Grant Number:	1R03CA101492-01A2 Interpret this number
Primary Investigator:	Smith, Sophia
Organization:	Univ Of North Carolina Chapel Hill
Project Title:	Quality of Life of Older Long-Term Lymphoma Survivors
Fiscal Year:	2004

DESCRIPTION (provided by applicant): While a large body of data exists regarding the short-term quality of life (QOL) following cancer diagnosis and treatment, little is known about the well-being of long-term survivors of adult cancer who are more than three years post-diagnosis; specifically, it is not known whether the impact on QOL that is experienced shortly after diagnosis and treatment persists throughout the life course. This small grant application addresses this gap in the literature by proposing a QOL assessment of these individuals. The specific aims are to: 1) identify and evaluate the well-being of 400 long-term survivors of adult non-Hodgkin's lymphoma (NHL) (aged 25-90+ years) as evidenced through reported QOL with particular emphasis on psychological distress (as defined by posttraumatic stress disorder; PTSD); and 2) examine the risk and protective factors associated with QOL and PTSD in adult survivors, with a focus on those that can be used for easy screening (e.g., having had multiple types of treatment) and are potentially modifiable (e.g., social support). These aims are consistent with the recent "Cancer Survivorship Research and Quality of Life Act of 2002", federal legislation introduced by the Lance Armstrong Foundation and a bipartisan Congressional group to expand research and quality of life programs for cancer survivors. The study consists of a mailed survey to approximately 900 long-term survivors of adult NHL of varying survival times (3 to 15 years since diagnosis). The survey will assess the QOL and needs of this population, and will incorporate the theoretical base underlying PTSD, a recently considered and promising framework to understand long-term survivors. The results of this study will determine if the QOL of long-term survivors of adult cancer is a cause for concern, and whether services might meet the needs of this growing segment of our population. In addition, findings could lead to the development of interventions that test strategies affecting the risk and protective factors associated with QOL.




Exploring the relationship between social support and mental health status among lymphoma survivors: Does patient-centered communication really matter? A brief report.
Authors: Caviness-Ashe N. , Zimmerman S. , Chappel-Aiken L. , Onsomu E.O. , Bryant A.L. , Smith S.K. .
Source: Journal Of Psychosocial Oncology, 2023; 41(2), p. 235-241.
EPub date: 2022-06-06 00:00:00.0.
PMID: 36815246
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Persistent fatigue among long-term non-Hodgkin lymphoma survivors.
Authors: LeBlanc M.R. , Zimmerman S. , LeBlanc T.W. , Bryant A.L. , Hudson K.E. , Smith S.K. .
Source: Leukemia & Lymphoma, 2021-10-06 00:00:00.0; , p. 1-9.
EPub date: 2021-10-06 00:00:00.0.
PMID: 34612771
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Quality of Life and Impact of Cancer: Differences in Rural and Nonrural Non-Hodgkin's Lymphoma Survivors.
Authors: Noonan D. , LeBlanc M. , Conley C. , Benecha H. , Leak-Bryant A. , Peter K. , Zimmerman S. , Mayer D. , Smith S. .
Source: The Journal Of Rural Health : Official Journal Of The American Rural Health Association And The National Rural Health Care Association, 2020-05-30 00:00:00.0; , .
EPub date: 2020-05-30 00:00:00.0.
PMID: 32472708
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Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors.
Authors: Sarker S.J. , Smith S.K. , Chowdhury K. , Ganz P.A. , Zimmerman S. , Gribben J. , Korszun A. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2017 03; 25(3), p. 739-748.
EPub date: 2016-11-08 00:00:00.0.
PMID: 27826873
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Quality of Life is Similar between Long-term Survivors of Indolent and Aggressive Non-Hodgkin Lymphoma.
Authors: Beaven A.W. , Samsa G. , Zimmerman S. , Smith S.K. .
Source: Cancer Investigation, 2016-07-02 00:00:00.0; 34(6), p. 279-85.
EPub date: 2016-07-05 00:00:00.0.
PMID: 27379565
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Are Lifestyle Behavioral Factors Associated With Health-related Quality Of Life In Long-term Survivors Of Non-hodgkin Lymphoma?
Authors: Spector D.J. , Noonan D. , Mayer D.K. , Benecha H. , Zimmerman S. , Smith S.K. .
Source: Cancer, 2015-09-15 00:00:00.0; 121(18), p. 3343-51.
