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Grant Details

Grant Number: 1R01CA098497-01A2 Interpret this number
Primary Investigator: Yuan, Jian-Min
Organization: University Of Southern California
Project Title: Dietary Factors in the Etiology of Colorectal Cancer
Fiscal Year: 2004


Abstract

DESCRIPTION (provided by applicant): Environmental and genetic factors play a role in the development of colorectal cancer. Heterocyclic aromatic amines (HAAs) in high-temperature cooked meat and cigarette smoke are potential human colorectal carcinogens. HAAs need to be metabolically activated before they exert their carcinogenic effects. Several enzymes that are encoded by cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2 (NAT2) and possibly NAT1 are involved in this HAA activating pathway. Tea polyphenols are found to inhibit the formation of HAA adducts in animals, and therefore, may protect against the development of colorectal cancer in humans. The proposed study will utilize two established residential cohorts of Chinese to study the effects of dietary and non-dietary HAAs and green tea consumption on the risk of colorectal cancer. The Shanghai Cohort Study enrolled 18,244 men aged 45-64 years in Shanghai, China, during 1986-89. The Singapore Chinese Health Study enrolled 27,959 men and 35,298 women aged 45-74 years during 1993-1998. At recruitment, all cohort members provided detailed dietary and medical histories. Blood and urine specimens were collected from all Shanghai cohort members and about 50% of Singapore cohort members. The cohorts have been followed for the occurrence of cancer and death through routine ascertainment of new cases from the population-based Shanghai and Singapore cancer registries and vital statistical databases, and for the Shanghai Cohort Study, annual visits to all known surviving cohort members. To date, the cohorts have accumulated more than 680,000 person-years of observation. Among cohort members, 8,255 subjects have died and 5,735 have developed cancer, including 793 colorectal cancers. During the next 5 years, study investigators will assess the roles of dietary HAAs and tea polyphenol in the development of colorectal cancer using validated biomarker assays. The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored.



Publications

The Association Between Dietary Omega-3 Fatty Acids And Cardiovascular Death: The Singapore Chinese Health Study
Authors: Koh A.S. , Pan A. , Wang R. , Odegaard A.O. , Pereira M.A. , Yuan J.M. , Koh W.P. .
Source: European Journal Of Preventive Cardiology, 2015 Mar; 22(3), p. 364-72.
PMID: 24343844
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Beverage Habits And Mortality In Chinese Adults
Authors: Odegaard A.O. , Koh W.P. , Yuan J.M. , Pereira M.A. .
Source: The Journal Of Nutrition, 2015 Mar; 145(3), p. 595-604.
PMID: 25733477
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Dietary Patterns And Mortality In A Chinese Population
Authors: Odegaard A.O. , Koh W.P. , Yuan J.M. , Gross M.D. , Pereira M.A. .
Source: The American Journal Of Clinical Nutrition, 2014 Sep; 100(3), p. 877-83.
PMID: 25057151
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Amount, Type, And Sources Of Carbohydrates In Relation To Ischemic Heart Disease Mortality In A Chinese Population: A Prospective Cohort Study
Authors: Rebello S.A. , Koh H. , Chen C. , Naidoo N. , Odegaard A.O. , Koh W.P. , Butler L.M. , Yuan J.M. , van Dam R.M. .
Source: The American Journal Of Clinical Nutrition, 2014 Jul; 100(1), p. 53-64.
PMID: 24787492
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Dietary Soy Intake Is Not Associated With Risk Of Cardiovascular Disease Mortality In Singapore Chinese Adults
Authors: Talaei M. , Koh W.P. , van Dam R.M. , Yuan J.M. , Pan A. .
Source: The Journal Of Nutrition, 2014 Jun; 144(6), p. 921-8.
PMID: 24699802
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Sleep Duration And Risk Of Stroke Mortality Among Chinese Adults: Singapore Chinese Health Study
Authors: Pan A. , De Silva D.A. , Yuan J.M. , Koh W.P. .
Source: Stroke; A Journal Of Cerebral Circulation, 2014 Jun; 45(6), p. 1620-5.
PMID: 24743442
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Body Mass Index And Risk Of Pancreatic Cancer In A Chinese Population
Authors: Untawale S. , Odegaard A.O. , Koh W.P. , Jin A.Z. , Yuan J.M. , Anderson K.E. .
