.
PMID: 27088489
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Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis.
Authors: McWilliams R.R. , Maisonneuve P. , Bamlet W.R. , Petersen G.M. , Li D. , Risch H.A. , Yu H. , Fontham E.T. , Luckett B. , Bosetti C. , et al. .
Source: Pancreas, 2016 Feb; 45(2), p. 311-6.
PMID: 26646264
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Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Waterhouse M. , Risch H.A. , Bosetti C. , Anderson K.E. , Petersen G.M. , Bamlet W.R. , Cotterchio M. , Cleary S.P. , Ibiebele T.I. , La Vecchia C. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2015 Aug; 26(8), p. 1776-83.
PMID: 25977560
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Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium.
Authors: Bosetti C. , Rosato V. , Li D. , Silverman D. , Petersen G.M. , Bracci P.M. , Neale R.E. , Muscat J. , Anderson K. , Gallinger S. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2014 Oct; 25(10), p. 2065-72.
PMID: 25057164
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Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bosetti C. , Lucenteforte E. , Bracci P.M. , Negri E. , Neale R.E. , Risch H.A. , Olson S.H. , Gallinger S. , Miller A.B. , Bueno-de-Mesquita H.B. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2013 Nov; 24(11), p. 2903-10.
PMID: 23970016
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Allergies and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Olson S.H. , Hsu M. , Satagopan J.M. , Maisonneuve P. , Silverman D.T. , Lucenteforte E. , Anderson K.E. , Borgida A. , Bracci P.M. , Bueno-de-Mesquita H.B. , et al. .
Source: American Journal Of Epidemiology, 2013-09-01 00:00:00.0; 178(5), p. 691-700.
EPub date: 2013-09-01 00:00:00.0.
PMID: 23820785
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Dietary patterns and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.
Authors: Chan J.M. , Gong Z. , Holly E.A. , Bracci P.M. .
Source: Nutrition And Cancer, 2013; 65(1), p. 157-64.
PMID: 23368926
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An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein A.P. , Lindström S. , Mendelsohn J.B. , Steplowski E. , Arslan A.A. , Bueno-de-Mesquita H.B. , Fuchs C.S. , Gallinger S. , Gross M. , Helzlsouer K. , et al. .
Source: Plos One, 2013; 8(9), p. e72311.
PMID: 24058443
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Obesity and survival in population-based patients with pancreatic cancer in the San Francisco Bay Area.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2012 Dec; 23(12), p. 1929-37.
PMID: 23015286
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Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Authors: Bracci P.M. , Zhou M. , Young S. , Wiemels J. .
Source: Cancer, 2012-11-01 00:00:00.0; 118(21), p. 5384-94.
EPub date: 2012-11-01 00:00:00.0.
PMID: 22517435
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Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Duell E.J. , Lucenteforte E. , Olson S.H. , Bracci P.M. , Li D. , Risch H.A. , Silverman D.T. , Ji B.T. , Gallinger S. , Holly E.A. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Nov; 23(11), p. 2964-70.
PMID: 22767586
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Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).
Authors: Bosetti C. , Lucenteforte E. , Silverman D.T. , Petersen G. , Bracci P.M. , Ji B.T. , Negri E. , Li D. , Risch H.A. , Olson S.H. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Jul; 23(7), p. 1880-8.
PMID: 22104574
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Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D. , Duell E.J. , Yu K. , Risch H.A. , Olson S.H. , Kooperberg C. , Wolpin B.M. , Jiao L. , Dong X. , Wheeler B. , et al. .
Source: Carcinogenesis, 2012 Jul; 33(7), p. 1384-90.
PMID: 22523087
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Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Lucenteforte E. , La Vecchia C. , Silverman D. , Petersen G.M. , Bracci P.M. , Ji B.T. , Bosetti C. , Li D. , Gallinger S. , Miller A.B. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Feb; 23(2), p. 374-82.
PMID: 21536662
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Mitochondrial DNA sequence variation and risk of pancreatic cancer.
Authors: Lam E.T. , Bracci P.M. , Holly E.A. , Chu C. , Poon A. , Wan E. , White K. , Kwok P.Y. , Pawlikowska L. , Tranah G.J. .
