Grant Number:	1R01CA102042-01A1 Interpret this number
Primary Investigator:	Cortessis, Victoria
Organization:	University Of Southern California
Project Title:	A Genetic Linkage Study of Testicular Cancer
Fiscal Year:	2004

DESCRIPTION (provided by applicant): Testicular cancer is a disease of very young men. Until recently, it was the leading cancer among men aged 15-29, and it is now second only to the AIDS-related neoplasm, Kaposi's sarcoma. Although survival has improved, young men still die from this neoplasm, and many survivors live most of their adult years with very undesirable consequences of their disease. The steady rise in incidence of this group of tumors needs to be explained, and is made all the more alarming by the possibility that the set of factors responsible for increasing incidence rates of testicular cancer may also be causing a poorly measured increase in the prevalence of various urogenital malformations in male infants. The two established risk factors are family history of testis cancer (relative risk of 10 for brothers) and a personal history of cryptorchidism or congenitally undescended testicles (relative risk 2.5-18). Familial risk, segregation analysis and preliminary linkage analyses suggest that major susceptibility genes predispose to testis cancer and possibly to the antecedent condition cryptorchidism. Linkage analysis of 180 families conducted by the International Testis Cancer Linkage Consortium (ITCLC) identified a region of Xq27 with significant evidence for linkage, with a pattern of occurrence suggesting that a gene in the region, TGCT1, confers risk of both testis cancer and cryptorchidism. We have identified and partially enrolled a population- based sample of 301 multiple case families informative for genetic linkage analysis of testis cancer and cryptorchidism. To search for major susceptibility genes, we propose to complete enrollment of a full set of 497 such families; contribute to the ongoing effort to clone TGCT; and conduct a two-stage genome scan among this series of 497 families in which we will collaborate with the ITCLC both to identify regions to be studied in the second, fine mapping stage, and to implement fine mapping efforts. The 497 enrolled families will be the largest set of informative families assembled, and this research should substantially accelerate discovery of genes predisposing to these conditions. Because this is a population-based study, the resource assembled in the proposed research will be appropriate for immediate gene characterization upon identification and cloning of major susceptibility genes for these conditions.




Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk.
Authors: Grasso C. , Popovic M. , Isaevska E. , Lazzarato F. , Fiano V. , Zugna D. , Pluta J. , Weathers B. , D'Andrea K. , Almstrup K. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-06-14 00:00:00.0; , .
EPub date: 2022-06-14 00:00:00.0.
PMID: 35700037
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Identification of 22 susceptibility loci associated with testicular germ cell tumors.
Authors: Pluta J. , Pyle L.C. , Nead K.T. , Wilf R. , Li M. , Mitra N. , Weathers B. , D'Andrea K. , Almstrup K. , Anson-Cartwright L. , et al. .
Source: Nature Communications, 2021-07-23 00:00:00.0; 12(1), p. 4487.
EPub date: 2021-07-23 00:00:00.0.
PMID: 34301922
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Incident testicular cancer in relation to using marijuana and smoking tobacco: A systematic review and meta-analysis of epidemiologic studies.
Authors: Song A. , Myung N.K. , Bogumil D. , Ihenacho U. , Burg M.L. , Cortessis V.K. .
Source: Urologic Oncology, 2020 Jul; 38(7), p. 642.e1-642.e9.
EPub date: 2020-05-12 00:00:00.0.
PMID: 32409200
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Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol.
Authors: Hom M. , Sriprasert I. , Ihenacho U. , Castelao J.E. , Siegmund K. , Bernstein L. , Cortessis V.K. .
Source: Jnci Cancer Spectrum, 2019 Sep; 3(3), p. pkz045.
EPub date: 2019-06-28 00:00:00.0.
PMID: 31555759
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Null Association Between Histology Of First And Second Primary Malignancies In Men With Bilateral Testicular Germ Cell Tumors
Authors: Thomas J.P. , Davis-Dao C. , Lewinger J.P. , Siegmund K.D. , Hamilton A.S. , Daneshmand S. , Skinner E.C. , Thomas D.C. , Cortessis V.K. .
Source: American Journal Of Epidemiology, 2013-10-15 00:00:00.0; 178(8), p. 1240-5.
PMID: 23928263
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Testicular Germ Cell Tumor Susceptibility Associated With The Uck2 Locus On Chromosome 1q23
Authors: Schumacher F.R. , Wang Z. , Skotheim R.I. , Koster R. , Chung C.C. , Hildebrandt M.A. , Kratz C.P. , Bakken A.C. , Bishop D.T. , Cook M.B. , et al. .
Source: Human Molecular Genetics, 2013-07-01 00:00:00.0; 22(13), p. 2748-53.
PMID: 23462292
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Meta-analysis Identifies Four New Loci Associated With Testicular Germ Cell Tumor
Authors: Chung C.C. , Kanetsky P.A. , Wang Z. , Hildebrandt M.A. , Koster R. , Skotheim R.I. , Kratz C.P. , Turnbull C. , Cortessis V.K. , Bakken A.C. , et al. .
Source: Nature Genetics, 2013 Jun; 45(6), p. 680-5.
PMID: 23666239
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Potential Impact Of Age At First Marijuana Use On The Development Of Nonseminomatous Testicular Germ Cell Tumors
Authors: Lacson J.C. , Bernstein L. , Cortessis V.K. .
Source: Cancer, 2013-03-15 00:00:00.0; 119(6), p. 1284-5.
PMID: 23233189
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Population-based Case-control Study Of Recreational Drug Use And Testis Cancer Risk Confirms An Association Between Marijuana Use And Nonseminoma Risk
Authors: Lacson J.C. , Carroll J.D. , Tuazon E. , Castelao E.J. , Bernstein L. , Cortessis V.K. .
Source: Cancer, 2012-11-01 00:00:00.0; 118(21), p. 5374-83.
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Cryptorchidism And Testicular Germ Cell Tumors: Comprehensive Meta-analysis Reveals That Association Between These Conditions Diminished Over Time And Is Modified By Clinical Characteristics
Authors: Banks K. , Tuazon E. , Berhane K. , Koh C.J. , De Filippo R.E. , Chang A. , Kim S.S. , Daneshmand S. , Davis-Dao C. , Lewinger J.P. , et al. .
Source: Frontiers In Endocrinology, 2012; 3, p. 182.
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Heterogenous Effect Of Androgen Receptor Cag Tract Length On Testicular Germ Cell Tumor Risk: Shorter Repeats Associated With Seminoma But Not Other Histologic Types
Authors: Davis-Dao C.A. , Siegmund K.D. , Vandenberg D.J. , Skinner E.C. , Coetzee G.A. , Thomas D.C. , Pike M.C. , Cortessis V.K. .
Source: Carcinogenesis, 2011 Aug; 32(8), p. 1238-43.
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Analysis Of The Dnd1 Gene In Men With Sporadic And Familial Testicular Germ Cell Tumors
Authors: Linger R. , Dudakia D. , Huddart R. , Tucker K. , Friedlander M. , Phillips K.A. , Hogg D. , Jewett M.A. , Lohynska R. , Daugaard G. , et al. .
Source: Genes, Chromosomes & Cancer, 2008 Mar; 47(3), p. 247-52.
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Male Infertility And Variation In Cag Repeat Length In The Androgen Receptor Gene: A Meta-analysis
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Source: The Journal Of Clinical Endocrinology And Metabolism, 2007 Nov; 92(11), p. 4319-26.
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Genome-wide Linkage Screen For Testicular Germ Cell Tumour Susceptibility Loci
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