PMID: 26036473
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An Exploratory Path Model Of The Relationships Between Positive And Negative Adaptation To Cancer On Quality Of Life Among Non-hodgkin Lymphoma Survivors
Authors: Bryant A.L. , Smith S.K. , Zimmer C. , Crandell J. , Jenerette C.M. , Bailey D.E. , Zimmerman S. , Mayer D.K. .
Source: Journal Of Psychosocial Oncology, 2015; 33(3), p. 310-31.
PMID: 25751114
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Is there a relationship between posttraumatic stress and growth after a lymphoma diagnosis?
Authors: Smith S.K. , Samsa G. , Ganz P.A. , Zimmerman S. .
Source: Psycho-oncology, 2014 Mar; 23(3), p. 315-21.
PMID: 24123368
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Assessing The Impact Of Cancer Among Dutch Non-hodgkin Lymphoma Survivors Compared With Their American Counterparts: A Cross-national Study
Authors: Oerlemans S. , Smith S.K. , Crespi C.M. , Zimmerman S. , van de Poll-Franse L.V. , Ganz P.A. .
Source: Psycho-oncology, 2013 Jun; 22(6), p. 1258-65.
PMID: 22833503
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Demographic And Disease Characteristics Associated With Non-hodgkin Lymphoma Survivors' Quality Of Life: Does Age Matter?
Authors: Leak A. , Smith S.K. , Crandell J. , Jenerette C. , Bailey D.E. , Zimmerman S. , Mayer D.K. .
Source: Oncology Nursing Forum, 2013 Mar; 40(2), p. 157-62.
PMID: 23448740
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A Procedure For Obtaining Impact Of Cancer Version 2 Scores Using Version 1 Responses
Authors: Crespi C.M. , Ganz P.A. , Petersen L. , Smith S.K. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2013 Feb; 22(1), p. 103-9.
PMID: 22302619
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Quality Of Life Among Long-term Survivors Of Non-hodgkin Lymphoma: A Follow-up Study
Authors: Smith S.K. , Mayer D.K. , Zimmerman S. , Williams C.S. , Benecha H. , Ganz P.A. , Edwards L.J. , Abernethy A.P. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-01-10 00:00:00.0; 31(2), p. 272-9.
PMID: 23213093
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Post-traumatic Stress Symptoms In Long-term Non-hodgkin's Lymphoma Survivors: Does Time Heal?
Authors: Smith S.K. , Zimmerman S. , Williams C.S. , Benecha H. , Abernethy A.P. , Mayer D.K. , Edwards L.J. , Ganz P.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-12-01 00:00:00.0; 29(34), p. 4526-33.
PMID: 21990412
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Quality Of Life Domains Among Non-hodgkin Lymphoma Survivors: An Integrative Literature Review
Authors: Leak A. , Mayer D.K. , Smith S. .
Source: Leukemia & Lymphoma, 2011 Jun; 52(6), p. 972-85.
PMID: 21534866
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An Exploratory Model Of The Relationships Between Cancer-related Trauma Outcomes On Quality Of Life In Non-hodgkin Lymphoma Survivors
Authors: Smith S.K. , Williams C.S. , Zimmer C.R. , Zimmerman S. .
Source: Journal Of Psychosocial Oncology, 2011; 29(1), p. 19-34.
PMID: 21240723
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The Impact Of Cancer And Quality Of Life For Post-treatment Non-hodgkin Lymphoma Survivors
Authors: Smith S.K. , Crespi C.M. , Petersen L. , Zimmerman S. , Ganz P.A. .
Source: Psycho-oncology, 2010 Dec; 19(12), p. 1259-67.
PMID: 20099255
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Measuring The Impact Of Cancer: A Comparison Of Non-hodgkin Lymphoma And Breast Cancer Survivors
Authors: Crespi C.M. , Smith S.K. , Petersen L. , Zimmerman S. , Ganz P.A. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2010 Mar; 4(1), p. 45-58.
PMID: 19967410
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Health Status And Quality Of Life Among Non-hodgkin Lymphoma Survivors
Authors: Smith S.K. , Zimmerman S. , Williams C.S. , Zebrack B.J. .
Source: Cancer, 2009-07-15 00:00:00.0; 115(14), p. 3312-23.
PMID: 19452546
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Post-traumatic Stress Outcomes In Non-hodgkin's Lymphoma Survivors
Authors: Smith S.K. , Zimmerman S. , Williams C.S. , Preisser J.S. , Clipp E.C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-02-20 00:00:00.0; 26(6), p. 934-41.
PMID: 18281667
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