Grant Number:	1R01CA098858-01A2 Interpret this number
Primary Investigator:	Malone, Kathleen
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Breast Cancer Prognostic Factors/Pathobiology
Fiscal Year:	2004

DESCRIPTION (provided by applicant): Breast cancer mortality is the second leading cause of cancer death in women. In spite of improvements in stage and advances in treatment, mortality from breast cancer continues to be substantial and there exists a paucity of insights regarding factors that influence disease progression and mortality. In particular, little is known about how patient and tumor characteristics relate to mortality in middle- and older aged women. We propose to conduct a population-based molecular-epidemiologic cohort study of factors that predict mortality in women diagnosed with invasive breast cancer at ages 45 through 79. The overall goal of the study is to evaluate patient and tumor characteristics for their relationship with the risk of breast cancer mortality. The proposed cohort consists of 2337 women diagnosed with a first invasive breast cancer at 45-79 years of age during the period 1993-1999, all of whom previously completed an extensive interview regarding exposures prior to diagnosis and will now be followed for mortality. Telephone interviews and medical record reviews will be used to collect information on exposures after diagnosis, disease recurrences, and treatment details. Tumor characteristics and markers will be assessed in relation to both mortality and patient factors as a basis for understanding determinants of prognosis. The aims of this study are: (1) to determine if patient characteristics and exposures (before and after diagnosis), including some which are potentially modifiable, are related to the risk of dying from breast cancer, (2) to determine if patient characteristics and exposures prior to diagnosis are associated with histopathologic features and tumor markers, (3) to assess the relationship of histopathologic factors and tumor markers, including both well characterized prognostic markers and less well-characterized cell cycle proteins, with the risk of dying from breast cancer, (4) to build tissue microarrays that will allow rapid assessment of future markers as they are identified, (5) to build a comprehensive resource for future ancillary studies. The investigation of tumor and patient characteristics in relation to mortality could provide etiologic and clinical insights regarding determinants of prognosis and help to generate clues regarding the biology of breast cancer progression.




CYP2D6-inhibiting medication use and inherited CYP2D6 variation in relation to adverse breast cancer outcomes after tamoxifen therapy.
Authors: Mayer S.E. , Weiss N.S. , Chubak J. , Doody D.R. , Carlson C.S. , Makar K.W. , Wurscher M.A. , Malone K.E. .
Source: Cancer Causes & Control : Ccc, 2019 Jan; 30(1), p. 103-112.
EPub date: 2018-12-12 00:00:00.0.
PMID: 30542984
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Bisphosphonate Use and Risk of Recurrence, Second Primary Breast Cancer, and Breast Cancer Mortality in a Population-Based Cohort of Breast Cancer Patients.
Authors: Korde L.A. , Doody D.R. , Hsu L. , Porter P.L. , Malone K.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018 Feb; 27(2), p. 165-173.
EPub date: 2017-12-18 00:00:00.0.
PMID: 29254937
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Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer.
Authors: Malone K.E. , Daling J.R. , Doody D.R. , O'Brien C. , Resler A. , Ostrander E.A. , Porter P.L. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2011 Dec; 20(12), p. 2560-71.
PMID: 21960690
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Age-related Variation In The Relationship Between Menopausal Hormone Therapy And The Risk Of Dying From Breast Cancer
Authors: Reding K.W. , Doody D.R. , McTiernan A. , Hsu L. , Davis S. , Daling J.R. , Porter P.L. , Malone K.E. .
Source: Breast Cancer Research And Treatment, 2011 Apr; 126(3), p. 749-61.
PMID: 20878463
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Missing Genetic Information In Case-control Family Data With General Semi-parametric Shared Frailty Model
Authors: Graber-Naidich A. , Gorfine M. , Malone K.E. , Hsu L. .
Source: Lifetime Data Analysis, 2011 Apr; 17(2), p. 175-94.
PMID: 21153764
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Gene expression array testing of FFPE archival breast tumor samples: an optimized protocol for WG-DASL sample preparation.
Authors: Ton C.C. , Vartanian N. , Chai X. , Lin M.G. , Yuan X. , Malone K.E. , Li C.I. , Dawson A. , Sather C. , Delrow J. , et al. .
Source: Breast Cancer Research And Treatment, 2011 Feb; 125(3), p. 879-83.
PMID: 20842525
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Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.
Authors: Reding K.W. , Li C.I. , Weiss N.S. , Chen C. , Carlson C.S. , Duggan D. , Thummel K.E. , Daling J.R. , Malone K.E. .
Source: American Journal Of Epidemiology, 2009-11-15 00:00:00.0; 170(10), p. 1241-9.
EPub date: 2009-11-15 00:00:00.0.
PMID: 19846565
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Risk factors for triple-negative breast cancer in women under the age of 45 years.
Authors: Dolle J.M. , Daling J.R. , White E. , Brinton L.A. , Doody D.R. , Porter P.L. , Malone K.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Apr; 18(4), p. 1157-66.
PMID: 19336554
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Breast Cancer Risk And Hormone Receptor Status In Older Women By Parity, Age Of First Birth, And Breastfeeding: A Case-control Study
Authors: Lord S.J. , Bernstein L. , Johnson K.A. , Malone K.E. , McDonald J.A. , Marchbanks P.A. , Simon M.S. , Strom B.L. , Press M.F. , Folger S.G. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Jul; 17(7), p. 1723-30.
PMID: 18628424
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