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Grant Details

Grant Number: 5P50DA013332-05 Interpret this number
Primary Investigator: Leslie, Frances
Organization: University Of California-Irvine
Project Title: Center on Tobacco Use Susceptibility and Intervention
Fiscal Year: 2003


Abstract

The proposed TTURC reflects several unique strengths. First, the Center brings together five eminent project leaders with diverse expertise in the field of tobacco research (Drs. Leslie, Janner, PotInn, Pechman, and Tengs). Each of these scholars has achieved distinction in their respective disciplines of pharmacology, neuroscience, human development, social and health psychology, community health promotion, and health policy analysis. These scientists will work collaboratively to identify key predictor of nicotine dependency in animals and tobacco susceptibility and use in humans. A major goal of the collaboration is to establish a shared conceptual model of tobacco susceptibility and use that can be used to integrate experimental findings across multiple levels of analysis (i.e., biological, behavioral, developmental, interpersonal, and epidemiological/community levels), and to translate these findings into intervention strategics (i.e., pharmacological, behavioral, social marketing, and health policy strategies) that will be evaluated for their public health efficacy and cost effectiveness. A second major strength of the TTURC is its incorporation of four highly interactive cores, each strategically designed to promote successful transdisciplinary collaboration in the field of tobacco susceptibility, use, and intervention. The Transdisciplinary Core will implement structured activities to foster scientific collaboration (e.g., team workshops, retreats), and also conduct a systematic self study of collaboration among members of the TIURC over a five-year period, based on a taxonomic model of the antecedents, intermediate processes, and scientific outcomes of transdisciplinary research. The Informatics Core (led by Dr. Shankle) will develop several valuable informational resources, including a shared relational data base to facilitate the integration of data sets and research findings across multiple TTURC projects and an interactive TTURC web site), all designed to promote more effective transdisciplinary collaboration The Career Development Core (co-directed by Drs. Whitely and Fallon) integrates the theoretical and methodological perspectives emphasized in the research projects and the Transdisciplinary, and Informatics Cores. It will afford a wide array of transdisciplinary training opportunities that are directly responsive to the training priorities outlined in the Report of the Working Groups of the Youth Tobacco Prevention Initiative (1998). Finally, the Administrative Core will be co-directed by Drs. Leslie and Stokols, both of whom have extensive university administrative experience and are active in the fields of pharmacology, neuro5cience, community health promotion, social ecology, and transdisciplinary theory development. The CO-PIs will oversee interactive activities of the TTURC with the goal of promoting effective transdisciplinary collaboration among the project team members research trainees and staff and members of the External and Internal Advisory Boards.



Publications

I (should) need a cigarette: adolescent social anxiety and cigarette smoking.
Authors: Henry S.L. , Jamner L.D. , Whalen C.K. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2012 Jun; 43(3), p. 383-93.
PMID: 22270264
Related Citations

Bummed out now, feeling sick later: weekday versus weekend negative affect and physical symptom reports in high school freshmen.
Authors: Butler J.M. , Whalen C.K. , Jamner L.D. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2009 May; 44(5), p. 452-7.
PMID: 19380092
Related Citations

Nicotine-induced brain metabolism associated with anger provocation.
Authors: Gehricke J.G. , Potkin S.G. , Leslie F.M. , Loughlin S.E. , Whalen C.K. , Jamner L.D. , Mbogori J. , Fallon J.H. .
Source: Behavioral And Brain Functions : Bbf, 2009-04-24 00:00:00.0; 5, p. 19.
EPub date: 2009-04-24 00:00:00.0.
PMID: 19393039
Related Citations

Enhancing transdisciplinary research through collaborative leadership.
Authors: Gray B. .
Source: American Journal Of Preventive Medicine, 2008 Aug; 35(2 Suppl), p. S124-32.
PMID: 18619392
Related Citations

Raising taxes to reduce smoking prevalence in the US: a simulation of the anticipated health and economic impacts.
Authors: Ahmad S. , Franz G.A. .
Source: Public Health, 2008 Jan; 122(1), p. 3-10.
PMID: 17610918
Related Citations

Smoking to self-medicate attentional and emotional dysfunctions.
Authors: Gehricke J.G. , Loughlin S.E. , Whalen C.K. , Potkin S.G. , Fallon J.H. , Jamner L.D. , Belluzzi J.D. , Leslie F.M. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2007 Nov; 9 Suppl 4, p. S523-36.
PMID: 18067030
Related Citations

Limiting youth access to tobacco: comparing the long-term health impacts of increasing cigarette excise taxes and raising the legal smoking age to 21 in the United States.
Authors: Ahmad S. , Billimek J. .
Source: Health Policy (amsterdam, Netherlands), 2007 Mar; 80(3), p. 378-91.
PMID: 16698112
Related Citations

Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats.
Authors: Park M.K. , Belluzzi J.D. , Han S.H. , Cao J. , Leslie F.M. .
Source: Pharmacology, Biochemistry, And Behavior, 2007 Feb; 86(2), p. 297-305.
PMID: 17141304
Related Citations

Toward a science of transdisciplinary action research.
Authors: Stokols D. .
Source: American Journal Of Community Psychology, 2006 Sep; 38(1-2), p. 63-77.
PMID: 16791514
Related Citations

Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.
Authors: Villégier A.S. , Salomon L. , Granon S. , Changeux J.P. , Belluzzi J.D. , Leslie F.M. , Tassin J.P. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2006 Aug; 31(8), p. 1704-13.
PMID: 16395299
Related Citations

Nicotine modulation of stress-related peptide neurons.
Authors: Loughlin S.E. , Islas M.I. , Cheng M.Y. , Lee A.G. , Villegier A.S. , Leslie F.M. .
Source: The Journal Of Comparative Neurology, 2006-08-01 00:00:00.0; 497(4), p. 575-88.
PMID: 16739166
Related Citations

The reinforcing effects of nicotine and stimulant medication in the everyday lives of adult smokers with ADHD: A preliminary examination.
Authors: Gehricke J.G. , Whalen C.K. , Jamner L.D. , Wigal T.L. , Steinhoff K. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2006 Feb; 8(1), p. 37-47.
PMID: 16497598
Related Citations

Closing the youth access gap: the projected health benefits and cost savings of a national policy to raise the legal smoking age to 21 in the United States.
Authors: Ahmad S. .
Source: Health Policy (amsterdam, Netherlands), 2005 Dec; 75(1), p. 74-84.
PMID: 16298230
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Estimating the health impacts of tobacco harm reduction policies: a simulation modeling approach.
Authors: Ahmad S. , Billimek J. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2005 Aug; 25(4), p. 801-12.
PMID: 16268930
Related Citations

Increasing excise taxes on cigarettes in California: a dynamic simulation of health and economic impacts.
Authors: Ahmad S. .
Source: Preventive Medicine, 2005 Jul; 41(1), p. 276-83.
PMID: 15917022
Related Citations

The cost-effectiveness of raising the legal smoking age in California.
Authors: Ahmad S. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2005 May-Jun; 25(3), p. 330-40.
PMID: 15951460
Related Citations

Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
Authors: Belluzzi J.D. , Wang R. , Leslie F.M. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2005 Apr; 30(4), p. 705-12.
PMID: 15496937
Related Citations

Gender: a major determinant of brain response to nicotine.
Authors: Fallon J.H. , Keator D.B. , Mbogori J. , Taylor D. , Potkin S.G. .
Source: The International Journal Of Neuropsychopharmacology / Official Scientific Journal Of The Collegium Internationale Neuropsychopharmacologicum (cinp), 2005 Mar; 8(1), p. 17-26.
PMID: 15579215
Related Citations

Regulation of Homer and group I metabotropic glutamate receptors by nicotine.
Authors: Kane J.K. , Hwang Y. , Konu O. , Loughlin S.E. , Leslie F.M. , Li M.D. .
Source: The European Journal Of Neuroscience, 2005 Mar; 21(5), p. 1145-54.
PMID: 15813924
Related Citations

The AMA proposal to mandate nicotine reduction in cigarettes: a simulation of the population health impacts.
Authors: Tengs T.O. , Ahmad S. , Savage J.M. , Moore R. , Gage E. .
Source: Preventive Medicine, 2005 Feb; 40(2), p. 170-80.
PMID: 15533526
Related Citations

In vivo studies of transdisciplinary scientific collaboration Lessons learned and implications for active living research.
Authors: Stokols D. , Harvey R. , Gress J. , Fuqua J. , Phillips K. .
Source: American Journal Of Preventive Medicine, 2005 Feb; 28(2 Suppl 2), p. 202-13.
PMID: 15694529
Related Citations

Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate.
Authors: Chattopadhyay S. , Xue B. , Collins D. , Pichika R. , Bagnera R. , Leslie F.M. , Christian B.T. , Shi B. , Narayanan T.K. , Potkin S.G. , et al. .
Source: Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine, 2005 Jan; 46(1), p. 130-40.
PMID: 15632043
Related Citations

Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats.
Authors: Belluzzi J.D. , Lee A.G. , Oliff H.S. , Leslie F.M. .
Source: Psychopharmacology, 2004 Jul; 174(3), p. 389-95.
PMID: 14740150
Related Citations

Adolescent development of forebrain stimulant responsiveness: insights from animal studies.
Authors: Leslie F.M. , Loughlin S.E. , Wang R. , Perez L. , Lotfipour S. , Belluzzia J.D. .
Source: Annals Of The New York Academy Of Sciences, 2004 Jun; 1021, p. 148-59.
PMID: 15251884
Related Citations

