Grant Number:	1R03CA101442-01 Interpret this number
Primary Investigator:	Brennan, Paul
Organization:	International Agency For Res On Cancer
Project Title:	Multicentric Pooled Analysis of Second Primary Cancer
Fiscal Year:	2003

DESCRIPTION (provided by applicant): With increasing success of modern cancer therapy in achieving long-term remission in many patients, second primary cancers are a rapidly increasing disease category. The increased occurrence of second primary tumors after a first primary tumor could arise from: (i) intensive medical surveillance after the first diagnosis; (ii) therapy induced exposure to chemical or physical carcinogens; and (iii) shared environmental and hereditary factors between the first and second cancer. Studies of multiple primary cancers can be rewarding for several reasons. First of all, they can help to identify common risk factors between a second and a first primary cancer, including environmental exposures and genetic factors. Studies on second primaries may also identify groups of cancer patients who are in need of increased surveillance aimed at early detection, allowing measures to prevent the occurrence of subsequent cancer incidence and mortality. Studies of second primary cancers, therefore, have the potential to provide relevant insights into cancer epidemiology, etiology and clinical practice. Until recently, most studies on second primary cancers have been based on individual cancer registries. This is problematic when trying to assess the consistency and validity of reported associations; specifically, when it comes to the more rare cancer types. In order to conduct a systematic analysis of second primary neoplasms for all cancer sites, we have developed an international multi-center study of second primary cancers incorporating 15 large cancer registries, which have been in operation for at least 25 years. Data pooling and verification is now complete for 13 of the 15 cancer registries, resulting in a cohort of 3,722,434 individuals with a cancer and 22,376,682 2-person years of follow-up. It is expected that the final database comprising information from all 15 cancer registries will be available by December 2002. Using this database we propose to conduct a systematic analysis of second primary cancers. This analysis will concentrate on specific hypotheses including: (i) an investigation of groups of cancers potentially related to specific exposures (e.g., ultraviolet light); (ii) an investigation of rare cancer types (e.g., bone cancer or sarcomas); and (iii) an investigation of second primary cancers which may be increased due to treatment of a first primary cancer (e.g., leukemia).




Second malignancies after childhood noncentral nervous system solid cancer: Results from 13 cancer registries.
Authors: Maule M. , Scélo G. , Pastore G. , Brennan P. , Hemminki K. , Olsen J.H. , Tracey E. , Pukkala E. , Weiderpass E. , Brewster D.H. , et al. .
Source: International Journal Of Cancer, 2011-10-15 00:00:00.0; 129(8), p. 1940-52.
EPub date: 2011-10-15 00:00:00.0.
PMID: 21520035
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High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries.
Authors: Bosetti C. , Scelo G. , Chuang S.C. , Tonita J.M. , Tamaro S. , Jonasson J.G. , Kliewer E.V. , Hemminki K. , Weiderpass E. , Pukkala E. , et al. .
Source: International Journal Of Cancer, 2011-07-01 00:00:00.0; 129(1), p. 173-9.
EPub date: 2011-07-01 00:00:00.0.
PMID: 20824702
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Risks of second primary cancer among patients with major histological types of lung cancers in both men and women.
Authors: Chuang S.C. , Scélo G. , Lee Y.C. , Friis S. , Pukkala E. , Brewster D.H. , Hemminki K. , Tracey E. , Weiderpass E. , Tamaro S. , et al. .
Source: British Journal Of Cancer, 2010-03-30 00:00:00.0; 102(7), p. 1190-5.
PMID: 20354532
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Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries.
Authors: Chuang S.C. , Scelo G. , Tonita J.M. , Tamaro S. , Jonasson J.G. , Kliewer E.V. , Hemminki K. , Weiderpass E. , Pukkala E. , Tracey E. , et al. .
Source: International Journal Of Cancer, 2008-11-15 00:00:00.0; 123(10), p. 2390-6.