Source: Plos One, 2014; 9(1), p. e85149.
PMID: 24454807
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Higher Parity Is Associated With An Increased Risk Of Type-ii Diabetes In Chinese Women: The Singapore Chinese Health Study
Authors: Mueller N.T. , Mueller N.J. , Odegaard A.O. , Gross M.D. , Koh W.P. , Yuan J.M. , Pereira M.A. .
Source: Bjog : An International Journal Of Obstetrics And Gynaecology, 2013 Nov; 120(12), p. 1483-9.
PMID: 23786390
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Combined Lifestyle Factors And Risk Of Incident Colorectal Cancer In A Chinese Population
Authors: Odegaard A.O. , Koh W.P. , Yuan J.M. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2013 Apr; 6(4), p. 360-7.
PMID: 23275007
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Asthma And The Risk Of Type 2 Diabetes In The Singapore Chinese Health Study
Authors: Mueller N.T. , Koh W.P. , Odegaard A.O. , Gross M.D. , Yuan J.M. , Pereira M.A. .
Source: Diabetes Research And Clinical Practice, 2013 Feb; 99(2), p. 192-9.
PMID: 23260853
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Soy Intake And Risk Of Type 2 Diabetes In Chinese Singaporeans [corrected]
Authors: Mueller N.T. , Odegaard A.O. , Gross M.D. , Koh W.P. , Yu M.C. , Yuan J.M. , Pereira M.A. .
Source: European Journal Of Nutrition, 2012 Dec; 51(8), p. 1033-40.
PMID: 22094581
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Age At Menarche And Cardiovascular Disease Mortality In Singaporean Chinese Women: The Singapore Chinese Health Study
Authors: Mueller N.T. , Odegaard A.O. , Gross M.D. , Koh W.P. , Yuan J.M. , Pereira M.A. .
Source: Annals Of Epidemiology, 2012 Oct; 22(10), p. 717-22.
PMID: 22939833
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Mitochondrial Copy Number Is Associated With Colorectal Cancer Risk
Authors: Thyagarajan B. , Wang R. , Barcelo H. , Koh W.P. , Yuan J.M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Sep; 21(9), p. 1574-81.
PMID: 22787200
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Western-style Fast Food Intake And Cardiometabolic Risk In An Eastern Country
Authors: Odegaard,A.O. , Koh,W.P. , Yuan,J.M. , Gross,M.D. , Pereira,M.A. .
Source: Circulation, 2012-07-10 00:00:00.0; 126(2), p. 182-8.
PMID: 22753304
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Mortality due to coronary heart disease and kidney disease among middle-aged and elderly men and women with gout in the Singapore Chinese Health Study.
Authors: Teng G.G. , Ang L.W. , Saag K.G. , Yu M.C. , Yuan J.M. , Koh W.P. .
Source: Annals Of The Rheumatic Diseases, 2012 Jun; 71(6), p. 924-8.
PMID: 22172492
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Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults.
Authors: Naidoo N. , van Dam R.M. , Koh W.P. , Chen C. , Lee Y.P. , Yuan J.M. , Ong C.N. .
Source: The Journal Of Nutrition, 2012 Jun; 142(6), p. 1046-52.
PMID: 22513986
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Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese.
Authors: Thean L.F. , Li H.H. , Teo Y.Y. , Koh W.P. , Yuan J.M. , Teoh M.L. , Koh P.K. , Tang C.L. , Cheah P.Y. .
Source: Plos One, 2012; 7(8), p. e42407.
PMID: 22879968
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Combined Lifestyle Factors And Cardiovascular Disease Mortality In Chinese Men And Women: The Singapore Chinese Health Study
Authors: Odegaard A.O. , Koh W.P. , Gross M.D. , Yuan J.M. , Pereira M.A. .
Source: Circulation, 2011-12-20 00:00:00.0; 124(25), p. 2847-54.
PMID: 22104554
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Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study.
Authors: Koh W.P. , Robien K. , Wang R. , Govindarajan S. , Yuan J.M. , Yu M.C. .
Source: British Journal Of Cancer, 2011-10-25 00:00:00.0; 105(9), p. 1430-5.
EPub date: 2011-10-25 00:00:00.0.
