||5R21CA094550-03 Interpret this number
||Univ Of Med/Dent Nj-R W Johnson Med Sch
||Passive Pah and Micro-Camera Personal Monitoring System
DESCRIPTION (provided by applicant):
The overall objective of the research is to develop a new sensitive passive
diffusion sampler and couple its use to a miniaturized personal portable video
camera system (MPPVCS) for the measurement and assessment of personal exposure
to carcinogenic organics in personal air. The proposed research, will: 1.
determine the sampling rate under different sampling conditions (different air
concentration, sampling duration, temperature, humidity, and face velocity);
2. evaluate the performance of the sampler in side-by-side comparisons with
proven active sampling method; 3. evaluate the ability of subjects to
successfully wear and manage battery and tape changes; and 4. evaluate the
combined effectiveness of the sampler and MPPVCS to capture information about
volunteer personal exposures to carcinogenic organics. The new passive sampler
consists of a denuder, which is made from 10 0.5-cm (or longer) sections of a
multi-capillary gas chromatography (GC) column (900 of 40-micrometer internal
diameter). Due to the high value of diffusive area (inner cylindrical surface)
to diffusive path length (the radius of the each column), the sampling rate
will be about 1000 times higher than the traditional badge or tube-type
diffusive samplers. The denuder-type geometry would allow constant sampling
rates in a wide range of sampling conditions. Also, the stationary phase of
the capillary column allows directly thermal desorption of analytes to an
analytical instrument, which avoids dilution of the sample by solvent and
increase the sensitivity by a factor of 100. The sampler can be used
repeatedly without any regeneration process. During the exposure session, a
lightweight, unobtrusive, MPPVCS will be attached to the subject to obtain
real time information about proximity to sources of carcinogenic organics and
the individual's activities at a given period of time. MPPVCS is less than 1
pound and can be comfortable for individuals to wear. The use of MPPVCS can
reduce the costs and burden associated with having a videographer track the
individual, reduce the burden associated with having subject completing
questionnaires and time/activity diaries, and avoid information loss due to
subjects' completion failure and loss of awareness of their activities and the
environment. In summary, we propose to develop and validate a sensitive,
simple, and cost-effective technique to directly measure personal exposure to
carcinogenic organics. Joint use of the new diffusive sampler and MPPVCS would
capture both the levels of exposure and the locations of exposure, and
possible sources. The combined approach will improve the accuracy of community
or residential assessments of personal exposure to carcinogens for prospective
epidemiologieal studies, and provide the improved characterization of exposure
for risk assessments.
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