PMID: 18729183
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Risk of second primary cancer among esophageal cancer patients: a pooled analysis of 13 cancer registries.
Authors: Chuang S.C. , Hashibe M. , Scelo G. , Brewster D.H. , Pukkala E. , Friis S. , Tracey E. , Weiderpass E. , Hemminki K. , Tamaro S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Jun; 17(6), p. 1543-9.
PMID: 18559572
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Risk of second malignant neoplasms after childhood central nervous system malignant tumours: an international study.
Authors: Maule M. , Scélo G. , Pastore G. , Brennan P. , Hemminki K. , Pukkala E. , Weiderpass E. , Olsen J.H. , Tracey E. , McBride M.L. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2008 Apr; 44(6), p. 830-9.
PMID: 18329873
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Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation.
Authors: Tuohimaa P. , Pukkala E. , Scélo G. , Olsen J.H. , Brewster D.H. , Hemminki K. , Tracey E. , Weiderpass E. , Kliewer E.V. , Pompe-Kirn V. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2007 Jul; 43(11), p. 1701-12.
PMID: 17540555
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Second primary malignancies in females with primary fallopian tube cancer.
Authors: Riska A. , Pukkala E. , Scélo G. , Mellemkjaer L. , Hemminki K. , Weiderpass E. , McBride M.L. , Pompe-Kirn V. , Tracey E. , Brewster D.H. , et al. .
Source: International Journal Of Cancer, 2007-05-01 00:00:00.0; 120(9), p. 2047-51.
PMID: 17266029
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Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries.
Authors: Scélo G. , Boffetta P. , Corbex M. , Chia K.S. , Hemminki K. , Friis S. , Pukkala E. , Weiderpass E. , McBride M.L. , Tracey E. , et al. .
Source: Cancer Causes & Control : Ccc, 2007 Apr; 18(3), p. 269-78.
PMID: 17237987
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Second malignancies among survivors of germ-cell testicular cancer: a pooled analysis between 13 cancer registries.
Authors: Richiardi L. , Scélo G. , Boffetta P. , Hemminki K. , Pukkala E. , Olsen J.H. , Weiderpass E. , Tracey E. , Brewster D.H. , McBride M.L. , et al. .
Source: International Journal Of Cancer, 2007-02-01 00:00:00.0; 120(3), p. 623-31.
PMID: 17096341
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Associations between ocular melanoma and other primary cancers: an international population-based study.
Authors: Scélo G. , Boffetta P. , Autier P. , Hemminki K. , Pukkala E. , Olsen J.H. , Weiderpass E. , Tracey E. , Brewster D.H. , McBride M.L. , et al. .
Source: International Journal Of Cancer, 2007-01-01 00:00:00.0; 120(1), p. 152-9.
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Risk of second cancer among women with breast cancer.
Authors: Mellemkjaer L. , Friis S. , Olsen J.H. , Scélo G. , Hemminki K. , Tracey E. , Andersen A. , Brewster D.H. , Pukkala E. , McBride M.L. , et al. .
Source: International Journal Of Cancer, 2006-05-01 00:00:00.0; 118(9), p. 2285-92.
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Associations between small intestine cancer and other primary cancers: an international population-based study.
Authors: Scélo G. , Boffetta P. , Hemminki K. , Pukkala E. , Olsen J.H. , Andersen A. , Tracey E. , Brewster D.H. , McBride M.L. , Kliewer E.V. , et al. .
Source: International Journal Of Cancer, 2006-01-01 00:00:00.0; 118(1), p. 189-96.
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Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma.
Authors: Brennan P. , Scélo G. , Hemminki K. , Mellemkjaer L. , Tracey E. , Andersen A. , Brewster D.H. , Pukkala E. , McBride M.L. , Kliewer E.V. , et al. .
Source: British Journal Of Cancer, 2005-07-11 00:00:00.0; 93(1), p. 159-66.
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