PMID: 21915129
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Body Mass Index And Risk Of Colorectal Cancer In Chinese Singaporeans: The Singapore Chinese Health Study
Authors: Odegaard A.O. , Koh W.P. , Yu M.C. , Yuan J.M. .
Source: Cancer, 2011-08-15 00:00:00.0; 117(16), p. 3841-9.
PMID: 21815135
Related Citations

Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.
Authors: Koh W.P. , Yuan J.M. , Wang R. , Govindarajan S. , Oppenheimer R. , Zhang Z.Q. , Yu M.C. , Ingles S.A. .
Source: Cancer, 2011-08-01 00:00:00.0; 117(15), p. 3383-92.
EPub date: 2011-08-01 00:00:00.0.
PMID: 21319151
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Omega-3 Fatty Acids And Incident Type 2 Diabetes: The Singapore Chinese Health Study
Authors: Brostow D.P. , Odegaard A.O. , Koh W.P. , Duval S. , Gross M.D. , Yuan J.M. , Pereira M.A. .
Source: The American Journal Of Clinical Nutrition, 2011 Aug; 94(2), p. 520-6.
PMID: 21593505
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DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.
Authors: Nauwelaers G. , Bessette E.E. , Gu D. , Tang Y. , Rageul J. , Fessard V. , Yuan J.M. , Yu M.C. , Langouët S. , Turesky R.J. .
Source: Chemical Research In Toxicology, 2011-06-20 00:00:00.0; 24(6), p. 913-25.
EPub date: 2011-06-20 00:00:00.0.
PMID: 21456541
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Dietary Patterns And Incident Type 2 Diabetes In Chinese Men And Women: The Singapore Chinese Health Study
Authors: Odegaard A.O. , Koh W.P. , Butler L.M. , Duval S. , Gross M.D. , Yu M.C. , Yuan J.M. , Pereira M.A. .
Source: Diabetes Care, 2011 Apr; 34(4), p. 880-5.
PMID: 21330641
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Coffee intake and risk of colorectal cancer among Chinese in Singapore: the Singapore Chinese Health Study.
Authors: Peterson S. , Yuan J.M. , Koh W.P. , Sun C.L. , Wang R. , Turesky R.J. , Yu M.C. .
Source: Nutrition And Cancer, 2010; 62(1), p. 21-9.
PMID: 20043256
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Genetic Association Between The Comt Genotype And Urinary Levels Of Tea Polyphenols And Their Metabolites Among Daily Green Tea Drinkers
Authors: Inoue-Choi M. , Yuan J.M. , Yang C.S. , Van Den Berg D.J. , Lee M.J. , Gao Y.T. , Yu M.C. .
Source: International Journal Of Molecular Epidemiology And Genetics, 2010; 1(2), p. 114-123.
PMID: 21191472
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Isothiocyanates, Glutathione S-transferase M1 And T1 Polymorphisms And Gastric Cancer Risk: A Prospective Study Of Men In Shanghai, China
Authors: Moy K.A. , Yuan J.M. , Chung F.L. , Wang X.L. , Van Den Berg D. , Wang R. , Gao Y.T. , Yu M.C. .
Source: International Journal Of Cancer, 2009-12-01 00:00:00.0; 125(11), p. 2652-9.
PMID: 19610060
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Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.
Authors: Ognjanovic S. , Yuan J.M. , Chaptman A.K. , Fan Y. , Yu M.C. .
Source: Carcinogenesis, 2009 May; 30(5), p. 758-62.
PMID: 19126646
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Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.
Authors: Stern M.C. , Butler L.M. , Corral R. , Joshi A.D. , Yuan J.M. , Koh W.P. , Yu M.C. .
Source: Journal Of Nutrigenetics And Nutrigenomics, 2009; 2(6), p. 273-9.
PMID: 20559012
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Sleep duration and coronary heart disease mortality among Chinese adults in Singapore: a population-based cohort study.
Authors: Shankar A. , Koh W.P. , Yuan J.M. , Lee H.P. , Yu M.C. .
Source: American Journal Of Epidemiology, 2008-12-15 00:00:00.0; 168(12), p. 1367-73.
EPub date: 2008-12-15 00:00:00.0.
PMID: 18952563
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Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach.
Authors: Wong H.L. , Koh W.P. , Probst-Hensch N.M. , Van den Berg D. , Yu M.C. , Ingles S.A. .