Source: Cancer Research, 2012-02-01 00:00:00.0; 72(3), p. 686-95.
EPub date: 2012-02-01 00:00:00.0.
PMID: 22174369
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Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms.
Authors: Bracci P.M. .
Source: Molecular Carcinogenesis, 2012 Jan; 51(1), p. 53-63.
PMID: 22162231
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Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: American Journal Of Epidemiology, 2011-12-15 00:00:00.0; 174(12), p. 1373-81.
EPub date: 2011-12-15 00:00:00.0.
PMID: 22047824
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Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bertuccio P. , La Vecchia C. , Silverman D.T. , Petersen G.M. , Bracci P.M. , Negri E. , Li D. , Risch H.A. , Olson S.H. , Gallinger S. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2011 Jun; 22(6), p. 1420-6.
PMID: 21245160
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Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area.
Authors: Tranah G.J. , Holly E.A. , Wang F. , Bracci P.M. .
Source: Bmc Cancer, 2011-04-15 00:00:00.0; 11, p. 138.
EPub date: 2011-04-15 00:00:00.0.
PMID: 21496267
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Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies.
Authors: Li D. , Tang H. , Hassan M.M. , Holly E.A. , Bracci P.M. , Silverman D.T. .
Source: Cancer Causes & Control : Ccc, 2011 Feb; 22(2), p. 189-97.
PMID: 21104117
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Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area.
Authors: Zablotska L.B. , Gong Z. , Wang F. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2011 Jan; 22(1), p. 91-100.
PMID: 21072578
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Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.
Authors: Gong Z. , Holly E.A. , Wang F. , Chan J.M. , Bracci P.M. .
Source: International Journal Of Cancer, 2010-10-15 00:00:00.0; 127(8), p. 1893-904.
PMID: 20104522
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Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.
Authors: Gupta S. , Wang F. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2010 Jul; 21(7), p. 1047-59.
PMID: 20349126
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Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Duell E.J. , Holly E.A. , Kelsey K.T. , Bracci P.M. .
Source: International Journal Of Cancer, 2010-02-01 00:00:00.0; 126(3), p. 790-5.
PMID: 19642097
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Pancreatitis and pancreatic cancer in two large pooled case-control studies.
Authors: Bracci P.M. , Wang F. , Hassan M.M. , Gupta S. , Li D. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2009 Nov; 20(9), p. 1723-1731.
PMID: 19760029
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Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2009 Oct; 20(8), p. 1317-25.
PMID: 19415507
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Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study.
Authors: Chan J.M. , Wang F. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2009 Aug; 20(6), p. 835-46.
PMID: 19277880
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Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer.
Authors: Duell E.J. , Bracci P.M. , Moore J.H. , Burk R.D. , Kelsey K.T. , Holly E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Jun; 17(6), p. 1470-9.
PMID: 18559563
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Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California.
Authors: Chan J.M. , Wang F. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2007 Dec; 18(10), p. 1153-67.
PMID: 17805983
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Whole grains and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area, California.
Authors: Chan J.M. , Wang F. , Holly E.A. .
Source: American Journal Of Epidemiology, 2007-11-15 00:00:00.0; 166(10), p. 1174-85.
EPub date: 2007-11-15 00:00:00.0.
PMID: 17881383
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Pancreatic cancer and medical history in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Ko A.H. , Wang F. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2007 Oct; 18(8), p. 809-19.
PMID: 17632765
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Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Wang F. , Gupta S. , Holly E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Aug; 15(8), p. 1458-63.
PMID: 16896032
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Survival among patients with adenocarcinoma of the pancreas: a population-based study (United States).
Authors: Cress R.D. , Yin D. , Clarke L. , Bold R. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2006 May; 17(4), p. 403-9.
PMID: 16596292
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Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma.
Authors: Duell E.J. , Casella D.P. , Burk R.D. , Kelsey K.T. , Holly E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Apr; 15(4), p. 726-31.
PMID: 16614115
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Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay area.
Authors: Chan J.M. , Wang F. , Holly E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2005 Sep; 14(9), p. 2093-7.
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