Grant Number:	1R01CA101849-01A1 Interpret this number
Primary Investigator:	Phillips, Katheryn
Organization:	University Of California, San Francisco
Project Title:	Screening for Colorectal Cancer: an Integrated Approach
Fiscal Year:	2004

DESCRIPTION (provided by applicant): Colorectal cancer screening procedures are highly underused. We propose an integrated, interdisciplinary, and multi-level approach to understanding and increasing the use of colorectal cancer screening. We will conduct a study with a series of integrated aims to examine who gets screening and what tests they get, why people don't get screening, and what the most cost-effective methods of screening are. The results will be useful in developing new approaches, interventions, and policies to increase screening and in developing new screening methods. Specific aims are to: (1) Examine the Individual and Area-Level Predictors of Colorectal Cancer Screening Utilization We will use nationally representative data from the National Health Interview Survey and Medical Expenditure Panel Survey that we will link to provider/plan and area-level data. We will focus particularly on the impact of (a) specific health plan characteristics and (b) area-level characteristics. (2) Analyze Patient Preferences for Colorectal Cancer Screening Methods We will use a quantitative and economic-theory based approach as well as a qualitative approach to measuring preferences. We will focus particularly on (a) how much patients value the various attributes of current and new screening tests; (b) how utilization of screening methods is associated with preferences for those methods; and (c) how differences across and within health care insurance systems influence perceptions of screening methods, cost, and willingness-to-pay. (3) Conduct Cost-Effectiveness and Cost-Benefit Analyses of Colorectal Cancer Screening. We will adapt a previously developed, validated cancer screening model to examine the cost-effectiveness and net benefits of colorectal cancer screening methods. We will focus particularly on the influence of (a) utilization rates (Aim #1) and (b) patient preferences for current and new screening methods (Aim #2).




Health technology assessment and private payers's coverage of personalized medicine.
Authors: Trosman J.R. , Van Bebber S.L. , Phillips K.A. .
Source: The American Journal Of Managed Care, 2011 May; 17 Suppl 5 Developing, p. SP53-60.
PMID: 21711078
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Do economic evaluations of targeted therapy provide support for decision makers?
Authors: Ferrusi I.L. , Leighl N.B. , Kulin N.A. , Marshall D.A. .
Source: The American Journal Of Managed Care, 2011 May; 17 Suppl 5 Developing, p. SP61-70.
PMID: 21711079
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Health technology assessment and private payers' coverage of personalized medicine.
Authors: Trosman J.R. , Van Bebber S.L. , Phillips K.A. .
Source: Journal Of Oncology Practice / American Society Of Clinical Oncology, 2011 May; 7(3 Suppl), p. 18s-24s.
PMID: 21886515
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Do economic evaluations of targeted therapy provide support for decision makers?
Authors: Ferrusi I.L. , Leighl N.B. , Kulin N.A. , Marshall D.A. .
Source: Journal Of Oncology Practice / American Society Of Clinical Oncology, 2011 May; 7(3 Suppl), p. 36s-45s.
PMID: 21886518
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Cost-effectiveness of colorectal cancer screening in high-risk Spanish patients: use of a validated model to inform public policy.
Authors: Ladabaum U. , Ferrandez A. , Lanas A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Nov; 19(11), p. 2765-76.
PMID: 20810603
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Coverage policy development for personalized medicine: private payer perspectives on developing policy for the 21-gene assay.
Authors: Trosman J.R. , Van Bebber S.L. , Phillips K.A. .
Source: Journal Of Oncology Practice / American Society Of Clinical Oncology, 2010 Sep; 6(5), p. 238-42.
PMID: 21197187
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Effects of simplifying choice tasks on estimates of taste heterogeneity in stated-choice surveys.
Authors: Johnson F.R. , Ozdemir S. , Phillips K.A. .
Source: Social Science & Medicine (1982), 2010 Jan; 70(2), p. 183-90.
PMID: 19880234
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How do physician assessments of patient preferences for colorectal cancer screening tests differ from actual preferences? A comparison in Canada and the United States using a stated-choice survey.
Authors: Marshall D.A. , Johnson F.R. , Kulin N.A. , Ozdemir S. , Walsh J.M. , Marshall J.K. , Van Bebber S. , Phillips K.A. .
Source: Health Economics, 2009 Dec; 18(12), p. 1420-39.
PMID: 19191268
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Medicare formulary coverage for top-selling biologics.
Authors: Liang S.Y. , Haas J.S. , Phillips K.A. .
Source: Nature Biotechnology, 2009 Dec; 27(12), p. 1082-4.
PMID: 20010576
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Clinical practice patterns and cost effectiveness of human epidermal growth receptor 2 testing strategies in breast cancer patients.
Authors: Phillips K.A. , Marshall D.A. , Haas J.S. , Elkin E.B. , Liang S.Y. , Hassett M.J. , Ferrusi I. , Brock J.E. , Van Bebber S.L. .
Source: Cancer, 2009-11-15 00:00:00.0; 115(22), p. 5166-74.
PMID: 19753618
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Acculturation and colorectal cancer screening among older Latino adults: differential associations by national origin.
Authors: Afable-Munsuz A. , Liang S.Y. , Ponce N.A. , Walsh J.M. .
Source: Journal Of General Internal Medicine, 2009 Aug; 24(8), p. 963-70.
PMID: 19472016
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Can calcium chemoprevention of adenoma recurrence substitute or serve as an adjunct for colonoscopic surveillance?
Authors: Shaukat A. , Parekh M. , Lipscomb J. , Ladabaum U. .
Source: International Journal Of Technology Assessment In Health Care, 2009 Apr; 25(2), p. 222-31.
PMID: 19331713
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Looking back at 10 years of trastuzumab therapy: what is the role of HER2 testing? A systematic review of health economic analyses.
Authors: Ferrusi I.L. , Marshall D.A. , Kulin N.A. , Leighl N.B. , Phillips K.A. .
Source: Personalized Medicine, 2009 Mar; 6(2), p. 193-215.
PMID: 20668661
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Closing the evidence gap in the use of emerging testing technologies in clinical practice.
Authors: Phillips K.A. .
Source: Jama : The Journal Of The American Medical Association, 2008-12-03 00:00:00.0; 300(21), p. 2542-4.
PMID: 19050197
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Challenges to the translation of genomic information into clinical practice and health policy: Utilization, preferences and economic value.
Authors: Phillips K.A. , Liang S.Y. , Van Bebber S. , Canpers Research Group .
Source: Current Opinion In Molecular Therapeutics, 2008 Jun; 10(3), p. 260-6.
PMID: 18535933
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As tests evolve and costs of cancer care rise: reappraising stool-based screening for colorectal neoplasia.
Authors: Parekh M. , Fendrick A.M. , Ladabaum U. .
Source: Alimentary Pharmacology & Therapeutics, 2008 Apr; 27(8), p. 697-712.
PMID: 18248653
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Colorectal cancer screening differential costs for younger versus older Americans.
Authors: Ladabaum U. , Phillips K.A. .
Source: American Journal Of Preventive Medicine, 2006 May; 30(5), p. 378-84.
PMID: 16627125
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Projected national impact of colorectal cancer screening on clinical and economic outcomes and health services demand.
Authors: Ladabaum U. , Song K. .
Source: Gastroenterology, 2005 Oct; 129(4), p. 1151-62.
PMID: 16230069
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