Source: Gut, 2008 Aug; 57(8), p. 1090-6.
PMID: 18308828
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Urinary Total Isothiocyanates And Colorectal Cancer: A Prospective Study Of Men In Shanghai, China
Authors: Moy K.A. , Yuan J.M. , Chung F.L. , Van Den Berg D. , Wang R. , Gao Y.T. , Yu M.C. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Jun; 17(6), p. 1354-9.
PMID: 18559550
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Alcohol, Cofactors And The Genetics Of Hepatocellular Carcinoma
Authors: Yu,M.C. , Yuan,J.M. , Lu,S.C. .
Source: Journal Of Gastroenterology And Hepatology, 2008 Mar; 23 Suppl 1, p. S92-7.
PMID: 18336674
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Alcohol, Tobacco, And Diet In Relation To Esophageal Cancer: The Shanghai Cohort Study
Authors: Fan Y. , Yuan J.M. , Wang R. , Gao Y.T. , Yu M.C. .
Source: Nutrition And Cancer, 2008; 60(3), p. 354-63.
PMID: 18444169
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DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
Authors: Stern M.C. , Conti D.V. , Siegmund K.D. , Corral R. , Yuan J.M. , Koh W.P. , Yu M.C. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Nov; 16(11), p. 2363-72.
PMID: 18006925
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Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study.
Authors: Sun C.L. , Yuan J.M. , Koh W.P. , Lee H.P. , Yu M.C. .
Source: Carcinogenesis, 2007 Oct; 28(10), p. 2143-8.
PMID: 17724377
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Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Authors: Yuan J.M. , Lu S.C. , Van Den Berg D. , Govindarajan S. , Zhang Z.Q. , Mato J.M. , Yu M.C. .
Source: Hepatology (baltimore, Md.), 2007 Sep; 46(3), p. 749-58.
PMID: 17659576
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Tobacco Smoking And Urinary Levels Of 2-amino-9h-pyrido[2,3-b]indole In Men Of Shanghai, China
Authors: Turesky R.J. , Yuan J.M. , Wang R. , Peterson S. , Yu M.C. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Aug; 16(8), p. 1554-60.
PMID: 17684128
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Urinary Biomarkers Of Tea Polyphenols And Risk Of Colorectal Cancer In The Shanghai Cohort Study
Authors: Yuan,J.M. , Gao,Y.T. , Yang,C.S. , Yu,M.C. .
Source: International Journal Of Cancer. Journal International Du Cancer, 2007-03-15 00:00:00.0; 120(6), p. 1344-50.
PMID: 17149697
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Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study.
Authors: Tsong W.H. , Koh W.P. , Yuan J.M. , Wang R. , Sun C.L. , Yu M.C. .
Source: British Journal Of Cancer, 2007-03-12 00:00:00.0; 96(5), p. 821-7.
EPub date: 2007-03-12 00:00:00.0.
PMID: 17311023
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Beta-cryptoxanthin And Lung Cancer In Shanghai, China--an Examination Of Potential Confounding With Cigarette Smoking Using Urinary Cotinine As A Biomarker For True Tobacco Exposure
Authors: Stram D.O. , Yuan J.M. , Chan K.K. , Gao Y.T. , Ross R.K. , Yu M.C. .
Source: Nutrition And Cancer, 2007; 57(2), p. 123-9.
PMID: 17571944
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Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore.
Authors: Koh W.P. , Yuan J.M. , Van Den Berg D. , Ingles S.A. , Yu M.C. .
Source: Carcinogenesis, 2006 Sep; 27(9), p. 1797-802.
PMID: 16513680
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Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma.
Authors: Yuan J.M. , Gao Y.T. , Ong C.N. , Ross R.K. , Yu M.C. .
Source: Journal Of The National Cancer Institute, 2006-04-05 00:00:00.0; 98(7), p. 482-90.
PMID: 16595784
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Diabetes mellitus and risk of colorectal cancer in the Singapore Chinese Health Study.
Authors: Seow A. , Yuan J.M. , Koh W.P. , Lee H.P. , Yu M.C. .
Source: Journal Of The National Cancer Institute, 2006-01-18 00:00:00.0; 98(2), p. 135-8.
PMID: 16418516
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