Hostility differentiates the brain metabolic effects of nicotine.
Authors: Fallon J.H. , Keator D.B. , Mbogori J. , Turner J. , Potkin S.G. .
Source: Brain Research. Cognitive Brain Research, 2004 Jan; 18(2), p. 142-8.
PMID: 14736573
Related Citations

Transdisciplinary collaboration as a basis for enhancing the science and prevention of Substance use and "Abuse".
Authors: Fuqua J. , Stokols D. , Gress J. , Phillips K. , Harvey R. .
Source: Substance Use & Misuse, 2004; 39(10-12), p. 1457-514.
PMID: 15587944
Related Citations

Is there a link between adolescent cigarette smoking and pharmacotherapy for ADHD?
Authors: Whalen C.K. , Jamner L.D. , Henker B. , Gehricke J.G. , King P.S. .
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2003 Dec; 17(4), p. 332-5.
PMID: 14640830
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Tobacco use across the formative years: a road map to developmental vulnerabilities.
Authors: Jamner L.D. , Whalen C.K. , Loughlin S.E. , Mermelstein R. , Audrain-McGovern J. , Krishnan-Sarin S. , Worden J.K. , Leslie F.M. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2003 Dec; 5 Suppl 1, p. S71-87.
PMID: 14668088
Related Citations

Gender specific effect of neonatal handling on stress reactivity of adolescent rats.
Authors: Park M.K. , Hoang T.A. , Belluzzi J.D. , Leslie F.M. .
Source: Journal Of Neuroendocrinology, 2003 Mar; 15(3), p. 289-95.
PMID: 12588518
Related Citations

Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum.
Authors: O'Leary K.T. , Leslie F.M. .
Source: Journal Of Neurochemistry, 2003 Mar; 84(5), p. 952-9.
PMID: 12603820
Related Citations

Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Authors: Solbrig M.V. , Koob G.F. .
Source: Pharmacology, Biochemistry, And Behavior, 2003 Mar; 74(4), p. 777-87.
PMID: 12667891
Related Citations

Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons.
Authors: Azam L. , Winzer-Serhan U. , Leslie F.M. .
Source: Neuroscience, 2003; 119(4), p. 965-77.
PMID: 12831856
Related Citations

Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception.
Authors: Lin S.H. , Leslie F.M. , Civelli O. .
Source: Brain Research, 2002-10-11 00:00:00.0; 952(1), p. 15-30.
PMID: 12363400
Related Citations

Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1.
Authors: Maidment N.T. , Chen Y. , Tan A.M. , Murphy N.P. , Leslie F.M. .
Source: Neuroreport, 2002-07-02 00:00:00.0; 13(9), p. 1137-40.
PMID: 12151756
Related Citations

Anxiety, affect, and activity in teenagers: monitoring daily life with electronic diaries.
Authors: Henker B. , Whalen C.K. , Jamner L.D. , Delfino R.J. .
Source: Journal Of The American Academy Of Child And Adolescent Psychiatry, 2002 Jun; 41(6), p. 660-70.
PMID: 12049440
Related Citations

Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons.
Authors: Azam L. , Winzer-Serhan U.H. , Chen Y. , Leslie F.M. .
Source: The Journal Of Comparative Neurology, 2002-03-12 00:00:00.0; 444(3), p. 260-74.
PMID: 11840479
Related Citations

Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.
Authors: Hilgenberg L.G. , Ho K.D. , Lee D. , O'Dowd D.K. , Smith M.A. .
Source: Molecular And Cellular Neurosciences, 2002 Jan; 19(1), p. 97-110.
PMID: 11817901
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The ADHD spectrum and everyday life: experience sampling of adolescent moods, activities, smoking, and drinking.
Authors: Whalen C.K. , Jamner L.D. , Henker B. , Delfino R.J. , Lozano J.M. .
Source: Child Development, 2002 Jan-Feb; 73(1), p. 209-27.
PMID: 14717253
Related Citations

The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat.
Authors: Clark S.D. , Nothacker H.P. , Wang Z. , Saito Y. , Leslie F.M. , Civelli O. .
Source: Brain Research, 2001-12-27 00:00:00.0; 923(1-2), p. 120-7.
PMID: 11743979
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The cost-effectiveness of intensive national school-based anti-tobacco education: results from the tobacco policy model.
Authors: Tengs T.O. , Osgood N.D. , Chen L.L. .
Source: Preventive Medicine, 2001 Dec; 33(6), p. 558-70.
PMID: 11716651
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Public health impact of changes in smoking behavior: results from the Tobacco Policy Model.
Authors: Tengs T.O. , Osgood N.D. , Lin T.H. .
Source: Medical Care, 2001 Oct; 39(10), p. 1131-41.
PMID: 11567175
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Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain.
Authors: Saito Y. , Cheng M. , Leslie F.M. , Civelli O. .
Source: The Journal Of Comparative Neurology, 2001-06-18 00:00:00.0; 435(1), p. 26-40.
PMID: 11370009
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