||5R03CA096434-02 Interpret this number
||Fred Hutchinson Can Res Ctr
||Smoking During Pregnancy and Breast Cancer
DESCRIPTION (provided by applicant):
Although cigarette smoking has been linked to the etiology of several cancers,
the relationship between smoking and breast cancer remains unclear. A woman's
first pregnancy represents a period of rapid breast cell growth and
differentiation and thus, a period of vulnerability to the influences of
smoking or other exposures. During pregnancy, tobacco mutagens and free
radical formation caused by smoking may affect rapidly growing breast tissue
or act synergistically with elevated estrogens to increase breast cancer risk.
Because breast tissue is less differentiated at the onset of first pregnancy,
it may be more susceptible to mutagenesis than in subsequent pregnancies.
The proposed population-based case-control study will utilize linked vital
statistics - cancer registry data to test the hypothesis that cigarette
smoking during first pregnancy is related to the risk of breast cancer. The
specific aims of this study are to: 1)measure the risk of breast cancer
associated with smoking during a first pregnancy relative to not smoking
during the first pregnancy, and 2)evaluate possible differences in the
relation between smoking during first pregnancy and breast cancer by tumor
estrogen receptor status. To the extent possible, the study will also evaluate
a possible dose response relation between the average number of cigarettes
smoked per day during first pregnancy and breast cancer risk, and measure
possible differences in the relation between smoking during first pregnancy
and breast cancer risk by subject characteristics such as parity at the time
of diagnosis and pre-pregnancy weight. This study will be among the first to
examine smoking during first pregnancy and breast cancer risk. The
clarification of the role of smoking during first pregnancy in breast cancer
development will aid in understanding the complex etiology of breast cancer,
and may identify a specific preventive strategy to help reduce breast cancer
Smoking during first pregnancy and breast cancer: a case-control study using Washington State registry data.
, Cummings P.
, Daling J.R.
, Mueller B.A.
Annals of epidemiology, 2011 Jan; 21(1), p. 53-5.