||3U01CA078284-05S1 Interpret this number
||Massachusetts General Hospital
||Coordinating Center for the Cancer Genetics Network
DESCRIPTION: (Applicant's Description)
We propose to be part of the Informatics and Information Technology Group
which provides informatics support for the NCI's Cancer Genetics Network, a
multicenter interdisciplinary cooperative that will provide the
infrastructure for research investigations of the genetic basis of human
cancer susceptibility, explore mechanisms for integrating this information
into medical practice, and identify means to address the public health
issues associated with human cancer genetics. The Informatics Network will
consist of three aspects:
1. Information support for a Registry of individuals of who are interested
in participating in investigations.
2. An Electronic Access to Genetic Services, educational materials, and
research protocols and
3. A Coordinating Center for Network Research Protocols.
Our proposal is to fulfill the third task, to provide the coordination and
implementation of network research protocols.
We will provide expert biostatistical support to help design studies. We
will coordinate protocol development, forms development, randomization and
the collection and storage of patient specimens. We assume the Informatics
Support Group for the Registry will provide a distributed data acquisition
system. Personnel at each site will be responsible for maintaining their
data using the system, and we will be responsible for maintaining their data
using the system, and we will have a database which is a replicate of those
at the sites. We will review the incoming data for completeness and
accuracy and generate reports that monitor accrual and data quality. In
addition we will periodically visit each site to audit a random sample of
the transmitted data and review how well the site is following study
procedures. We will generate interim statistical reports and generate a
final repot when studies are completed. We will develop new statistical and
data management methods, where necessary, to meet the goals of the network.
In addition we will organize network steering committee meetings and
establish a communications system for the network based on electronic mail,
the World Wide Web, telephone conference calls, and periodic mailings. We
will coordinate our activities with the other members of the Informatics
None. See parent grant details.