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Grant Details

Grant Number: 5R21CA098794-02 Interpret this number
Primary Investigator: Wenzel, Lari
Organization: University Of California-Irvine
Project Title: Psychoneuroimmunology and Cervical Cancer
Fiscal Year: 2004


Abstract

DESCRIPTION (provided by applicant): Cervical cancer patients experience significant illness-specific stress that includes physical, emotional and sexual problems years after diagnosis. However, there is a paucity of literature on interventions designed to minimize the stressors and disruptions associated with cervical cancer. An intervention that reduces stress and enhances adaptive coping skills could decrease the burden caused by cervical cancer by improving QoL and health outcomes. For example, recent descriptions of neurologic and neuroendocrine interactions with the immune system provide a rational basis for the mind-body bridge between the psychosocial (QoL) and physiologic (anti-tumor) clinical effects. An underpinning for modulations of the immunologic environment could affect acute and memory anti-tumor immune responses. Therefore, our long-term objective is to test a psychosocial telephone counseling (PTC) intervention, which could positively impact the quality of life of cervical cancer patients, with an associated modulation of the psychoneuroimmunologic axis resulting in an accentuated Th1 and anti-tumor memory T cell immune response. The proposed exploratory study will permit us to examine the methodologic feasibility and benefits associated with a novel counseling intervention, and test the hypothesis that intervention-induced longitudinal modulations in quality of life measures will be associated with longitudinal modulations in neuroendocrine and immune parameters. SPECIFIC AIMS: 1) Determine the methodologic feasibility and QoL benefits of a psychosocial telephone counseling (PTC) intervention for cervical cancer patients, 2) evaluate longitudinal immune and neuroendocrine parameters in cervical cancer patients +/- PTC, and 3) evaluate the correlation between PTC associated modulation of QoL measures and biologic parameters (neuroendocrine and immune). To achieve these aims, we will randomize cervical cancer patients to telephone counseling (N=25) or usual care (N=25), and collect neuroimmune and quality of life data on all patients at baseline (3-9 months post diagnosis), and four months post enrollment. All patients will be identified through the Cancer Surveillance Program of Orange, Imperial and San Diego Counties (CSPOC/SanDIOC).



Publications

Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention.
Authors: Biegler K.A. , Anderson A.K. , Wenzel L.B. , Osann K. , Nelson E.L. .
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Oct; 5(10), p. 1173-82.
EPub date: 2012-07-24.
PMID: 22827974
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Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial.
Authors: Osann K. , Wenzel L. , Dogan A. , Hsieh S. , Chase D.M. , Sappington S. , Monk B.J. , Nelson E.L. .
Source: Gynecologic oncology, 2011-06-01; 121(3), p. 558-64.
EPub date: 2011-03-12.
PMID: 21402400
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Stress, immunity, and cervical cancer: biobehavioral outcomes of a randomized clinical trial [corrected].
Authors: Nelson E.L. , Wenzel L.B. , Osann K. , Dogan-Ates A. , Chantana N. , Reina-Patton A. , Laust A.K. , Nishimoto K.P. , Chicz-DeMet A. , du Pont N. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2008-04-01; 14(7), p. 2111-8.
PMID: 18381952
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