Grant Details
Grant Number: |
5R01CA082378-04 Interpret this number |
Primary Investigator: |
Phipps, Sean |
Organization: |
St. Jude Children'S Research Hospital |
Project Title: |
Measurement of Adaptive Style in Children with Cancer |
Fiscal Year: |
2003 |
Abstract
Description (adapted from investigator's abstract): The construct of adaptive
style provides a heuristic model for understanding the frequently reported
findings of lower self-reports of psychological distress in children with
cancer, in comparison to healthy children. Assessment of adaptive style allows
for differentiation between truly low anxious individuals, who accurately
report low levels of distress, and repressors, who maladaptively avoid the
perception of negative affect of distress. In adults, repressive adaptation has
been associated with altered patterns of physiological response to stress, and
is related to numerous adverse health outcomes. Such relationships have not yet
been studied in children. Recent studies have demonstrated a significantly
higher incidence of repressors in children with cancer relative to healthy
children, which accounts, in part, for the lower levels of distress by
self-report in these children. Given the higher incidence of repressive
adaptation in children with cancer, adaptive style may be a particularly
important predictor of health outcomes in this population. The present proposal
aims to improve measurement of adaptive style in children by combining
self-report and psychophysiological assessment techniques, while examining the
clinical significance of adaptive style in children undergoing treatment for
cancer. The specific aims of the project are: 1) To determine the physiological
concomitants of adaptive style in healthy children and children with cancer; 2)
To assess the concordance in measurement of adaptive style by self-report and
physiological indices; and 3) to determine the relationship of adaptive style
to tolerance of anti-cancer therapy in children with recently diagnosed
malignancies. These aims will be accomplished through two related studies.
Study 1 will use a two group, case control design, pairing children who have
completed treatment for cancer with healthy children matched on age, race, and
gender. Participants will complete a battery of self report measures assessing
adaptive style and then undergo physiological monitoring (heart rate, blood
pressure, muscle tension, skin conductance, salivary cortisol) in a laboratory
stress assessment task. Study 2 utilizes a single group, short term
longitudinal design to determine the significance of adaptive style as a
predictor of tolerance to anti-cancer therapy in terms of treatment side
effects, acute toxicities and medical complications. Newly diagnosed pediatric
cancer patients will undergo an identical procedure of self-report measures,
stress tasks, and physiological assessment to assess adaptive style, and then
be followed prospectively for 6 months while on active therapy. This study will
advance knowledge regarding adaptive style in children, which can help to
improve identification of truly distressed and non-distressed children, as well
as those who may be at high risk for adverse healthy outcomes as a function of
adaptive style.
Publications
Concordance of parent proxy report and child self-report of posttraumatic stress in children with cancer and healthy children: influence of parental posttraumatic stress.
Authors: Clawson A.H.
, Jurbergs N.
, Lindwall J.
, Phipps S.
.
Source: Psycho-oncology, 2013 Nov; 22(11), p. 2593-600.
PMID: 23723147
Related Citations
Adaptive style and physiological reactivity during a laboratory stress paradigm in children with cancer and healthy controls.
Authors: Williams N.A.
, Allen M.T.
, Phipps S.
.
Source: Journal Of Behavioral Medicine, 2011 Oct; 34(5), p. 372-80.
PMID: 21305350
Related Citations
Optimism and pessimism in children with cancer and healthy children: confirmatory factor analysis of the youth life orientation test and relations with health-related quality of life.
Authors: Williams N.A.
, Davis G.
, Hancock M.
, Phipps S.
.
Source: Journal Of Pediatric Psychology, 2010 Jul; 35(6), p. 672-82.
PMID: 19797406
Related Citations
Brief report: Children's response to serious illness: perceptions of benefit and burden in a pediatric cancer population.
Authors: Currier J.M.
, Hermes S.
, Phipps S.
.
Source: Journal Of Pediatric Psychology, 2009 Nov-Dec; 34(10), p. 1129-34.
PMID: 19342537
Related Citations
Symptoms of post-traumatic stress in children with cancer: does personality trump health status?
Authors: Phipps S.
, Jurbergs N.
, Long A.
.
Source: Psycho-oncology, 2009 Sep; 18(9), p. 992-1002.
PMID: 19177432
Related Citations
Stressful life events and posttraumatic stress symptoms in children with cancer.
Authors: Currier J.M.
, Jobe-Shields L.E.
, Phipps S.
.
Source: Journal Of Traumatic Stress, 2009 Feb; 22(1), p. 28-35.
PMID: 19117041
Related Citations
Symptoms of posttraumatic stress in parents of children with cancer: are they elevated relative to parents of healthy children?
Authors: Jurbergs N.
, Long A.
, Ticona L.
, Phipps S.
.
Source: Journal Of Pediatric Psychology, 2009 Jan-Feb; 34(1), p. 4-13.
PMID: 18073235
Related Citations
The Anger Expression Scale for Children: initial validation among healthy children and children with cancer.
Authors: Steele R.G.
, Legerski J.P.
, Nelson T.D.
, Phipps S.
.
Source: Journal Of Pediatric Psychology, 2009 Jan-Feb; 34(1), p. 51-62.
PMID: 18556672
Related Citations
Benefit Finding Scale for Children: preliminary findings from a childhood cancer population.
Authors: Phipps S.
, Long A.M.
, Ogden J.
.
Source: Journal Of Pediatric Psychology, 2007 Nov-Dec; 32(10), p. 1264-71.
PMID: 17210581
Related Citations
Adaptive style in children with cancer: implications for a positive psychology approach.
Authors: Phipps S.
.
Source: Journal Of Pediatric Psychology, 2007 Oct; 32(9), p. 1055-66.
PMID: 17698880
Related Citations
Self-report of somatic symptoms in survivors of childhood cancer: effects of adaptive style.
Authors: Jurbergs N.
, Long A.
, Hudson M.
, Phipps S.
.
Source: Pediatric Blood & Cancer, 2007 Jul; 49(1), p. 84-9.
PMID: 16847928
Related Citations
Assessment of health-related quality of life in children with cancer: consistency and agreement between parent and child reports.
Authors: Russell K.M.
, Hudson M.
, Long A.
, Phipps S.
.
Source: Cancer, 2006-05-15 00:00:00.0; 106(10), p. 2267-74.
PMID: 16604563
Related Citations
Adaptive style and symptoms of posttraumatic stress in children with cancer and their parents.
Authors: Phipps S.
, Larson S.
, Long A.
, Rai S.N.
.
Source: Journal Of Pediatric Psychology, 2006 Apr; 31(3), p. 298-309.
PMID: 15917493
Related Citations
Symptoms of post-traumatic stress in children with cancer and their parents: effects of informant and time from diagnosis.
Authors: Phipps S.
, Long A.
, Hudson M.
, Rai S.N.
.
Source: Pediatric Blood & Cancer, 2005 Dec; 45(7), p. 952-9.
PMID: 15806541
Related Citations
Commentary: contexts and challenges in pediatric psychosocial oncology research: chasing moving targets and embracing "good news" outcomes.
Authors: Phipps S.
.
Source: Journal Of Pediatric Psychology, 2005 Jan-Feb; 30(1), p. 41-5.
PMID: 15610983
Related Citations